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Items: 16


Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease.

Pearsall RS, Davies MV, Cannell M, Li J, Widrick J, Mulivor AW, Wallner S, Troy ME, Spaits M, Liharska K, Sako D, Castonguay R, Keates S, Grinberg AV, Suragani RNVS, Kumar R.

Sci Rep. 2019 Aug 6;9(1):11392. doi: 10.1038/s41598-019-47818-w.


Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity.

Goebel EJ, Corpina RA, Hinck CS, Czepnik M, Castonguay R, Grenha R, Boisvert A, Miklossy G, Fullerton PT, Matzuk MM, Idone VJ, Economides AN, Kumar R, Hinck AP, Thompson TB.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15505-15513. doi: 10.1073/pnas.1906253116. Epub 2019 Jul 17.


Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle.

Castonguay R, Lachey J, Wallner S, Strand J, Liharska K, Watanabe AE, Cannell M, Davies MV, Sako D, Troy ME, Krishnan L, Mulivor AW, Li H, Keates S, Alexander MJ, Pearsall RS, Kumar R.

J Pharmacol Exp Ther. 2019 Mar;368(3):435-445. doi: 10.1124/jpet.118.252304. Epub 2018 Dec 18.


Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.

Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV.

J Biol Chem. 2011 Aug 26;286(34):30034-46. doi: 10.1074/jbc.M111.260133. Epub 2011 Jul 7.


De novo helical peptides as target sequences for a specific, fluorogenic protein labelling strategy.

Guy J, Castonguay R, Campos-Reales Pineda NB, Jacquier V, Caron K, Michnick SW, Keillor JW.

Mol Biosyst. 2010 Jun;6(6):976-87. doi: 10.1039/b918205e. Epub 2010 Feb 23.


Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb.

Sako D, Grinberg AV, Liu J, Davies MV, Castonguay R, Maniatis S, Andreucci AJ, Pobre EG, Tomkinson KN, Monnell TE, Ucran JA, Martinez-Hackert E, Pearsall RS, Underwood KW, Seehra J, Kumar R.

J Biol Chem. 2010 Jul 2;285(27):21037-48. doi: 10.1074/jbc.M110.114959. Epub 2010 Apr 12.


ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth.

Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS, Underwood KW, Seehra J, Kumar R.

Mol Cancer Ther. 2010 Feb;9(2):379-88. doi: 10.1158/1535-7163.MCT-09-0650. Epub 2010 Feb 2.


Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase.

Castonguay R, Valenzano CR, Chen AY, Keatinge-Clay A, Khosla C, Cane DE.

J Am Chem Soc. 2008 Sep 3;130(35):11598-9. doi: 10.1021/ja804453p. Epub 2008 Aug 12.


Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidase.

Castonguay R, Halim D, Morin M, Furtos A, Lherbet C, Bonneil E, Thibault P, Keillor JW.

Biochemistry. 2007 Oct 30;46(43):12253-62. Epub 2007 Oct 9.


Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase.

Castonguay R, He W, Chen AY, Khosla C, Cane DE.

J Am Chem Soc. 2007 Nov 7;129(44):13758-69. Epub 2007 Oct 6.


Gamma-glutamyl transpeptidase substrate specificity and catalytic mechanism.

Keillor JW, Castonguay R, Lherbet C.

Methods Enzymol. 2005;401:449-67.


Kinetic studies of rat kidney gamma-glutamyltranspeptidase deacylation reveal a general base-catalyzed mechanism.

Castonguay R, Lherbet C, Keillor JW.

Biochemistry. 2003 Oct 7;42(39):11504-13.


Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and their kinetic studies with gamma-glutamyltranspeptidase.

Lherbet C, Morin M, Castonguay R, Keillor JW.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):997-1000.


Expression, purification, crystallization and preliminary crystallographic analysis of Trypanosoma brucei phosphofructokinase.

Keillor JW, Lherbet C, Castonguay R, Lapierre D, Martinez-Oyanedel J, Fothergill-Gilmore LA, Walkinshaw MD.

Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):532-4. Epub 2003 Feb 21.


Mapping of the active site of rat kidney gamma-glutamyl transpeptidase using activated esters and their amide derivatives.

Castonguay R, Lherbet C, Keillor JW.

Bioorg Med Chem. 2002 Dec;10(12):4185-91.


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