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Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.

Li W, Ward FR, McClure KF, Chang ST, Montabana E, Liras S, Dullea RG, Cate JHD.

Nat Struct Mol Biol. 2019 Jun;26(6):501-509. doi: 10.1038/s41594-019-0236-8. Epub 2019 Jun 3.


Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation.

Liu JJ, Zhang GC, Kwak S, Oh EJ, Yun EJ, Chomvong K, Cate JHD, Jin YS.

Nat Commun. 2019 Mar 22;10(1):1356. doi: 10.1038/s41467-019-09288-6.


Cellular response to small molecules that selectively stall protein synthesis by the ribosome.

Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD.

PLoS Genet. 2019 Mar 15;15(3):e1008057. doi: 10.1371/journal.pgen.1008057. eCollection 2019 Mar.


Differences in the path to exit the ribosome across the three domains of life.

Dao Duc K, Batra SS, Bhattacharya N, Cate JHD, Song YS.

Nucleic Acids Res. 2019 May 7;47(8):4198-4210. doi: 10.1093/nar/gkz106.


Bacterial ribosome heterogeneity: Changes in ribosomal protein composition during transition into stationary growth phase.

Lilleorg S, Reier K, Pulk A, Liiv A, Tammsalu T, Peil L, Cate JHD, Remme J.

Biochimie. 2019 Jan;156:169-180. doi: 10.1016/j.biochi.2018.10.013. Epub 2018 Oct 23.


Modulating long-range energetics via helix stabilization: A case study using T4 lysozyme.

Rosemond SN, Hamadani KM, Cate JHD, Marqusee S.

Protein Sci. 2018 Dec;27(12):2084-2093. doi: 10.1002/pro.3521.


Engineering Kluyveromyces marxianus as a Robust Synthetic Biology Platform Host.

Cernak P, Estrela R, Poddar S, Skerker JM, Cheng YF, Carlson AK, Chen B, Glynn VM, Furlan M, Ryan OW, Donnelly MK, Arkin AP, Taylor JW, Cate JHD.

MBio. 2018 Sep 25;9(5). pii: e01410-18. doi: 10.1128/mBio.01410-18.


Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.

Londregan AT, Wei L, Xiao J, Lintner NG, Petersen D, Dullea RG, McClure KF, Bolt MW, Warmus JS, Coffey SB, Limberakis C, Genovino J, Thuma BA, Hesp KD, Aspnes GE, Reidich B, Salatto CT, Chabot JR, Cate JHD, Liras S, Piotrowski DW.

J Med Chem. 2018 Jul 12;61(13):5704-5718. doi: 10.1021/acs.jmedchem.8b00650. Epub 2018 Jun 25.


Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate JHD.

PLoS Biol. 2018 Apr 17;16(4):e1002628. doi: 10.1371/journal.pbio.1002628. eCollection 2018 Apr.


Enhanced cellobiose fermentation by engineered Saccharomyces cerevisiae expressing a mutant cellodextrin facilitator and cellobiose phosphorylase.

Kim H, Oh EJ, Lane ST, Lee WH, Cate JHD, Jin YS.

J Biotechnol. 2018 Jun 10;275:53-59. doi: 10.1016/j.jbiotec.2018.04.008. Epub 2018 Apr 13.


Evolutionary engineering improves tolerance for medium-chain alcohols in Saccharomyces cerevisiae.

Davis López SA, Griffith DA, Choi B, Cate JHD, Tullman-Ercek D.

Biotechnol Biofuels. 2018 Apr 2;11:90. doi: 10.1186/s13068-018-1089-9. eCollection 2018.


Programmable RNA recognition using a CRISPR-associated Argonaute.

Lapinaite A, Doudna JA, Cate JHD.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3368-3373. doi: 10.1073/pnas.1717725115. Epub 2018 Mar 12.


Metabolic engineering of yeast for lignocellulosic biofuel production.

Jin YS, Cate JH.

Curr Opin Chem Biol. 2017 Dec;41:99-106. doi: 10.1016/j.cbpa.2017.10.025. Epub 2017 Nov 8. Review.


Role for ribosome-associated complex and stress-seventy subfamily B (RAC-Ssb) in integral membrane protein translation.

Acosta-Sampson L, Döring K, Lin Y, Yu VY, Bukau B, Kramer G, Cate JHD.

J Biol Chem. 2017 Dec 1;292(48):19610-19627. doi: 10.1074/jbc.M117.813857. Epub 2017 Oct 2.


Screening of transporters to improve xylodextrin utilization in the yeast Saccharomyces cerevisiae.

Zhang C, Acosta-Sampson L, Yu VY, Cate JHD.

PLoS One. 2017 Sep 8;12(9):e0184730. doi: 10.1371/journal.pone.0184730. eCollection 2017.


Cellobiose Consumption Uncouples Extracellular Glucose Sensing and Glucose Metabolism in Saccharomyces cerevisiae.

Chomvong K, Benjamin DI, Nomura DK, Cate JHD.

MBio. 2017 Aug 8;8(4). pii: e00855-17. doi: 10.1128/mBio.00855-17.


An in vitro tag-and-modify protein sample generation method for single-molecule fluorescence resonance energy transfer.

Hamadani KM, Howe J, Jensen MK, Wu P, Cate JHD, Marqusee S.

J Biol Chem. 2017 Sep 22;292(38):15636-15648. doi: 10.1074/jbc.M117.791723. Epub 2017 Jul 28.


Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate JH.

PLoS Biol. 2017 Mar 21;15(3):e2001882. doi: 10.1371/journal.pbio.2001882. eCollection 2017 Mar. Erratum in: PLoS Biol. 2018 Apr 17;16(4):e1002628.


Monolayer-crystal streptavidin support films provide an internal standard of cryo-EM image quality.

Han BG, Watson Z, Cate JHD, Glaeser RM.

J Struct Biol. 2017 Dec;200(3):307-313. doi: 10.1016/j.jsb.2017.02.009. Epub 2017 Mar 1.


Human eIF3: from 'blobology' to biological insight.

Cate JH.

Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19;372(1716). pii: 20160176. doi: 10.1098/rstb.2016.0176. Review.


Quantitative determination of ribosome nascent chain stability.

Samelson AJ, Jensen MK, Soto RA, Cate JH, Marqusee S.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13402-13407. Epub 2016 Nov 7.


Internalization of Heterologous Sugar Transporters by Endogenous α-Arrestins in the Yeast Saccharomyces cerevisiae.

Sen A, Acosta-Sampson L, Alvaro CG, Ahn JS, Cate JH, Thorner J.

Appl Environ Microbiol. 2016 Nov 21;82(24):7074-7085. Print 2016 Dec 15.


Relief of Xylose Binding to Cellobiose Phosphorylase by a Single Distal Mutation.

Chomvong K, Lin E, Blaisse M, Gillespie AE, Cate JH.

ACS Synth Biol. 2017 Feb 17;6(2):206-210. doi: 10.1021/acssynbio.6b00211. Epub 2016 Oct 3.


Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.

East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA.

Nature. 2016 Oct 13;538(7624):270-273. doi: 10.1038/nature19802. Epub 2016 Sep 26.


eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

Lee AS, Kranzusch PJ, Doudna JA, Cate JH.

Nature. 2016 Aug 4;536(7614):96-9. Epub 2016 Jul 27.


Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.

Cocozaki AI, Altman RB, Huang J, Buurman ET, Kazmirski SL, Doig P, Prince DB, Blanchard SC, Cate JH, Ferguson AD.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8188-93. doi: 10.1073/pnas.1605127113. Epub 2016 Jul 5.


Bypassing the Pentose Phosphate Pathway: Towards Modular Utilization of Xylose.

Chomvong K, Bauer S, Benjamin DI, Li X, Nomura DK, Cate JH.

PLoS One. 2016 Jun 23;11(6):e0158111. doi: 10.1371/journal.pone.0158111. eCollection 2016.


CRISPR-Cas9 Genome Engineering in Saccharomyces cerevisiae Cells.

Ryan OW, Poddar S, Cate JH.

Cold Spring Harb Protoc. 2016 Jun 1;2016(6). doi: 10.1101/pdb.prot086827.


Assembly of eIF3 Mediated by Mutually Dependent Subunit Insertion.

Smith MD, Arake-Tacca L, Nitido A, Montabana E, Park A, Cate JH.

Structure. 2016 Jun 7;24(6):886-96. doi: 10.1016/j.str.2016.02.024. Epub 2016 May 19.


STRUCTURE. A Big Bang in spliceosome structural biology.

Cate JH.

Science. 2016 Mar 25;351(6280):1390-2. doi: 10.1126/science.aaf4465. No abstract available.


Editorial overview: Energy biotechnology.

Cate JH, Ball AS.

Curr Opin Biotechnol. 2016 Apr;38:v-vii. doi: 10.1016/j.copbio.2016.02.019. Epub 2016 Mar 7. No abstract available.


Energy biotechnology in the CRISPR-Cas9 era.

Estrela R, Cate JH.

Curr Opin Biotechnol. 2016 Apr;38:79-84. doi: 10.1016/j.copbio.2016.01.005. Epub 2016 Feb 10. Review.


Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation.

Thakor N, Smith MD, Roberts L, Faye MD, Patel H, Wieden HJ, Cate JHD, Holcik M.

RNA Biol. 2017 May 4;14(5):553-567. doi: 10.1080/15476286.2015.1137419. Epub 2016 Feb 1.


Comparison of xylose fermentation by two high-performance engineered strains of Saccharomyces cerevisiae.

Li X, Park A, Estrela R, Kim SR, Jin YS, Cate JH.

Biotechnol Rep (Amst). 2016 Jan 22;9:53-56. doi: 10.1016/j.btre.2016.01.003. eCollection 2016 Mar.


Factors that Influence the Formation and Stability of Thin, Cryo-EM Specimens.

Glaeser RM, Han BG, Csencsits R, Killilea A, Pulk A, Cate JH.

Biophys J. 2016 Feb 23;110(4):749-55. doi: 10.1016/j.bpj.2015.07.050. Epub 2015 Sep 17. Review.


Cellobionic acid utilization: from Neurospora crassa to Saccharomyces cerevisiae.

Li X, Chomvong K, Yu VY, Liang JM, Lin Y, Cate JHD.

Biotechnol Biofuels. 2015 Aug 16;8:120. doi: 10.1186/s13068-015-0303-2. eCollection 2015.


Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions.

Wasserman MR, Pulk A, Zhou Z, Altman RB, Zinder JC, Green KD, Garneau-Tsodikova S, Cate JH, Blanchard SC.

Nat Commun. 2015 Jul 30;6:7896. doi: 10.1038/ncomms8896.


eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

Lee AS, Kranzusch PJ, Cate JH.

Nature. 2015 Jun 4;522(7554):111-4. doi: 10.1038/nature14267. Epub 2015 Apr 6.


High-resolution structure of the Escherichia coli ribosome.

Noeske J, Wasserman MR, Terry DS, Altman RB, Blanchard SC, Cate JH.

Nat Struct Mol Biol. 2015 Apr;22(4):336-41. doi: 10.1038/nsmb.2994. Epub 2015 Mar 16.


Expanding xylose metabolism in yeast for plant cell wall conversion to biofuels.

Li X, Yu VY, Lin Y, Chomvong K, Estrela R, Park A, Liang JM, Znameroski EA, Feehan J, Kim SR, Jin YS, Glass NL, Cate JH.

Elife. 2015 Feb 3;4. doi: 10.7554/eLife.05896.


Simultaneous utilization of cellobiose, xylose, and acetic acid from lignocellulosic biomass for biofuel production by an engineered yeast platform.

Wei N, Oh EJ, Million G, Cate JH, Jin YS.

ACS Synth Biol. 2015 Jun 19;4(6):707-13. doi: 10.1021/sb500364q. Epub 2015 Jan 27.


Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase.

Rui Z, Li X, Zhu X, Liu J, Domigan B, Barr I, Cate JH, Zhang W.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18237-42. doi: 10.1073/pnas.1419701112. Epub 2014 Dec 8.


Leveraging transcription factors to speed cellobiose fermentation by Saccharomyces cerevisiae.

Lin Y, Chomvong K, Acosta-Sampson L, Estrela R, Galazka JM, Kim SR, Jin YS, Cate JH.

Biotechnol Biofuels. 2014 Aug 27;7(1):126. doi: 10.1186/s13068-014-0126-6. eCollection 2014.


Multiplex engineering of industrial yeast genomes using CRISPRm.

Ryan OW, Cate JH.

Methods Enzymol. 2014;546:473-89. doi: 10.1016/B978-0-12-801185-0.00023-4.


Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

Olivier NB, Altman RB, Noeske J, Basarab GS, Code E, Ferguson AD, Gao N, Huang J, Juette MF, Livchak S, Miller MD, Prince DB, Cate JH, Buurman ET, Blanchard SC.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16274-9. doi: 10.1073/pnas.1414401111. Epub 2014 Nov 3.


Construction of a quadruple auxotrophic mutant of an industrial polyploid saccharomyces cerevisiae strain by using RNA-guided Cas9 nuclease.

Zhang GC, Kong II, Kim H, Liu JJ, Cate JH, Jin YS.

Appl Environ Microbiol. 2014 Dec;80(24):7694-701. doi: 10.1128/AEM.02310-14. Epub 2014 Oct 3.


Selection of chromosomal DNA libraries using a multiplex CRISPR system.

Ryan OW, Skerker JM, Maurer MJ, Li X, Tsai JC, Poddar S, Lee ME, DeLoache W, Dueber JE, Arkin AP, Cate JH.

Elife. 2014 Aug 19;3. doi: 10.7554/eLife.03703.


Synergy of streptogramin antibiotics occurs independently of their effects on translation.

Noeske J, Huang J, Olivier NB, Giacobbe RA, Zambrowski M, Cate JH.

Antimicrob Agents Chemother. 2014 Sep;58(9):5269-79. doi: 10.1128/AAC.03389-14. Epub 2014 Jun 23.


Overcoming inefficient cellobiose fermentation by cellobiose phosphorylase in the presence of xylose.

Chomvong K, Kordić V, Li X, Bauer S, Gillespie AE, Ha SJ, Oh EJ, Galazka JM, Jin YS, Cate JH.

Biotechnol Biofuels. 2014 Jun 7;7:85. doi: 10.1186/1754-6834-7-85. eCollection 2014.


The proteome and phosphoproteome of Neurospora crassa in response to cellulose, sucrose and carbon starvation.

Xiong Y, Coradetti ST, Li X, Gritsenko MA, Clauss T, Petyuk V, Camp D, Smith R, Cate JHD, Yang F, Glass NL.

Fungal Genet Biol. 2014 Nov;72:21-33. doi: 10.1016/j.fgb.2014.05.005. Epub 2014 May 29.

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