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A more efficient conditional mouse model of Dravet syndrome: Implications for epigenetic selection and sex-dependent behaviors.

Williams AD, Kalume F, Westenbroek RE, Catterall WA.

J Neurosci Methods. 2019 Jun 29;325:108315. doi: 10.1016/j.jneumeth.2019.108315. [Epub ahead of print]


The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation.

Weyrer C, Turecek J, Niday Z, Liu PW, Nanou E, Catterall WA, Bean BP, Regehr WG.

Cell Rep. 2019 Feb 26;26(9):2289-2297.e3. doi: 10.1016/j.celrep.2019.01.114.


Fenestrations control resting-state block of a voltage-gated sodium channel.

Gamal El-Din TM, Lenaeus MJ, Zheng N, Catterall WA.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13111-13116. doi: 10.1073/pnas.1814928115. Epub 2018 Dec 5.


Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb.

Gamal El-Din TM, Lenaeus MJ, Ramanadane K, Zheng N, Catterall WA.

J Gen Physiol. 2019 Feb 4;151(2):174-185. doi: 10.1085/jgp.201711884. Epub 2018 Dec 3.


Dravet Syndrome: A Sodium Channel Interneuronopathy.

Catterall WA.

Curr Opin Physiol. 2018 Apr;2:42-50. doi: 10.1016/j.cophys.2017.12.007. Epub 2017 Dec 23.


Structural basis for gating pore current in periodic paralysis.

Jiang D, Gamal El-Din TM, Ing C, Lu P, Pomès R, Zheng N, Catterall WA.

Nature. 2018 May;557(7706):590-594. doi: 10.1038/s41586-018-0120-4. Epub 2018 May 16.


The AKAP Cypher/Zasp contributes to β-adrenergic/PKA stimulation of cardiac CaV1.2 calcium channels.

Yu H, Yuan C, Westenbroek RE, Catterall WA.

J Gen Physiol. 2018 Jun 4;150(6):883-889. doi: 10.1085/jgp.201711818. Epub 2018 May 9.


Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease.

Nanou E, Catterall WA.

Neuron. 2018 May 2;98(3):466-481. doi: 10.1016/j.neuron.2018.03.017. Review.


Progress in Understanding and Treating SCN2A-Mediated Disorders.

Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL Jr, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, Otis TS, Petrou S, Pitt G, Schust LF, Taylor CM, Tjernagel J, Spiro JE, Bender KJ.

Trends Neurosci. 2018 Jul;41(7):442-456. doi: 10.1016/j.tins.2018.03.011. Epub 2018 Apr 23. Review.


Control of Excitation/Inhibition Balance in a Hippocampal Circuit by Calcium Sensor Protein Regulation of Presynaptic Calcium Channels.

Nanou E, Lee A, Catterall WA.

J Neurosci. 2018 May 2;38(18):4430-4440. doi: 10.1523/JNEUROSCI.0022-18.2018. Epub 2018 Apr 13.


Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective.

Gamal El-Din TM, Lenaeus MJ, Catterall WA.

Handb Exp Pharmacol. 2018;246:53-72. doi: 10.1007/164_2017_61. Review.


Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.

Kaplan JS, Stella N, Catterall WA, Westenbroek RE.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11229-11234. doi: 10.1073/pnas.1711351114. Epub 2017 Oct 2.


Forty Years of Sodium Channels: Structure, Function, Pharmacology, and Epilepsy.

Catterall WA.

Neurochem Res. 2017 Sep;42(9):2495-2504. doi: 10.1007/s11064-017-2314-9. Epub 2017 Jun 7. Review.


The chemical basis for electrical signaling.

Catterall WA, Wisedchaisri G, Zheng N.

Nat Chem Biol. 2017 Apr 13;13(5):455-463. doi: 10.1038/nchembio.2353. Review.


Structures of closed and open states of a voltage-gated sodium channel.

Lenaeus MJ, Gamal El-Din TM, Ing C, Ramanadane K, Pomès R, Zheng N, Catterall WA.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3051-E3060. doi: 10.1073/pnas.1700761114. Epub 2017 Mar 27.


Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.

Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo MF, Hell JW.

Sci Signal. 2017 Jan 24;10(463). pii: eaaf9659. doi: 10.1126/scisignal.aaf9659.


Association of rare missense variants in the second intracellular loop of NaV1.7 sodium channels with familial autism.

Rubinstein M, Patowary A, Stanaway IB, McCord E, Nesbitt RR, Archer M, Scheuer T, Nickerson D, Raskind WH, Wijsman EM, Bernier R, Catterall WA, Brkanac Z.

Mol Psychiatry. 2018 Feb;23(2):231-239. doi: 10.1038/mp.2016.222. Epub 2016 Dec 13.


Loss of β-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure.

Yang L, Dai DF, Yuan C, Westenbroek RE, Yu H, West N, de la Iglesia HO, Catterall WA.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7976-E7985. Epub 2016 Nov 18.


Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to long-term potentiation and spatial learning.

Nanou E, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13209-13214. Epub 2016 Oct 31.


Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs.

Tang L, Gamal El-Din TM, Swanson TM, Pryde DC, Scheuer T, Zheng N, Catterall WA.

Nature. 2016 Sep 1;537(7618):117-121. doi: 10.1038/nature19102. Epub 2016 Aug 24.


K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome.

Levin MD, Singh GK, Zhang HX, Uchida K, Kozel BA, Stein PK, Kovacs A, Westenbroek RE, Catterall WA, Grange DK, Nichols CG.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6773-8. doi: 10.1073/pnas.1606465113. Epub 2016 May 31.


Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.

Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW.

EMBO J. 2016 Jun 15;35(12):1330-45. doi: 10.15252/embj.201593409. Epub 2016 Apr 21.


Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons.

Nanou E, Sullivan JM, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1062-7. doi: 10.1073/pnas.1524636113. Epub 2016 Jan 11.


Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic CaV2.1 Ca2+ channels.

Nanou E, Yan J, Whitehead NP, Kim MJ, Froehner SC, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1068-73. doi: 10.1073/pnas.1524650113. Epub 2016 Jan 11.


The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels.

Alexander SP, Catterall WA, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators.

Br J Pharmacol. 2015 Dec;172(24):5904-41. doi: 10.1111/bph.13349.


The Concise Guide to PHARMACOLOGY 2015/16: Overview.

Alexander SP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA; CGTP Collaborators.

Br J Pharmacol. 2015 Dec;172(24):5729-43. doi: 10.1111/bph.13347.


The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands.

Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SP, Buneman OP, Davenport AP, McGrath JC, Peters JA, Spedding M, Catterall WA, Fabbro D, Davies JA; NC-IUPHAR.

Nucleic Acids Res. 2016 Jan 4;44(D1):D1054-68. doi: 10.1093/nar/gkv1037. Epub 2015 Oct 12.


Finding Channels.

Catterall WA.

J Biol Chem. 2015 Nov 20;290(47):28357-73. doi: 10.1074/jbc.X115.683383. Epub 2015 Oct 2. No abstract available.


Phosphorylation sites in the Hook domain of CaVβ subunits differentially modulate CaV1.2 channel function.

Brunet S, Emrick MA, Sadilek M, Scheuer T, Catterall WA.

J Mol Cell Cardiol. 2015 Oct;87:248-56. doi: 10.1016/j.yjmcc.2015.08.006. Epub 2015 Aug 10.


Deciphering voltage-gated Na(+) and Ca(2+) channels by studying prokaryotic ancestors.

Catterall WA, Zheng N.

Trends Biochem Sci. 2015 Sep;40(9):526-34. doi: 10.1016/j.tibs.2015.07.002. Epub 2015 Aug 5. Review.


Dissecting the phenotypes of Dravet syndrome by gene deletion.

Rubinstein M, Han S, Tai C, Westenbroek RE, Hunker A, Scheuer T, Catterall WA.

Brain. 2015 Aug;138(Pt 8):2219-33. doi: 10.1093/brain/awv142. Epub 2015 May 27.


Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response.

Catterall WA.

Curr Mol Pharmacol. 2015;8(1):12-21. Review.


The First 50 Years of Molecular Pharmacology.

Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF.

Mol Pharmacol. 2015 Jul;88(1):139-40. doi: 10.1124/mol.115.099564. Epub 2015 May 5. Review.


Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels.

Catterall WA, Swanson TM.

Mol Pharmacol. 2015 Jul;88(1):141-50. doi: 10.1124/mol.114.097659. Epub 2015 Apr 6. Review.


Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.


Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome.

Kalume F, Oakley JC, Westenbroek RE, Gile J, de la Iglesia HO, Scheuer T, Catterall WA.

Neurobiol Dis. 2015 May;77:141-54. doi: 10.1016/j.nbd.2015.02.016. Epub 2015 Mar 10.


Modulation of CaV2.1 channels by neuronal calcium sensor-1 induces short-term synaptic facilitation.

Yan J, Leal K, Magupalli VG, Nanou E, Martinez GQ, Scheuer T, Catterall WA.

Mol Cell Neurosci. 2014 Nov;63:124-31.


Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700.

Fu Y, Westenbroek RE, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16598-603. doi: 10.1073/pnas.1419129111. Epub 2014 Nov 3.


Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.

Rubinstein M, Westenbroek RE, Yu FH, Jones CJ, Scheuer T, Catterall WA.

Neurobiol Dis. 2015 Jan;73:106-17. doi: 10.1016/j.nbd.2014.09.017. Epub 2014 Oct 2.


Tracking S4 movement by gating pore currents in the bacterial sodium channel NaChBac.

Gamal El-Din TM, Scheuer T, Catterall WA.

J Gen Physiol. 2014 Aug;144(2):147-57. doi: 10.1085/jgp.201411210.


International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP, Sexton PM, Kenakin TP, Ehlert FJ, Spedding M, Langmead CJ.

Pharmacol Rev. 2014 Oct;66(4):918-47. doi: 10.1124/pr.114.008862.


Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome.

Tai C, Abe Y, Westenbroek RE, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3139-48. doi: 10.1073/pnas.1411131111. Epub 2014 Jul 14.


AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling.

Murphy JG, Sanderson JL, Gorski JA, Scott JD, Catterall WA, Sather WA, Dell'Acqua ML.

Cell Rep. 2014 Jun 12;7(5):1577-1588. doi: 10.1016/j.celrep.2014.04.027. Epub 2014 May 15.


Enhancement of inhibitory neurotransmission by GABAA receptors having α2,3-subunits ameliorates behavioral deficits in a mouse model of autism.

Han S, Tai C, Jones CJ, Scheuer T, Catterall WA.

Neuron. 2014 Mar 19;81(6):1282-1289. doi: 10.1016/j.neuron.2014.01.016.


Differential regulation of CaV1.2 channels by cAMP-dependent protein kinase bound to A-kinase anchoring proteins 15 and 79/150.

Fuller MD, Fu Y, Scheuer T, Catterall WA.

J Gen Physiol. 2014 Mar;143(3):315-24. doi: 10.1085/jgp.201311075.


The Concise Guide to PHARMACOLOGY 2013/14: ion channels.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators.

Br J Pharmacol. 2013 Dec;170(8):1607-51. doi: 10.1111/bph.12447.


The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.


PDE4B mediates local feedback regulation of β₁-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes.

Mika D, Richter W, Westenbroek RE, Catterall WA, Conti M.

J Cell Sci. 2014 Mar 1;127(Pt 5):1033-42. doi: 10.1242/jcs.140251. Epub 2014 Jan 10.


Sodium channels, inherited epilepsy, and antiepileptic drugs.

Catterall WA.

Annu Rev Pharmacol Toxicol. 2014;54:317-38. doi: 10.1146/annurev-pharmtox-011112-140232. Review.


Structural basis for Ca2+ selectivity of a voltage-gated calcium channel.

Tang L, Gamal El-Din TM, Payandeh J, Martinez GQ, Heard TM, Scheuer T, Zheng N, Catterall WA.

Nature. 2014 Jan 2;505(7481):56-61. doi: 10.1038/nature12775. Epub 2013 Nov 24.

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