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Analysis of DNA Interstrand Cross-Links and their Repair by Modified Comet Assay.

Swift LP, Castle L, McHugh PJ.

Methods Mol Biol. 2020;2119:79-88. doi: 10.1007/978-1-0716-0323-9_7.


Appropriateness of Prescription and Safety of Wearable Cardioverter Defibrillators: A Single-center Experience.

Sundhu M, Gul S, Syed MA, Afzal O, Shah B, Castle L.

Cureus. 2019 Jun 7;11(6):e4854. doi: 10.7759/cureus.4854.


Arrhythmias and Adaptations of the Cardiac Conduction System in Former National Football League Players.

Aagaard P, Sharma S, McNamara DA, Joshi P, Ayers CR, de Lemos JA, Lincoln AE, Baranowski B, Mandsager K, Hill E, Castle L, Gentry J 3rd, Lang R, Dunn RE, Alexander K, Tucker AM, Phelan D.

J Am Heart Assoc. 2019 Aug 6;8(15):e010401. doi: 10.1161/JAHA.118.010401. Epub 2019 Jul 24.


A systematic review and meta-analysis of patient data from the West Africa (2013-16) Ebola virus disease epidemic.

Rojek AM, Salam A, Ragotte RJ, Liddiard E, Elhussain A, Carlqvist A, Butler M, Kayem N, Castle L, Odondi L', Stepniewska K, Horby PW.

Clin Microbiol Infect. 2019 Nov;25(11):1307-1314. doi: 10.1016/j.cmi.2019.06.032. Epub 2019 Jul 5. Review.


Hawaiian monk seals exhibit behavioral flexibility when targeting prey of different size and shape.

Kienle SS, Cacanindin A, Kendall T, Richter B, Ribeiro-French C, Castle L, Lentes G, Costa DP, Mehta RS.

J Exp Biol. 2019 Mar 4;222(Pt 5). pii: jeb194985. doi: 10.1242/jeb.194985.


Members of the GH3 Family of Proteins Conjugate 2,4-D and Dicamba with Aspartate and Glutamate.

Chiu LW, Heckert MJ, You Y, Albanese N, Fenwick T, Siehl DL, Castle LA, Tao Y.

Plant Cell Physiol. 2018 Nov 1;59(11):2366-2380. doi: 10.1093/pcp/pcy160.


Factors affecting migration kinetics from a generic epoxy-phenolic food can coating system.

Wagner J, Castle L, Oldring PKT, Moschakis T, Wedzicha BL.

Food Res Int. 2018 Apr;106:183-192. doi: 10.1016/j.foodres.2017.12.059. Epub 2017 Dec 26.


Clinical assessment is a neglected component of outbreak preparedness: evidence from refugee camps in Greece.

Rojek AM, Gkolfinopoulou K, Veizis A, Lambrou A, Castle L, Georgakopoulou T, Blanchet K, Panagiotopoulos T, Horby PW; Epidemic Diseases Research Group field team.

BMC Med. 2018 Mar 19;16(1):43. doi: 10.1186/s12916-018-1015-9.


Regulatory and Operational Complexities of Conducting a Clinical Treatment Trial During an Ebola Virus Disease Epidemic.

Rojek AM, Dunning J, Leliogdowicz A, Castle L, Van Lieshout M, Carson G, Sahr F, Olliaro P, Horby PW.

Clin Infect Dis. 2018 Apr 17;66(9):1454-1457. doi: 10.1093/cid/cix1061.


Resectable Clinical N2 Non-Small Cell Lung Cancer; What Is the Optimal Treatment Strategy? An Update by the British Thoracic Society Lung Cancer Specialist Advisory Group.

Evison M, Clive A, Castle L, Powell H, Thomas R, Buttery R, Masani V, Harden S, West D, Woolhouse I.

J Thorac Oncol. 2017 Sep;12(9):1434-1441. doi: 10.1016/j.jtho.2017.05.023. Epub 2017 Jun 15. Erratum in: J Thorac Oncol. 2019 Feb;14(2):314.


Clinical Characteristics and Outcomes of Patients with Ischemic and Non-Ischemic Complete Heart Block.

Sundhu M, Yildiz M, Syed M, Shah B, Gul S, Afzal O, Castle L.

Cureus. 2017 May 12;9(5):e1244. doi: 10.7759/cureus.1244.


Genotoxicity testing approaches for the safety assessment of substances used in food contact materials prior to their authorization in the European Union.

Bolognesi C, Castoldi AF, Crebelli R, Barthélémy E, Maurici D, Wölfle D, Volk K, Castle L.

Environ Mol Mutagen. 2017 Jun;58(5):361-374. doi: 10.1002/em.22094. Epub 2017 May 28. Review.


Experimental Treatment of Ebola Virus Disease with Brincidofovir.

Dunning J, Kennedy SB, Antierens A, Whitehead J, Ciglenecki I, Carson G, Kanapathipillai R, Castle L, Howell-Jones R, Pardinaz-Solis R, Grove J, Scott J, Lang T, Olliaro P, Horby PW; RAPIDE-BCV trial team.

PLoS One. 2016 Sep 9;11(9):e0162199. doi: 10.1371/journal.pone.0162199. eCollection 2016.


Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial.

Dunning J, Sahr F, Rojek A, Gannon F, Carson G, Idriss B, Massaquoi T, Gandi R, Joseph S, Osman HK, Brooks TJ, Simpson AJ, Goodfellow I, Thorne L, Arias A, Merson L, Castle L, Howell-Jones R, Pardinaz-Solis R, Hope-Gill B, Ferri M, Grove J, Kowalski M, Stepniewska K, Lang T, Whitehead J, Olliaro P, Samai M, Horby PW; RAPIDE-TKM trial team.

PLoS Med. 2016 Apr 19;13(4):e1001997. doi: 10.1371/journal.pmed.1001997. eCollection 2016 Apr.


The HeartMate II Risk Score: An Adjusted Score for Evaluation of All Continuous-Flow Left Ventricular Assist Devices.

Cowger JA, Castle L, Aaronson KD, Slaughter MS, Moainie S, Walsh M, Salerno C.

ASAIO J. 2016 May-Jun;62(3):281-5. doi: 10.1097/MAT.0000000000000362.


Determination of key diffusion and partition parameters and their use in migration modelling of benzophenone from low-density polyethylene (LDPE) into different foodstuffs.

Maia J, Rodríguez-Bernaldo de Quirós A, Sendón R, Cruz JM, Seiler A, Franz R, Simoneau C, Castle L, Driffield M, Mercea P, Oldring P, Tosa V, Paseiro P.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016;33(4):715-24. doi: 10.1080/19440049.2016.1156165. Epub 2016 Mar 16.


A statement on the developmental immunotoxicity of bisphenol A (BPA): answer to the question from the Dutch Ministry of Health, Welfare and Sport.

Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF), Silano V, Bolognesi C, Castle L, Cravedi JP, Engel KH, Fowler P, Franz R, Grob K, Gürtler R, Kärenlampi S, Mennes W, Milana MR, Penninks A, Smith A, de Fátima Tavares Poças M, Tlustos C, Wölfle D, Zorn H, Zugravu CA, Anderson S, Germolec D, Pieters R, Castoldi AF, Husøy T.

EFSA J. 2016;14(10):e04580. doi: 10.2903/j.efsa.2016.4580. Epub 2016 Oct 13.


Migration of melamine from thermally cured, amino cross-linked can coatings into an aqueous ethanol food simulant: aspects of hydrolysis, relative reactivity and migration.

Magami SM, Oldring PK, Castle L, Guthrie JT.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(3):403-9. doi: 10.1080/19440049.2014.1003150. Epub 2015 Jan 30.


Use of atmospheric pressure solids analysis probe time-of-flight mass spectrometry to screen for plasticisers in gaskets used in contact with foods.

Driffield M, Bradley E, Castle L, Lloyd A, Parmar M, Speck D, Roberts D, Stead S.

Rapid Commun Mass Spectrom. 2015 Sep 15;29(17):1603-1610. doi: 10.1002/rcm.7255.


Broad 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicide tolerance in soybean with an optimized enzyme and expression cassette.

Siehl DL, Tao Y, Albert H, Dong Y, Heckert M, Madrigal A, Lincoln-Cabatu B, Lu J, Fenwick T, Bermudez E, Sandoval M, Horn C, Green JM, Hale T, Pagano P, Clark J, Udranszky IA, Rizzo N, Bourett T, Howard RJ, Johnson DH, Vogt M, Akinsola G, Castle LA.

Plant Physiol. 2014 Nov;166(3):1162-76. doi: 10.1104/pp.114.247205. Epub 2014 Sep 5.


Model studies of migration from paper and board into fruit and vegetables and into Tenax as a food simulant.

Bradley EL, Castle L, Speck DR.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(7):1301-9. doi: 10.1080/19440049.2014.914633. Epub 2014 May 14.


Printing ink compounds in foods: UK survey results.

Bradley EL, Stratton JS, Leak J, Lister L, Castle L.

Food Addit Contam Part B Surveill. 2013;6(2):73-83. doi: 10.1080/19393210.2012.725774. Epub 2012 Oct 2.


Molecular and phenotypic characterization of Als1 and Als2 mutations conferring tolerance to acetolactate synthase herbicides in soybean.

Walter KL, Strachan SD, Ferry NM, Albert HH, Castle LA, Sebastian SA.

Pest Manag Sci. 2014 Dec;70(12):1831-9. doi: 10.1002/ps.3725. Epub 2014 Mar 6.


Estimates of dietary exposure to bisphenol A (BPA) from light metal packaging using food consumption and packaging usage data: a refined deterministic approach and a fully probabilistic (FACET) approach.

Oldring PK, Castle L, O'Mahony C, Dixon J.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(3):466-89. doi: 10.1080/19440049.2013.860240. Epub 2014 Jan 20.


Safety evaluation of mechanical recycling processes used to produce polyethylene terephthalate (PET) intended for food contact applications.

Barthélémy E, Spyropoulos D, Milana MR, Pfaff K, Gontard N, Lampi E, Castle L.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(3):490-7. doi: 10.1080/19440049.2013.871755. Epub 2014 Feb 14.


Development of a new modelling tool (FACET) to assess exposure to chemical migrants from food packaging.

Oldring PK, O'Mahony C, Dixon J, Vints M, Mehegan J, Dequatre C, Castle L.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(3):444-65. doi: 10.1080/19440049.2013.862348. Epub 2014 Jan 15.


Analytical screening studies on irradiated food packaging.

Driffield M, Bradley EL, Leon I, Lister L, Speck DR, Castle L, Potter EL.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(3):556-65. doi: 10.1080/19440049.2013.865087. Epub 2014 Jan 16.


Methods of analysis for 2-dodecylcyclobutanone and studies to support its role as a unique marker of food irradiation.

Driffield M, Speck D, Lloyd AS, Parmar M, Crews C, Castle L, Thomas C.

Food Chem. 2014 Mar 1;146:308-13. doi: 10.1016/j.foodchem.2013.09.046. Epub 2013 Sep 18.


Exposure to phthalic acid, phthalate diesters and phthalate monoesters from foodstuffs: UK total diet study results.

Bradley EL, Burden RA, Bentayeb K, Driffield M, Harmer N, Mortimer DN, Speck DR, Ticha J, Castle L.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(4):735-42. doi: 10.1080/19440049.2013.781684. Epub 2013 May 3.


Determination of phthalate diesters in foods.

Bradley EL, Burden RA, Leon I, Mortimer DN, Speck DR, Castle L.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(4):722-34. doi: 10.1080/19440049.2013.781683. Epub 2013 Apr 24.


Endobronchial ultrasound doppler image features correlate with mRNA expression of HIF1-α and VEGF-C in patients with non-small-cell lung cancer.

Nakajima T, Anayama T, Koike T, Shingyoji M, Castle L, Kimura H, Yoshino I, Yasufuku K.

J Thorac Oncol. 2012 Nov;7(11):1661-7. doi: 10.1097/JTO.0b013e318265b4df.


Molecular monitoring of chronic myeloid leukemia: a personalized approach to optimizing treatment response.

Nichols L, Pippins J, Castle L, Cassler M, Fuller C.

Per Med. 2012 Sep;9(7):727-737. doi: 10.2217/pme.12.81.


B-type natriuretic peptide concentrations in contemporary Eisenmenger syndrome patients: predictive value and response to disease targeting therapy.

Diller GP, Alonso-Gonzalez R, Kempny A, Dimopoulos K, Inuzuka R, Giannakoulas G, Castle L, Lammers AE, Hooper J, Uebing A, Swan L, Gatzoulis M, Wort SJ.

Heart. 2012 May;98(9):736-42. doi: 10.1136/heartjnl-2011-301522. Epub 2012 Mar 7.


Characterization and significance of adhesion and junction-related proteins in mouse ovarian follicles.

Mora JM, Fenwick MA, Castle L, Baithun M, Ryder TA, Mobberley M, Carzaniga R, Franks S, Hardy K.

Biol Reprod. 2012 May 17;86(5):153, 1-14. doi: 10.1095/biolreprod.111.096156. Print 2012 May.


Recent advances in the risk assessment of melamine and cyanuric acid in animal feed.

Dorne JL, Doerge DR, Vandenbroeck M, Fink-Gremmels J, Mennes W, Knutsen HK, Vernazza F, Castle L, Edler L, Benford D.

Toxicol Appl Pharmacol. 2013 Aug 1;270(3):218-29. doi: 10.1016/j.taap.2012.01.012. Epub 2012 Jan 25. Review.


Exploring the sensitivity of the zone of inhibition test for leachable biocides from paper and board food contact materials, and improvements thereof.

Castle L, Kelly J, Jickells SM, Johns SM, Mountfort KA.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29(1):139-48. doi: 10.1080/19440049.2011.616951. Epub 2011 Oct 31.


Identification of unknown migrants from food contact materials.

Driffield M, Bradley EL, Castle L, Coulier L.

Methods Mol Biol. 2011;747:357-72. doi: 10.1007/978-1-61779-136-9_14.


A twenty-volunteer study using deuterium labelling to determine the kinetics and fractional excretion of primary and secondary urinary metabolites of di-2-ethylhexylphthalate and di-iso-nonylphthalate.

Anderson WA, Castle L, Hird S, Jeffery J, Scotter MJ.

Food Chem Toxicol. 2011 Sep;49(9):2022-9. doi: 10.1016/j.fct.2011.05.013. Epub 2011 May 15.


Migration of melamine from can coatings cross-linked with melamine-based resins, into food simulants and foods.

Bradley EL, Castle L, Day JS, Leak J.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 Feb;28(2):243-50. doi: 10.1080/19440049.2010.536167. Epub 2010 Dec 17.


Comparison of the migration of melamine from melamine-formaldehyde plastics ('melaware') into various food simulants and foods themselves.

Bradley EL, Castle L, Day JS, Ebner I, Ehlert K, Helling R, Koster S, Leak J, Pfaff K.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Dec;27(12):1755-64. doi: 10.1080/19440049.2010.513339.


Determination of polyadipates migrating from lid gaskets of glass jars. Hydrolysis to adipic acid and measurement by LC-MS/MS.

Driffield M, Bradley EL, Harmer N, Castle L, Klump S, Mottier P.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Oct;27(10):1487-95. doi: 10.1080/19440049.2010.506202.


Migration of formaldehyde from melamine-ware: UK 2008 survey results.

Potter EL, Bradley EL, Davies CR, Barnes KA, Castle L.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Jun;27(6):879-83. doi: 10.1080/19440041003636638.


Analysis of reaction products of food contaminants and ingredients: bisphenol A diglycidyl ether (BADGE) in canned foods.

Coulier L, Bradley EL, Bas RC, Verhoeckx KC, Driffield M, Harmer N, Castle L.

J Agric Food Chem. 2010 Apr 28;58(8):4873-82. doi: 10.1021/jf904160a.


Safety evaluation of food contact paper and board using chemical tests and in vitro bioassays: role of known and unknown substances.

Honkalampi-Hämäläinen U, Bradley EL, Castle L, Severin I, Dahbi L, Dahlman O, Lhuguenot JC, Andersson MA, Hakulinen P, Hoornstra D, Mäki-Paakkanen J, Salkinoja-Salonen M, Turco L, Stammati A, Zucco F, Weber A, von Wright A.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Mar;27(3):406-15. doi: 10.1080/19440040903401358.


Analytical approaches to identify potential migrants in polyester-polyurethane can coatings.

Louise Bradley E, Driffield M, Guthrie J, Harmer N, Thomas Oldring PK, Castle L.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Dec;26(12):1602-10. doi: 10.1080/19440040903252256.


Development and single-laboratory validation of an HPLC method for the determination of cyclamate sweetener in foodstuffs.

Scotter MJ, Castle L, Roberts DP, Macarthur R, Brereton PA, Hasnip SK, Katz N.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 May;26(5):614-22. doi: 10.1080/02652030802695480.


Use of overall migration methodology to test for food-contact substances with specific migration limits.

Bradley EL, Castle L, Jickells SM, Mountfort KA, Read WA.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Apr;26(4):574-82. doi: 10.1080/02652030802477947.


New hierarchical classification of food items for the assessment of exposure to packaging migrants: use of hub codes for different food groups.

Northing P, Oldring PK, Castle L, Mason PA.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Apr;26(4):534-62. doi: 10.1080/02652030802598049.


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