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Items: 25


Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration.

Smith B, Kiessling A, Lledo-Garcia R, Dixon KL, Christodoulou L, Catley MC, Atherfold P, D'Hooghe LE, Finney H, Greenslade K, Hailu H, Kevorkian L, Lightwood D, Meier C, Munro R, Qureshi O, Sarkar K, Shaw SP, Tewari R, Turner A, Tyson K, West S, Shaw S, Brennan FR.

MAbs. 2018 Oct;10(7):1111-1130. doi: 10.1080/19420862.2018.1505464. Epub 2018 Sep 12.


Patient stratification and the unmet need in asthma.

Swedin L, Saarne T, Rehnberg M, Glader P, Niedzielska M, Johansson G, Hazon P, Catley MC.

Pharmacol Ther. 2017 Jan;169:13-34. doi: 10.1016/j.pharmthera.2016.06.016. Epub 2016 Jul 1. Review.


OX40 blockade inhibits house dust mite driven allergic lung inflammation in mice and in vitro allergic responses in humans.

Burrows KE, Dumont C, Thompson CL, Catley MC, Dixon KL, Marshall D.

Eur J Immunol. 2015 Apr;45(4):1116-28. doi: 10.1002/eji.201445163. Epub 2015 Jan 21.


Cigarette smoke induced airway inflammation is independent of NF-κB signalling.

Rastrick JM, Stevenson CS, Eltom S, Grace M, Davies M, Kilty I, Evans SM, Pasparakis M, Catley MC, Lawrence T, Adcock IM, Belvisi MG, Birrell MA.

PLoS One. 2013;8(1):e54128. doi: 10.1371/journal.pone.0054128. Epub 2013 Jan 22. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/754d7b19-2dac-479b-a23c-db9fed0431be.


Monoclonal antibodies for the treatment of asthma.

Catley MC, Coote J, Bari M, Tomlinson KL.

Pharmacol Ther. 2011 Dec;132(3):333-51. doi: 10.1016/j.pharmthera.2011.09.005. Epub 2011 Sep 12. Review.


P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke.

Eltom S, Stevenson CS, Rastrick J, Dale N, Raemdonck K, Wong S, Catley MC, Belvisi MG, Birrell MA.

PLoS One. 2011;6(9):e24097. doi: 10.1371/journal.pone.0024097. Epub 2011 Sep 6.


Asthma & COPD--IQPC's Second Conference.

Catley MC.

IDrugs. 2010 Sep;13(9):601-4.


Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth.

Birrell MA, De Alba J, Catley MC, Hardaker E, Wong S, Collins M, Clarke DL, Farrow SN, Willson TM, Collins JL, Belvisi MG.

J Immunol. 2008 Sep 15;181(6):4265-71.


PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells.

Callister ME, Pinhu L, Catley MC, Westwell AD, Newton R, Leaver SK, Quinlan GJ, Evans TW, Griffiths MJ, Burke-Gaffney A.

Br J Pharmacol. 2008 Nov;155(5):661-72. doi: 10.1038/bjp.2008.258. Epub 2008 Jun 30.


Estrogen receptor beta: expression profile and possible anti-inflammatory role in disease.

Catley MC, Birrell MA, Hardaker EL, de Alba J, Farrow S, Haj-Yahia S, Belvisi MG.

J Pharmacol Exp Ther. 2008 Jul;326(1):83-8. doi: 10.1124/jpet.108.136275. Epub 2008 Mar 28.


The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells.

Tudhope SJ, Catley MC, Fenwick PS, Russell RE, Rumsey WL, Newton R, Barnes PJ, Donnelly LE.

J Immunol. 2007 Nov 1;179(9):6237-45.


Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses.

Birrell MA, Catley MC, Hardaker E, Wong S, Willson TM, McCluskie K, Leonard T, Farrow SN, Collins JL, Haj-Yahia S, Belvisi MG.

J Biol Chem. 2007 Nov 2;282(44):31882-90. Epub 2007 Aug 31.


Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages.

Birrell MA, Wong S, Catley MC, Belvisi MG.

J Cell Physiol. 2008 Jan;214(1):27-37.


Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors.

Newton R, Holden NS, Catley MC, Oyelusi W, Leigh R, Proud D, Barnes PJ.

J Pharmacol Exp Ther. 2007 May;321(2):734-42. Epub 2007 Feb 22.


Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle.

Catley MC, Sukkar MB, Chung KF, Jaffee B, Liao SM, Coyle AJ, Haddad el-B, Barnes PJ, Newton R.

Mol Pharmacol. 2006 Aug;70(2):697-705. Epub 2006 May 10.


IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic.

Birrell MA, Wong S, Hardaker EL, Catley MC, McCluskie K, Collins M, Haj-Yahia S, Belvisi MG.

Mol Pharmacol. 2006 Jun;69(6):1791-800. Epub 2006 Mar 3.


Second-generation inhibitors demonstrate the involvement of p38 mitogen-activated protein kinase in post-transcriptional modulation of inflammatory mediator production in human and rodent airways.

Birrell MA, Wong S, McCluskie K, Catley MC, Hardaker EL, Haj-Yahia S, Belvisi MG.

J Pharmacol Exp Ther. 2006 Mar;316(3):1318-27. Epub 2005 Dec 20.


Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release.

Chivers JE, Cambridge LM, Catley MC, Mak JC, Donnelly LE, Barnes PJ, Newton R.

Eur J Biochem. 2004 Oct;271(20):4042-52.


Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF.

Clarke DL, Belvisi MG, Catley MC, Yacoub MH, Newton R, Giembycz MA.

Br J Pharmacol. 2004 Apr;141(7):1141-50. Epub 2004 Mar 15.


Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding.

Catley MC, Cambridge LM, Nasuhara Y, Ito K, Chivers JE, Beaton A, Holden NS, Bergmann MW, Barnes PJ, Newton R.

J Biol Chem. 2004 Apr 30;279(18):18457-66. Epub 2004 Feb 19.


ICAM-1 expression is highly NF-kappaB-dependent in A549 cells. No role for ERK and p38 MAPK.

Holden NS, Catley MC, Cambridge LM, Barnes PJ, Newton R.

Eur J Biochem. 2004 Feb;271(4):785-91.


IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase.

Catley MC, Chivers JE, Cambridge LM, Holden N, Slater DM, Staples KJ, Bergmann MW, Loser P, Barnes PJ, Newton R.

FEBS Lett. 2003 Jul 17;547(1-3):75-9.


Influence of the pontine and medullary reticular formation on synchrony of gamma motoneurone discharge in the cat.

Baker JR, Catley MC, Davey NJ, Ellaway PH.

Exp Brain Res. 1991;87(3):604-14.


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