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Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy.

King JH, Kwan STC, Bae S, Klatt KC, Yan J, Malysheva OV, Jiang X, Roberson MS, Caudill MA.

J Nutr Biochem. 2019 Jul 8;72:108210. doi: 10.1016/j.jnutbio.2019.07.001. [Epub ahead of print]


Choline: Exploring the Growing Science on Its Benefits for Moms and Babies.

Korsmo HW, Jiang X, Caudill MA.

Nutrients. 2019 Aug 7;11(8). pii: E1823. doi: 10.3390/nu11081823.


Choline: The Neurocognitive Essential Nutrient of Interest to Obstetricians and Gynecologists.

Wallace TC, Blusztajn JK, Caudill MA, Klatt KC, Zeisel SH.

J Diet Suppl. 2019 Aug 6:1-20. doi: 10.1080/19390211.2019.1639875. [Epub ahead of print]


Formate concentrations in maternal plasma during pregnancy and in cord blood in a cohort of pregnant Canadian women: relations to genetic polymorphisms and plasma metabolites.

Brosnan JT, Plumptre L, Brosnan ME, Pongnopparat T, Masih SP, Visentin CE, Berger H, Lamers Y, Caudill MA, Malysheva OV, O'Connor DL, Kim YI.

Am J Clin Nutr. 2019 Jul 27. pii: nqz152. doi: 10.1093/ajcn/nqz152. [Epub ahead of print]


Prenatal Nutritional Intervention Reduces Autistic-Like Behavior Rates Among Mthfr-Deficient Mice.

Orenbuch A, Fortis K, Taesuwan S, Yaffe R, Caudill MA, Golan HM.

Front Neurosci. 2019 May 2;13:383. doi: 10.3389/fnins.2019.00383. eCollection 2019.


Choline: The Underconsumed and Underappreciated Essential Nutrient.

Wallace TC, Blusztajn JK, Caudill MA, Klatt KC, Natker E, Zeisel SH, Zelman KM.

Nutr Today. 2018 Nov-Dec;53(6):240-253. doi: 10.1097/NT.0000000000000302. Epub 2018 Nov 13.


Relation of choline intake with blood pressure in the National Health and Nutrition Examination Survey 2007-2010.

Taesuwan S, Vermeylen F, Caudill MA, Cassano PA.

Am J Clin Nutr. 2019 Mar 1;109(3):648-655. doi: 10.1093/ajcn/nqy330.


Maternal Choline Supplementation Modulates Placental Markers of Inflammation, Angiogenesis, and Apoptosis in a Mouse Model of Placental Insufficiency.

King JH, Kwan STC, Yan J, Jiang X, Fomin VG, Levine SP, Wei E, Roberson MS, Caudill MA.

Nutrients. 2019 Feb 12;11(2). pii: E374. doi: 10.3390/nu11020374.


Association between one-carbon metabolism indices and DNA methylation status in maternal and cord blood.

Knight AK, Park HJ, Hausman DB, Fleming JM, Bland VL, Rosa G, Kennedy EM, Caudill MA, Malysheva O, Kauwell GPA, Sokolow A, Fisher S, Smith AK, Bailey LB.

Sci Rep. 2018 Nov 15;8(1):16873. doi: 10.1038/s41598-018-35111-1.


Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver.

Leclerc D, Christensen KE, Cauvi O, Yang E, Fournelle F, Bahous RH, Malysheva OV, Deng L, Wu Q, Zhou Z, Gao ZH, Chaurand P, Caudill MA, Rozen R.

Mol Nutr Food Res. 2019 Feb;63(3):e1801001. doi: 10.1002/mnfr.201801001. Epub 2018 Nov 23.


Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.

Bahous RH, Cosín-Tomás M, Deng L, Leclerc D, Malysheva O, Ho MK, Pallàs M, Kaliman P, Bedell BJ, Caudill MA, Rozen R.

Mol Neurobiol. 2019 Jun;56(6):4175-4191. doi: 10.1007/s12035-018-1375-3. Epub 2018 Oct 4.


Maternal betaine supplementation affects fetal growth and lipid metabolism of high-fat fed mice in a temporal-specific manner.

Joselit Y, Nanobashvili K, Jack-Roberts C, Greenwald E, Malysheva OV, Caudill MA, Saxena A, Jiang X.

Nutr Diabetes. 2018 May 24;8(1):41. doi: 10.1038/s41387-018-0035-z.


Fetal one-carbon nutrient concentrations may be affected by gestational diabetes.

Barzilay E, Moon A, Plumptre L, Masih SP, Sohn KJ, Visentin CE, Ly A, Malysheva O, Croxford R, Caudill MA, O'Connor DL, Kim YI, Berger H.

Nutr Res. 2018 Jul;55:57-64. doi: 10.1016/j.nutres.2018.04.010. Epub 2018 Apr 21.


Choline Supplementation Prevents a Hallmark Disturbance of Kwashiorkor in Weanling Mice Fed a Maize Vegetable Diet: Hepatic Steatosis of Undernutrition.

May T, Klatt KC, Smith J, Castro E, Manary M, Caudill MA, Jahoor F, Fiorotto ML.

Nutrients. 2018 May 22;10(5). pii: E653. doi: 10.3390/nu10050653.


Effects of Egg Consumption and Choline Supplementation on Plasma Choline and Trimethylamine-N-Oxide in a Young Population.

Lemos BS, Medina-Vera I, Malysheva OV, Caudill MA, Fernandez ML.

J Am Coll Nutr. 2018 May 15:1-8. doi: 10.1080/07315724.2018.1466213. [Epub ahead of print]


Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.

Christensen KE, Bahous RH, Hou W, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R.

J Nutr. 2018 Apr 1;148(4):501-509. doi: 10.1093/jn/nxy013.


Maternal Choline Supplementation during Normal Murine Pregnancy Alters the Placental Epigenome: Results of an Exploratory Study.

Kwan STC, King JH, Grenier JK, Yan J, Jiang X, Roberson MS, Caudill MA.

Nutrients. 2018 Mar 28;10(4). pii: E417. doi: 10.3390/nu10040417.



Zeisel SH, Klatt KC, Caudill MA.

Adv Nutr. 2018 Jan 1;9(1):58-60. doi: 10.1093/advances/nmx004. No abstract available.


Compared to an Oatmeal Breakfast, Two Eggs/Day Increased Plasma Carotenoids and Choline without Increasing Trimethyl Amine N-Oxide Concentrations.

Missimer A, Fernandez ML, DiMarco DM, Norris GH, Blesso CN, Murillo AG, Vergara-Jimenez M, Lemos BS, Medina-Vera I, Malysheva OV, Caudill MA.

J Am Coll Nutr. 2018 Feb;37(2):140-148. doi: 10.1080/07315724.2017.1365026. Epub 2018 Jan 9.


Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study.

Caudill MA, Strupp BJ, Muscalu L, Nevins JEH, Canfield RL.

FASEB J. 2018 Apr;32(4):2172-2180. doi: 10.1096/fj.201700692RR. Epub 2018 Jan 5.


Vitamin D binding protein rs7041 genotype alters vitamin D metabolism in pregnant women.

Ganz AB, Park H, Malysheva OV, Caudill MA.

FASEB J. 2018 Apr;32(4):2012-2020. doi: 10.1096/fj.201700992R. Epub 2018 Jan 5.


Placental vitamin D metabolism and its associations with circulating vitamin D metabolites in pregnant women.

Park H, Wood MR, Malysheva OV, Jones S, Mehta S, Brannon PM, Caudill MA.

Am J Clin Nutr. 2017 Dec;106(6):1439-1448. doi: 10.3945/ajcn.117.153429. Epub 2017 Oct 11.


Maternal Choline Supplementation Modulates Placental Nutrient Transport and Metabolism in Late Gestation of Mouse Pregnancy.

Kwan STC, King JH, Yan J, Wang Z, Jiang X, Hutzler JS, Klein HR, Brenna JT, Roberson MS, Caudill MA.

J Nutr. 2017 Nov;147(11):2083-2092. doi: 10.3945/jn.117.256107. Epub 2017 Sep 20.


Choline prevents fetal overgrowth and normalizes placental fatty acid and glucose metabolism in a mouse model of maternal obesity.

Nam J, Greenwald E, Jack-Roberts C, Ajeeb TT, Malysheva OV, Caudill MA, Axen K, Saxena A, Semernina E, Nanobashvili K, Jiang X.

J Nutr Biochem. 2017 Nov;49:80-88. doi: 10.1016/j.jnutbio.2017.08.004. Epub 2017 Aug 12.


Choline Supplementation Normalizes Fetal Adiposity and Reduces Lipogenic Gene Expression in a Mouse Model of Maternal Obesity.

Jack-Roberts C, Joselit Y, Nanobashvili K, Bretter R, Malysheva OV, Caudill MA, Saxena A, Axen K, Gomaa A, Jiang X.

Nutrients. 2017 Aug 18;9(8). pii: E899. doi: 10.3390/nu9080899.


Common Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements.

Ganz AB, Klatt KC, Caudill MA.

Nutrients. 2017 Aug 4;9(8). pii: E837. doi: 10.3390/nu9080837. Review.


Maternal Choline Supplementation Alters Fetal Growth Patterns in a Mouse Model of Placental Insufficiency.

King JH, Kwan STC, Yan J, Klatt KC, Jiang X, Roberson MS, Caudill MA.

Nutrients. 2017 Jul 18;9(7). pii: E765. doi: 10.3390/nu9070765.


Maternal choline supplementation during murine pregnancy modulates placental markers of inflammation, apoptosis and vascularization in a fetal sex-dependent manner.

Kwan STC, King JH, Yan J, Jiang X, Wei E, Fomin VG, Roberson MS, Caudill MA.

Placenta. 2017 May;53:57-65. doi: 10.1016/j.placenta.2017.03.019. Epub 2017 Mar 30.


The metabolic fate of isotopically labeled trimethylamine-N-oxide (TMAO) in humans.

Taesuwan S, Cho CE, Malysheva OV, Bender E, King JH, Yan J, Thalacker-Mercer AE, Caudill MA.

J Nutr Biochem. 2017 Jul;45:77-82. doi: 10.1016/j.jnutbio.2017.02.010. Epub 2017 Apr 13.


Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations.

Ganz AB, Cohen VV, Swersky CC, Stover J, Vitiello GA, Lovesky J, Chuang JC, Shields K, Fomin VG, Lopez YS, Mohan S, Ganti A, Carrier B, Malysheva OV, Caudill MA.

Int J Mol Sci. 2017 Jan 26;18(2). pii: E252. doi: 10.3390/ijms18020252.


Intake of up to 3 Eggs/Day Increases HDL Cholesterol and Plasma Choline While Plasma Trimethylamine-N-oxide is Unchanged in a Healthy Population.

DiMarco DM, Missimer A, Murillo AG, Lemos BS, Malysheva OV, Caudill MA, Blesso CN, Fernandez ML.

Lipids. 2017 Mar;52(3):255-263. doi: 10.1007/s11745-017-4230-9. Epub 2017 Jan 13.


Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment.

Dam K, Füchtemeier M, Farr TD, Boehm-Sturm P, Foddis M, Dirnagl U, Malysheva O, Caudill MA, Jadavji NM.

Behav Brain Res. 2017 Mar 15;321:201-208. doi: 10.1016/j.bbr.2016.12.041. Epub 2017 Jan 11.


High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.

Bahous RH, Jadavji NM, Deng L, Cosín-Tomás M, Lu J, Malysheva O, Leung KY, Ho MK, Pallàs M, Kaliman P, Greene NDE, Bedell BJ, Caudill MA, Rozen R.

Hum Mol Genet. 2017 Mar 1;26(5):888-900. doi: 10.1093/hmg/ddx004.


Maternal vitamin D biomarkers are associated with maternal and fetal bone turnover among pregnant women consuming controlled amounts of vitamin D, calcium, and phosphorus.

Park H, Brannon PM, West AA, Yan J, Jiang X, Perry CA, Malysheva O, Mehta S, Caudill MA.

Bone. 2017 Feb;95:183-191. doi: 10.1016/j.bone.2016.12.002. Epub 2016 Dec 8.


Trimethylamine-N-Oxide: Friend, Foe, or Simply Caught in the Cross-Fire?

Cho CE, Caudill MA.

Trends Endocrinol Metab. 2017 Feb;28(2):121-130. doi: 10.1016/j.tem.2016.10.005. Epub 2016 Nov 5. Review.


Perinatal Dietary Choline Deficiency in Sows Influences Concentrations of Choline Metabolites, Fatty Acids, and Amino Acids in Milk throughout Lactation.

Mudd AT, Alexander LS, Johnson SK, Getty CM, Malysheva OV, Caudill MA, Dilger RN.

J Nutr. 2016 Nov;146(11):2216-2223. Epub 2016 Oct 12.


Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development.

Christensen KE, Hou W, Bahous RH, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R.

Am J Clin Nutr. 2016 Nov;104(5):1459-1469. Epub 2016 Oct 5.


Sex-Specific Associations between One-Carbon Metabolism Indices and Posttranslational Histone Modifications in Arsenic-Exposed Bangladeshi Adults.

Howe CG, Liu X, Hall MN, Ilievski V, Caudill MA, Malysheva O, Lomax-Luu AM, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Graziano JH, Costa M, Gamble MV.

Cancer Epidemiol Biomarkers Prev. 2017 Feb;26(2):261-269. doi: 10.1158/1055-9965.EPI-16-0202. Epub 2016 Oct 20.


Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial.

Cho CE, Taesuwan S, Malysheva OV, Bender E, Tulchinsky NF, Yan J, Sutter JL, Caudill MA.

Mol Nutr Food Res. 2017 Jan;61(1). doi: 10.1002/mnfr.201600324. Epub 2016 Aug 3.


Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.

Ganz AB, Shields K, Fomin VG, Lopez YS, Mohan S, Lovesky J, Chuang JC, Ganti A, Carrier B, Yan J, Taeswuan S, Cohen VV, Swersky CC, Stover JA, Vitiello GA, Malysheva OV, Mudrak E, Caudill MA.

FASEB J. 2016 Oct;30(10):3321-3333. Epub 2016 Jun 24.


Vitamin D Metabolism Varies among Women in Different Reproductive States Consuming the Same Intakes of Vitamin D and Related Nutrients.

Park H, Brannon PM, West AA, Yan J, Jiang X, Perry CA, Malysheva OV, Mehta S, Caudill MA.

J Nutr. 2016 Aug;146(8):1537-45. doi: 10.3945/jn.116.229971. Epub 2016 Jun 22.


Supplementation with Folic Acid, but Not Creatine, Increases Plasma Betaine, Decreases Plasma Dimethylglycine, and Prevents a Decrease in Plasma Choline in Arsenic-Exposed Bangladeshi Adults.

Hall MN, Howe CG, Liu X, Caudill MA, Malysheva O, Ilievski V, Lomax-Luu AM, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV.

J Nutr. 2016 May;146(5):1062-7. doi: 10.3945/jn.115.227132. Epub 2016 Apr 6.


Maternal obesity disrupts the methionine cycle in baboon pregnancy.

Nathanielsz PW, Yan J, Green R, Nijland M, Miller JW, Wu G, McDonald TJ, Caudill MA.

Physiol Rep. 2015 Nov;3(11). pii: e12564. doi: 10.14814/phy2.12564.


Biomarkers of Nutrition for Development-Folate Review.

Bailey LB, Stover PJ, McNulty H, Fenech MF, Gregory JF 3rd, Mills JL, Pfeiffer CM, Fazili Z, Zhang M, Ueland PM, Molloy AM, Caudill MA, Shane B, Berry RJ, Bailey RL, Hausman DB, Raghavan R, Raiten DJ.

J Nutr. 2015 Jul;145(7):1636S-1680S. doi: 10.3945/jn.114.206599. Epub 2015 Jun 3. Review.


Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease.

Strupp BJ, Powers BE, Velazquez R, Ash JA, Kelley CM, Alldred MJ, Strawderman M, Caudill MA, Mufson EJ, Ginsberg SD.

Curr Alzheimer Res. 2016;13(1):97-106.


Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study.

Cheng TY, Makar KW, Neuhouser ML, Miller JW, Song X, Brown EC, Beresford SA, Zheng Y, Poole EM, Galbraith RL, Duggan DJ, Habermann N, Bailey LB, Maneval DR, Caudill MA, Toriola AT, Green R, Ulrich CM.

Cancer. 2015 Oct 15;121(20):3684-91. doi: 10.1002/cncr.29465. Epub 2015 Jun 24.


Choline intakes exceeding recommendations during human lactation improve breast milk choline content by increasing PEMT pathway metabolites.

Davenport C, Yan J, Taesuwan S, Shields K, West AA, Jiang X, Perry CA, Malysheva OV, Stabler SP, Allen RH, Caudill MA.

J Nutr Biochem. 2015 Sep;26(9):903-11. doi: 10.1016/j.jnutbio.2015.03.004. Epub 2015 Apr 15.


Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes.

Bae S, West AA, Yan J, Jiang X, Perry CA, Malysheva O, Stabler SP, Allen RH, Caudill MA.

J Nutr. 2015 Jul;145(7):1507-14. doi: 10.3945/jn.115.210757. Epub 2015 May 20.


Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations.

Visentin CE, Masih S, Plumptre L, Malysheva O, Nielsen DE, Sohn KJ, Ly A, Lausman AY, Berger H, Croxford R, El-Sohemy A, Caudill MA, O'Connor DL, Kim YI.

J Nutr. 2015 Jul;145(7):1491-7. doi: 10.3945/jn.115.211136. Epub 2015 May 13.


MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring.

Jadavji NM, Deng L, Malysheva O, Caudill MA, Rozen R.

Neuroscience. 2015 Aug 6;300:1-9. doi: 10.1016/j.neuroscience.2015.04.067. Epub 2015 May 6.


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