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From the Amazon: A comprehensive liver transcriptome dataset of the teleost fish tambaqui, Colossoma macropomum.

Machado AM, Ferraz R, Ribeiro RDA, Ozório R, Castro LFC.

Data Brief. 2019 Mar 7;23:103751. doi: 10.1016/j.dib.2019.103751. eCollection 2019 Apr.


Linking chemical exposure to lipid homeostasis: A municipal waste water treatment plant influent is obesogenic for zebrafish larvae.

Barbosa MAG, Capela R, Rodolfo J, Fonseca E, Montes R, André A, Capitão A, Carvalho AP, Quintana JB, Castro LFC, Santos MM.

Ecotoxicol Environ Saf. 2019 Oct 30;182:109406. doi: 10.1016/j.ecoenv.2019.109406. Epub 2019 Jul 6.


Tributyltin Affects Retinoid X Receptor-Mediated Lipid Metabolism in the Marine Rotifer Brachionus koreanus.

Lee MC, Fonseca E, Park JC, Yoon DS, Choi H, Kim M, Han J, Cho HS, Shin KH, Santos ML, Jung JH, Castro LFC, Lee JS.

Environ Sci Technol. 2019 Jul 2;53(13):7830-7839. doi: 10.1021/acs.est.9b01359. Epub 2019 Jun 19.


Fibrous Dysplasia/McCune-Albright Syndrome.

Boyce AM, Florenzano P, de Castro LF, Collins MT.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2015 Feb 26 [updated 2019 Jun 27].


Giant cabergoline-resistant prolactinoma in a man who presented with a psychotic episode during treatment: a case report.

Casulari LA, de Castro LF, Kessler IM, Mendonça JL, de Fátima Magalhães Gonzaga M.

J Med Case Rep. 2019 Jun 16;13(1):183. doi: 10.1186/s13256-019-2071-2.


The evolutionary road to invertebrate thyroid hormone signaling: Perspectives for endocrine disruption processes.

Sainath SB, André A, Castro LFC, Santos MM.

Comp Biochem Physiol C Toxicol Pharmacol. 2019 Sep;223:124-138. doi: 10.1016/j.cbpc.2019.05.014. Epub 2019 May 25. Review.


The evolution of S100A7: an unusual gene expansion in Myotis bats.

Águeda-Pinto A, Castro LFC, Esteves PJ.

BMC Evol Biol. 2019 May 14;19(1):102. doi: 10.1186/s12862-019-1433-0.


Evolutionary Plasticity in Detoxification Gene Modules: The Preservation and Loss of the Pregnane X Receptor in Chondrichthyes Lineages.

Fonseca ESS, Ruivo R, Machado AM, Conrado F, Tay BH, Venkatesh B, Santos MM, Castro LFC.

Int J Mol Sci. 2019 May 10;20(9). pii: E2331. doi: 10.3390/ijms20092331.


Convergent inactivation of the skin-specific C-C motif chemokine ligand 27 in mammalian evolution.

Lopes-Marques M, Alves LQ, Fonseca MM, Secci-Petretto G, Machado AM, Ruivo R, Castro LFC.

Immunogenetics. 2019 May;71(5-6):363-372. doi: 10.1007/s00251-019-01114-z. Epub 2019 May 2.


Dietary Creatine Supplementation in Gilthead Seabream (Sparus aurata) Increases Dorsal Muscle Area and the Expression of myod1 and capn1 Genes.

Ramos-Pinto L, Lopes G, Sousa V, Castro LFC, Schrama D, Rodrigues P, Valente LMP.

Front Endocrinol (Lausanne). 2019 Mar 28;10:161. doi: 10.3389/fendo.2019.00161. eCollection 2019.


Salivary diagnostics on paper microfluidic devices and their use as wearable sensors for glucose monitoring.

de Castro LF, de Freitas SV, Duarte LC, de Souza JAC, Paixão TRLC, Coltro WKT.

Anal Bioanal Chem. 2019 Jul;411(19):4919-4928. doi: 10.1007/s00216-019-01788-0. Epub 2019 Apr 2.


Evolution of Penicillin Non-susceptibility Among Streptococcus pneumoniae Isolates Recovered From Asymptomatic Carriage and Invasive Disease Over 25 years in Brazil, 1990-2014.

Pinto TCA, Neves FPG, Souza ARV, Oliveira LMA, Costa NS, Castro LFS, Mendonça-Souza CRV, Peralta JM, Teixeira LM.

Front Microbiol. 2019 Mar 14;10:486. doi: 10.3389/fmicb.2019.00486. eCollection 2019.


Ecotoxicology of deep-sea environments: Functional and biochemical effects of suspended sediments in the model species Mytilus galloprovincialis under hyperbaric conditions.

Pinheiro M, Caetano M, Neuparth T, Barros S, Soares J, Raimundo J, Vale C, Coimbra J, Castro LFC, Santos MM.

Sci Total Environ. 2019 Jun 20;670:218-225. doi: 10.1016/j.scitotenv.2019.03.196. Epub 2019 Mar 14.


Complete Inactivation of Sebum-Producing Genes Parallels the Loss of Sebaceous Glands in Cetacea.

Lopes-Marques M, Machado AM, Alves LQ, Fonseca MM, Barbosa S, Sinding MS, Rasmussen MH, Iversen MR, Frost Bertelsen M, Campos PF, da Fonseca R, Ruivo R, Castro LFC.

Mol Biol Evol. 2019 Jun 1;36(6):1270-1280. doi: 10.1093/molbev/msz068.


The last frontier: Coupling technological developments with scientific challenges to improve hazard assessment of deep-sea mining.

Santos MM, Jorge PAS, Coimbra J, Vale C, Caetano M, Bastos L, Iglesias I, Guimarães L, Reis-Henriques MA, Teles LO, Vieira MN, Raimundo J, Pinheiro M, Nogueira V, Pereira R, Neuparth T, Ribeiro MC, Silva E, Castro LFC.

Sci Total Environ. 2018 Jun 15;627:1505-1514. doi: 10.1016/j.scitotenv.2018.01.221. Epub 2018 Feb 20. Review.


In Vivo Formation of Stable Hyaline Cartilage by Naïve Human Bone Marrow Stromal Cells with Modified Fibrin Microbeads.

Kuznetsov SA, Hailu-Lazmi A, Cherman N, de Castro LF, Robey PG, Gorodetsky R.

Stem Cells Transl Med. 2019 Jun;8(6):586-592. doi: 10.1002/sctm.18-0129. Epub 2019 Feb 14.


The Singularity of Cetacea Behavior Parallels the Complete Inactivation of Melatonin Gene Modules.

Lopes-Marques M, Ruivo R, Alves LQ, Sousa N, Machado AM, Castro LFC.

Genes (Basel). 2019 Feb 6;10(2). pii: E121. doi: 10.3390/genes10020121.


Molecular ontogeny of the stomach in the catshark Scyliorhinus canicula.

Gonçalves O, Freitas R, Ferreira P, Araújo M, Zhang G, Mazan S, Cohn MJ, Castro LFC, Wilson JM.

Sci Rep. 2019 Jan 24;9(1):586. doi: 10.1038/s41598-018-36413-0.


Age-Related Changes and Effects of Bisphosphonates on Bone Turnover and Disease Progression in Fibrous Dysplasia of Bone.

Florenzano P, Pan KS, Brown SM, Paul SM, Kushner H, Guthrie LC, de Castro LF, Collins MT, Boyce AM.

J Bone Miner Res. 2019 Apr;34(4):653-660. doi: 10.1002/jbmr.3649. Epub 2019 Jan 15.


The retinoic acid receptor (RAR) in molluscs: Function, evolution and endocrine disruption insights.

André A, Ruivo R, Fonseca E, Froufe E, Castro LFC, Santos MM.

Aquat Toxicol. 2019 Mar;208:80-89. doi: 10.1016/j.aquatox.2019.01.002. Epub 2019 Jan 7.


Prolactinomas Resistant to Treatment With Dopamine Agonists: Long-Term Follow-Up of Six Cases.

Gonzaga MFM, de Castro LF, Naves LA, Mendonça JL, Oton de Lima B, Kessler I, Casulari LA.

Front Endocrinol (Lausanne). 2018 Nov 13;9:625. doi: 10.3389/fendo.2018.00625. eCollection 2018.


Silencing of PPARαBb mRNA in brown trout primary hepatocytes: effects on molecular and morphological targets under the influence of an estrogen and a PPARα agonist.

Madureira TV, Pinheiro I, Malhão F, Castro LFC, Rocha E, Urbatzka R.

Comp Biochem Physiol B Biochem Mol Biol. 2019 Mar;229:1-9. doi: 10.1016/j.cbpb.2018.12.001. Epub 2018 Dec 7.


Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden.

de Castro LF, Burke AB, Wang HD, Tsai J, Florenzano P, Pan KS, Bhattacharyya N, Boyce AM, Gafni RI, Molinolo AA, Robey PG, Collins MT.

J Bone Miner Res. 2019 Feb;34(2):290-294. doi: 10.1002/jbmr.3602. Epub 2018 Nov 29.


Comparative Analysis of the Adhesive Proteins of the Adult Stalked Goose Barnacle Pollicipes pollicipes (Cirripedia: Pedunculata).

Rocha M, Antas P, Castro LFC, Campos A, Vasconcelos V, Pereira F, Cunha I.

Mar Biotechnol (NY). 2019 Feb;21(1):38-51. doi: 10.1007/s10126-018-9856-y. Epub 2018 Nov 10.


Evolutionary Exploitation of Vertebrate Peroxisome Proliferator-Activated Receptor γ by Organotins.

Capitão AMF, Lopes-Marques MS, Ishii Y, Ruivo R, Fonseca ESS, Páscoa I, Jorge RP, Barbosa MAG, Hiromori Y, Miyagi T, Nakanishi T, Santos MM, Castro LFC.

Environ Sci Technol. 2018 Dec 4;52(23):13951-13959. doi: 10.1021/acs.est.8b04399. Epub 2018 Nov 19.


Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates.

Lopes-Marques M, Kabeya N, Qian Y, Ruivo R, Santos MM, Venkatesh B, Tocher DR, Castro LFC, Monroig Ó.

BMC Evol Biol. 2018 Oct 19;18(1):157. doi: 10.1186/s12862-018-1271-5.


A complete enzymatic capacity for long-chain polyunsaturated fatty acid biosynthesis is present in the Amazonian teleost tambaqui, Colossoma macropomum.

Ferraz RB, Kabeya N, Lopes-Marques M, Machado AM, Ribeiro RA, Salaro AL, Ozório R, Castro LFC, Monroig Ó.

Comp Biochem Physiol B Biochem Mol Biol. 2019 Jan;227:90-97. doi: 10.1016/j.cbpb.2018.09.003. Epub 2018 Oct 2.


Combinatorial cassettes to systematically evaluate tissue-engineered constructs in recipient mice.

Bodhak S, de Castro LF, Kuznetsov SA, Azusa M, Bonfim D, Robey PG, Simon CG Jr.

Biomaterials. 2018 Dec;186:31-43. doi: 10.1016/j.biomaterials.2018.09.035. Epub 2018 Sep 24.


Cetacea are natural knockouts for IL20.

Lopes-Marques M, Machado AM, Barbosa S, Fonseca MM, Ruivo R, Castro LFC.

Immunogenetics. 2018 Nov;70(10):681-687. doi: 10.1007/s00251-018-1071-5. Epub 2018 Jul 12.


Skeletal Consequences of Nephropathic Cystinosis.

Florenzano P, Ferreira C, Nesterova G, Roberts MS, Tella SH, de Castro LF, Brown SM, Whitaker A, Pereira RC, Bulas D, Gafni RI, Salusky IB, Gahl WA, Collins MT.

J Bone Miner Res. 2018 Oct;33(10):1870-1880. doi: 10.1002/jbmr.3522. Epub 2018 Jul 20.


A resource for sustainable management: De novo assembly and annotation of the liver transcriptome of the Atlantic chub mackerel, Scomber colias.

Machado AM, Felício M, Fonseca E, da Fonseca RR, Castro LFC.

Data Brief. 2018 Mar 13;18:276-284. doi: 10.1016/j.dib.2018.03.013. eCollection 2018 Jun.


Sex-steroids and hypolipidemic chemicals impacts on brown trout lipid and peroxisome signaling - Molecular, biochemical and morphological insights.

Madureira TV, Malhão F, Simões T, Pinheiro I, Lopes C, Gonçalves JF, Urbatzka R, Castro LFC, Lemos MFL, Rocha E.

Comp Biochem Physiol C Toxicol Pharmacol. 2018 Oct;212:1-17. doi: 10.1016/j.cbpc.2018.06.001. Epub 2018 Jun 7.


Effect of ArtinM on Human Blood Cells During Infection With Paracoccidioides brasiliensis.

Ruas LP, Genaro LM, Justo-Junior AS, Coser LO, de Castro LF, Trabasso P, Mamoni RL, Roque-Barreira MC, Blotta MHSL.

Front Microbiol. 2018 May 4;9:867. doi: 10.3389/fmicb.2018.00867. eCollection 2018.


NLRP3 inflammasome is involved in the recognition of Paracoccidioides brasiliensis by human dendritic cells and in the induction of Th17 cells.

de Castro LF, Longhi LNA, Paião MR, Justo-Júnior ADS, de Jesus MB, Blotta MHSL, Mamoni RL.

J Infect. 2018 Aug;77(2):137-144. doi: 10.1016/j.jinf.2018.03.004. Epub 2018 May 7.


Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals.

Kabeya N, Fonseca MM, Ferrier DEK, Navarro JC, Bay LK, Francis DS, Tocher DR, Castro LFC, Monroig Ó.

Sci Adv. 2018 May 2;4(5):eaar6849. doi: 10.1126/sciadv.aar6849. eCollection 2018 May.


Identifying the gaps: Resources and perspectives on the use of nuclear receptor based-assays to improve hazard assessment of emerging contaminants.

Santos MM, Ruivo R, Capitão A, Fonseca E, Castro LFC.

J Hazard Mater. 2018 Sep 15;358:508-511. doi: 10.1016/j.jhazmat.2018.04.076. Epub 2018 Apr 30.


Expansion, retention and loss in the Acyl-CoA synthetase "Bubblegum" (Acsbg) gene family in vertebrate history.

Lopes-Marques M, Machado AM, Ruivo R, Fonseca E, Carvalho E, Castro LFC.

Gene. 2018 Jul 20;664:111-118. doi: 10.1016/j.gene.2018.04.058. Epub 2018 Apr 23.


Female epispadias: Single-stage approach - A technique to achieve continence.

Santos JVQVD, Abreu FJ, Castro LFC, Tavares PM, Neto BS, Rosito TE.

J Pediatr Urol. 2018 Jun;14(3):296-297. doi: 10.1016/j.jpurol.2018.01.026. Epub 2018 Mar 15.


The cycling gonad: retinoic-acid synthesis and degradation patterns during adult zebrafish Danio rerio oogenesis.

Ruivo R, Capitão A, Castro LFC, Santos MM.

J Fish Biol. 2018 Apr;92(4):1051-1064. doi: 10.1111/jfb.13564. Epub 2018 Feb 21.


Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance.

Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, Collins MT, Gutkind JS.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E428-E437. doi: 10.1073/pnas.1713710115. Epub 2017 Dec 27.


Testosterone-induced modulation of peroxisomal morphology and peroxisome-related gene expression in brown trout (Salmo trutta f. fario) primary hepatocytes.

Lopes C, Malhão F, Guimarães C, Pinheiro I, Gonçalves JF, Castro LFC, Rocha E, Madureira TV.

Aquat Toxicol. 2017 Dec;193:30-39. doi: 10.1016/j.aquatox.2017.09.026. Epub 2017 Sep 28.


Differential production of interleukin-1 family cytokines (IL-1β, IL-18, IL-33 and IL-37) in patients with paracoccidioidomycosis: correlation with clinical form and antifungal therapy.

Alves ABRM, David MA, de Castro LF, da Silva RM, Longhi LNA, Blotta MHSL, Mamoni RL.

Med Mycol. 2018 Apr 1;56(3):332-343. doi: 10.1093/mmy/myx050.


Beneficial Effects of High Doses of Cabergoline in the Treatment of Giant Prolactinoma Resistant to Dopamine Agonists: A Case Report with a 21-Year Follow-Up.

de Castro LF, Magalhães Gonzaga MF, Naves LA, Luiz Mendonça J, Oton de Lima B, Casulari LA.

Horm Res Paediatr. 2018;89(1):63-70. doi: 10.1159/000479511. Epub 2017 Sep 26.


Unusual loss of chymosin in mammalian lineages parallels neo-natal immune transfer strategies.

Lopes-Marques M, Ruivo R, Fonseca E, Teixeira A, Castro LFC.

Mol Phylogenet Evol. 2017 Nov;116:78-86. doi: 10.1016/j.ympev.2017.08.014. Epub 2017 Aug 26.


Simvastatin modulates gene expression of key receptors in zebrafish embryos.

Cunha V, Santos MM, Moradas-Ferreira P, Castro LFC, Ferreira M.

J Toxicol Environ Health A. 2017;80(9):465-476. doi: 10.1080/15287394.2017.1335258. Epub 2017 Jul 6.


Obesogens in the aquatic environment: an evolutionary and toxicological perspective.

Capitão A, Lyssimachou A, Castro LFC, Santos MM.

Environ Int. 2017 Sep;106:153-169. doi: 10.1016/j.envint.2017.06.003. Epub 2017 Jun 26. Review.


Two alternative pathways for docosahexaenoic acid (DHA, 22:6n-3) biosynthesis are widespread among teleost fish.

Oboh A, Kabeya N, Carmona-Antoñanzas G, Castro LFC, Dick JR, Tocher DR, Monroig O.

Sci Rep. 2017 Jun 20;7(1):3889. doi: 10.1038/s41598-017-04288-2.


Manufacturing Differences Affect Human Bone Marrow Stromal Cell Characteristics and Function: Comparison of Production Methods and Products from Multiple Centers.

Liu S, de Castro LF, Jin P, Civini S, Ren J, Reems JA, Cancelas J, Nayak R, Shaw G, O'Brien T, McKenna DH, Armant M, Silberstein L, Gee AP, Hei DJ, Hematti P, Kuznetsov SA, Robey PG, Stroncek DF.

Sci Rep. 2017 Apr 27;7:46731. doi: 10.1038/srep46731.


Total substitution of dietary fish oil by vegetable oils stimulates muscle hypertrophic growth in Senegalese sole and the upregulation of fgf6.

Lopes G, Castro LFC, Valente LMP.

Food Funct. 2017 May 24;8(5):1869-1879. doi: 10.1039/c7fo00340d.


Cross-interference of two model peroxisome proliferators in peroxisomal and estrogenic pathways in brown trout hepatocytes.

Madureira TV, Pinheiro I, Malhão F, Lopes C, Urbatzka R, Castro LFC, Rocha E.

Aquat Toxicol. 2017 Jun;187:153-162. doi: 10.1016/j.aquatox.2017.04.001. Epub 2017 Apr 6.


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