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Topical delivery of mTOR inhibitor halts scarring.

Webber LP, Yip B, Nascimento Filho CHVD, Park HB, Castilho RM, Squarize CH.

J Dermatol Sci. 2019 Aug;95(2):76-79. doi: 10.1016/j.jdermsci.2019.06.008. Epub 2019 Jul 4. No abstract available.


Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence.

Webber LP, Yujra VQ, Vargas PA, Martins MD, Squarize CH, Castilho RM.

Cancer Lett. 2019 Oct 1;461:10-20. doi: 10.1016/j.canlet.2019.06.019. Epub 2019 Jun 29.


Characterization of macrophage polarization in periodontal disease.

Garaicoa-Pazmino C, Fretwurst T, Squarize CH, Berglundh T, Giannobile WV, Larsson L, Castilho RM.

J Clin Periodontol. 2019 Aug;46(8):830-839. doi: 10.1111/jcpe.13156. Epub 2019 Jun 25.


Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma.

Markman RL, Webber LP, Nascimento Filho CHV, Reis LA, Vargas PA, Lopes MA, Zanella V, Martins MD, Squarize CH, Castilho RM.

Cell Oncol (Dordr). 2019 Apr;42(2):143-155. doi: 10.1007/s13402-018-0416-2. Epub 2018 Dec 11.


UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line.

Warner KA, Oklejas AE, Pearson AT, Zhang Z, Wu W, Divi V, Rodriguez-Ramirez C, Castilho RM, Polverini PJ, Nör JE.

Oral Oncol. 2018 Dec;87:21-28. doi: 10.1016/j.oraloncology.2018.10.012. Epub 2018 Oct 18.


Dental implants-associated release of titanium particles: A systematic review.

Suárez-López Del Amo F, Garaicoa-Pazmiño C, Fretwurst T, Castilho RM, Squarize CH.

Clin Oral Implants Res. 2018 Oct 2. doi: 10.1111/clr.13372. [Epub ahead of print] Review.


Targeting histone deacetylase and NFκB signaling as a novel therapy for Mucoepidermoid Carcinomas.

Wagner VP, Martins MD, Martins MAT, Almeida LO, Warner KA, Nör JE, Squarize CH, Castilho RM.

Sci Rep. 2018 Feb 1;8(1):2065. doi: 10.1038/s41598-018-20345-w.


DNA intercalators based on (1,10-phenanthrolin-2-yl)isoxazolidin-5-yl core with better growth inhibition and selectivity than cisplatin upon head and neck squamous cells carcinoma.

Varrica MG, Zagni C, Mineo PG, Floresta G, Monciino G, Pistarà V, Abbadessa A, Nicosia A, Castilho RM, Amata E, Rescifina A.

Eur J Med Chem. 2018 Jan 1;143:583-590. doi: 10.1016/j.ejmech.2017.11.067. Epub 2017 Nov 26.


Titanium Activates the DNA Damage Response Pathway in Oral Epithelial Cells: A Pilot Study.

Suárez-López Del Amo F, Rudek I, Wagner VP, Martins MD, O'Valle F, Galindo-Moreno P, Giannobile WV, Wang HL, Castilho RM.

Int J Oral Maxillofac Implants. 2017 Nov/Dec;32(6):1413-1420. doi: 10.11607/jomi.6077.


Serendipitous discovery of potent human head and neck squamous cell carcinoma anti-cancer molecules: A fortunate failure of a rational molecular design.

Zagni C, Pistarà V, Oliveira LA, Castilho RM, Romeo G, Chiacchio U, Rescifina A.

Eur J Med Chem. 2017 Dec 1;141:188-196. doi: 10.1016/j.ejmech.2017.09.075. Epub 2017 Oct 5.


Histones Acetylation and Cancer Stem Cells (CSCs).

Wagner VP, Martins MD, Castilho RM.

Methods Mol Biol. 2018;1692:179-193. doi: 10.1007/978-1-4939-7401-6_16.


When epigenetics meets bioengineering-A material characteristics and surface topography perspective.

Larsson L, Pilipchuk SP, Giannobile WV, Castilho RM.

J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):2065-2071. doi: 10.1002/jbm.b.33953. Epub 2017 Jul 25. Review.


Evaluation of DNA methylation of inflammatory genes following treatment of chronic periodontitis: A pilot case-control study.

Asa'ad F, Bollati V, Pagni G, Castilho RM, Rossi E, Pomingi F, Tarantini L, Consonni D, Giannobile WV, Rasperini G.

J Clin Periodontol. 2017 Sep;44(9):905-914. doi: 10.1111/jcpe.12783. Epub 2017 Aug 17.


Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy.

Castilho RM, Squarize CH, Almeida LO.

Int J Mol Sci. 2017 Jul 12;18(7). pii: E1506. doi: 10.3390/ijms18071506. Review.


PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells.

Zagni C, Almeida LO, Balan T, Martins MT, Rosselli-Murai LK, Papagerakis P, Castilho RM, Squarize CH.

Stem Cell Reports. 2017 Jul 11;9(1):304-314. doi: 10.1016/j.stemcr.2017.05.006. Epub 2017 Jun 8.


Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence.

Almeida LO, Guimarães DM, Martins MD, Martins MAT, Warner KA, Nör JE, Castilho RM, Squarize CH.

Stem Cell Res. 2017 May;21:94-105. doi: 10.1016/j.scr.2017.04.003. Epub 2017 Apr 8. No abstract available.


Hypoacetylation of acetyl-histone H3 (H3K9ac) as marker of poor prognosis in oral cancer.

Webber LP, Wagner VP, Curra M, Vargas PA, Meurer L, Carrard VC, Squarize CH, Castilho RM, Martins MD.

Histopathology. 2017 Aug;71(2):278-286. doi: 10.1111/his.13218. Epub 2017 May 23.


Reduced chromatin acetylation of malignant salivary gland tumors correlates with enhanced proliferation.

Wagner VP, Martins MD, Guimaraes DM, Vasconcelos AC, Meurer L, Vargas PA, Fonseca FP, Squarize CH, Castilho RM.

J Oral Pathol Med. 2017 Oct;46(9):792-797. doi: 10.1111/jop.12557. Epub 2017 Apr 9.


Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis.

Wagner VP, Martins MA, Martins MD, Warner KA, Webber LP, Squarize CH, Nör JE, Castilho RM.

Oncotarget. 2016 Nov 8;7(45):73032-73044. doi: 10.18632/oncotarget.12195.


Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells.

Guimarães DM, Almeida LO, Martins MD, Warner KA, Silva AR, Vargas PA, Nunes FD, Squarize CH, Nör JE, Castilho RM.

Oncotarget. 2016 Jul 5;7(27):42447-42460. doi: 10.18632/oncotarget.9884.


PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells.

Matsumoto CS, Almeida LO, Guimarães DM, Martins MD, Papagerakis P, Papagerakis S, Leopoldino AM, Castilho RM, Squarize CH.

Oncotarget. 2016 Jul 5;7(27):42393-42407. doi: 10.18632/oncotarget.9877.


Overexpression of MutSα Complex Proteins Predicts Poor Prognosis in Oral Squamous Cell Carcinoma.

Wagner VP, Webber LP, Salvadori G, Meurer L, Fonseca FP, Castilho RM, Squarize CH, Vargas PA, Martins MD.

Medicine (Baltimore). 2016 May;95(22):e3725. doi: 10.1097/MD.0000000000003725.


Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma.

Warner KA, Nör F, Acasigua GA, Martins MD, Zhang Z, McLean SA, Spector ME, Chepeha DB, Helman J, Wick MJ, Moskaluk CA, Castilho RM, Pearson AT, Wang S, Nör JE.

Clin Cancer Res. 2016 Jul 15;22(14):3550-9. doi: 10.1158/1078-0432.CCR-15-1698. Epub 2016 Mar 2.


Corrigendum: TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer.

Banerjee R, Russo N, Liu M, Basrur V, Bellile E, Palanisamy N, Scanlon CS, van Tubergen E, Inglehart RC, Metwally T, Mani RS, Yocum A, Nyati MK, Castilho RM, Varambally S, Chinnaiyan AM, D'Silva NJ.

Nat Commun. 2016 Feb 24;7:10726. doi: 10.1038/ncomms10726. No abstract available.


Profiling the Behavior of Distinct Populations of Head and Neck Cancer Stem Cells.

Almeida LO, Guimarães DM, Squarize CH, Castilho RM.

Cancers (Basel). 2016 Jan 4;8(1). pii: E7. doi: 10.3390/cancers8010007.


mTOR pathway protein immunoexpression as a prognostic factor for survival in head and neck cancer patients: a systematic review and meta-analysis.

Marques AE, Elias ST, Porporatti AL, Castilho RM, Squarize CH, De Luca Canto G, Guerra EN.

J Oral Pathol Med. 2016 May;45(5):319-28. doi: 10.1111/jop.12390. Epub 2015 Dec 12. Review.


Epigenetic Modifications of Histones in Periodontal Disease.

Martins MD, Jiao Y, Larsson L, Almeida LO, Garaicoa-Pazmino C, Le JM, Squarize CH, Inohara N, Giannobile WV, Castilho RM.

J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.


ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas.

Adams A, Warner K, Pearson AT, Zhang Z, Kim HS, Mochizuki D, Basura G, Helman J, Mantesso A, Castilho RM, Wicha MS, Nör JE.

Oncotarget. 2015 Sep 29;6(29):26633-50. doi: 10.18632/oncotarget.5782.


Keratoacanthoma of the Lip: Activation of the mTOR Pathway, Tumor Suppressor Proteins, and Tumor Senescence.

Dillenburg CS, Martins MD, Meurer L, Castilho RM, Squarize CH.

Medicine (Baltimore). 2015 Sep;94(38):e1552. doi: 10.1097/MD.0000000000001552.


HPV Infection of the Head and Neck Region and Its Stem Cells.

Pullos AN, Castilho RM, Squarize CH.

J Dent Res. 2015 Nov;94(11):1532-43. doi: 10.1177/0022034515605456. Epub 2015 Sep 9. Review.


Epigenetic Modifications and Accumulation of DNA Double-Strand Breaks in Oral Lichen Planus Lesions Presenting Poor Response to Therapy.

Dillenburg CS, Martins MA, Almeida LO, Meurer L, Squarize CH, Martins MD, Castilho RM.

Medicine (Baltimore). 2015 Jul;94(30):e997. doi: 10.1097/MD.0000000000000997.


Immunoprofile of c-MET/PI3K signaling in human salivary gland tumors.

Vasconcelos AC, Wagner VP, Meurer L, Vargas PA, de Souza LB, Fonseca FP, Squarize CH, Castilho RM, Martins MD.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Aug;120(2):238-47. doi: 10.1016/j.oooo.2015.04.003. Epub 2015 Apr 24.


Histogenesis of keratoacanthoma: histochemical and immunohistochemical study.

Wagner VP, Martins MD, Dillenburg CS, Meurer L, Castilho RM, Squarize CH.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Mar;119(3):310-7. doi: 10.1016/j.oooo.2014.10.006. Epub 2014 Oct 18.


Histone modifications: Targeting head and neck cancer stem cells.

Le JM, Squarize CH, Castilho RM.

World J Stem Cells. 2014 Nov 26;6(5):511-25. doi: 10.4252/wjsc.v6.i5.511. Review.


Epigenetics and its role in periodontal diseases: a state-of-the-art review.

Larsson L, Castilho RM, Giannobile WV.

J Periodontol. 2015 Apr;86(4):556-68. doi: 10.1902/jop.2014.140559. Epub 2014 Nov 21. Review.


TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer.

Banerjee R, Russo N, Liu M, Basrur V, Bellile E, Palanisamy N, Scanlon CS, van Tubergen E, Inglehart RC, Metwally T, Mani RS, Yocum A, Nyati MK, Castilho RM, Varambally S, Chinnaiyan AM, D'Silva NJ.

Nat Commun. 2014 Jul 31;5:4527. doi: 10.1038/ncomms5527. Erratum in: Nat Commun. 2016;7:10726.


Efficacy of laser phototherapy in comparison to topical clobetasol for the treatment of oral lichen planus: a randomized controlled trial.

Dillenburg CS, Martins MA, Munerato MC, Marques MM, Carrard VC, Sant'Ana Filho M, Castilho RM, Martins MD.

J Biomed Opt. 2014 Jun;19(6):068002. doi: 10.1117/1.JBO.19.6.068002.


Laser phototherapy triggers the production of reactive oxygen species in oral epithelial cells without inducing DNA damage.

Dillenburg CS, Almeida LO, Martins MD, Squarize CH, Castilho RM.

J Biomed Opt. 2014 Apr;19(4):048002. doi: 10.1117/1.JBO.19.4.048002.


Laser phototherapy accelerates oral keratinocyte migration through the modulation of the mammalian target of rapamycin signaling pathway.

Pellicioli AC, Martins MD, Dillenburg CS, Marques MM, Squarize CH, Castilho RM.

J Biomed Opt. 2014 Feb;19(2):028002. doi: 10.1117/1.JBO.19.2.028002.


NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC).

Almeida LO, Abrahao AC, Rosselli-Murai LK, Giudice FS, Zagni C, Leopoldino AM, Squarize CH, Castilho RM.

FEBS Open Bio. 2013 Dec 30;4:96-104. doi: 10.1016/j.fob.2013.12.003. eCollection 2014.


Periostin responds to mechanical stress and tension by activating the MTOR signaling pathway.

Rosselli-Murai LK, Almeida LO, Zagni C, Galindo-Moreno P, Padial-Molina M, Volk SL, Murai MJ, Rios HF, Squarize CH, Castilho RM.

PLoS One. 2013 Dec 13;8(12):e83580. doi: 10.1371/journal.pone.0083580. eCollection 2013.


Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma.

Warner KA, Adams A, Bernardi L, Nor C, Finkel KA, Zhang Z, McLean SA, Helman J, Wolf GT, Divi V, Queimado L, Kaye FJ, Castilho RM, Nör JE.

Oral Oncol. 2013 Nov;49(11):1059-66. doi: 10.1016/j.oraloncology.2013.08.004. Epub 2013 Sep 12.


Histones: Controlling Tumor Signaling Circuitry.

Martins MD, Castilho RM.

J Carcinog Mutagen. 2013 Jul 29;1(Suppl 5):1-12.


Cyclin D1-induced proliferation is independent of beta-catenin in head and neck cancer.

Sales KU, Giudice FS, Castilho RM, Salles FT, Squarize CH, Abrahao AC, Pinto DS Jr.

Oral Dis. 2014 Apr;20(3):e42-8. doi: 10.1111/odi.12124. Epub 2013 Jun 4.


PTEN deficiency contributes to the development and progression of head and neck cancer.

Squarize CH, Castilho RM, Abrahao AC, Molinolo A, Lingen MW, Gutkind JS.

Neoplasia. 2013 May;15(5):461-71.


Inhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancer.

Giudice FS, Pinto DS Jr, Nör JE, Squarize CH, Castilho RM.

PLoS One. 2013;8(3):e58672. doi: 10.1371/journal.pone.0058672. Epub 2013 Mar 20.


Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing.

Castilho RM, Squarize CH, Gutkind JS.

Oral Dis. 2013 Sep;19(6):551-8. doi: 10.1111/odi.12070. Epub 2013 Feb 4. Review.


A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation.

Abrahao AC, Castilho RM, Squarize CH, Molinolo AA, dos Santos-Pinto D Jr, Gutkind JS.

Oral Oncol. 2010 Dec;46(12):880-7. doi: 10.1016/j.oraloncology.2010.09.005. Epub 2010 Oct 14.


Accelerated wound healing by mTOR activation in genetically defined mouse models.

Squarize CH, Castilho RM, Bugge TH, Gutkind JS.

PLoS One. 2010 May 13;5(5):e10643. doi: 10.1371/journal.pone.0010643.


Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice.

Castilho RM, Squarize CH, Leelahavanichkul K, Zheng Y, Bugge T, Gutkind JS.

PLoS One. 2010 May 6;5(5):e10503. doi: 10.1371/journal.pone.0010503.

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