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Items: 35


Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration.

Hetmanski JHR, de Belly H, Busnelli I, Waring T, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C, Swift J, Del Campo A, Starborg T, Zech T, Goetz JG, Paluch EK, Schwartz JM, Caswell PT.

Dev Cell. 2019 Nov 18;51(4):460-475.e10. doi: 10.1016/j.devcel.2019.09.006. Epub 2019 Oct 10.


Control of adhesion and protrusion in cell migration by Rho GTPases.

Warner H, Wilson BJ, Caswell PT.

Curr Opin Cell Biol. 2019 Feb;56:64-70. doi: 10.1016/ Epub 2018 Oct 3. Review.


Modeling Rho GTPase Dynamics Using Boolean Logic.

Hetmanski JHR, Schwartz JM, Caswell PT.

Methods Mol Biol. 2018;1821:37-46. doi: 10.1007/978-1-4939-8612-5_3.


Vesicle trafficking pathways that direct cell migration in 3D matrices and in vivo.

Wilson BJ, Allen JL, Caswell PT.

Traffic. 2018 Dec;19(12):899-909. doi: 10.1111/tra.12605. Epub 2018 Sep 10. Review.


Actin-Based Cell Protrusion in a 3D Matrix.

Caswell PT, Zech T.

Trends Cell Biol. 2018 Oct;28(10):823-834. doi: 10.1016/j.tcb.2018.06.003. Epub 2018 Jun 30. Review.


Correction to: JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells.

Caswell PT, Dickens M.

Mol Cell Biochem. 2018 Jul;444(1-2):15. doi: 10.1007/s11010-018-3354-4.


JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells.

Caswell PT, Dickens M.

Mol Cell Biochem. 2018 Jul;444(1-2):1-13. doi: 10.1007/s11010-017-3222-7. Epub 2017 Nov 20. Erratum in: Mol Cell Biochem. 2018 May 3;:.


Extracellular matrix promotes clathrin-dependent endocytosis of prolactin and STAT5 activation in differentiating mammary epithelial cells.

Bridgewater RE, Streuli CH, Caswell PT.

Sci Rep. 2017 Jul 4;7(1):4572. doi: 10.1038/s41598-017-04783-6.


Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.

Gundry C, Marco S, Rainero E, Miller B, Dornier E, Mitchell L, Caswell PT, Campbell AD, Hogeweg A, Sansom OJ, Morton JP, Norman JC.

Nat Commun. 2017 Mar 15;8:14646. doi: 10.1038/ncomms14646.


Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion.

Hetmanski JH, Schwartz JM, Caswell PT.

Biochem Soc Trans. 2016 Dec 15;44(6):1695-1700.


Rationalizing Rac1 and RhoA GTPase signaling: A mathematical approach.

Hetmanski JHR, Schwartz JM, Caswell PT.

Small GTPases. 2018 May 4;9(3):224-229. doi: 10.1080/21541248.2016.1218406. Epub 2016 Aug 30.


A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell Invasion.

Hetmanski JH, Zindy E, Schwartz JM, Caswell PT.

PLoS Comput Biol. 2016 May 3;12(5):e1004909. doi: 10.1371/journal.pcbi.1004909. eCollection 2016 May.


Endocytic Trafficking of Integrins in Cell Migration.

Paul NR, Jacquemet G, Caswell PT.

Curr Biol. 2015 Nov 16;25(22):R1092-105. doi: 10.1016/j.cub.2015.09.049. Review.


α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3.

Paul NR, Allen JL, Chapman A, Morlan-Mairal M, Zindy E, Jacquemet G, Fernandez del Ama L, Ferizovic N, Green DM, Howe JD, Ehler E, Hurlstone A, Caswell PT.

J Cell Biol. 2015 Sep 14;210(6):1013-31. doi: 10.1083/jcb.201502040.


Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration.

Rainero E, Howe JD, Caswell PT, Jamieson NB, Anderson K, Critchley DR, Machesky L, Norman JC.

Cell Rep. 2015 Jan 20;10(3):398-413. doi: 10.1016/j.celrep.2014.12.037. Epub 2015 Jan 15.


Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype.

Muller PA, Trinidad AG, Caswell PT, Norman JC, Vousden KH.

J Biol Chem. 2014 Jan 3;289(1):122-32. doi: 10.1074/jbc.M113.502138. Epub 2013 Nov 12.


RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex.

Jacquemet G, Green DM, Bridgewater RE, von Kriegsheim A, Humphries MJ, Norman JC, Caswell PT.

J Cell Biol. 2013 Sep 16;202(6):917-35. doi: 10.1083/jcb.201302041. Epub 2013 Sep 9.


Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway.

Jacquemet G, Morgan MR, Byron A, Humphries JD, Choi CK, Chen CS, Caswell PT, Humphries MJ.

J Cell Sci. 2013 Sep 15;126(Pt 18):4121-35. doi: 10.1242/jcs.121988. Epub 2013 Jul 10.


Role of adhesion receptor trafficking in 3D cell migration.

Jacquemet G, Humphries MJ, Caswell PT.

Curr Opin Cell Biol. 2013 Oct;25(5):627-32. doi: 10.1016/ Epub 2013 Jun 21. Review.


Integrin trafficking at a glance.

Bridgewater RE, Norman JC, Caswell PT.

J Cell Sci. 2012 Aug 15;125(Pt 16):3695-701. doi: 10.1242/jcs.095810. Review. No abstract available.


Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.

Muller PA, Trinidad AG, Timpson P, Morton JP, Zanivan S, van den Berghe PV, Nixon C, Karim SA, Caswell PT, Noll JE, Coffill CR, Lane DP, Sansom OJ, Neilsen PM, Norman JC, Vousden KH.

Oncogene. 2013 Mar 7;32(10):1252-65. doi: 10.1038/onc.2012.148. Epub 2012 May 14.


Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.

Rainero E, Caswell PT, Muller PA, Grindlay J, McCaffrey MW, Zhang Q, Wakelam MJ, Vousden KH, Graziani A, Norman JC.

J Cell Biol. 2012 Jan 23;196(2):277-95. doi: 10.1083/jcb.201109112.


Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.

Dozynkiewicz MA, Jamieson NB, Macpherson I, Grindlay J, van den Berghe PV, von Thun A, Morton JP, Gourley C, Timpson P, Nixon C, McKay CJ, Carter R, Strachan D, Anderson K, Sansom OJ, Caswell PT, Norman JC.

Dev Cell. 2012 Jan 17;22(1):131-45. doi: 10.1016/j.devcel.2011.11.008. Epub 2011 Dec 22.


Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells.

Eva R, Dassie E, Caswell PT, Dick G, ffrench-Constant C, Norman JC, Fawcett JW.

J Neurosci. 2010 Sep 1;30(35):11654-69. doi: 10.1523/JNEUROSCI.2425-10.2010.


Mutant p53 drives invasion by promoting integrin recycling.

Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH.

Cell. 2009 Dec 24;139(7):1327-41. doi: 10.1016/j.cell.2009.11.026.


Integrins: masters and slaves of endocytic transport.

Caswell PT, Vadrevu S, Norman JC.

Nat Rev Mol Cell Biol. 2009 Dec;10(12):843-53. doi: 10.1038/nrm2799. Review.


VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching.

Jones MC, Caswell PT, Moran-Jones K, Roberts M, Barry ST, Gampel A, Mellor H, Norman JC.

Traffic. 2009 Jun;10(6):754-66. doi: 10.1111/j.1600-0854.2009.00898.x.


Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

Valdembri D, Caswell PT, Anderson KI, Schwarz JP, König I, Astanina E, Caccavari F, Norman JC, Humphries MJ, Bussolino F, Serini G.

PLoS Biol. 2009 Jan 27;7(1):e25. doi: 10.1371/journal.pbio.1000025.


Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.

Caswell PT, Chan M, Lindsay AJ, McCaffrey MW, Boettiger D, Norman JC.

J Cell Biol. 2008 Oct 6;183(1):143-55. doi: 10.1083/jcb.200804140.


Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion.

Kim M, Jang HR, Kim JH, Noh SM, Song KS, Cho JS, Jeong HY, Norman JC, Caswell PT, Kang GH, Kim SY, Yoo HS, Kim YS.

Carcinogenesis. 2008 Mar;29(3):629-37. doi: 10.1093/carcin/bgm291. Epub 2008 Feb 17.


Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.

Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC.

Dev Cell. 2007 Oct;13(4):496-510.


Endocytic recycling pathways: emerging regulators of cell migration.

Jones MC, Caswell PT, Norman JC.

Curr Opin Cell Biol. 2006 Oct;18(5):549-57. Epub 2006 Aug 9. Review.


Integrin trafficking and the control of cell migration.

Caswell PT, Norman JC.

Traffic. 2006 Jan;7(1):14-21. Review.


PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions.

Woods AJ, White DP, Caswell PT, Norman JC.

EMBO J. 2004 Jul 7;23(13):2531-43. Epub 2004 Jun 10.

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