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Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.

Londregan AT, Wei L, Xiao J, Lintner NG, Petersen D, Dullea RG, McClure KF, Bolt MW, Warmus JS, Coffey SB, Limberakis C, Genovino J, Thuma BA, Hesp KD, Aspnes GE, Reidich B, Salatto CT, Chabot JR, Cate JHD, Liras S, Piotrowski DW.

J Med Chem. 2018 Jul 12;61(13):5704-5718. doi: 10.1021/acs.jmedchem.8b00650. Epub 2018 Jun 25.


Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate JHD.

PLoS Biol. 2018 Apr 17;16(4):e1002628. doi: 10.1371/journal.pbio.1002628. eCollection 2018 Apr.


Enhanced cellobiose fermentation by engineered Saccharomyces cerevisiae expressing a mutant cellodextrin facilitator and cellobiose phosphorylase.

Kim H, Oh EJ, Lane ST, Lee WH, Cate JHD, Jin YS.

J Biotechnol. 2018 Jun 10;275:53-59. doi: 10.1016/j.jbiotec.2018.04.008. Epub 2018 Apr 13.


Evolutionary engineering improves tolerance for medium-chain alcohols in Saccharomyces cerevisiae.

Davis López SA, Griffith DA, Choi B, Cate JHD, Tullman-Ercek D.

Biotechnol Biofuels. 2018 Apr 2;11:90. doi: 10.1186/s13068-018-1089-9. eCollection 2018.


Programmable RNA recognition using a CRISPR-associated Argonaute.

Lapinaite A, Doudna JA, Cate JHD.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3368-3373. doi: 10.1073/pnas.1717725115. Epub 2018 Mar 12.


Long-term remineralizing effect of MI Paste Plus on regression of early caries after orthodontic fixed appliance treatment: a 12-month follow-up randomized controlled trial.

Beerens MW, Ten Cate JM, Buijs MJ, van der Veen MH.

Eur J Orthod. 2017 Nov 17. doi: 10.1093/ejo/cjx085. [Epub ahead of print]


Metabolic engineering of yeast for lignocellulosic biofuel production.

Jin YS, Cate JH.

Curr Opin Chem Biol. 2017 Dec;41:99-106. doi: 10.1016/j.cbpa.2017.10.025. Epub 2017 Nov 8. Review.


Comparison of Composition and Anticaries Effect of Galla Chinensis Extracts with Different Isolation Methods.

Huang X, Deng M, Liu M, Cheng L, Exterkate RAM, Li J, Zhou X, Ten Cate JM.

Open Dent J. 2017 Aug 31;11:447-459. doi: 10.2174/1874210601711010447. eCollection 2017.


Role for ribosome-associated complex and stress-seventy subfamily B (RAC-Ssb) in integral membrane protein translation.

Acosta-Sampson L, Döring K, Lin Y, Yu VY, Bukau B, Kramer G, Cate JHD.

J Biol Chem. 2017 Dec 1;292(48):19610-19627. doi: 10.1074/jbc.M117.813857. Epub 2017 Oct 2.


Screening of transporters to improve xylodextrin utilization in the yeast Saccharomyces cerevisiae.

Zhang C, Acosta-Sampson L, Yu VY, Cate JHD.

PLoS One. 2017 Sep 8;12(9):e0184730. doi: 10.1371/journal.pone.0184730. eCollection 2017.


Cellobiose Consumption Uncouples Extracellular Glucose Sensing and Glucose Metabolism in Saccharomyces cerevisiae.

Chomvong K, Benjamin DI, Nomura DK, Cate JHD.

MBio. 2017 Aug 8;8(4). pii: e00855-17. doi: 10.1128/mBio.00855-17.


An in vitro tag-and-modify protein sample generation method for single-molecule fluorescence resonance energy transfer.

Hamadani KM, Howe J, Jensen MK, Wu P, Cate JHD, Marqusee S.

J Biol Chem. 2017 Sep 22;292(38):15636-15648. doi: 10.1074/jbc.M117.791723. Epub 2017 Jul 28.


Effect of arginine on the growth and biofilm formation of oral bacteria.

Huang X, Zhang K, Deng M, Exterkate RAM, Liu C, Zhou X, Cheng L, Ten Cate JM.

Arch Oral Biol. 2017 Oct;82:256-262. doi: 10.1016/j.archoralbio.2017.06.026. Epub 2017 Jun 24.


Second Era of OMICS in Caries Research: Moving Past the Phase of Disillusionment.

Nascimento MM, Zaura E, Mira A, Takahashi N, Ten Cate JM.

J Dent Res. 2017 Jul;96(7):733-740. doi: 10.1177/0022034517701902. Epub 2017 Apr 6. Review.


Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate JH.

PLoS Biol. 2017 Mar 21;15(3):e2001882. doi: 10.1371/journal.pbio.2001882. eCollection 2017 Mar. Erratum in: PLoS Biol. 2018 Apr 17;16(4):e1002628.


Monolayer-crystal streptavidin support films provide an internal standard of cryo-EM image quality.

Han BG, Watson Z, Cate JHD, Glaeser RM.

J Struct Biol. 2017 Dec;200(3):307-313. doi: 10.1016/j.jsb.2017.02.009. Epub 2017 Mar 1.


Microbial profile of dental plaque associated to white spot lesions in orthodontic patients immediately after the bracket removal.

Beerens MW, Ten Cate JM, van der Veen MH.

Arch Oral Biol. 2017 Jun;78:88-93. doi: 10.1016/j.archoralbio.2017.02.011. Epub 2017 Feb 9.


Human eIF3: from 'blobology' to biological insight.

Cate JH.

Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19;372(1716). pii: 20160176. doi: 10.1098/rstb.2016.0176. Review.


Red fluorescence of dental plaque in children -A cross-sectional study.

Volgenant CM, Zaura E, Brandt BW, Buijs MJ, Tellez M, Malik G, Ismail AI, Ten Cate JM, van der Veen MH.

J Dent. 2017 Mar;58:40-47. doi: 10.1016/j.jdent.2017.01.007. Epub 2017 Jan 20.


Red and Green Fluorescence from Oral Biofilms.

Volgenant CM, Hoogenkamp MA, Krom BP, Janus MM, Ten Cate JM, de Soet JJ, Crielaard W, van der Veen MH.

PLoS One. 2016 Dec 20;11(12):e0168428. doi: 10.1371/journal.pone.0168428. eCollection 2016.


Quantitative determination of ribosome nascent chain stability.

Samelson AJ, Jensen MK, Soto RA, Cate JH, Marqusee S.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13402-13407. Epub 2016 Nov 7.


Changes in the oral ecosystem induced by the use of 8% arginine toothpaste.

Koopman JE, Hoogenkamp MA, Buijs MJ, Brandt BW, Keijser BJ, Crielaard W, Ten Cate JM, Zaura E.

Arch Oral Biol. 2017 Jan;73:79-87. doi: 10.1016/j.archoralbio.2016.09.008. Epub 2016 Sep 26.


Internalization of Heterologous Sugar Transporters by Endogenous α-Arrestins in the Yeast Saccharomyces cerevisiae.

Sen A, Acosta-Sampson L, Alvaro CG, Ahn JS, Cate JH, Thorner J.

Appl Environ Microbiol. 2016 Nov 21;82(24):7074-7085. Print 2016 Dec 15.


Relief of Xylose Binding to Cellobiose Phosphorylase by a Single Distal Mutation.

Chomvong K, Lin E, Blaisse M, Gillespie AE, Cate JH.

ACS Synth Biol. 2017 Feb 17;6(2):206-210. doi: 10.1021/acssynbio.6b00211. Epub 2016 Oct 3.


Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.

East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA.

Nature. 2016 Oct 13;538(7624):270-273. doi: 10.1038/nature19802. Epub 2016 Sep 26.


eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

Lee AS, Kranzusch PJ, Doudna JA, Cate JH.

Nature. 2016 Aug 4;536(7614):96-9. Epub 2016 Jul 27.


Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.

Cocozaki AI, Altman RB, Huang J, Buurman ET, Kazmirski SL, Doig P, Prince DB, Blanchard SC, Cate JH, Ferguson AD.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8188-93. doi: 10.1073/pnas.1605127113. Epub 2016 Jul 5.


Bypassing the Pentose Phosphate Pathway: Towards Modular Utilization of Xylose.

Chomvong K, Bauer S, Benjamin DI, Li X, Nomura DK, Cate JH.

PLoS One. 2016 Jun 23;11(6):e0158111. doi: 10.1371/journal.pone.0158111. eCollection 2016.


Long shelf-life streptavidin support-films suitable for electron microscopy of biological macromolecules.

Han BG, Watson Z, Kang H, Pulk A, Downing KH, Cate J, Glaeser RM.

J Struct Biol. 2016 Aug;195(2):238-244. doi: 10.1016/j.jsb.2016.06.009. Epub 2016 Jun 15.


CRISPR-Cas9 Genome Engineering in Saccharomyces cerevisiae Cells.

Ryan OW, Poddar S, Cate JH.

Cold Spring Harb Protoc. 2016 Jun 1;2016(6). doi: 10.1101/pdb.prot086827.


Assembly of eIF3 Mediated by Mutually Dependent Subunit Insertion.

Smith MD, Arake-Tacca L, Nitido A, Montabana E, Park A, Cate JH.

Structure. 2016 Jun 7;24(6):886-96. doi: 10.1016/j.str.2016.02.024. Epub 2016 May 19.


Red fluorescent biofilm: the thick, the old, and the cariogenic.

Volgenant CM, Hoogenkamp MA, Buijs MJ, Zaura E, Ten Cate JM, van der Veen MH.

J Oral Microbiol. 2016 Apr 7;8:30346. doi: 10.3402/jom.v8.30346. eCollection 2016.


STRUCTURE. A Big Bang in spliceosome structural biology.

Cate JH.

Science. 2016 Mar 25;351(6280):1390-2. doi: 10.1126/science.aaf4465. No abstract available.


Comparison of red autofluorescing plaque and disclosed plaque-a cross-sectional study.

Volgenant CMC, Fernandez Y Mostajo M, Rosema NAM, van der Weijden FA, Ten Cate JM, van der Veen MH.

Clin Oral Investig. 2016 Dec;20(9):2551-2558. doi: 10.1007/s00784-016-1761-z. Epub 2016 Mar 18.


Editorial overview: Energy biotechnology.

Cate JH, Ball AS.

Curr Opin Biotechnol. 2016 Apr;38:v-vii. doi: 10.1016/j.copbio.2016.02.019. Epub 2016 Mar 7. No abstract available.


MicroCT study on the enamel mineral density of primary molars.

Elfrink ME, Kalin K, van Ruijven LJ, ten Cate JM, Veerkamp JS.

Eur J Paediatr Dent. 2016 Mar;17(1):60-4.


Three-dimensional time reversal communications in elastic media.

Anderson BE, Ulrich TJ, Le Bas PY, Ten Cate JA.

J Acoust Soc Am. 2016 Feb;139(2):EL25-30. doi: 10.1121/1.4942629.


Dynamics of red fluorescent dental plaque during experimental gingivitis--A cohort study.

van der Veen MH, Volgenant CM, Keijser B, Ten Cate JB, Crielaard W.

J Dent. 2016 May;48:71-6. doi: 10.1016/j.jdent.2016.02.010. Epub 2016 Feb 24.


Energy biotechnology in the CRISPR-Cas9 era.

Estrela R, Cate JH.

Curr Opin Biotechnol. 2016 Apr;38:79-84. doi: 10.1016/j.copbio.2016.01.005. Epub 2016 Feb 10. Review.


Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation.

Thakor N, Smith MD, Roberts L, Faye MD, Patel H, Wieden HJ, Cate JHD, Holcik M.

RNA Biol. 2017 May 4;14(5):553-567. doi: 10.1080/15476286.2015.1137419. Epub 2016 Feb 1.


Comparison of xylose fermentation by two high-performance engineered strains of Saccharomyces cerevisiae.

Li X, Park A, Estrela R, Kim SR, Jin YS, Cate JH.

Biotechnol Rep (Amst). 2016 Jan 22;9:53-56. doi: 10.1016/j.btre.2016.01.003. eCollection 2016 Mar.


Trends in practice of blood glucose control in critically ill patients in the Netherlands.

van Hooijdonk RT, Eslami S, de Keizer NF, Bakhshi-Raiez F, Bosman RJ, Dongelmans DA, van der Voort PH, Streefkerk JO, Engelbrecht WJ, ten Cate J, Huissoon S, van Driel EM, van Dijk I, Cimic N, Beck OF, Snellen FT, Holman ND, Mulder HC, Abu-Hanna A, Schultz MJ.

Neth J Med. 2015 Dec;73(10):455-63.


Factors that Influence the Formation and Stability of Thin, Cryo-EM Specimens.

Glaeser RM, Han BG, Csencsits R, Killilea A, Pulk A, Cate JH.

Biophys J. 2016 Feb 23;110(4):749-55. doi: 10.1016/j.bpj.2015.07.050. Epub 2015 Sep 17. Review.


The Effect of Fixed Orthodontic Appliances and Fluoride Mouthwash on the Oral Microbiome of Adolescents - A Randomized Controlled Clinical Trial.

Koopman JE, van der Kaaij NC, Buijs MJ, Elyassi Y, van der Veen MH, Crielaard W, Ten Cate JM, Zaura E.

PLoS One. 2015 Sep 2;10(9):e0137318. doi: 10.1371/journal.pone.0137318. eCollection 2015.


Cellobionic acid utilization: from Neurospora crassa to Saccharomyces cerevisiae.

Li X, Chomvong K, Yu VY, Liang JM, Lin Y, Cate JHD.

Biotechnol Biofuels. 2015 Aug 16;8:120. doi: 10.1186/s13068-015-0303-2. eCollection 2015.


Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions.

Wasserman MR, Pulk A, Zhou Z, Altman RB, Zinder JC, Green KD, Garneau-Tsodikova S, Cate JH, Blanchard SC.

Nat Commun. 2015 Jul 30;6:7896. doi: 10.1038/ncomms8896.


A prospective, randomized placebo-controlled clinical trial on the effects of a fluoride rinse on white spot lesion development and bleeding in orthodontic patients.

van der Kaaij NC, van der Veen MH, van der Kaaij MA, ten Cate JM.

Eur J Oral Sci. 2015 Jun;123(3):186-93. doi: 10.1111/eos.12186. Epub 2015 Apr 25.


Towards understanding oral health.

Zaura E, ten Cate JM.

Caries Res. 2015;49 Suppl 1:55-61. doi: 10.1159/000377733. Epub 2015 Apr 13. Review.


Models and role models.

ten Cate JM.

Caries Res. 2015;49 Suppl 1:3-10. doi: 10.1159/000380870. Epub 2015 Apr 13.


eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

Lee AS, Kranzusch PJ, Cate JH.

Nature. 2015 Jun 4;522(7554):111-4. doi: 10.1038/nature14267. Epub 2015 Apr 6.

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