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Items: 17


Leishmania amazonensis hijacks host cell lysosomes involved in plasma membrane repair to induce invasion in fibroblasts.

Cavalcante-Costa VS, Costa-Reginaldo M, Queiroz-Oliveira T, Oliveira ACS, Couto NF, Dos Anjos DO, Lima-Santos J, Andrade LO, Horta MF, Castro-Gomes T.

J Cell Sci. 2019 Mar 25;132(6). pii: jcs226183. doi: 10.1242/jcs.226183.


The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals.

Batista NV, Barbagallo M, Oliveira VLS, Castro-Gomes T, Oliveira RDR, Louzada-Junior P, Pinheiro GRC, Mantovani A, Teixeira MM, Garlanda C, Amaral FA.

J Immunol. 2019 Mar 15;202(6):1807-1814. doi: 10.4049/jimmunol.1701531. Epub 2019 Feb 4.


Metacyclogenesis of Leishmania (Viannia) guyanensis: a comprehensive study of the main transformation features in axenic culture and purification of metacyclic promastigotes by negative selection with Bauhinia purpurea lectin.

Mendes BP, da Silva IA, DaMata JP, Castro-Gomes T, Vieira LQ, Ribeiro-Dias F, Horta MF.

Parasitology. 2018 Dec 27:1-12. doi: 10.1017/S0031182018002111. [Epub ahead of print]


Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia.

Mourão LC, Baptista RP, de Almeida ZB, Grynberg P, Pucci MM, Castro-Gomes T, Fontes CJF, Rathore S, Sharma YD, da Silva-Pereira RA, Bemquerer MP, Braga ÉM.

Sci Rep. 2018 Jun 8;8(1):8762. doi: 10.1038/s41598-018-27109-6.


Gaucher disease iPSC-derived osteoblasts have developmental and lysosomal defects that impair bone matrix deposition.

Panicker LM, Srikanth MP, Castro-Gomes T, Miller D, Andrews NW, Feldman RA.

Hum Mol Genet. 2018 Mar 1;27(5):811-822. doi: 10.1093/hmg/ddx442.


LAMP-2 absence interferes with plasma membrane repair and decreases T. cruzi host cell invasion.

Couto NF, Pedersane D, Rezende L, Dias PP, Corbani TL, Bentini LC, Oliveira ACS, Kelles LF, Castro-Gomes T, Andrade LO.

PLoS Negl Trop Dis. 2017 Jun 6;11(6):e0005657. doi: 10.1371/journal.pntd.0005657. eCollection 2017 Jun.


PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.

Fujiwara T, Ye S, Castro-Gomes T, Winchell CG, Andrews NW, Voth DE, Varughese KI, Mackintosh SG, Feng Y, Pavlos N, Nakamura T, Manolagas SC, Zhao H.

JCI Insight. 2016 Oct 20;1(17):e86330. doi: 10.1172/jci.insight.86330.


Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes.

Castro-Gomes T, Corrotte M, Tam C, Andrews NW.

PLoS One. 2016 Mar 30;11(3):e0152583. doi: 10.1371/journal.pone.0152583. eCollection 2016.


Lipid raft-dependent plasma membrane repair interferes with the activation of B lymphocytes.

Miller H, Castro-Gomes T, Corrotte M, Tam C, Maugel TK, Andrews NW, Song W.

J Cell Biol. 2015 Dec 21;211(6):1193-205. doi: 10.1083/jcb.201505030.


Above the fray: Surface remodeling by secreted lysosomal enzymes leads to endocytosis-mediated plasma membrane repair.

Andrews NW, Corrotte M, Castro-Gomes T.

Semin Cell Dev Biol. 2015 Sep;45:10-7. doi: 10.1016/j.semcdb.2015.09.022. Epub 2015 Oct 1. Review.


Approaches for plasma membrane wounding and assessment of lysosome-mediated repair responses.

Corrotte M, Castro-Gomes T, Koushik AB, Andrews NW.

Methods Cell Biol. 2015;126:139-58. doi: 10.1016/bs.mcb.2014.11.009. Epub 2015 Jan 14.


Potential immune mechanisms associated with anemia in Plasmodium vivax malaria: a puzzling question.

Castro-Gomes T, Mourão LC, Melo GC, Monteiro WM, Lacerda MV, Braga ÉM.

Infect Immun. 2014 Oct;82(10):3990-4000. doi: 10.1128/IAI.01972-14. Epub 2014 Aug 4. Review. Erratum in: Infect Immun. 2014 Dec;82(12):5346.


ESCRT: nipping the wound in the bud?

Castro-Gomes T, Koushik AB, Andrews NW.

Trends Biochem Sci. 2014 Jul;39(7):307-9. doi: 10.1016/j.tibs.2014.06.001. Epub 2014 Jun 20.


Identification of secreted virulence factors of Chromobacterium violaceum.

Castro-Gomes T, Cardoso MS, DaRocha WD, Laibida LA, Nascimento AM, Zuccherato LW, Horta MF, Bemquerer MP, Teixeira SM.

J Microbiol. 2014 Apr;52(4):350-3. doi: 10.1007/s12275-014-3202-5. Epub 2014 Feb 17.


Caveolae internalization repairs wounded cells and muscle fibers.

Corrotte M, Almeida PE, Tam C, Castro-Gomes T, Fernandes MC, Millis BA, Cortez M, Miller H, Song W, Maugel TK, Andrews NW.

Elife. 2013 Sep 17;2:e00926. doi: 10.7554/eLife.00926.


Activation of Leishmania spp. leishporin: evidence that dissociation of an inhibitor not only improves its lipid-binding efficiency but also endows it with the ability to form pores.

Almeida-Campos FR, Castro-Gomes T, Machado-Silva A, de Oliveira JS, Santoro MM, Frézard F, Horta MF.

Parasitol Res. 2013 Sep;112(9):3305-14. doi: 10.1007/s00436-013-3510-4. Epub 2013 Jun 30.


Membrane binding requirements for the cytolytic activity of Leishmania amazonensis leishporin.

Castro-Gomes T, Almeida-Campos FR, Calzavara-Silva CE, da Silva RA, Frézard F, Horta MF.

FEBS Lett. 2009 Oct 6;583(19):3209-14. doi: 10.1016/j.febslet.2009.09.005. Epub 2009 Sep 6.

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