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Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons.

Klein ME, Younts TJ, Cobo CF, Buxbaum AR, Aow J, Erdjument-Bromage H, Richard S, Malinow R, Neubert TA, Singer RH, Castillo PE, Jordan BA.

Cell Rep. 2019 Nov 12;29(7):1789-1799.e6. doi: 10.1016/j.celrep.2019.10.030.


Long-Term Plasticity of Neurotransmitter Release: Emerging Mechanisms and Contributions to Brain Function and Disease.

Monday HR, Younts TJ, Castillo PE.

Annu Rev Neurosci. 2018 Jul 8;41:299-322. doi: 10.1146/annurev-neuro-080317-062155. Epub 2018 Apr 25. Review.


Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation.

Weng FJ, Garcia RI, Lutzu S, Alviña K, Zhang Y, Dushko M, Ku T, Zemoura K, Rich D, Garcia-Dominguez D, Hung M, Yelhekar TD, Sørensen AT, Xu W, Chung K, Castillo PE, Lin Y.

Neuron. 2018 Mar 7;97(5):1137-1152.e5. doi: 10.1016/j.neuron.2018.01.026. Epub 2018 Feb 8.


Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis.

Nandi S, Alviña K, Lituma PJ, Castillo PE, Hébert JM.

Neuroscience. 2018 Jan 15;369:192-201. doi: 10.1016/j.neuroscience.2017.11.017. Epub 2017 Nov 16.


Unconventional NMDA Receptor Signaling.

Dore K, Stein IS, Brock JA, Castillo PE, Zito K, Sjöström PJ.

J Neurosci. 2017 Nov 8;37(45):10800-10807. doi: 10.1523/JNEUROSCI.1825-17.2017. Review.


LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.

Hashimotodani Y, Nasrallah K, Jensen KR, Chávez AE, Carrera D, Castillo PE.

Neuron. 2017 Aug 16;95(4):928-943.e3. doi: 10.1016/j.neuron.2017.07.028.


Synaptic functions of endocannabinoid signaling in health and disease.

Araque A, Castillo PE, Manzoni OJ, Tonini R.

Neuropharmacology. 2017 Sep 15;124:13-24. doi: 10.1016/j.neuropharm.2017.06.017. Epub 2017 Jun 15. Review.


Closing the gap: long-term presynaptic plasticity in brain function and disease.

Monday HR, Castillo PE.

Curr Opin Neurobiol. 2017 Aug;45:106-112. doi: 10.1016/j.conb.2017.05.011. Epub 2017 May 29. Review.


Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat.

Harony-Nicolas H, Kay M, du Hoffmann J, Klein ME, Bozdagi-Gunal O, Riad M, Daskalakis NP, Sonar S, Castillo PE, Hof PR, Shapiro ML, Baxter MG, Wagner S, Buxbaum JD.

Elife. 2017 Jan 31;6. pii: e18904. doi: 10.7554/eLife.18904.


Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination.

Jones BW, Deem J, Younts TJ, Weisenhaus M, Sanford CA, Slack MC, Chin J, Nachmanson D, McKennon A, Castillo PE, McKnight GS.

Elife. 2016 Dec 2;5. pii: e20695. doi: 10.7554/eLife.20695.


Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release.

Younts TJ, Monday HR, Dudok B, Klein ME, Jordan BA, Katona I, Castillo PE.

Neuron. 2016 Oct 19;92(2):479-492. doi: 10.1016/j.neuron.2016.09.040.


CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory.

Park J, Chávez AE, Mineur YS, Morimoto-Tomita M, Lutzu S, Kim KS, Picciotto MR, Castillo PE, Tomita S.

Neuron. 2016 Oct 5;92(1):75-83. doi: 10.1016/j.neuron.2016.09.002. Epub 2016 Sep 22.


De novo synaptogenesis induced by GABA in the developing mouse cortex.

Oh WC, Lutzu S, Castillo PE, Kwon HB.

Science. 2016 Sep 2;353(6303):1037-1040. Epub 2016 Aug 11.


APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.

Fanutza T, Del Prete D, Ford MJ, Castillo PE, D'Adamio L.

Elife. 2015 Nov 9;4:e09743. doi: 10.7554/eLife.09743.


Selective Dysregulation of Hippocampal Inhibition in the Mouse Lacking Autism Candidate Gene CNTNAP2.

Jurgensen S, Castillo PE.

J Neurosci. 2015 Oct 28;35(43):14681-7. doi: 10.1523/JNEUROSCI.1666-15.2015.


A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.

Ben-Simon Y, Rodenas-Ruano A, Alviña K, Lam AD, Stuenkel EL, Castillo PE, Ashery U.

Cell Rep. 2015 Jul 21;12(3):396-404. doi: 10.1016/j.celrep.2015.06.037. Epub 2015 Jul 9.


ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization.

Tindi JO, Chávez AE, Cvejic S, Calvo-Ochoa E, Castillo PE, Jordan BA.

J Neurosci. 2015 Jun 17;35(24):8986-96. doi: 10.1523/JNEUROSCI.4029-14.2015.


Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors.

Kalinowska M, Chávez AE, Lutzu S, Castillo PE, Bukauskas FF, Francesconi A.

J Biol Chem. 2015 Jun 26;290(26):15909-20. doi: 10.1074/jbc.M115.640136. Epub 2015 May 5.


Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD.

Klein ME, Castillo PE, Jordan BA.

Cell Rep. 2015 Mar 10;10(9):1459-1466. doi: 10.1016/j.celrep.2015.02.020. Epub 2015 Mar 5.


Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus.

Chávez AE, Hernández VM, Rodenas-Ruano A, Chan CS, Castillo PE.

J Neurosci. 2014 Dec 10;34(50):16621-9. doi: 10.1523/JNEUROSCI.3635-14.2014.


The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function.

Hou H, Chávez AE, Wang CC, Yang H, Gu H, Siddoway BA, Hall BJ, Castillo PE, Xia H.

J Neurosci. 2014 Oct 15;34(42):14006-12. doi: 10.1523/JNEUROSCI.1659-14.2014.


Synucleins regulate the kinetics of synaptic vesicle endocytosis.

Vargas KJ, Makani S, Davis T, Westphal CH, Castillo PE, Chandra SS.

J Neurosci. 2014 Jul 9;34(28):9364-76. doi: 10.1523/JNEUROSCI.4787-13.2014.


Endogenous cannabinoid signaling at inhibitory interneurons.

Younts TJ, Castillo PE.

Curr Opin Neurobiol. 2014 Jun;26:42-50. doi: 10.1016/j.conb.2013.12.006. Epub 2013 Dec 28. Review.


Presenilin-ryanodine receptor connection.

D'Adamio L, Castillo PE.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14825-6. doi: 10.1073/pnas.1313996110. Epub 2013 Aug 30. No abstract available.


CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses.

Younts TJ, Chevaleyre V, Castillo PE.

J Neurosci. 2013 Aug 21;33(34):13743-57. doi: 10.1523/JNEUROSCI.0817-13.2013.


Bidirectional NMDA receptor plasticity controls CA3 output and heterosynaptic metaplasticity.

Hunt DL, Puente N, Grandes P, Castillo PE.

Nat Neurosci. 2013 Aug;16(8):1049-59. doi: 10.1038/nn.3461. Epub 2013 Jul 14.


Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP.

Kaeser-Woo YJ, Younts TJ, Yang X, Zhou P, Wu D, Castillo PE, Südhof TC.

J Neurosci. 2013 Jun 5;33(23):9769-80. doi: 10.1523/JNEUROSCI.5814-12.2013.


Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions.

Hoy JL, Haeger PA, Constable JR, Arias RJ, McCallum R, Kyweriga M, Davis L, Schnell E, Wehr M, Castillo PE, Washbourne P.

J Neurosci. 2013 May 29;33(22):9364-84. doi: 10.1523/JNEUROSCI.4660-12.2013.


RNA-binding protein Sam68 controls synapse number and local β-actin mRNA metabolism in dendrites.

Klein ME, Younts TJ, Castillo PE, Jordan BA.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3125-30. doi: 10.1073/pnas.1209811110. Epub 2013 Feb 4.


Endocannabinoid signaling and synaptic function.

Castillo PE, Younts TJ, Chávez AE, Hashimotodani Y.

Neuron. 2012 Oct 4;76(1):70-81. doi: 10.1016/j.neuron.2012.09.020. Review.


REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors.

Rodenas-Ruano A, Chávez AE, Cossio MJ, Castillo PE, Zukin RS.

Nat Neurosci. 2012 Oct;15(10):1382-90. doi: 10.1038/nn.3214. Epub 2012 Sep 9.


Estradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats.

Inagaki T, Kaneko N, Zukin RS, Castillo PE, Etgen AM.

PLoS One. 2012;7(6):e38018. doi: 10.1371/journal.pone.0038018. Epub 2012 Jun 4.


Neto1 and Neto2: auxiliary subunits that determine key properties of native kainate receptors.

Tomita S, Castillo PE.

J Physiol. 2012 May 15;590(10):2217-23. doi: 10.1113/jphysiol.2011.221101. Epub 2012 Mar 19. Review.


Synaptic plasticity of NMDA receptors: mechanisms and functional implications.

Hunt DL, Castillo PE.

Curr Opin Neurobiol. 2012 Jun;22(3):496-508. doi: 10.1016/j.conb.2012.01.007. Epub 2012 Feb 8. Review.


Presynaptic LTP and LTD of excitatory and inhibitory synapses.

Castillo PE.

Cold Spring Harb Perspect Biol. 2012 Feb 1;4(2). pii: a005728. doi: 10.1101/cshperspect.a005728. Review.


Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning.

Tsetsenis T, Younts TJ, Chiu CQ, Kaeser PS, Castillo PE, Südhof TC.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14300-5. doi: 10.1073/pnas.1112237108. Epub 2011 Aug 15.


The battle over inhibitory synaptic plasticity in satiety brain circuits.

Younts TJ, Castillo PE.

Neuron. 2011 Aug 11;71(3):385-7. doi: 10.1016/j.neuron.2011.07.017.


Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.

Straub C, Hunt DL, Yamasaki M, Kim KS, Watanabe M, Castillo PE, Tomita S.

Nat Neurosci. 2011 May 29;14(7):866-73. doi: 10.1038/nn.2837.


Long-term plasticity at inhibitory synapses.

Castillo PE, Chiu CQ, Carroll RC.

Curr Opin Neurobiol. 2011 Apr;21(2):328-38. doi: 10.1016/j.conb.2011.01.006. Epub 2011 Feb 18. Review.


The extent and strength of electrical coupling between inferior olivary neurons is heterogeneous.

Hoge GJ, Davidson KG, Yasumura T, Castillo PE, Rash JE, Pereda AE.

J Neurophysiol. 2011 Mar;105(3):1089-101. doi: 10.1152/jn.00789.2010. Epub 2010 Dec 22.


TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus.

Chávez AE, Chiu CQ, Castillo PE.

Nat Neurosci. 2010 Dec;13(12):1511-8. doi: 10.1038/nn.2684. Epub 2010 Nov 14.


αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.

Greten-Harrison B, Polydoro M, Morimoto-Tomita M, Diao L, Williams AM, Nie EH, Makani S, Tian N, Castillo PE, Buchman VL, Chandra SS.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19573-8. doi: 10.1073/pnas.1005005107. Epub 2010 Oct 25.


Dopaminergic modulation of endocannabinoid-mediated plasticity at GABAergic synapses in the prefrontal cortex.

Chiu CQ, Puente N, Grandes P, Castillo PE.

J Neurosci. 2010 May 26;30(21):7236-48. doi: 10.1523/JNEUROSCI.0736-10.2010.


Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis.

Mukherjee K, Yang X, Gerber SH, Kwon HB, Ho A, Castillo PE, Liu X, Südhof TC.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6504-9. doi: 10.1073/pnas.1002307107. Epub 2010 Mar 23.


ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.

Kaeser PS, Deng L, Chávez AE, Liu X, Castillo PE, Südhof TC.

Neuron. 2009 Oct 29;64(2):227-39. doi: 10.1016/j.neuron.2009.09.019.


Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology.

Polydoro M, Acker CM, Duff K, Castillo PE, Davies P.

J Neurosci. 2009 Aug 26;29(34):10741-9. doi: 10.1523/JNEUROSCI.1065-09.2009.


Endocannabinoid signaling and long-term synaptic plasticity.

Heifets BD, Castillo PE.

Annu Rev Physiol. 2009;71:283-306. doi: 10.1146/annurev.physiol.010908.163149. Review.


Role of glutamate autoreceptors at hippocampal mossy fiber synapses.

Kwon HB, Castillo PE.

Neuron. 2008 Dec 26;60(6):1082-94. doi: 10.1016/j.neuron.2008.10.045.


RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions.

Kaeser PS, Kwon HB, Chiu CQ, Deng L, Castillo PE, Südhof TC.

J Neurosci. 2008 Dec 10;28(50):13435-47. doi: 10.1523/JNEUROSCI.3235-08.2008.


RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning.

Kaeser PS, Kwon HB, Blundell J, Chevaleyre V, Morishita W, Malenka RC, Powell CM, Castillo PE, Südhof TC.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14680-5. doi: 10.1073/pnas.0806679105. Epub 2008 Sep 17.

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