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Items: 1 to 50 of 92

1.

Mismatch Repair Protein Expression in Endometrioid Intraepithelial Neoplasia/Atypical Hyperplasia: Should We Screen for Lynch Syndrome in Precancerous Lesions?

Lucas E, Chen H, Molberg K, Castrillon DH, Rivera Colon G, Li L, Hinson S, Thibodeaux J, Lea J, Miller DS, Zheng W.

Int J Gynecol Pathol. 2018 Oct 31. doi: 10.1097/PGP.0000000000000557. [Epub ahead of print]

PMID:
30383610
2.

PI3K Pathway Effectors pAKT and FOXO1 as Novel Markers of Endometrioid Intraepithelial Neoplasia.

Strickland AL, Rivera G, Lucas E, John G, Cuevas I, Castrillon DH.

Int J Gynecol Pathol. 2018 Sep 25. doi: 10.1097/PGP.0000000000000549. [Epub ahead of print]

PMID:
30256235
3.

Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load.

Li HD, Cuevas I, Zhang M, Lu C, Alam MM, Fu YX, You MJ, Akbay EA, Zhang H, Castrillon DH.

J Clin Invest. 2018 Aug 31;128(9):4179-4191. doi: 10.1172/JCI122095. Epub 2018 Aug 20.

4.

Foxo3 Promotes Apoptosis of B Cell Receptor-Stimulated Immature B Cells, Thus Limiting the Window for Receptor Editing.

Ottens K, Hinman RM, Barrios E, Skaug B, Davis LS, Li QZ, Castrillon DH, Satterthwaite AB.

J Immunol. 2018 Aug 1;201(3):940-949. doi: 10.4049/jimmunol.1701070. Epub 2018 Jun 27.

PMID:
29950509
5.

CHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice.

Abe H, Alavattam KG, Kato Y, Castrillon DH, Pang Q, Andreassen PR, Namekawa SH.

Hum Mol Genet. 2018 Apr 1;27(7):1136-1149. doi: 10.1093/hmg/ddy022.

PMID:
29360988
6.

Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma.

Aguilera KY, Huang H, Du W, Hagopian MM, Wang Z, Hinz S, Hwang TH, Wang H, Fleming JB, Castrillon DH, Ren X, Ding K, Brekken RA.

Mol Cancer Ther. 2017 Nov;16(11):2473-2485. doi: 10.1158/1535-7163.MCT-16-0834. Epub 2017 Sep 1.

7.

Correction for Wolff et al., "Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia".

Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, Castrillon DH, Kabbani W, Brugarolas J.

Mol Cell Biol. 2017 Jun 15;37(13). pii: e00224-17. doi: 10.1128/MCB.00224-17. Print 2017 Jul 1. No abstract available.

8.

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.

Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ.

Nature. 2017 Jun 1;546(7656):168-172. doi: 10.1038/nature22359. Epub 2017 May 24.

9.

LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.

Peña CG, Castrillón DH.

Adv Exp Med Biol. 2017;943:211-241. Review.

PMID:
27910069
10.

Visualization and Lineage Tracing of Pax7+ Spermatogonial Stem Cells in the Mouse.

Aloisio GM, Cuevas I, Nakada Y, Peña CG, Castrillon DH.

Methods Mol Biol. 2017;1463:139-154.

PMID:
27734354
11.

Control of Oocyte Reawakening by Kit.

Saatcioglu HD, Cuevas I, Castrillon DH.

PLoS Genet. 2016 Aug 8;12(8):e1006215. doi: 10.1371/journal.pgen.1006215. eCollection 2016 Aug.

12.

A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas.

Thu KL, Papari-Zareei M, Stastny V, Song K, Peyton M, Martinez VD, Zhang YA, Castro IB, Varella-Garcia M, Liang H, Xing C, Kittler R, Milchgrub S, Castrillon DH, Davidson HL, Reynolds CP, Lam WL, Lea J, Gazdar AF.

Oncotarget. 2016 Jun 10;8(31):50489-50499. doi: 10.18632/oncotarget.9929. eCollection 2017 Aug 1.

13.

Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer.

Wang M, Topalovski M, Toombs JE, Wright CM, Moore ZR, Boothman DA, Yanagisawa H, Wang H, Witkiewicz A, Castrillon DH, Brekken RA.

Cancer Res. 2015 Dec 1;75(23):5058-69. doi: 10.1158/0008-5472.CAN-15-0744. Epub 2015 Nov 17.

14.

Regulation of FOXO3 subcellular localization by Kit ligand in the neonatal mouse ovary.

Ezzati MM, Baker MD, Saatcioglu HD, Aloisio GM, Pena CG, Nakada Y, Cuevas I, Carr BR, Castrillon DH.

J Assist Reprod Genet. 2015 Dec;32(12):1741-7. doi: 10.1007/s10815-015-0589-9. Epub 2015 Oct 27.

15.

LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment.

Peña CG, Nakada Y, Saatcioglu HD, Aloisio GM, Cuevas I, Zhang S, Miller DS, Lea JS, Wong KK, DeBerardinis RJ, Amelio AL, Brekken RA, Castrillon DH.

J Clin Invest. 2015 Nov 2;125(11):4063-76. doi: 10.1172/JCI82152. Epub 2015 Sep 28.

16.

Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo.

Caserta E, Egriboz O, Wang H, Martin C, Koivisto C, Pecót T, Kladney RD, Shen C, Shim KS, Pham T, Karikomi MK, Mauntel MJ, Majumder S, Cuitino MC, Tang X, Srivastava A, Yu L, Wallace J, Mo X, Park M, Fernandez SA, Pilarski R, La Perle KM, Rosol TJ, Coppola V, Castrillon DH, Timmers C, Cohn DE, O'Malley DM, Backes F, Suarez AA, Goodfellow P, Chamberlin HM, Macrae ER, Shapiro CL, Ostrowski MC, Leone G.

Genes Dev. 2015 Aug 15;29(16):1707-20. doi: 10.1101/gad.262568.115.

17.

FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development.

Liu Z, Ren YA, Pangas SA, Adams J, Zhou W, Castrillon DH, Wilhelm D, Richards JS.

Mol Endocrinol. 2015 Jul;29(7):1006-24. doi: 10.1210/me.2015-1103. Epub 2015 Jun 10.

18.

PAX7 expression defines germline stem cells in the adult testis.

Aloisio GM, Nakada Y, Saatcioglu HD, Peña CG, Baker MD, Tarnawa ED, Mukherjee J, Manjunath H, Bugde A, Sengupta AL, Amatruda JF, Cuevas I, Hamra FK, Castrillon DH.

J Clin Invest. 2014 Sep;124(9):3929-44. doi: 10.1172/JCI75943. Epub 2014 Aug 18.

19.

Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression.

Xu C, Fillmore CM, Koyama S, Wu H, Zhao Y, Chen Z, Herter-Sprie GS, Akbay EA, Tchaicha JH, Altabef A, Reibel JB, Walton Z, Ji H, Watanabe H, Jänne PA, Castrillon DH, Rustgi AK, Bass AJ, Freeman GJ, Padera RF, Dranoff G, Hammerman PS, Kim CF, Wong KK.

Cancer Cell. 2014 May 12;25(5):590-604. doi: 10.1016/j.ccr.2014.03.033. Epub 2014 May 1.

20.

The small GTPase Rheb is required for spermatogenesis but not oogenesis.

Baker MD, Ezzati M, Aloisio GM, Tarnawa ED, Cuevas I, Nakada Y, Castrillon DH.

Reproduction. 2014 Apr 8;147(5):615-25. doi: 10.1530/REP-13-0304. Print 2014 May.

21.

Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma.

Aguilera KY, Rivera LB, Hur H, Carbon JG, Toombs JE, Goldstein CD, Dellinger MT, Castrillon DH, Brekken RA.

Cancer Res. 2014 Feb 15;74(4):1032-44. doi: 10.1158/0008-5472.CAN-13-2800. Epub 2013 Dec 17.

22.

The LKB1 tumor suppressor as a biomarker in mouse and human tissues.

Nakada Y, Stewart TG, Peña CG, Zhang S, Zhao N, Bardeesy N, Sharpless NE, Wong KK, Hayes DN, Castrillon DH.

PLoS One. 2013 Sep 25;8(9):e73449. doi: 10.1371/journal.pone.0073449. eCollection 2013.

23.

Screening and familial characterization of copy-number variations in NR5A1 in 46,XY disorders of sex development and premature ovarian failure.

Harrison SM, Campbell IM, Keays M, Granberg CF, Villanueva C, Tannin G, Zinn AR, Castrillon DH, Shaw CA, Stankiewicz P, Baker LA.

Am J Med Genet A. 2013 Oct;161A(10):2487-94. doi: 10.1002/ajmg.a.36084. Epub 2013 Aug 5.

24.

Gonadal expression of Foxo1, but not Foxo3, is conserved in diverse Mammalian species.

Tarnawa ED, Baker MD, Aloisio GM, Carr BR, Castrillon DH.

Biol Reprod. 2013 Apr 25;88(4):103. doi: 10.1095/biolreprod.112.105791. Print 2013 Apr.

25.

Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.

Burd CE, Sorrentino JA, Clark KS, Darr DB, Krishnamurthy J, Deal AM, Bardeesy N, Castrillon DH, Beach DH, Sharpless NE.

Cell. 2013 Jan 17;152(1-2):340-51. doi: 10.1016/j.cell.2012.12.010.

26.

FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH.

Liu Z, Castrillon DH, Zhou W, Richards JS.

Mol Endocrinol. 2013 Feb;27(2):238-52. doi: 10.1210/me.2012-1296. Epub 2013 Jan 15.

27.

Chromatin associated Sin3A is essential for male germ cell lineage in the mouse.

Pellegrino J, Castrillon DH, David G.

Dev Biol. 2012 Sep 15;369(2):349-55. doi: 10.1016/j.ydbio.2012.07.006. Epub 2012 Jul 20.

28.

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.

Liu W, Monahan KB, Pfefferle AD, Shimamura T, Sorrentino J, Chan KT, Roadcap DW, Ollila DW, Thomas NE, Castrillon DH, Miller CR, Perou CM, Wong KK, Bear JE, Sharpless NE.

Cancer Cell. 2012 Jun 12;21(6):751-64. doi: 10.1016/j.ccr.2012.03.048.

29.

Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis.

Akbay EA, Peña CG, Ruder D, Michel JA, Nakada Y, Pathak S, Multani AS, Chang S, Castrillon DH.

Oncogene. 2013 Apr 25;32(17):2211-9. doi: 10.1038/onc.2012.232. Epub 2012 Jun 11.

30.

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.

Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, Liu Y, Tupper T, Ouyang J, Li J, Gao P, Woo MS, Xu C, Yanagita M, Altabef A, Wang S, Lee C, Nakada Y, Peña CG, Sun Y, Franchetti Y, Yao C, Saur A, Cameron MD, Nishino M, Hayes DN, Wilkerson MD, Roberts PJ, Lee CB, Bardeesy N, Butaney M, Chirieac LR, Costa DB, Jackman D, Sharpless NE, Castrillon DH, Demetri GD, Jänne PA, Pandolfi PP, Cantley LC, Kung AL, Engelman JA, Wong KK.

Nature. 2012 Mar 18;483(7391):613-7. doi: 10.1038/nature10937.

31.

Insights into primary ovarian insufficiency through genetically engineered mouse models.

Sullivan SD, Castrillon DH.

Semin Reprod Med. 2011 Jul;29(4):283-98. doi: 10.1055/s-0031-1280914. Epub 2011 Oct 4. Review. Erratum in: Semin Reprod Med. 2011 Nov;29(6):569.

PMID:
21972066
32.

Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis.

Goertz MJ, Wu Z, Gallardo TD, Hamra FK, Castrillon DH.

J Clin Invest. 2011 Sep;121(9):3456-66. doi: 10.1172/JCI57984. Epub 2011 Aug 25.

33.

Up-regulation of Foxo4 mediated by hepatitis B virus X protein confers resistance to oxidative stress-induced cell death.

Srisuttee R, Koh SS, Park EH, Cho IR, Min HJ, Jhun BH, Yu DY, Park S, Park DY, Lee MO, Castrillon DH, Johnston RN, Chung YH.

Int J Mol Med. 2011 Aug;28(2):255-60. doi: 10.3892/ijmm.2011.699. Epub 2011 May 11.

PMID:
21567078
34.

Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.

Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, Castrillon DH, Kabbani W, Brugarolas J.

Mol Cell Biol. 2011 May;31(9):1870-84. doi: 10.1128/MCB.01393-10. Epub 2011 Mar 7. Erratum in: Mol Cell Biol. 2017 Jun 15;37(13):.

35.

GATA-like protein-1 (GLP-1) is required for normal germ cell development during embryonic oogenesis.

Strauss TJ, Castrillon DH, Hammes SR.

Reproduction. 2011 Feb;141(2):173-81. doi: 10.1530/REP-10-0376. Epub 2010 Dec 1.

PMID:
21123517
36.

GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer.

Lynn KD, Udugamasooriya DG, Roland CL, Castrillon DH, Kodadek TJ, Brekken RA.

BMC Cancer. 2010 Jul 30;10:397. doi: 10.1186/1471-2407-10-397.

37.

Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.

Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, García-Echeverría C, Bardeesy N, Sharpless NE, Hayes ND, Kim WY, Engelman JA, Wong KK.

Cancer Cell. 2010 Jun 15;17(6):547-59. doi: 10.1016/j.ccr.2010.04.026.

38.

Mouse models of uterine corpus tumors: clinical significance and utility.

Friel AM, Growdon WB, McCann CK, Olawaiye AB, Munro EG, Schorge JO, Castrillon DH, Broaddus RR, Rueda BR.

Front Biosci (Elite Ed). 2010 Jun 1;2:882-905. Review.

PMID:
20515761
39.

Pathology quiz case 2: salivary duct carcinoma (SDC) of the parotid gland with mucinous differentiation.

Fishero BA, Sailors JL, Castrillon DH, Myers LL.

Arch Otolaryngol Head Neck Surg. 2010 May;136(5):523, 525-6. doi: 10.1001/archoto.2010.46-a. No abstract available.

PMID:
20479389
40.

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.

Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, Bardeesy N, Takahashi M, Settleman J, Wong KK, Castrillon DH.

Dis Model Mech. 2010 Mar-Apr;3(3-4):181-93. doi: 10.1242/dmm.004440. Epub 2010 Feb 8.

41.

Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma.

Arnold SA, Rivera LB, Miller AF, Carbon JG, Dineen SP, Xie Y, Castrillon DH, Sage EH, Puolakkainen P, Bradshaw AD, Brekken RA.

Dis Model Mech. 2010 Jan-Feb;3(1-2):57-72. doi: 10.1242/dmm.003228. Epub 2009 Dec 9.

42.

FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation.

Zhou W, Cao Q, Peng Y, Zhang QJ, Castrillon DH, DePinho RA, Liu ZP.

Gastroenterology. 2009 Oct;137(4):1403-14. doi: 10.1053/j.gastro.2009.06.049. Epub 2009 Jun 26.

43.

Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution.

Hinman RM, Nichols WA, Diaz TM, Gallardo TD, Castrillon DH, Satterthwaite AB.

Int Immunol. 2009 Jul;21(7):831-42. doi: 10.1093/intimm/dxp049. Epub 2009 Jun 5.

44.

Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation.

John GB, Shidler MJ, Besmer P, Castrillon DH.

Dev Biol. 2009 Jul 15;331(2):292-9. doi: 10.1016/j.ydbio.2009.05.546. Epub 2009 May 15.

45.

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells.

Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick SM.

Nat Immunol. 2009 May;10(5):504-13. doi: 10.1038/ni.1729. Epub 2009 Apr 12.

46.

Somatic LKB1 mutations promote cervical cancer progression.

Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, Shimamura T, Miller DS, Sharpless NE, Bardeesy N, Kwiatkowski DJ, Schorge JO, Wong KK, Castrillon DH.

PLoS One. 2009;4(4):e5137. doi: 10.1371/journal.pone.0005137. Epub 2009 Apr 2.

47.

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM.

Nat Immunol. 2009 Feb;10(2):176-84. doi: 10.1038/ni.1689. Epub 2009 Jan 11.

48.

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.

Dengler HS, Baracho GV, Omori SA, Bruckner S, Arden KC, Castrillon DH, DePinho RA, Rickert RC.

Nat Immunol. 2008 Dec;9(12):1388-98. doi: 10.1038/ni.1667. Epub 2008 Nov 2.

49.

DNA methyltransferase loading, but not de novo methylation, is an oocyte-autonomous process stimulated by SCF signalling.

Lees-Murdock DJ, Lau HT, Castrillon DH, De Felici M, Walsh CP.

Dev Biol. 2008 Sep 1;321(1):238-50. doi: 10.1016/j.ydbio.2008.06.024. Epub 2008 Jun 25.

50.

Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth.

John GB, Gallardo TD, Shirley LJ, Castrillon DH.

Dev Biol. 2008 Sep 1;321(1):197-204. doi: 10.1016/j.ydbio.2008.06.017. Epub 2008 Jun 20.

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