Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 37

1.

Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice.

Figueiredo CP, Barros-Aragão FGQ, Neris RLS, Frost PS, Soares C, Souza INO, Zeidler JD, Zamberlan DC, de Sousa VL, Souza AS, Guimarães ALA, Bellio M, Marcondes de Souza J, Alves-Leon SV, Neves GA, Paula-Neto HA, Castro NG, De Felice FG, Assunção-Miranda I, Clarke JR, Da Poian AT, Ferreira ST.

Nat Commun. 2019 Sep 5;10(1):3890. doi: 10.1038/s41467-019-11866-7.

2.

Generation of iPSC-Derived Human Peripheral Sensory Neurons Releasing Substance P Elicited by TRPV1 Agonists.

Guimarães MZP, De Vecchi R, Vitória G, Sochacki JK, Paulsen BS, Lima I, Rodrigues da Silva F, da Costa RFM, Castro NG, Breton L, Rehen SK.

Front Mol Neurosci. 2018 Aug 22;11:277. doi: 10.3389/fnmol.2018.00277. eCollection 2018.

3.

Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.

Dias Viegas FP, de Freitas Silva M, Divino da Rocha M, Castelli MR, Riquiel MM, Machado RP, Vaz SM, Simões de Lima LM, Mancini KC, Marques de Oliveira PC, Morais ÉP, Gontijo VS, da Silva FMR, D'Alincourt da Fonseca Peçanha D, Castro NG, Neves GA, Giusti-Paiva A, Vilela FC, Orlandi L, Camps I, Veloso MP, Leomil Coelho LF, Ionta M, Ferreira-Silva GÁ, Pereira RM, Dardenne LE, Guedes IA, de Oliveira Carneiro Junior W, Quaglio Bellozi PM, Pinheiro de Oliveira AC, Ferreira FF, Pruccoli L, Tarozzi A, Viegas C Jr.

Eur J Med Chem. 2018 Mar 10;147:48-65. doi: 10.1016/j.ejmech.2018.01.066. Epub 2018 Jan 31.

PMID:
29421570
4.

Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.

Dias KS, de Paula CT, Dos Santos T, Souza IN, Boni MS, Guimarães MJ, da Silva FM, Castro NG, Neves GA, Veloso CC, Coelho MM, de Melo IS, Giusti FC, Giusti-Paiva A, da Silva ML, Dardenne LE, Guedes IA, Pruccoli L, Morroni F, Tarozzi A, Viegas C Jr.

Eur J Med Chem. 2017 Apr 21;130:440-457. doi: 10.1016/j.ejmech.2017.02.043. Epub 2017 Feb 21.

PMID:
28282613
5.

Dopamine promotes NMDA receptor hypofunction in the retina through D1 receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation.

Socodato R, Santiago FN, Portugal CC, Domith I, Encarnação TG, Loiola EC, Ventura AL, Cossenza M, Relvas JB, Castro NG, Paes-de-Carvalho R.

Sci Rep. 2017 Jan 18;7:40912. doi: 10.1038/srep40912.

6.

Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.

Lemes LFN, de Andrade Ramos G, de Oliveira AS, da Silva FMR, de Castro Couto G, da Silva Boni M, Guimarães MJR, Souza INO, Bartolini M, Andrisano V, do Nascimento Nogueira PC, Silveira ER, Brand GD, Soukup O, Korábečný J, Romeiro NC, Castro NG, Bolognesi ML, Romeiro LAS.

Eur J Med Chem. 2016 Jan 27;108:687-700. doi: 10.1016/j.ejmech.2015.12.024. Epub 2015 Dec 17.

PMID:
26735910
7.

Basal Metabolic Rate of Adolescent Modern Pentathlon Athletes: Agreement between Indirect Calorimetry and Predictive Equations and the Correlation with Body Parameters.

Loureiro LL, Fonseca S Jr, Castro NG, Dos Passos RB, Porto CP, Pierucci AP.

PLoS One. 2015 Nov 16;10(11):e0142859. doi: 10.1371/journal.pone.0142859. eCollection 2015.

8.

Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase.

Petronilho Eda C, Rennó Mdo N, Castro NG, da Silva FM, Pinto Ada C, Figueroa-Villar JD.

J Enzyme Inhib Med Chem. 2016 Dec;31(6):1069-78. doi: 10.3109/14756366.2015.1094468. Epub 2015 Nov 11.

PMID:
26558640
9.

Waveform Similarity Analysis: A Simple Template Comparing Approach for Detecting and Quantifying Noisy Evoked Compound Action Potentials.

Potas JR, de Castro NG, Maddess T, de Souza MN.

PLoS One. 2015 Sep 1;10(9):e0136992. doi: 10.1371/journal.pone.0136992. eCollection 2015.

10.

Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson's disease.

Acquarone M, de Melo TM, Meireles F, Brito-Moreira J, Oliveira G, Ferreira ST, Castro NG, Tovar-Moll F, Houzel JC, Rehen SK.

Front Cell Neurosci. 2015 Apr 8;9:97. doi: 10.3389/fncel.2015.00097. eCollection 2015.

11.

Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling.

Diniz LP, Tortelli V, Garcia MN, Araújo AP, Melo HM, Silva GS, Felice FG, Alves-Leon SV, Souza JM, Romão LF, Castro NG, Gomes FC.

Glia. 2014 Dec;62(12):1917-31. doi: 10.1002/glia.22713. Epub 2014 Jul 10.

PMID:
25042347
12.

Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells.

Setti-Perdigão P, Serrano MA, Flausino OA Jr, Bolzani VS, Guimarães MZ, Castro NG.

PLoS One. 2013 Dec 13;8(12):e82726. doi: 10.1371/journal.pone.0082726. eCollection 2013.

13.

Astrocyte-induced synaptogenesis is mediated by transforming growth factor β signaling through modulation of D-serine levels in cerebral cortex neurons.

Diniz LP, Almeida JC, Tortelli V, Vargas Lopes C, Setti-Perdigão P, Stipursky J, Kahn SA, Romão LF, de Miranda J, Alves-Leon SV, de Souza JM, Castro NG, Panizzutti R, Gomes FC.

J Biol Chem. 2012 Nov 30;287(49):41432-45. doi: 10.1074/jbc.M112.380824. Epub 2012 Oct 10.

14.

Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient.

Paulsen Bda S, de Moraes Maciel R, Galina A, Souza da Silveira M, dos Santos Souza C, Drummond H, Nascimento Pozzatto E, Silva H Jr, Chicaybam L, Massuda R, Setti-Perdigão P, Bonamino M, Belmonte-de-Abreu PS, Castro NG, Brentani H, Rehen SK.

Cell Transplant. 2012;21(7):1547-59.

PMID:
21975034
15.

Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action.

Marques-da-Silva C, Chaves MM, Castro NG, Coutinho-Silva R, Guimaraes MZ.

Br J Pharmacol. 2011 Jul;163(5):912-26. doi: 10.1111/j.1476-5381.2011.01254.x.

16.

LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation.

Tributino JL, Santos ML, Mesquita CM, Lima CK, Silva LL, Maia RC, Duarte CD, Barreiro EJ, Fraga CA, Castro NG, Miranda AL, Guimaraes MZ.

Br J Pharmacol. 2010 Apr;159(8):1716-23.

17.

Geissospermum vellosii stembark: anticholinesterase activity and improvement of scopolamine-induced memory deficits.

Lima JA, Costa RS, Epifânio RA, Castro NG, Rocha MS, Pinto AC.

Pharmacol Biochem Behav. 2009 May;92(3):508-13. doi: 10.1016/j.pbb.2009.01.024. Epub 2009 Feb 5.

PMID:
19463267
18.

New potential AChE inhibitor candidates.

de Paula AA, Martins JB, dos Santos ML, Nascente Lde C, Romeiro LA, Areas TF, Vieira KS, Gambôa NF, Castro NG, Gargano R.

Eur J Med Chem. 2009 Sep;44(9):3754-9. doi: 10.1016/j.ejmech.2009.03.045. Epub 2009 Apr 16.

PMID:
19446931
19.

Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.

Tributino JL, Duarte CD, Corrêa RS, Doriguetto AC, Ellena J, Romeiro NC, Castro NG, Miranda AL, Barreiro EJ, Fraga CA.

Bioorg Med Chem. 2009 Feb 1;17(3):1125-31. doi: 10.1016/j.bmc.2008.12.045. Epub 2008 Dec 25.

PMID:
19135376
20.

CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline.

Castro NG, Costa RS, Pimentel LS, Danuello A, Romeiro NC, Viegas C Jr, Barreiro EJ, Fraga CA, Bolzani VS, Rocha MS.

Eur J Pharmacol. 2008 Feb 12;580(3):339-49. Epub 2007 Nov 28.

PMID:
18096154
21.

The magnitude of alpha7 nicotinic receptor currents in rat hippocampal neurons is dependent upon GABAergic activity and depolarization.

Santos HR, Ribeiro HS, Setti-Perdigão P, Albuquerque EX, Castro NG.

J Pharmacol Exp Ther. 2006 Oct;319(1):376-85. Epub 2006 Jul 12.

PMID:
16837558
22.

New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids.

Viegas C Jr, Bolzani VS, Pimentel LS, Castro NG, Cabral RF, Costa RS, Floyd C, Rocha MS, Young MC, Barreiro EJ, Fraga CA.

Bioorg Med Chem. 2005 Jul 1;13(13):4184-90.

PMID:
15878668
23.

Binding of [3H]MK-801 in subcellular fractions of Schistosoma mansoni: evidence for interaction with nicotinic receptors.

Pessôa RF, Castro NG, Noël F.

Biochem Pharmacol. 2005 May 15;69(10):1509-16.

PMID:
15857615
24.

Stereoselective synthesis and preliminary evaluation of new D-3-heteroarylcarbonylalanines as ligands of the NMDA receptor.

Lima PG, Caruso RR, Alves SO, Pessôa RF, Mendonça-Silva DL, Nunes RJ, Noël F, Castro NG, Costa PR.

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4399-403.

PMID:
15357961
25.

Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor.

Lopes DV, Caruso RR, Castro NG, Costa PR, da Silva AJ, Noël F.

Eur J Pharmacol. 2004 Jul 14;495(2-3):87-96. Erratum in: Eur J Pharmacol. 2004 Oct 11;502(1-2):157.

PMID:
15249156
26.

Spine density and dendritic branching pattern of hippocampal CA1 pyramidal neurons in neonatal rats chronically exposed to the organophosphate paraoxon.

Santos HR, Cintra WM, Aracava Y, Maciel CM, Castro NG, Albuquerque EX.

Neurotoxicology. 2004 Mar;25(3):481-94.

PMID:
15019311
27.

Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.

Barreiro EJ, Camara CA, Verli H, Brazil-Más L, Castro NG, Cintra WM, Aracava Y, Rodrigues CR, Fraga CA.

J Med Chem. 2003 Mar 27;46(7):1144-52.

PMID:
12646025
28.

Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors.

Santos MD, Pereira EF, Aracava Y, Castro NG, Fawcett WP, Randall WR, Albuquerque EX.

J Pharmacol Exp Ther. 2003 Jan;304(1):254-65.

PMID:
12490599
29.

Synthesis and preliminary pharmacological evaluation of new (+/-) 1,4-naphthoquinones structurally related to lapachol.

da Silva AJ, Buarque CD, Brito FV, Aurelian L, Macedo LF, Malkas LH, Hickey RJ, Lopes DV, Noël F, Murakami YL, Silva NM, Melo PA, Caruso RR, Castro NG, Costa PR.

Bioorg Med Chem. 2002 Aug;10(8):2731-8.

PMID:
12057662
30.

A novel thienylhydrazone, (2-thienylidene)3,4-methylenedioxybenzoylhydrazine, increases inotropism and decreases fatigue of skeletal muscle.

Gonzalez-Serratos H, Chang R, Pereira EF, Castro NG, Aracava Y, Melo PA, Lima PC, Fraga CA, Barreiro EJ, Albuquerque EX.

J Pharmacol Exp Ther. 2001 Nov;299(2):558-66.

PMID:
11602667
32.

Direct inhibition of the N-methyl-D-aspartate receptor channel by dopamine and (+)-SKF38393.

Castro NG, de Mello MC, de Mello FG, Aracava Y.

Br J Pharmacol. 1999 Apr;126(8):1847-55.

33.

Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function.

Albuquerque EX, Alkondon M, Pereira EF, Castro NG, Schrattenholz A, Barbosa CT, Bonfante-Cabarcas R, Aracava Y, Eisenberg HM, Maelicke A.

J Pharmacol Exp Ther. 1997 Mar;280(3):1117-36. No abstract available.

PMID:
9067295
34.

Nicotinic receptor function in the mammalian central nervous system.

Albuquerque EX, Pereira EF, Castro NG, Alkondon M, Reinhardt S, Schröder H, Maelicke A.

Ann N Y Acad Sci. 1995 May 10;757:48-72. Review.

PMID:
7611705
35.
36.
37.

A novel agonist binding site on nicotinic acetylcholine receptors.

Pereira EF, Alkondon M, Tano T, Castro NG, Fróes-Ferrão MM, Rozental R, Aronstam RS, Schrattenholz A, Maelicke A, Albuquerque EX.

J Recept Res. 1993;13(1-4):413-36.

PMID:
8450498

Supplemental Content

Loading ...
Support Center