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Items: 46


Neutrophils: New insights and open questions.

Ley K, Hoffman HM, Kubes P, Cassatella MA, Zychlinsky A, Hedrick CC, Catz SD.

Sci Immunol. 2018 Dec 7;3(30). pii: eaat4579. doi: 10.1126/sciimmunol.aat4579. Epub 2018 Dec 7. Review.


Noncanonical Hippo Signalling in the Regulation of Leukocyte Function.

Kurz ARM, Catz SD, Sperandio M.

Trends Immunol. 2018 Aug;39(8):656-669. doi: 10.1016/ Epub 2018 Jun 26. Review.


Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis.

Johnson JL, Ramadass M, Haimovich A, McGeough MD, Zhang J, Hoffman HM, Catz SD.

Front Cell Infect Microbiol. 2017 Dec 11;7:507. doi: 10.3389/fcimb.2017.00507. eCollection 2017.


Editorial: The secrets of secretion.

Catz SD.

J Leukoc Biol. 2017 Jul;102(1):4-6. doi: 10.1189/jlb.3CE0217-046R. No abstract available.


Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.

Zhang J, Johnson JL, He J, Napolitano G, Ramadass M, Rocca C, Kiosses WB, Bucci C, Xin Q, Gavathiotis E, Cuervo AM, Cherqui S, Catz SD.

J Biol Chem. 2017 Jun 23;292(25):10328-10346. doi: 10.1074/jbc.M116.764076. Epub 2017 May 2.


MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.

Kurz AR, Pruenster M, Rohwedder I, Ramadass M, Schäfer K, Harrison U, Gouveia G, Nussbaum C, Immler R, Wiessner JR, Margraf A, Lim DS, Walzog B, Dietzel S, Moser M, Klein C, Vestweber D, Haas R, Catz SD, Sperandio M.

J Clin Invest. 2016 Nov 1;126(11):4125-4139. doi: 10.1172/JCI87043. Epub 2016 Oct 4.


Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.

Johnson JL, Ramadass M, He J, Brown SJ, Zhang J, Abgaryan L, Biris N, Gavathiotis E, Rosen H, Catz SD.

J Biol Chem. 2016 Dec 9;291(50):25965-25982. Epub 2016 Oct 4.


Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis.

Ramadass M, Johnson JL, Catz SD.

J Leukoc Biol. 2017 Mar;101(3):693-702. doi: 10.1189/jlb.3AB0416-189RR. Epub 2016 Oct 12.


Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation.

Ramadass M, Catz SD.

Immunol Rev. 2016 Sep;273(1):249-65. doi: 10.1111/imr.12452. Review.


Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells.

Rega LR, Polishchuk E, Montefusco S, Napolitano G, Tozzi G, Zhang J, Bellomo F, Taranta A, Pastore A, Polishchuk R, Piemonte F, Medina DL, Catz SD, Ballabio A, Emma F.

Kidney Int. 2016 Apr;89(4):862-73. doi: 10.1016/j.kint.2015.12.045.


Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses.

He J, Johnson JL, Monfregola J, Ramadass M, Pestonjamasp K, Napolitano G, Zhang J, Catz SD.

Mol Biol Cell. 2016 Feb 1;27(3):572-87. doi: 10.1091/mbc.E15-05-0283. Epub 2015 Dec 17.


Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.

Johnson JL, He J, Ramadass M, Pestonjamasp K, Kiosses WB, Zhang J, Catz SD.

J Biol Chem. 2016 Feb 12;291(7):3423-38. doi: 10.1074/jbc.M115.705871. Epub 2015 Dec 4.


Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis.

Napolitano G, Johnson JL, He J, Rocca CJ, Monfregola J, Pestonjamasp K, Cherqui S, Catz SD.

EMBO Mol Med. 2015 Feb;7(2):158-74. doi: 10.15252/emmm.201404223.


Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency.

Sasaki T, Lian S, Qi J, Bayliss PE, Carr CE, Johnson JL, Guha S, Kobler P, Catz SD, Gill M, Jia K, Klionsky DJ, Kishi S.

PLoS Genet. 2014 Jun 26;10(6):e1004409. doi: 10.1371/journal.pgen.1004409. eCollection 2014 Jun.


The role of Rab27a in the regulation of neutrophil function.

Catz SD.

Cell Microbiol. 2014 Sep;16(9):1301-10. doi: 10.1111/cmi.12328. Epub 2014 Aug 4. Review.


Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis.

Johnson JL, Napolitano G, Monfregola J, Rocca CJ, Cherqui S, Catz SD.

Mol Cell Biol. 2013 Aug;33(15):2950-62. doi: 10.1128/MCB.00417-13. Epub 2013 May 28.


Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors.

Catz SD.

J Leukoc Biol. 2013 Oct;94(4):613-22. doi: 10.1189/jlb.1112600. Epub 2013 Feb 1. Review.


Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion.

Singh RK, Mizuno K, Wasmeier C, Wavre-Shapton ST, Recchi C, Catz SD, Futter C, Tolmachova T, Hume AN, Seabra MC.

FEBS J. 2013 Feb;280(3):892-903. doi: 10.1111/febs.12081. Epub 2013 Jan 2.


MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils.

Monfregola J, Johnson JL, Meijler MM, Napolitano G, Catz SD.

J Biol Chem. 2012 Dec 28;287(53):44603-18. doi: 10.1074/jbc.M112.414029. Epub 2012 Oct 31.


Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.

Johnson JL, Monfregola J, Napolitano G, Kiosses WB, Catz SD.

Mol Biol Cell. 2012 May;23(10):1902-16. doi: 10.1091/mbc.E11-12-1001. Epub 2012 Mar 21.


Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.

Johnson JL, Hong H, Monfregola J, Catz SD.

Infect Immun. 2011 Sep;79(9):3607-18. doi: 10.1128/IAI.05043-11. Epub 2011 Jul 11.


Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils.

Johnson JL, Hong H, Monfregola J, Kiosses WB, Catz SD.

J Biol Chem. 2011 Feb 18;286(7):5647-56. doi: 10.1074/jbc.M110.184762. Epub 2010 Dec 9.


Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms.

Johnson JL, Brzezinska AA, Tolmachova T, Munafo DB, Ellis BA, Seabra MC, Hong H, Catz SD.

Traffic. 2010 Apr;11(4):533-47. doi: 10.1111/j.1600-0854.2009.01029.x. Epub 2009 Dec 17.


DNase I inhibits a late phase of reactive oxygen species production in neutrophils.

Munafo DB, Johnson JL, Brzezinska AA, Ellis BA, Wood MR, Catz SD.

J Innate Immun. 2009;1(6):527-42. doi: 10.1159/000235860. Epub 2009 Aug 27.


The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules.

Brzezinska AA, Johnson JL, Munafo DB, Crozat K, Beutler B, Kiosses WB, Ellis BA, Catz SD.

Traffic. 2008 Dec;9(12):2151-64. doi: 10.1111/j.1600-0854.2008.00838.x. Epub 2008 Oct 30.


Cross-talk between IRAK-4 and the NADPH oxidase.

Pacquelet S, Johnson JL, Ellis BA, Brzezinska AA, Lane WS, Munafo DB, Catz SD.

Biochem J. 2007 May 1;403(3):451-61.


Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes.

Munafó DB, Johnson JL, Ellis BA, Rutschmann S, Beutler B, Catz SD.

Biochem J. 2007 Mar 1;402(2):229-39.


Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation.

Johnson JL, Pacquelet S, Lane WS, Eam B, Catz SD.

Traffic. 2005 Aug;6(8):667-81.


Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase.

Hoyal CR, Gutierrez A, Young BM, Catz SD, Lin JH, Tsichlis PN, Babior BM.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5130-5. Epub 2003 Apr 18.


BCL-2 in prostate cancer: a minireview.

Catz SD, Johnson JL.

Apoptosis. 2003 Jan;8(1):29-37. Review.


The C2A domain of JFC1 binds to 3'-phosphorylated phosphoinositides and directs plasma membrane association in living cells.

Catz SD, Johnson JL, Babior BM.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11652-7. Epub 2002 Aug 20.


Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1.

Catz SD, Johnson JL, Babior BM.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11230-5. Epub 2001 Sep 11.


JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase.

McAdara Berkowitz JK, Catz SD, Johnson JL, Ruedi JM, Thon V, Babior BM.

J Biol Chem. 2001 Jun 1;276(22):18855-62. Epub 2001 Mar 13.


Polyphosphoinositide synthesis in human neutrophils. Effects of a low metabolic energy state.

Catz SD, Speziale EH, Sterin-Speziale NB.

Prostaglandins Other Lipid Mediat. 1998 Mar;55(4):245-64.


Nitric oxide synthase inhibitors decrease human polymorphonuclear leukocyte luminol-dependent chemiluminescence.

Catz SD, Carreras MC, Poderoso JJ.

Free Radic Biol Med. 1995 Dec;19(6):741-8.


Biochemical and morphological changes in the developing kidney.

Kahane VL, Cutrin JC, Setton CP, del Carmen Fernandez M, Catz SD, Sterin-Speziale NB.

Biol Neonate. 1995;68(2):141-52.


Evaluation of the blood components considered as risk predictors in coronary heart disease.

Hoschoian JC, Catz SD, Borruel MA, Wikinski RL, Rodríguez MP.

Medicina (B Aires). 1993;53(1):13-20.


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