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Items: 22

1.

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity.

Castillo-Quan JI, Tain LS, Kinghorn KJ, Li L, Grönke S, Hinze Y, Blackwell TK, Bjedov I, Partridge L.

Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20817-20819. doi: 10.1073/pnas.1913212116. Epub 2019 Sep 30.

2.

Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling.

Ewald CY, Castillo-Quan JI, Blackwell TK.

Gerontology. 2018;64(1):96-104. doi: 10.1159/000480504. Epub 2017 Sep 22.

3.

The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease.

Kinghorn KJ, Asghari AM, Castillo-Quan JI.

Neural Regen Res. 2017 Mar;12(3):380-384. doi: 10.4103/1673-5374.202934. Review.

4.

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.

Kerr F, Sofola-Adesakin O, Ivanov DK, Gatliff J, Gomez Perez-Nievas B, Bertrand HC, Martinez P, Callard R, Snoeren I, Cochemé HM, Adcott J, Khericha M, Castillo-Quan JI, Wells G, Noble W, Thornton J, Partridge L.

PLoS Genet. 2017 Mar 2;13(3):e1006593. doi: 10.1371/journal.pgen.1006593. eCollection 2017 Mar.

5.

Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging.

Castillo-Quan JI, Blackwell TK.

Cell. 2016 Dec 15;167(7):1670-1671. doi: 10.1016/j.cell.2016.11.058.

6.

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin.

Kinghorn KJ, Grönke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L.

J Neurosci. 2016 Nov 16;36(46):11654-11670.

7.

Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications.

Kinghorn KJ, Castillo-Quan JI, Li L, Bhatia KP, Abramov AY, Hardy J, Partridge L.

Brain. 2016 Dec;139(Pt 12):e68. Epub 2016 Aug 6. No abstract available.

PMID:
27497489
8.

Mitochondrial dysfunction and defects in lipid homeostasis as therapeutic targets in neurodegeneration with brain iron accumulation.

Kinghorn KJ, Castillo-Quan JI.

Rare Dis. 2016 Jan 25;4(1):e1128616. doi: 10.1080/21675511.2015.1128616. eCollection 2016.

9.

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis.

Castillo-Quan JI, Li L, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, Kerr F, Nespital T, Thornton J, Hardy J, Bjedov I, Partridge L.

Cell Rep. 2016 Apr 19;15(3):638-650. doi: 10.1016/j.celrep.2016.03.041. Epub 2016 Apr 7.

10.

Genetics and pharmacology of longevity: the road to therapeutics for healthy aging.

Castillo-Quan JI, Kinghorn KJ, Bjedov I.

Adv Genet. 2015;90:1-101. doi: 10.1016/bs.adgen.2015.06.002. Epub 2015 Jul 29. Review.

PMID:
26296933
11.

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction.

Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cochemé HM, Khan S, Asghari S, Bhatia KP, Hardy J, Abramov AY, Partridge L.

Brain. 2015 Jul;138(Pt 7):1801-16. doi: 10.1093/brain/awv132. Epub 2015 May 22.

12.

Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease.

Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Tain LS, Bjedov I, Rogers I, Li L, Martinez P, Khericha M, Cabecinha M, Bähler J, Partridge L.

Front Aging Neurosci. 2014 Jul 30;6:190. doi: 10.3389/fnagi.2014.00190. eCollection 2014.

13.

[Molecular gerontology: towards healthy aging].

Castillo-Quan JI, Kinghorn KJ.

Gac Med Mex. 2013 Nov-Dec;149(6):680-5. Review. Spanish.

14.

From white to brown fat through the PGC-1α-dependent myokine irisin: implications for diabetes and obesity.

Castillo-Quan JI.

Dis Model Mech. 2012 May;5(3):293-5. doi: 10.1242/dmm.009894. No abstract available.

15.

Parkin' control: regulation of PGC-1α through PARIS in Parkinson's disease.

Castillo-Quan JI.

Dis Model Mech. 2011 Jul;4(4):427-9. doi: 10.1242/dmm.008227. No abstract available.

16.

[Depression and diabetes: from epidemiology to neurobiology].

Castillo-Quan JI, Barrera-Buenfil DJ, Pérez-Osorio JM, Alvarez-Cervera FJ.

Rev Neurol. 2010 Sep 16;51(6):347-59. Review. Spanish.

17.

Rosiglitazone effects to ameliorate Alzheimer's disease pathogenic features: insulin signaling and neurotrophic factors.

Castillo-Quan JI.

J Neuropsychiatry Clin Neurosci. 2009 Summer;21(3):347-8. doi: 10.1176/appi.neuropsych.21.3.347. No abstract available.

PMID:
19776322
18.

[Alzheimer's disease and methylenetetrahydrofolate reductase gene polymorphisms: a potential nutrigenomic approach for Mexico].

Castillo-Quan JI, Pérez-Osorio JM.

Gac Med Mex. 2009 Mar-Apr;145(2):147-50. Spanish.

PMID:
19518022
19.

[Nutritional genomics: an approach to the genome-environment interaction].

Xacur-García F, Castillo-Quan JI, Hernández-Escalante VM, Laviada-Molina H.

Rev Med Chil. 2008 Nov;136(11):1460-7. Review. Spanish.

PMID:
19301779
20.

Insulin resistance, hypercortisolism, polycystic ovarian syndrome, and depression--nonrandom associations?

Castillo-Quan JI.

Fertil Steril. 2008 Apr;89(4):1029-30; author reply 1030. doi: 10.1016/j.fertnstert.2008.01.024. Epub 2008 Mar 5. No abstract available.

PMID:
18325512
21.

Insulin-cortisol interaction in depression and other neurological diseases: an alternative hypothesis.

Castillo-Quan JI, Herrera-González A, Pérez-Osorio JM.

Psychoneuroendocrinology. 2007 Aug;32(7):854-5; author reply 856. Epub 2007 Jun 18. No abstract available.

PMID:
17574343
22.

Cortisol secretion in patients with type 2 diabetes: relationship with chronic complications: response to Chiodini et al.

Castillo-Quan JI, Pérez-Osorio JM.

Diabetes Care. 2007 Jun;30(6):e49; author reply e50. No abstract available.

PMID:
17526811

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