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Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study.

Neeland IJ, Singh S, McGuire DK, Vega GL, Roddy T, Reilly DF, Castro-Perez J, Kozlitina J, Scherer PE.

Diabetologia. 2018 Dec;61(12):2570-2579. doi: 10.1007/s00125-018-4720-1. Epub 2018 Aug 29.


Ultra-fast-track extubation vs. conventional extubation after cardiac surgery in a cardiovascular reference centre in Colombia. A longitudinal study.

Guerrero Gómez A, González Jaramillo N, Castro Pérez JA.

Rev Esp Anestesiol Reanim. 2019 Jan;66(1):10-17. doi: 10.1016/j.redar.2018.06.005. Epub 2018 Jul 24. English, Spanish.


Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.

Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5197-E5206. doi: 10.1073/pnas.1705312114. Epub 2017 Jun 12.


Cyp8b1 ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption.

Bertaggia E, Jensen KK, Castro-Perez J, Xu Y, Di Paolo G, Chan RB, Wang L, Haeusler RA.

Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E121-E133. doi: 10.1152/ajpendo.00409.2016. Epub 2017 Apr 4.


Duodenal-jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice.

Shang J, Castro-Perez JM, Shen X, Zhu Y, Liu H, Qian Y, Previs S, Howard AD, Erion M, Kelley DE, Wang L.

Obesity (Silver Spring). 2016 Sep;24(9):1938-45. doi: 10.1002/oby.21583. Epub 2016 Jul 26.


The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

Mancina RM, Dongiovanni P, Petta S, Pingitore P, Meroni M, Rametta R, Borén J, Montalcini T, Pujia A, Wiklund O, Hindy G, Spagnuolo R, Motta BM, Pipitone RM, Craxì A, Fargion S, Nobili V, Käkelä P, Kärjä V, Männistö V, Pihlajamäki J, Reilly DF, Castro-Perez J, Kozlitina J, Valenti L, Romeo S.

Gastroenterology. 2016 May;150(5):1219-1230.e6. doi: 10.1053/j.gastro.2016.01.032. Epub 2016 Feb 2.


Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity.

Haeusler RA, Camastra S, Nannipieri M, Astiarraga B, Castro-Perez J, Xie D, Wang L, Chakravarthy M, Ferrannini E.

J Clin Endocrinol Metab. 2016 May;101(5):1935-44. doi: 10.1210/jc.2015-2583. Epub 2015 Dec 18.


Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.

McLaren DG, Previs SF, Phair RD, Stout SJ, Xie D, Chen Y, Salituro GM, Xu SS, Castro-Perez JM, Opiteck GJ, Akinsanya KO, Cleary MA, Dansky HM, Johns DG, Roddy TP.

J Lipid Res. 2016 Mar;57(3):398-409. doi: 10.1194/jlr.M063842. Epub 2015 Dec 9.


Quantitative profiling of oxylipins in plasma and atherosclerotic plaques of hypercholesterolemic rabbits.

Bojic LA, McLaren DG, Harms AC, Hankemeier T, Dane A, Wang SP, Rosa R, Previs SF, Johns DG, Castro-Perez JM.

Anal Bioanal Chem. 2016 Jan;408(1):97-105. doi: 10.1007/s00216-015-9105-4. Epub 2015 Oct 28.


Multiplexed Quantification of Proglucagon-Derived Peptides by Immunoaffinity Enrichment and Tandem Mass Spectrometry after a Meal Tolerance Test.

Lee AY, Chappell DL, Bak MJ, Judo M, Liang L, Churakova T, Ayanoglu G, Castro-Perez J, Zhou H, Previs S, Souza SC, Lassman ME, Laterza OF.

Clin Chem. 2016 Jan;62(1):227-35. doi: 10.1373/clinchem.2015.244251. Epub 2015 Oct 1.


Glucagon receptor antagonism induces increased cholesterol absorption.

Guan HP, Yang X, Lu K, Wang SP, Castro-Perez JM, Previs S, Wright M, Shah V, Herath K, Xie D, Szeto D, Forrest G, Xiao JC, Palyha O, Sun LP, Andryuk PJ, Engel SS, Xiong Y, Lin S, Kelley DE, Erion MD, Davis HR, Wang L.

J Lipid Res. 2015 Nov;56(11):2183-95. doi: 10.1194/jlr.M060897. Epub 2015 Sep 15.


Effect of Error Propagation in Stable Isotope Tracer Studies: An Approach for Estimating Impact on Apparent Biochemical Flux.

Previs SF, Herath K, Castro-Perez J, Mahsut A, Zhou H, McLaren DG, Shah V, Rohm RJ, Stout SJ, Zhong W, Wang SP, Johns DG, Hubbard BK, Cleary MA, Roddy TP.

Methods Enzymol. 2015;561:331-58. doi: 10.1016/bs.mie.2015.06.021. Epub 2015 Aug 19. Review.


Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Hoyt SB, Petrilli W, London C, Liang GB, Tata J, Hu Q, Yin L, van Koppen CJ, Hartmann RW, Struthers M, Wisniewski T, Ren N, Bopp C, Sok A, Cai TQ, Stribling S, Pai LY, Ma X, Metzger J, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Buist N, Clemas J, Zhou G, Gibson J, Maxwell CA, Lassman M, McLaughlin T, Castro-Perez J, Szeto D, Forrest G, Hajdu R, Rosenbach M, Xiong Y.

ACS Med Chem Lett. 2015 Jul 17;6(8):861-5. doi: 10.1021/acsmedchemlett.5b00048. eCollection 2015 Aug 13.


Inhibition of cholesteryl ester transfer protein increases cholesteryl ester content of large HDL independently of HDL-to-HDL homotypic transfer: in vitro vs in vivo comparison using anacetrapib and dalcetrapib.

Johns DG, Chen Y, Wang SP, Castro-Perez J, Previs SF, Roddy TP.

Eur J Pharmacol. 2015 Sep 5;762:256-62. doi: 10.1016/j.ejphar.2015.05.061. Epub 2015 Jun 3.


Increased Bile Acid Synthesis and Deconjugation After Biliopancreatic Diversion.

Ferrannini E, Camastra S, Astiarraga B, Nannipieri M, Castro-Perez J, Xie D, Wang L, Chakravarthy M, Haeusler RA.

Diabetes. 2015 Oct;64(10):3377-85. doi: 10.2337/db15-0214. Epub 2015 May 26.


Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Hoyt SB, Park MK, London C, Xiong Y, Tata J, Bennett DJ, Cooke A, Cai J, Carswell E, Robinson J, MacLean J, Brown L, Belshaw S, Clarkson TR, Liu K, Liang GB, Struthers M, Cully D, Wisniewski T, Ren N, Bopp C, Sok A, Cai TQ, Stribling S, Pai LY, Ma X, Metzger J, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Buist N, Kuethe J, Rivera N, Clemas J, Zhou G, Gibson J, Maxwell CA, Lassman M, McLaughlin T, Castro-Perez J, Szeto D, Forrest G, Hajdu R, Rosenbach M, Ali A.

ACS Med Chem Lett. 2015 Apr 7;6(5):573-8. doi: 10.1021/acsmedchemlett.5b00054. eCollection 2015 May 14.


Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.

Chu X, Shih SJ, Shaw R, Hentze H, Chan GH, Owens K, Wang S, Cai X, Newton D, Castro-Perez J, Salituro G, Palamanda J, Fernandis A, Ng CK, Liaw A, Savage MJ, Evers R.

Drug Metab Dispos. 2015 Jun;43(6):851-63. doi: 10.1124/dmd.115.063347. Epub 2015 Mar 26.


Lipidome of atherosclerotic plaques from hypercholesterolemic rabbits.

Bojic LA, McLaren DG, Shah V, Previs SF, Johns DG, Castro-Perez JM.

Int J Mol Sci. 2014 Dec 15;15(12):23283-93. doi: 10.3390/ijms151223283.


In vivo isotopically labeled atherosclerotic aorta plaques in ApoE KO mice and molecular profiling by matrix-assisted laser desorption/ionization mass spectrometric imaging.

Castro-Perez J, Hatcher N, Kofi Karikari N, Wang SP, Mendoza V, Shion H, Millar A, Shockcor J, Towers M, McLaren D, Shah V, Previs S, Akinsanya K, Cleary M, Roddy TP, Johns DG.

Rapid Commun Mass Spectrom. 2014 Nov 30;28(22):2471-9. doi: 10.1002/rcm.7039.


Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS.

Pan Y, Zhou H, Mahsut A, Rohm RJ, Berejnaia O, Price O, Chen Y, Castro-Perez J, Lassman ME, McLaren D, Conway J, Jensen KK, Thomas T, Reyes-Soffer G, Ginsberg HN, Gutstein DE, Cleary M, Previs SF, Roddy TP.

J Lipid Res. 2014 Jun;55(6):1179-87. doi: 10.1194/jlr.D047829. Epub 2014 Apr 2.


Determination of low levels of 2H-labeling using high-resolution mass spectrometry: application in studies of lipid flux and beyond.

Herath KB, Zhong W, Yang J, Mahsut A, Rohm RJ, Shah V, Castro-Perez J, Zhou H, Attygalle AB, Kang L, Singh S, Johns DG, Cleary MA, Hubbard BK, Previs SF, Roddy TP.

Rapid Commun Mass Spectrom. 2014 Feb 15;28(3):239-44. doi: 10.1002/rcm.6776.


An ultrasensitive method for the quantitation of active and inactive GLP-1 in human plasma via immunoaffinity LC-MS/MS.

Chappell DL, Lee AY, Castro-Perez J, Zhou H, Roddy TP, Lassman ME, Shankar SS, Yates NA, Wang W, Laterza OF.

Bioanalysis. 2014 Jan;6(1):33-42. doi: 10.4155/bio.13.280.


Enhanced data-independent analysis of lipids using ion mobility-TOFMSE to unravel quantitative and qualitative information in human plasma.

Shah V, Castro-Perez JM, McLaren DG, Herath KB, Previs SF, Roddy TP.

Rapid Commun Mass Spectrom. 2013 Oct 15;27(19):2195-200. doi: 10.1002/rcm.6675.


In vivo effects of anacetrapib on preβ HDL: improvement in HDL remodeling without effects on cholesterol absorption.

Wang SP, Daniels E, Chen Y, Castro-Perez J, Zhou H, Akinsanya KO, Previs SF, Roddy TP, Johns DG.

J Lipid Res. 2013 Oct;54(10):2858-65. doi: 10.1194/jlr.M041541. Epub 2013 Jul 29.


New methodologies for studying lipid synthesis and turnover: looking backwards to enable moving forwards.

Previs SF, McLaren DG, Wang SP, Stout SJ, Zhou H, Herath K, Shah V, Miller PL, Wilsie L, Castro-Perez J, Johns DG, Cleary MA, Roddy TP.

Biochim Biophys Acta. 2014 Mar;1842(3):402-13. doi: 10.1016/j.bbadis.2013.05.019. Epub 2013 May 22. Review.


Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry.

Zhou H, Castro-Perez J, Lassman ME, Thomas T, Li W, McLaughlin T, Dan X, Jumes P, Wagner JA, Gutstein DE, Hubbard BK, Rader DJ, Millar JS, Ginsberg HN, Reyes-Soffer G, Cleary M, Previs SF, Roddy TP.

Rapid Commun Mass Spectrom. 2013 Jun 30;27(12):1294-302. doi: 10.1002/rcm.6572.


Use of [13C18] oleic acid and mass isotopomer distribution analysis to study synthesis of plasma triglycerides in vivo: analytical and experimental considerations.

McLaren DG, Cardasis HL, Stout SJ, Wang SP, Mendoza V, Castro-Perez JM, Miller PL, Murphy BA, Cumiskey AM, Cleary MA, Johns DG, Previs SF, Roddy TP.

Anal Chem. 2013 Jul 2;85(13):6287-94. doi: 10.1021/ac400363k. Epub 2013 Jun 10.


The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans.

Singaraja RR, Sivapalaratnam S, Hovingh K, Dubé MP, Castro-Perez J, Collins HL, Adelman SJ, Riwanto M, Manz J, Hubbard B, Tietjen I, Wong K, Mitnaul LJ, van Heek M, Lin L, Roddy TA, McEwen J, Dallinge-Thie G, van Vark-van der Zee L, Verwoert G, Winther M, van Duijn C, Hofman A, Trip MD, Marais AD, Asztalos B, Landmesser U, Sijbrands E, Kastelein JJ, Hayden MR.

Circ Cardiovasc Genet. 2013 Feb;6(1):54-62. doi: 10.1161/CIRCGENETICS.111.962613. Epub 2012 Dec 14.


Tracking fatty acid kinetics in distinct lipoprotein fractions in vivo: a novel high-throughput approach for studying dyslipidemia in rodent models.

McLaren DG, Wang SP, Stout SJ, Xie D, Miller PL, Mendoza V, Rosa R, Castro-Perez J, Previs SF, Johns DG, Roddy TP.

J Lipid Res. 2013 Jan;54(1):276-81. doi: 10.1194/jlr.D030791. Epub 2012 Oct 5.


Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, Castro-Perez J, Cohen JC, Hobbs HH.

J Clin Invest. 2012 Nov;122(11):4130-44.


Comparison of lipoprotein separation and lipid analysis methodologies for human and cynomolgus monkey plasma samples.

Han S, Flattery AM, McLaren D, Raubertas R, Lee SH, Mendoza V, Rosa R, Geoghagen N, Castro-Perez JM, Roddy TP, Forrest G, Johns D, Hubbard BK, Li J.

J Cardiovasc Transl Res. 2012 Feb;5(1):75-83. doi: 10.1007/s12265-011-9340-9. Epub 2011 Dec 23.


A rapid method for cross-species quantitation of apolipoproteins A1, B48 and B100 in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.

Lassman ME, McLaughlin TM, Somers EP, Stefanni AC, Chen Z, Murphy BA, Bierilo KK, Flattery AM, Wong KK, Castro-Perez JM, Hubbard BK, Roddy TP.

Rapid Commun Mass Spectrom. 2012 Jan 30;26(2):101-8. doi: 10.1002/rcm.5296.


Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters.

Chen Z, Wang SP, Krsmanovic ML, Castro-Perez J, Gagen K, Mendoza V, Rosa R, Shah V, He T, Stout SJ, Geoghagen NS, Lee SH, McLaren DG, Wang L, Roddy TP, Plump AS, Hubbard BK, Sinz CJ, Johns DG.

Metabolism. 2012 Apr;61(4):470-81. doi: 10.1016/j.metabol.2011.08.006. Epub 2011 Oct 14.


High-resolution chromatography/time-of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening.

Barbara JE, Castro-Perez JM.

Rapid Commun Mass Spectrom. 2011 Oct 30;25(20):3029-40. doi: 10.1002/rcm.5197.


Localization of fatty acyl and double bond positions in phosphatidylcholines using a dual stage CID fragmentation coupled with ion mobility mass spectrometry.

Castro-Perez J, Roddy TP, Nibbering NM, Shah V, McLaren DG, Previs S, Attygalle AB, Herath K, Chen Z, Wang SP, Mitnaul L, Hubbard BK, Vreeken RJ, Johns DG, Hankemeier T.

J Am Soc Mass Spectrom. 2011 Sep;22(9):1552-67. doi: 10.1007/s13361-011-0172-2. Epub 2011 Jun 24. Erratum in: J Am Soc Mass Spectrom. 2011 Sep;22(9):1568-9.


Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters.

Castro-Perez J, Briand F, Gagen K, Wang SP, Chen Y, McLaren DG, Shah V, Vreeken RJ, Hankemeier T, Sulpice T, Roddy TP, Hubbard BK, Johns DG.

J Lipid Res. 2011 Nov;52(11):1965-73. doi: 10.1194/jlr.M016410. Epub 2011 Aug 14.


ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5).

Ason B, Castro-Perez J, Tep S, Stefanni A, Tadin-Strapps M, Roddy T, Hankemeier T, Hubbard B, Sachs AB, Michael Flanagan W, Kuklin NA, Mitnaul LJ.

Lipids. 2011 Nov;46(11):991-1003. doi: 10.1007/s11745-011-3596-3. Epub 2011 Aug 9.


AAV8-mediated long-term expression of human LCAT significantly improves lipid profiles in hCETP;Ldlr(+/-) mice.

Chen Z, Chu D, Castro-Perez JM, Ni W, Zhang A, Krsmanovic ML, Xie D, Shah V, Stout SJ, McLaren DG, Stefanni AC, Lee SH, Roddy TP, Plump AS, Hubbard BK, Vogt TF, Zhou HH.

J Cardiovasc Transl Res. 2011 Dec;4(6):801-10. doi: 10.1007/s12265-011-9309-8. Epub 2011 Aug 6.


Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.

Castro-Perez JM, Roddy TP, Shah V, Wang SP, Ouyang X, Ogawa A, McLaren DG, Tadin-Strapps M, Robinson MJ, Bartz SR, Ason B, Chen Y, Previs SF, Wong KK, Vreeken RJ, Johns DG, Hubbard BK, Hankemeier T, Mitnaul L.

J Proteome Res. 2011 Oct 7;10(10):4683-91. doi: 10.1021/pr200475g. Epub 2011 Aug 26.


Identifying static and kinetic lipid phenotypes by high resolution UPLC-MS: unraveling diet-induced changes in lipid homeostasis by coupling metabolomics and fluxomics.

Castro-Perez JM, Roddy TP, Shah V, McLaren DG, Wang SP, Jensen K, Vreeken RJ, Hankemeier T, Johns DG, Previs SF, Hubbard BK.

J Proteome Res. 2011 Sep 2;10(9):4281-90. doi: 10.1021/pr200480g. Epub 2011 Aug 4.


The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species.

McLaren DG, He T, Wang SP, Mendoza V, Rosa R, Gagen K, Bhat G, Herath K, Miller PL, Stribling S, Taggart A, Imbriglio J, Liu J, Chen D, Pinto S, Balkovec JM, Devita RJ, Marsh DJ, Castro-Perez JM, Strack A, Johns DG, Previs SF, Hubbard BK, Roddy TP.

J Lipid Res. 2011 Jun;52(6):1150-61. doi: 10.1194/jlr.M011049. Epub 2011 Mar 17.


An ultraperformance liquid chromatography method for the normal-phase separation of lipids.

McLaren DG, Miller PL, Lassman ME, Castro-Perez JM, Hubbard BK, Roddy TP.

Anal Biochem. 2011 Jul 15;414(2):266-72. doi: 10.1016/j.ab.2011.03.009. Epub 2011 Mar 12.


siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids.

Tadin-Strapps M, Peterson LB, Cumiskey AM, Rosa RL, Mendoza VH, Castro-Perez J, Puig O, Zhang L, Strapps WR, Yendluri S, Andrews L, Pickering V, Rice J, Luo L, Chen Z, Tep S, Ason B, Somers EP, Sachs AB, Bartz SR, Tian J, Chin J, Hubbard BK, Wong KK, Mitnaul LJ.

J Lipid Res. 2011 Jun;52(6):1084-97. doi: 10.1194/jlr.M012872. Epub 2011 Mar 11.


Collision cross-section determination and tandem mass spectrometric analysis of isomeric carotenoids using electrospray ion mobility time-of-flight mass spectrometry.

Dong L, Shion H, Davis RG, Terry-Penak B, Castro-Perez J, van Breemen RB.

Anal Chem. 2010 Nov 1;82(21):9014-21. doi: 10.1021/ac101974g. Epub 2010 Oct 7.


In vivo D2O labeling to quantify static and dynamic changes in cholesterol and cholesterol esters by high resolution LC/MS.

Castro-Perez J, Previs SF, McLaren DG, Shah V, Herath K, Bhat G, Johns DG, Wang SP, Mitnaul L, Jensen K, Vreeken R, Hankemeier T, Roddy TP, Hubbard BK.

J Lipid Res. 2011 Jan;52(1):159-69. doi: 10.1194/jlr.D009787. Epub 2010 Sep 30.


UPLC-MS, HPLC-radiometric, and NMR-spectroscopic studies on the metabolic fate of 3-fluoro-[U-14C]-aniline in the bile-cannulated rat.

Athersuch TJ, Castro-Perez J, Rodgers C, Nicholson JK, Wilson ID.

Xenobiotica. 2010 Jul;40(7):510-23. doi: 10.3109/00498254.2010.483294.


Comprehensive LC-MS E lipidomic analysis using a shotgun approach and its application to biomarker detection and identification in osteoarthritis patients.

Castro-Perez JM, Kamphorst J, DeGroot J, Lafeber F, Goshawk J, Yu K, Shockcor JP, Vreeken RJ, Hankemeier T.

J Proteome Res. 2010 May 7;9(5):2377-89. doi: 10.1021/pr901094j. Erratum in: J Proteome Res. 2011 Jul 1;10(7):3303-8.


Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters.

Mortishire-Smith RJ, Castro-Perez JM, Yu K, Shockcor JP, Goshawk J, Hartshorn MJ, Hill A.

Rapid Commun Mass Spectrom. 2009 Apr;23(7):939-48. doi: 10.1002/rcm.3951.


Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration.

Cuyckens F, Hurkmans R, Castro-Perez JM, Leclercq L, Mortishire-Smith RJ.

Rapid Commun Mass Spectrom. 2009 Jan;23(2):327-32. doi: 10.1002/rcm.3881.


Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies.

Tiller PR, Yu S, Bateman KP, Castro-Perez J, McIntosh IS, Kuo Y, Baillie TA.

Rapid Commun Mass Spectrom. 2008 Nov;22(22):3510-6. doi: 10.1002/rcm.3758.


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