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Items: 1 to 50 of 209

1.

Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients.

Orrù CD, Soldau K, Cordano C, Llibre-Guerra J, Green AJ, Sanchez H, Groveman BR, Edland SD, Safar JG, Lin JH, Caughey B, Geschwind MD, Sigurdson CJ.

MBio. 2018 Nov 20;9(6). pii: e02095-18. doi: 10.1128/mBio.02095-18.

2.

Cell-free prion protein conversion assays in screening for anti-prion drug candidates.

Ferreira NDC, Caughey B.

Curr Opin Pharmacol. 2018 Nov 6;44:1-7. doi: 10.1016/j.coph.2018.10.001. [Epub ahead of print] Review.

PMID:
30412823
3.

Prion-related peripheral neuropathy in sporadic Creutzfeldt-Jakob disease.

Baiardi S, Redaelli V, Ripellino P, Rossi M, Franceschini A, Moggio M, Sola P, Ladogana A, Fociani P, Magherini A, Capellari S, Giese A, Caughey B, Caroppo P, Parchi P.

J Neurol Neurosurg Psychiatry. 2018 Oct 24. pii: jnnp-2018-319221. doi: 10.1136/jnnp-2018-319221. [Epub ahead of print]

PMID:
30355606
4.

Ultrasensitive RT-QuIC Seed Amplification Assays for Disease-Associated Tau, α-Synuclein, and Prion Aggregates.

Saijo E, Groveman BR, Kraus A, Metrick M, Orrù CD, Hughson AG, Caughey B.

Methods Mol Biol. 2019;1873:19-37. doi: 10.1007/978-1-4939-8820-4_2.

PMID:
30341601
5.

Design, implementation, and interpretation of amplification studies for prion detection.

Haley NJ, Richt JA, Davenport KA, Henderson DM, Hoover EA, Manca M, Caughey B, Marthaler D, Bartz J, Gilch S.

Prion. 2018 Mar 4;12(2):73-82. doi: 10.1080/19336896.2018.1443000. Epub 2018 Mar 9.

PMID:
29468946
6.

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.

Groveman BR, Orrù CD, Hughson AG, Raymond LD, Zanusso G, Ghetti B, Campbell KJ, Safar J, Galasko D, Caughey B.

Acta Neuropathol Commun. 2018 Feb 9;6(1):7. doi: 10.1186/s40478-018-0508-2.

7.

Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease.

Orrú CD, Yuan J, Appleby BS, Li B, Li Y, Winner D, Wang Z, Zhan YA, Rodgers M, Rarick J, Wyza RE, Joshi T, Wang GX, Cohen ML, Zhang S, Groveman BR, Petersen RB, Ironside JW, Quiñones-Mateu ME, Safar JG, Kong Q, Caughey B, Zou WQ.

Sci Transl Med. 2017 Nov 22;9(417). pii: eaam7785. doi: 10.1126/scitranslmed.aam7785.

8.

A Promising Antiprion Trimethoxychalcone Binds to the Globular Domain of the Cellular Prion Protein and Changes Its Cellular Location.

Ferreira NC, Ascari LM, Hughson AG, Cavalheiro GR, Góes CF, Fernandes PN, Hollister JR, da Conceição RA, Silva DS, Souza AMT, Barbosa MLC, Lara FA, Martins RAP, Caughey B, Cordeiro Y.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01441-17. doi: 10.1128/AAC.01441-17. Print 2018 Feb.

9.

Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma.

Xu RH, Wei W, Krawczyk M, Wang W, Luo H, Flagg K, Yi S, Shi W, Quan Q, Li K, Zheng L, Zhang H, Caughey BA, Zhao Q, Hou J, Zhang R, Xu Y, Cai H, Li G, Hou R, Zhong Z, Lin D, Fu X, Zhu J, Duan Y, Yu M, Ying B, Zhang W, Wang J, Zhang E, Zhang C, Li O, Guo R, Carter H, Zhu JK, Hao X, Zhang K.

Nat Mater. 2017 Nov;16(11):1155-1161. doi: 10.1038/nmat4997. Epub 2017 Oct 9.

PMID:
29035356
10.

Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates.

Groveman BR, Raymond GJ, Campbell KJ, Race B, Raymond LD, Hughson AG, Orrú CD, Kraus A, Phillips K, Caughey B.

PLoS Pathog. 2017 Sep 14;13(9):e1006623. doi: 10.1371/journal.ppat.1006623. eCollection 2017 Sep.

11.

High diagnostic value of second generation CSF RT-QuIC across the wide spectrum of CJD prions.

Franceschini A, Baiardi S, Hughson AG, McKenzie N, Moda F, Rossi M, Capellari S, Green A, Giaccone G, Caughey B, Parchi P.

Sci Rep. 2017 Sep 6;7(1):10655. doi: 10.1038/s41598-017-10922-w.

12.

RT-QuIC Assays for Prion Disease Detection and Diagnostics.

Orrù CD, Groveman BR, Hughson AG, Manca M, Raymond LD, Raymond GJ, Campbell KJ, Anson KJ, Kraus A, Caughey B.

Methods Mol Biol. 2017;1658:185-203. doi: 10.1007/978-1-4939-7244-9_14.

PMID:
28861791
13.

Amplified Detection of Prions and Other Amyloids by RT-QuIC in Diagnostics and the Evaluation of Therapeutics and Disinfectants.

Caughey B, Orru CD, Groveman BR, Hughson AG, Manca M, Raymond LD, Raymond GJ, Race B, Saijo E, Kraus A.

Prog Mol Biol Transl Sci. 2017;150:375-388. doi: 10.1016/bs.pmbts.2017.06.003. Epub 2017 Jul 27. Review.

PMID:
28838670
14.

PrP P102L and Nearby Lysine Mutations Promote Spontaneous In Vitro Formation of Transmissible Prions.

Kraus A, Raymond GJ, Race B, Campbell KJ, Hughson AG, Anson KJ, Raymond LD, Caughey B.

J Virol. 2017 Oct 13;91(21). pii: e01276-17. doi: 10.1128/JVI.01276-17. Print 2017 Nov 1.

15.

Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity.

Wang F, Wang X, Orrú CD, Groveman BR, Surewicz K, Abskharon R, Imamura M, Yokoyama T, Kim YS, Vander Stel KJ, Sinniah K, Priola SA, Surewicz WK, Caughey B, Ma J.

PLoS Pathog. 2017 Jul 12;13(7):e1006491. doi: 10.1371/journal.ppat.1006491. eCollection 2017 Jul.

16.

DNA methylation markers for diagnosis and prognosis of common cancers.

Hao X, Luo H, Krawczyk M, Wei W, Wang W, Wang J, Flagg K, Hou J, Zhang H, Yi S, Jafari M, Lin D, Chung C, Caughey BA, Li G, Dhar D, Shi W, Zheng L, Hou R, Zhu J, Zhao L, Fu X, Zhang E, Zhang C, Zhu JK, Karin M, Xu RH, Zhang K.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7414-7419. doi: 10.1073/pnas.1703577114. Epub 2017 Jun 26.

17.

Enhanced neuroinvasion by smaller, soluble prions.

Bett C, Lawrence J, Kurt TD, Orru C, Aguilar-Calvo P, Kincaid AE, Surewicz WK, Caughey B, Wu C, Sigurdson CJ.

Acta Neuropathol Commun. 2017 Apr 21;5(1):32. doi: 10.1186/s40478-017-0430-z.

18.

Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid.

Saijo E, Ghetti B, Zanusso G, Oblak A, Furman JL, Diamond MI, Kraus A, Caughey B.

Acta Neuropathol. 2017 May;133(5):751-765. doi: 10.1007/s00401-017-1692-z. Epub 2017 Mar 14.

PMID:
28293793
19.

Extended and direct evaluation of RT-QuIC assays for Creutzfeldt-Jakob disease diagnosis.

Groveman BR, Orrú CD, Hughson AG, Bongianni M, Fiorini M, Imperiale D, Ladogana A, Pocchiari M, Zanusso G, Caughey B.

Ann Clin Transl Neurol. 2016 Dec 27;4(2):139-144. doi: 10.1002/acn3.378. eCollection 2017 Feb.

20.

Novel strain properties distinguishing sporadic prion diseases sharing prion protein genotype and prion type.

Cracco L, Notari S, Cali I, Sy MS, Chen SG, Cohen ML, Ghetti B, Appleby BS, Zou WQ, Caughey B, Safar JG, Gambetti P.

Sci Rep. 2017 Jan 16;7:38280. doi: 10.1038/srep38280.

21.

Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples.

Bongianni M, Orrù C, Groveman BR, Sacchetto L, Fiorini M, Tonoli G, Triva G, Capaldi S, Testi S, Ferrari S, Cagnin A, Ladogana A, Poleggi A, Colaizzo E, Tiple D, Vaianella L, Castriciano S, Marchioni D, Hughson AG, Imperiale D, Cattaruzza T, Fabrizi GM, Pocchiari M, Monaco S, Caughey B, Zanusso G.

JAMA Neurol. 2017 Feb 1;74(2):155-162. doi: 10.1001/jamaneurol.2016.4614.

PMID:
27942718
22.

Diagnostic and prognostic value of human prion detection in cerebrospinal fluid.

Foutz A, Appleby BS, Hamlin C, Liu X, Yang S, Cohen Y, Chen W, Blevins J, Fausett C, Wang H, Gambetti P, Zhang S, Hughson A, Tatsuoka C, Schonberger LB, Cohen ML, Caughey B, Safar JG.

Ann Neurol. 2017 Jan;81(1):79-92. doi: 10.1002/ana.24833.

23.

Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration.

Alibhai J, Blanco RA, Barria MA, Piccardo P, Caughey B, Perry VH, Freeman TC, Manson JC.

PLoS Biol. 2016 Nov 23;14(11):e1002579. doi: 10.1371/journal.pbio.1002579. eCollection 2016 Nov.

24.

The real-time quaking-induced conversion assay for detection of human prion disease and study of other protein misfolding diseases.

Schmitz M, Cramm M, Llorens F, Müller-Cramm D, Collins S, Atarashi R, Satoh K, Orrù CD, Groveman BR, Zafar S, Schulz-Schaeffer WJ, Caughey B, Zerr I.

Nat Protoc. 2016 Nov;11(11):2233-2242. doi: 10.1038/nprot.2016.120. Epub 2016 Oct 13.

PMID:
27735933
25.

MicroRNA Expression Profile on Solid Subtype of Invasive Lung Adenocarcinoma Reveals a Panel of Four miRNAs to Be Associated with Poor Prognosis in Chinese Patients.

Zhang YQ, Wang WY, Xue JX, Xu Y, Fan P, Caughey BA, Tan WW, Cao GQ, Jiang LL, Lu Y, Zhang K, Hu X.

J Cancer. 2016 Jul 18;7(12):1610-1620. eCollection 2016.

26.

Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid.

Hughson AG, Race B, Kraus A, Sangaré LR, Robins L, Groveman BR, Saijo E, Phillips K, Contreras L, Dhaliwal V, Manca M, Zanusso G, Terry D, Williams JF, Caughey B.

PLoS Pathog. 2016 Sep 29;12(9):e1005914. doi: 10.1371/journal.ppat.1005914. eCollection 2016 Sep.

27.

Genetic background modulates outcome of therapeutic amyloid peptides in treatment of neuroinflammation.

Kraus A, Race B, Phillips K, Winkler C, Saturday G, Kurnellas M, Rothbard JB, Groveman BR, Steinman L, Caughey B.

J Neuroimmunol. 2016 Sep 15;298:42-50. doi: 10.1016/j.jneuroim.2016.06.010. Epub 2016 Jun 27.

PMID:
27609274
28.

Advanced tests for early and accurate diagnosis of Creutzfeldt-Jakob disease.

Zanusso G, Monaco S, Pocchiari M, Caughey B.

Nat Rev Neurol. 2016 Jul;12(7):427. doi: 10.1038/nrneurol.2016.92. Epub 2016 Jun 17. No abstract available.

PMID:
27313104
29.

Factors That Improve RT-QuIC Detection of Prion Seeding Activity.

Orrú CD, Hughson AG, Groveman BR, Campbell KJ, Anson KJ, Manca M, Kraus A, Caughey B.

Viruses. 2016 May 23;8(5). pii: E140. doi: 10.3390/v8050140.

30.

Advanced tests for early and accurate diagnosis of Creutzfeldt-Jakob disease.

Zanusso G, Monaco S, Pocchiari M, Caughey B.

Nat Rev Neurol. 2016 Jun;12(6):325-33. doi: 10.1038/nrneurol.2016.65. Epub 2016 May 13. Review. Erratum in: Nat Rev Neurol. 2016 Jul;12(7):427.

PMID:
27174240
31.

Correction for Masujin et al., Detection of Atypical H-Type Bovine Spongiform Encephalopathy and Discrimination of Bovine Prion Strains by Real-Time Quaking-Induced Conversion.

Masujin K, Orrú CD, Miyazawa K, Groveman BR, Raymond LD, Hughson AG, Caughey B.

J Clin Microbiol. 2016 May;54(5):1407. doi: 10.1128/JCM.00472-16. No abstract available.

32.

Peptides Composed of Alternating L- and D-Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence.

Kellock J, Hopping G, Caughey B, Daggett V.

J Mol Biol. 2016 Jun 5;428(11):2317-2328. doi: 10.1016/j.jmb.2016.03.013. Epub 2016 Mar 21.

33.

PrPSc-Specific Antibody Reveals C-Terminal Conformational Differences between Prion Strains.

Saijo E, Hughson AG, Raymond GJ, Suzuki A, Horiuchi M, Caughey B.

J Virol. 2016 Apr 29;90(10):4905-4913. doi: 10.1128/JVI.00088-16. Print 2016 May 15.

34.

Seeded Amplification of Chronic Wasting Disease Prions in Nasal Brushings and Recto-anal Mucosa-Associated Lymphoid Tissues from Elk by Real-Time Quaking-Induced Conversion.

Haley NJ, Siepker C, Hoon-Hanks LL, Mitchell G, Walter WD, Manca M, Monello RJ, Powers JG, Wild MA, Hoover EA, Caughey B, Richt JA.

J Clin Microbiol. 2016 Apr;54(4):1117-26. doi: 10.1128/JCM.02700-15. Epub 2016 Feb 17.

35.

Detection of Atypical H-Type Bovine Spongiform Encephalopathy and Discrimination of Bovine Prion Strains by Real-Time Quaking-Induced Conversion.

Masujin K, Orrú CD, Miyazawa K, Groveman BR, Raymond LD, Hughson AG, Caughey B.

J Clin Microbiol. 2016 Mar;54(3):676-86. doi: 10.1128/JCM.02731-15. Epub 2016 Jan 6. Erratum in: J Clin Microbiol. 2016 May;54(5):1407.

36.

Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion.

Dassanayake RP, Orrú CD, Hughson AG, Caughey B, Graça T, Zhuang D, Madsen-Bouterse SA, Knowles DP, Schneider DA.

J Gen Virol. 2016 Mar;97(3):803-12. doi: 10.1099/jgv.0.000367. Epub 2015 Dec 10.

37.
38.

Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA.

Yin AH, Peng CF, Zhao X, Caughey BA, Yang JX, Liu J, Huang WW, Liu C, Luo DH, Liu HL, Chen YY, Wu J, Hou R, Zhang M, Ai M, Zheng L, Xue RQ, Mai MQ, Guo FF, Qi YM, Wang DM, Krawczyk M, Zhang D, Wang YN, Huang QF, Karin M, Zhang K.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14670-5. doi: 10.1073/pnas.1518151112. Epub 2015 Nov 9.

39.

Early Generation of New PrPSc on Blood Vessels after Brain Microinjection of Scrapie in Mice.

Chesebro B, Striebel J, Rangel A, Phillips K, Hughson A, Caughey B, Race B.

MBio. 2015 Sep 22;6(5):e01419-15. doi: 10.1128/mBio.01419-15.

40.

Correction: Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains.

Orrú CD, Groveman BR, Raymond LD, Hughson AG, Nonno R, Zou W, Ghetti B, Gambetti P, Caughey B.

PLoS Pathog. 2015 Aug 18;11(8):e1005117. doi: 10.1371/journal.ppat.1005117. eCollection 2015 Aug. No abstract available.

41.

Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype.

Crowell J, Hughson A, Caughey B, Bessen RA.

J Virol. 2015 Oct;89(20):10427-41. doi: 10.1128/JVI.01586-15. Epub 2015 Aug 5.

42.

Prion Protein Prolines 102 and 105 and the Surrounding Lysine Cluster Impede Amyloid Formation.

Kraus A, Anson KJ, Raymond LD, Martens C, Groveman BR, Dorward DW, Caughey B.

J Biol Chem. 2015 Aug 28;290(35):21510-22. doi: 10.1074/jbc.M115.665844. Epub 2015 Jul 14.

43.

Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains.

Orrú CD, Groveman BR, Raymond LD, Hughson AG, Nonno R, Zou W, Ghetti B, Gambetti P, Caughey B.

PLoS Pathog. 2015 Jun 18;11(6):e1004983. doi: 10.1371/journal.ppat.1004983. eCollection 2015 Jun. Erratum in: PLoS Pathog. 2015 Aug;11(8):e1005117.

44.

Detection and discrimination of classical and atypical L-type bovine spongiform encephalopathy by real-time quaking-induced conversion.

Orrú CD, Favole A, Corona C, Mazza M, Manca M, Groveman BR, Hughson AG, Acutis PL, Caramelli M, Zanusso G, Casalone C, Caughey B.

J Clin Microbiol. 2015 Apr;53(4):1115-20. doi: 10.1128/JCM.02906-14. Epub 2015 Jan 21.

45.

Rapid and sensitive RT-QuIC detection of human Creutzfeldt-Jakob disease using cerebrospinal fluid.

Orrú CD, Groveman BR, Hughson AG, Zanusso G, Coulthart MB, Caughey B.

MBio. 2015 Jan 20;6(1). pii: e02451-14. doi: 10.1128/mBio.02451-14.

46.

Charge neutralization of the central lysine cluster in prion protein (PrP) promotes PrP(Sc)-like folding of recombinant PrP amyloids.

Groveman BR, Kraus A, Raymond LD, Dolan MA, Anson KJ, Dorward DW, Caughey B.

J Biol Chem. 2015 Jan 9;290(2):1119-28. doi: 10.1074/jbc.M114.619627. Epub 2014 Nov 21.

47.

A test for Creutzfeldt-Jakob disease using nasal brushings.

Zanusso G, Bongianni M, Caughey B.

N Engl J Med. 2014 Nov 6;371(19):1842-3. doi: 10.1056/NEJMc1410732. No abstract available.

PMID:
25372096
48.

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.

Bejar R, Lord A, Stevenson K, Bar-Natan M, Pérez-Ladaga A, Zaneveld J, Wang H, Caughey B, Stojanov P, Getz G, Garcia-Manero G, Kantarjian H, Chen R, Stone RM, Neuberg D, Steensma DP, Ebert BL.

Blood. 2014 Oct 23;124(17):2705-12. doi: 10.1182/blood-2014-06-582809. Epub 2014 Sep 15.

49.

A test for Creutzfeldt-Jakob disease using nasal brushings.

Orrú CD, Bongianni M, Tonoli G, Ferrari S, Hughson AG, Groveman BR, Fiorini M, Pocchiari M, Monaco S, Caughey B, Zanusso G.

N Engl J Med. 2014 Aug 7;371(6):519-29. doi: 10.1056/NEJMoa1315200. Erratum in: N Engl J Med. 2014 Nov 6;371(19):1852.

50.

Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation.

Bejar R, Stevenson KE, Caughey B, Lindsley RC, Mar BG, Stojanov P, Getz G, Steensma DP, Ritz J, Soiffer R, Antin JH, Alyea E, Armand P, Ho V, Koreth J, Neuberg D, Cutler CS, Ebert BL.

J Clin Oncol. 2014 Sep 1;32(25):2691-8. doi: 10.1200/JCO.2013.52.3381. Epub 2014 Aug 4.

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