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Items: 1 to 50 of 284

1.

Design and Evaluation of PEGylated Liposomal Formulation of a Novel Multikinase Inhibitor for Enhanced Chemosensitivity and Inhibition of Metastatic Pancreatic Ductal Adenocarcinoma.

Madamsetty VS, Pal K, Dutta SK, Wang E, Thompson JR, Banerjee RK, Caulfield TR, Mody K, Yen Y, Mukhopadhyay D, Huang HS.

Bioconjug Chem. 2019 Oct 16;30(10):2703-2713. doi: 10.1021/acs.bioconjchem.9b00632. Epub 2019 Oct 4.

PMID:
31584260
2.

Molecular Inhibitor of QSOX1 Suppresses Tumor Growth in vivo.

Fifield AL, Hanavan PD, Faigel DO, Sergienko E, Bobkov A, Meurice N, Petit JL, Polito A, Caulfield TR, Castle EP, Copland JA, Mukhopadhyay D, Pal K, Dutta SK, Luo H, Ho TH, Lake DF.

Mol Cancer Ther. 2019 Oct 1. pii: molcanther.0233.2019. doi: 10.1158/1535-7163.MCT-19-0233. [Epub ahead of print]

PMID:
31575656
3.

Regulatory and policy tools to address unproven stem cell interventions in Canada: the need for action.

Caulfield T, Murdoch B.

BMC Med Ethics. 2019 Aug 6;20(1):51. doi: 10.1186/s12910-019-0388-4.

4.

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.

Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G.

Nat Rev Neurol. 2019 Sep;15(9):501-518. doi: 10.1038/s41582-019-0228-7. Epub 2019 Jul 31. Review.

PMID:
31367008
5.

Addressing Internalized Weight Bias and Changing Damaged Social Identities for People Living With Obesity.

Ramos Salas X, Forhan M, Caulfield T, Sharma AM, Raine KD.

Front Psychol. 2019 Jun 26;10:1409. doi: 10.3389/fpsyg.2019.01409. eCollection 2019.

6.

How to Peddle Hope: An Analysis of YouTube Patient Testimonials of Unproven Stem Cell Treatments.

Hawke B, Przybylo AR, Paciulli D, Caulfield T, Zarzeczny A, Master Z.

Stem Cell Reports. 2019 Jun 11;12(6):1186-1189. doi: 10.1016/j.stemcr.2019.05.009.

7.

The stem cell market and policy options: a call for clarity.

Zarzeczny A, Atkins H, Illes J, Kimmelman J, Master Z, Robillard JM, Snyder J, Turner L, Zettler PJ, Caulfield T.

J Law Biosci. 2018 Nov 20;5(3):743-758. doi: 10.1093/jlb/lsy025. eCollection 2018 Dec. No abstract available.

8.

Genomic Observations of a Rare/Pathogenic SMAD3 Variant in Loeys⁻Dietz Syndrome 3 Confirmed by Protein Informatics and Structural Investigations.

Richter JE Jr, Samreen A, Vadlamudi C, Helmi H, Mohammad AN, Wierenga K, Hines S, Atwal PS, Caulfield TR.

Medicina (Kaunas). 2019 May 15;55(5). pii: E137. doi: 10.3390/medicina55050137.

9.

Promotion of Testing for Celiac Disease and the Gluten-Free Diet Among Complementary and Alternative Medicine Practitioners.

Boyer G, Caulfield T, Green PHR, Lebwohl B.

Am J Gastroenterol. 2019 May;114(5):786-791. doi: 10.14309/ajg.0000000000000238.

PMID:
31082840
10.

Media portrayal of illness-related medical crowdfunding: A content analysis of newspaper articles in the United States and Canada.

Murdoch B, Marcon AR, Downie D, Caulfield T.

PLoS One. 2019 Apr 23;14(4):e0215805. doi: 10.1371/journal.pone.0215805. eCollection 2019.

11.

CRISPR in the North American popular press.

Marcon A, Master Z, Ravitsky V, Caulfield T.

Genet Med. 2019 Oct;21(10):2184-2189. doi: 10.1038/s41436-019-0482-5. Epub 2019 Apr 12.

12.

Privacy in Direct-to-Consumer Genetic Testing.

Park JY, Risher MT, Caulfield T, Baudhuin LM, Schwab AP.

Clin Chem. 2019 May;65(5):612-617. doi: 10.1373/clinchem.2018.298935. Epub 2019 Feb 28. No abstract available.

PMID:
30819664
13.

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.

Cohen I, Coban M, Shahar A, Sankaran B, Hockla A, Lacham S, Caulfield TR, Radisky ES, Papo N.

J Biol Chem. 2019 Mar 29;294(13):5105-5120. doi: 10.1074/jbc.RA118.007292. Epub 2019 Jan 30.

PMID:
30700553
14.

Protein informatics combined with multiple data sources enriches the clinical characterization of novel TRPV4 variant causing an intermediate skeletal dysplasia.

Hines SL, Richter JE Jr, Mohammad AN, Mahim J, Atwal PS, Caulfield TR.

Mol Genet Genomic Med. 2019 Mar;7(3):e566. doi: 10.1002/mgg3.566. Epub 2019 Jan 28.

15.

Integrative data fusion for comprehensive assessment of a novel CHEK2 variant using combined genomics, imaging, and functional-structural assessments via protein informatics.

Hines SL, Mohammad AN, Jackson J, Macklin S, Caulfield TR.

Mol Omics. 2019 Feb 11;15(1):59-66. doi: 10.1039/c8mo00137e.

PMID:
30633282
16.

Patients' crowdfunding campaigns for alternative cancer treatments.

Snyder J, Caulfield T.

Lancet Oncol. 2019 Jan;20(1):28-29. doi: 10.1016/S1470-2045(18)30950-1. No abstract available.

PMID:
30614463
17.

Spinning the Genome: Why Science Hype Matters.

Caulfield T.

Perspect Biol Med. 2018;61(4):560-571. doi: 10.1353/pbm.2018.0065.

PMID:
30613038
18.

Influenza vaccination discourse in major Canadian news media, 2017-2018.

Murdoch B, Caulfield T.

Heliyon. 2018 Nov 27;4(11):e00970. doi: 10.1016/j.heliyon.2018.e00970. eCollection 2018 Nov.

19.

The law of food allergy and accommodation in Canadian schools.

Murdoch B, Adams EM, Caulfield T.

Allergy Asthma Clin Immunol. 2018 Oct 22;14:67. doi: 10.1186/s13223-018-0273-6. eCollection 2018. Review.

20.

TRIO gene segregation in a family with cerebellar ataxia.

Hanna Al Shaikh R, Caulfield T, Strongosky AJ, Matthew M, Jansen-West KR, Prudencio M, Fryer JD, Petrucelli L, Uitti RJ, Wszolek ZK.

Neurol Neurochir Pol. 2018 Nov - Dec;52(6):743-749. doi: 10.1016/j.pjnns.2018.09.006. Epub 2018 Sep 22.

PMID:
30279051
21.

Protein modeling and clinical description of a novel in-frame GLB1 deletion causing GM1 gangliosidosis type II.

Richter JE Jr, Zimmermann MT, Blackburn PR, Mohammad AN, Klee EW, Pollard LM, Macmurdo CF, Atwal PS, Caulfield TR.

Mol Genet Genomic Med. 2018 Nov;6(6):1229-1235. doi: 10.1002/mgg3.454. Epub 2018 Sep 5.

22.

Elle Macpherson, "anti-vaxx" nonsense, and the opportunity to engage.

Caulfield T.

BMJ. 2018 Jul 31;362:k3255. doi: 10.1136/bmj.k3255. No abstract available.

PMID:
30065021
23.

Personalized molecular modeling for pinpointing associations of protein dysfunction and variants associated with hereditary cancer syndromes.

Macklin S, Mohammed A, Jackson J, Hines SL, Atwal PS, Caulfield T.

Mol Genet Genomic Med. 2018 Sep;6(5):805-810. doi: 10.1002/mgg3.447. Epub 2018 Jul 24.

24.

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.

Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, Van Damme P, Van Den Bosch L.

Cell Rep. 2018 Jul 17;24(3):529-537.e4. doi: 10.1016/j.celrep.2018.06.070.

25.

Protein molecular modeling techniques investigating novel TAB2 variant R347X causing cardiomyopathy and congenital heart defects in multigenerational family.

Caulfield TR, Richter JE Jr, Brown EE, Mohammad AN, Judge DP, Atwal PS.

Mol Genet Genomic Med. 2018 Apr 26. doi: 10.1002/mgg3.401. [Epub ahead of print]

26.

Whole Exome Sequencing and Molecular Modeling of a Missense Variant in TNFAIP3 That Segregates with Disease in a Family with Chronic Urticaria and Angioedema.

Harris AL, Blackburn PR, Richter JE Jr, Gass JM, Caulfield TR, Mohammad AN, Atwal PS.

Case Rep Genet. 2018 Feb 22;2018:6968395. doi: 10.1155/2018/6968395. eCollection 2018.

27.

Protein molecular modeling shows residue T599 is critical to wild-type function of POLG and description of a novel variant associated with the SANDO phenotype.

Richter JE, Robles HG, Mauricio E, Mohammad A, Atwal PS, Caulfield TR.

Hum Genome Var. 2018 Apr 5;5:18016. doi: 10.1038/hgv.2018.16. eCollection 2018.

28.

Geolocalisation of athletes for out-of-competition drug testing: ethical considerations. Position statement by the WADA Ethics Panel.

Borry P, Caulfield T, Estivill X, Loland S, McNamee M, Knoppers BM; WADA Ethics Panel.

Br J Sports Med. 2018 Apr;52(7):456-459. doi: 10.1136/bjsports-2017-098299. Epub 2018 Mar 2.

29.

Exploiting science? A systematic analysis of complementary and alternative medicine clinic websites' marketing of stem cell therapies.

Murdoch B, Zarzeczny A, Caulfield T.

BMJ Open. 2018 Feb 28;8(2):e019414. doi: 10.1136/bmjopen-2017-019414.

30.

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy.

von Roemeling CA, Caulfield TR, Marlow L, Bok I, Wen J, Miller JL, Hughes R, Hazlehurst L, Pinkerton AB, Radisky DC, Tun HW, Kim YSB, Lane AL, Copland JA.

Oncotarget. 2017 Oct 6;9(1):3-20. doi: 10.18632/oncotarget.21545. eCollection 2018 Jan 2.

31.

Authors' response to Invited Commentary by Brady and Beausoleil.

Ramos Salas X, Forhan M, Caulfield T, Sharma AM, Raine K.

Can J Public Health. 2018 Jan 22;108(5-6):e646-e647. doi: 10.17269/cjph.108.6559. No abstract available.

PMID:
29356679
32.

A critical analysis of obesity prevention policies and strategies.

Ramos Salas X, Forhan M, Caulfield T, Sharma AM, Raine K.

Can J Public Health. 2018 Jan 22;108(5-6):e598-e608. doi: 10.17269/cjph.108.6044.

PMID:
29356669
33.

Human gene editing: revisiting Canadian policy.

Knoppers BM, Isasi R, Caulfield T, Kleiderman E, Bedford P, Illes J, Ogbogu U, Ravitsky V, Rudnicki M.

NPJ Regen Med. 2017 Jan 5;2:3. doi: 10.1038/s41536-017-0007-2. eCollection 2017. No abstract available.

34.

Representing a "revolution": how the popular press has portrayed personalized medicine.

Marcon AR, Bieber M, Caulfield T.

Genet Med. 2018 Sep;20(9):950-956. doi: 10.1038/gim.2017.217. Epub 2018 Jan 4.

PMID:
29300377
35.

A novel splice site variant in CYP11A1 in trans with the p.E314K variant in a male patient with congenital adrenal insufficiency.

Lara-Velazquez M, Perdomo-Pantoja A, Blackburn PR, Gass JM, Caulfield TR, Atwal PS.

Mol Genet Genomic Med. 2017 Nov;5(6):781-787. doi: 10.1002/mgg3.322. Epub 2017 Jul 20.

36.

Fake news portrayals of stem cells and stem cell research.

Marcon AR, Murdoch B, Caulfield T.

Regen Med. 2017 Oct;12(7):765-775. doi: 10.2217/rme-2017-0060. Epub 2017 Nov 8.

37.

Family veto in organ donation in Canada: framing within English-language newspaper articles.

Anthony SJ, Toews M, Caulfield T, Wright L.

CMAJ Open. 2017 Oct 17;5(4):E768-E772. doi: 10.9778/cmajo.20170051.

38.

Multifaceted peptide assisted one-pot synthesis of gold nanoparticles for plectin-1 targeted gemcitabine delivery in pancreatic cancer.

Pal K, Al-Suraih F, Gonzalez-Rodriguez R, Dutta SK, Wang E, Kwak HS, Caulfield TR, Coffer JL, Bhattacharya S.

Nanoscale. 2017 Oct 19;9(40):15622-15634. doi: 10.1039/c7nr03172f.

39.

Implicit hype? Representations of platelet rich plasma in the news media.

Rachul C, Rasko JEJ, Caulfield T.

PLoS One. 2017 Aug 9;12(8):e0182496. doi: 10.1371/journal.pone.0182496. eCollection 2017.

40.

Genes, cells, and biobanks: Yes, there's still a consent problem.

Caulfield T, Murdoch B.

PLoS Biol. 2017 Jul 25;15(7):e2002654. doi: 10.1371/journal.pbio.2002654. eCollection 2017 Jul. Review.

41.

Walking Together: Towards a Collaborative Model for Maternal Health Care in Pastoralist Communities of Laikipia and Samburu, Kenya.

Kermode M, Morgan A, Nyagero J, Nderitu F, Caulfield T, Reeve M, Nduba J.

Matern Child Health J. 2017 Oct;21(10):1867-1873. doi: 10.1007/s10995-017-2337-5.

PMID:
28702863
42.

Marketing of unproven stem cell-based interventions: A call to action.

Sipp D, Caulfield T, Kaye J, Barfoot J, Blackburn C, Chan S, De Luca M, Kent A, McCabe C, Munsie M, Sleeboom-Faulkner M, Sugarman J, van Zimmeren E, Zarzeczny A, Rasko JEJ.

Sci Transl Med. 2017 Jul 5;9(397). pii: eaag0426. doi: 10.1126/scitranslmed.aag0426. Review.

43.

Waldenstrom macroglobulinemia cells devoid of BTKC481S or CXCR4WHIM-like mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment.

Paulus A, Akhtar S, Yousaf H, Manna A, Paulus SM, Bashir Y, Caulfield TR, Kuranz-Blake M, Chitta K, Wang X, Asmann Y, Hudec R, Springer W, Ailawadhi S, Chanan-Khan A.

Blood Cancer J. 2017 May 26;7(5):e565. doi: 10.1038/bcj.2017.40.

44.

Small molecule inhibitors of mesotrypsin from a structure-based docking screen.

Kayode O, Huang Z, Soares AS, Caulfield TR, Dong Z, Bode AM, Radisky ES.

PLoS One. 2017 May 2;12(5):e0176694. doi: 10.1371/journal.pone.0176694. eCollection 2017.

45.

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.

Ando M, Fiesel FC, Hudec R, Caulfield TR, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson VL, Dawson TM, Bu G, Ross OA, Wszolek ZK, Springer W.

Mol Neurodegener. 2017 Apr 24;12(1):32. doi: 10.1186/s13024-017-0174-z.

46.

Reply: Heterozygous PINK1 p.G411S in rapid eye movement sleep behaviour disorder.

Puschmann A, Fiesel FC, Caulfield TR, Hudec R, Ando M, Truban D, Hou X, Ogaki K, Heckman MG, James ED, Swanberg M, Jimenez-Ferrer I, Hansson O, Opala G, Siuda J, Boczarska-Jedynak M, Friedman A, Koziorowski D, Rudzinska-Bar M, Aasly JO, Lynch T, Mellick GD, Mohan M, Silburn PA, Sanotsky Y, Vilariño-Güell C, Farrer MJ, Chen L, Dawson VL, Dawson TM, Wszolek ZK, Ross OA, Springer W.

Brain. 2017 Jun 1;140(6):e33. doi: 10.1093/brain/awx077. No abstract available.

47.

Celebrities' impact on health-related knowledge, attitudes, behaviors, and status outcomes: protocol for a systematic review, meta-analysis, and meta-regression analysis.

Hoffman SJ, Mansoor Y, Natt N, Sritharan L, Belluz J, Caulfield T, Freedhoff Y, Lavis JN, Sharma AM.

Syst Rev. 2017 Jan 21;6(1):13. doi: 10.1186/s13643-016-0395-1.

48.

Non-invasive Prenatal Testing and the Unveiling of an Impaired Translation Process.

Murdoch B, Ravitsky V, Ogbogu U, Ali-Khan S, Bertier G, Birko S, Bubela T, De Beer J, Dupras C, Ellis M, Granados Moreno P, Joly Y, Kamenova K, Master Z, Marcon A, Paulden M, Rousseau F, Caulfield T.

J Obstet Gynaecol Can. 2017 Jan;39(1):10-17. doi: 10.1016/j.jogc.2016.09.004. Epub 2016 Oct 17.

PMID:
28062017
49.
50.

Evaluating the "family veto" of consent for organ donation.

Toews M, Caulfield T.

CMAJ. 2016 Dec 6;188(17-18):E436-E437. doi: 10.1503/cmaj.160752. Epub 2016 Nov 14. No abstract available.

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