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Structure of the Cardiac Sodium Channel.

Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA.

Cell. 2020 Jan 9;180(1):122-134.e10. doi: 10.1016/j.cell.2019.11.041. Epub 2019 Dec 19.


IgGs from patients with amyotrophic lateral sclerosis and diabetes target CaVα2δ1 subunits impairing islet cell function and survival.

Shi Y, Park KS, Kim SH, Yu J, Zhao K, Yu L, Oh KW, Lee K, Kim J, Chaggar K, Li Y, Dolphin AC, Catterall WA, Ryu SH, Yang SN, Berggren PO.

Proc Natl Acad Sci U S A. 2019 Dec 11. pii: 201911956. doi: 10.1073/pnas.1911956116. [Epub ahead of print]


Impairment of Sharp-Wave Ripples in a Murine Model of Dravet Syndrome.

Cheah CS, Lundstrom BN, Catterall WA, Oakley JC.

J Neurosci. 2019 Nov 13;39(46):9251-9260. doi: 10.1523/JNEUROSCI.0890-19.2019. Epub 2019 Sep 19.


Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels.

Catterall WA, Lenaeus MJ, Gamal El-Din TM.

Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:133-154. doi: 10.1146/annurev-pharmtox-010818-021757. Epub 2019 Sep 19.


Molecular Determinants of Brevetoxin Binding to Voltage-Gated Sodium Channels.

Konoki K, Baden DG, Scheuer T, Catterall WA.

Toxins (Basel). 2019 Sep 3;11(9). pii: E513. doi: 10.3390/toxins11090513.


Structural Basis for Diltiazem Block of a Voltage-Gated Ca2+ Channel.

Tang L, Gamal El-Din TM, Lenaeus MJ, Zheng N, Catterall WA.

Mol Pharmacol. 2019 Oct;96(4):485-492. doi: 10.1124/mol.119.117531. Epub 2019 Aug 7.


Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.

Wisedchaisri G, Tonggu L, McCord E, Gamal El-Din TM, Wang L, Zheng N, Catterall WA.

Cell. 2019 Aug 8;178(4):993-1003.e12. doi: 10.1016/j.cell.2019.06.031. Epub 2019 Jul 25.


Circadian regulation of sleep in a pre-clinical model of Dravet syndrome: dynamics of sleep stage and siesta re-entrainment.

Sanchez REA, Bussi IL, Ben-Hamo M, Caldart CS, Catterall WA, De La Iglesia HO.

Sleep. 2019 Dec 24;42(12). pii: zsz173. doi: 10.1093/sleep/zsz173.


Hippocampal deletion of NaV1.1 channels in mice causes thermal seizures and cognitive deficit characteristic of Dravet Syndrome.

Stein RE, Kaplan JS, Li J, Catterall WA.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16571-16576. doi: 10.1073/pnas.1906833116. Epub 2019 Jul 25.


A more efficient conditional mouse model of Dravet syndrome: Implications for epigenetic selection and sex-dependent behaviors.

Williams AD, Kalume F, Westenbroek RE, Catterall WA.

J Neurosci Methods. 2019 Sep 1;325:108315. doi: 10.1016/j.jneumeth.2019.108315. Epub 2019 Jun 29.


The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation.

Weyrer C, Turecek J, Niday Z, Liu PW, Nanou E, Catterall WA, Bean BP, Regehr WG.

Cell Rep. 2019 Feb 26;26(9):2289-2297.e3. doi: 10.1016/j.celrep.2019.01.114.


Fenestrations control resting-state block of a voltage-gated sodium channel.

Gamal El-Din TM, Lenaeus MJ, Zheng N, Catterall WA.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13111-13116. doi: 10.1073/pnas.1814928115. Epub 2018 Dec 5.


Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb.

Gamal El-Din TM, Lenaeus MJ, Ramanadane K, Zheng N, Catterall WA.

J Gen Physiol. 2019 Feb 4;151(2):174-185. doi: 10.1085/jgp.201711884. Epub 2018 Dec 3.


Dravet Syndrome: A Sodium Channel Interneuronopathy.

Catterall WA.

Curr Opin Physiol. 2018 Apr;2:42-50. doi: 10.1016/j.cophys.2017.12.007. Epub 2017 Dec 23.


Structural basis for gating pore current in periodic paralysis.

Jiang D, Gamal El-Din TM, Ing C, Lu P, Pomès R, Zheng N, Catterall WA.

Nature. 2018 May;557(7706):590-594. doi: 10.1038/s41586-018-0120-4. Epub 2018 May 16.


The AKAP Cypher/Zasp contributes to β-adrenergic/PKA stimulation of cardiac CaV1.2 calcium channels.

Yu H, Yuan C, Westenbroek RE, Catterall WA.

J Gen Physiol. 2018 Jun 4;150(6):883-889. doi: 10.1085/jgp.201711818. Epub 2018 May 9.


Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease.

Nanou E, Catterall WA.

Neuron. 2018 May 2;98(3):466-481. doi: 10.1016/j.neuron.2018.03.017. Review.


Progress in Understanding and Treating SCN2A-Mediated Disorders.

Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL Jr, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, Otis TS, Petrou S, Pitt G, Schust LF, Taylor CM, Tjernagel J, Spiro JE, Bender KJ.

Trends Neurosci. 2018 Jul;41(7):442-456. doi: 10.1016/j.tins.2018.03.011. Epub 2018 Apr 23. Review.


Control of Excitation/Inhibition Balance in a Hippocampal Circuit by Calcium Sensor Protein Regulation of Presynaptic Calcium Channels.

Nanou E, Lee A, Catterall WA.

J Neurosci. 2018 May 2;38(18):4430-4440. doi: 10.1523/JNEUROSCI.0022-18.2018. Epub 2018 Apr 13.


Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective.

Gamal El-Din TM, Lenaeus MJ, Catterall WA.

Handb Exp Pharmacol. 2018;246:53-72. doi: 10.1007/164_2017_61. Review.


Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.

Kaplan JS, Stella N, Catterall WA, Westenbroek RE.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11229-11234. doi: 10.1073/pnas.1711351114. Epub 2017 Oct 2.


Forty Years of Sodium Channels: Structure, Function, Pharmacology, and Epilepsy.

Catterall WA.

Neurochem Res. 2017 Sep;42(9):2495-2504. doi: 10.1007/s11064-017-2314-9. Epub 2017 Jun 7. Review.


The chemical basis for electrical signaling.

Catterall WA, Wisedchaisri G, Zheng N.

Nat Chem Biol. 2017 Apr 13;13(5):455-463. doi: 10.1038/nchembio.2353. Review.


Structures of closed and open states of a voltage-gated sodium channel.

Lenaeus MJ, Gamal El-Din TM, Ing C, Ramanadane K, Pomès R, Zheng N, Catterall WA.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3051-E3060. doi: 10.1073/pnas.1700761114. Epub 2017 Mar 27.


Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.

Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo MF, Hell JW.

Sci Signal. 2017 Jan 24;10(463). pii: eaaf9659. doi: 10.1126/scisignal.aaf9659.


Association of rare missense variants in the second intracellular loop of NaV1.7 sodium channels with familial autism.

Rubinstein M, Patowary A, Stanaway IB, McCord E, Nesbitt RR, Archer M, Scheuer T, Nickerson D, Raskind WH, Wijsman EM, Bernier R, Catterall WA, Brkanac Z.

Mol Psychiatry. 2018 Feb;23(2):231-239. doi: 10.1038/mp.2016.222. Epub 2016 Dec 13.


Loss of β-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure.

Yang L, Dai DF, Yuan C, Westenbroek RE, Yu H, West N, de la Iglesia HO, Catterall WA.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7976-E7985. Epub 2016 Nov 18.


Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to long-term potentiation and spatial learning.

Nanou E, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13209-13214. Epub 2016 Oct 31.


Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs.

Tang L, Gamal El-Din TM, Swanson TM, Pryde DC, Scheuer T, Zheng N, Catterall WA.

Nature. 2016 Sep 1;537(7618):117-121. doi: 10.1038/nature19102. Epub 2016 Aug 24.


K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome.

Levin MD, Singh GK, Zhang HX, Uchida K, Kozel BA, Stein PK, Kovacs A, Westenbroek RE, Catterall WA, Grange DK, Nichols CG.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6773-8. doi: 10.1073/pnas.1606465113. Epub 2016 May 31.


Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.

Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW.

EMBO J. 2016 Jun 15;35(12):1330-45. doi: 10.15252/embj.201593409. Epub 2016 Apr 21.


Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons.

Nanou E, Sullivan JM, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1062-7. doi: 10.1073/pnas.1524636113. Epub 2016 Jan 11.


Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic CaV2.1 Ca2+ channels.

Nanou E, Yan J, Whitehead NP, Kim MJ, Froehner SC, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1068-73. doi: 10.1073/pnas.1524650113. Epub 2016 Jan 11.


The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels.

Alexander SP, Catterall WA, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators.

Br J Pharmacol. 2015 Dec;172(24):5904-41. doi: 10.1111/bph.13349.


The Concise Guide to PHARMACOLOGY 2015/16: Overview.

Alexander SP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA; CGTP Collaborators.

Br J Pharmacol. 2015 Dec;172(24):5729-43. doi: 10.1111/bph.13347.


The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands.

Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SP, Buneman OP, Davenport AP, McGrath JC, Peters JA, Spedding M, Catterall WA, Fabbro D, Davies JA; NC-IUPHAR.

Nucleic Acids Res. 2016 Jan 4;44(D1):D1054-68. doi: 10.1093/nar/gkv1037. Epub 2015 Oct 12.


Finding Channels.

Catterall WA.

J Biol Chem. 2015 Nov 20;290(47):28357-73. doi: 10.1074/jbc.X115.683383. Epub 2015 Oct 2. No abstract available.


Phosphorylation sites in the Hook domain of CaVβ subunits differentially modulate CaV1.2 channel function.

Brunet S, Emrick MA, Sadilek M, Scheuer T, Catterall WA.

J Mol Cell Cardiol. 2015 Oct;87:248-56. doi: 10.1016/j.yjmcc.2015.08.006. Epub 2015 Aug 10.


Deciphering voltage-gated Na(+) and Ca(2+) channels by studying prokaryotic ancestors.

Catterall WA, Zheng N.

Trends Biochem Sci. 2015 Sep;40(9):526-34. doi: 10.1016/j.tibs.2015.07.002. Epub 2015 Aug 5. Review.


Dissecting the phenotypes of Dravet syndrome by gene deletion.

Rubinstein M, Han S, Tai C, Westenbroek RE, Hunker A, Scheuer T, Catterall WA.

Brain. 2015 Aug;138(Pt 8):2219-33. doi: 10.1093/brain/awv142. Epub 2015 May 27.


Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response.

Catterall WA.

Curr Mol Pharmacol. 2015;8(1):12-21. Review.


The First 50 Years of Molecular Pharmacology.

Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF.

Mol Pharmacol. 2015 Jul;88(1):139-40. doi: 10.1124/mol.115.099564. Epub 2015 May 5. Review.


Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels.

Catterall WA, Swanson TM.

Mol Pharmacol. 2015 Jul;88(1):141-50. doi: 10.1124/mol.114.097659. Epub 2015 Apr 6. Review.


Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.


Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome.

Kalume F, Oakley JC, Westenbroek RE, Gile J, de la Iglesia HO, Scheuer T, Catterall WA.

Neurobiol Dis. 2015 May;77:141-54. doi: 10.1016/j.nbd.2015.02.016. Epub 2015 Mar 10.


Modulation of CaV2.1 channels by neuronal calcium sensor-1 induces short-term synaptic facilitation.

Yan J, Leal K, Magupalli VG, Nanou E, Martinez GQ, Scheuer T, Catterall WA.

Mol Cell Neurosci. 2014 Nov;63:124-31.


Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700.

Fu Y, Westenbroek RE, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16598-603. doi: 10.1073/pnas.1419129111. Epub 2014 Nov 3.


Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.

Rubinstein M, Westenbroek RE, Yu FH, Jones CJ, Scheuer T, Catterall WA.

Neurobiol Dis. 2015 Jan;73:106-17. doi: 10.1016/j.nbd.2014.09.017. Epub 2014 Oct 2.


Tracking S4 movement by gating pore currents in the bacterial sodium channel NaChBac.

Gamal El-Din TM, Scheuer T, Catterall WA.

J Gen Physiol. 2014 Aug;144(2):147-57. doi: 10.1085/jgp.201411210.


International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP, Sexton PM, Kenakin TP, Ehlert FJ, Spedding M, Langmead CJ.

Pharmacol Rev. 2014 Oct;66(4):918-47. doi: 10.1124/pr.114.008862.


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