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Items: 43

1.

The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.

Pereira CM, Filev R, Dubiela FP, Brandão BB, Queiroz CM, Ludwig RG, Hipolide D, Longo BM, Mello LE, Mori MA, Castilho BA.

PLoS One. 2019 Jun 5;14(6):e0217287. doi: 10.1371/journal.pone.0217287. eCollection 2019.

2.

Topical Dexamethasone Administration Impairs Protein Synthesis and Neuronal Regeneration in the Olfactory Epithelium.

Crisafulli U, Xavier AM, Dos Santos FB, Cambiaghi TD, Chang SY, Porcionatto M, Castilho BA, Malnic B, Glezer I.

Front Mol Neurosci. 2018 Mar 6;11:50. doi: 10.3389/fnmol.2018.00050. eCollection 2018.

3.

A Rapid Extraction Method for mammalian cell cultures, suitable for quantitative immunoblotting analysis of proteins, including phosphorylated GCN2 and eIF2α.

Silva RC, Castilho BA, Sattlegger E.

MethodsX. 2017 Oct 28;5:75-82. doi: 10.1016/j.mex.2017.10.008. eCollection 2018.

4.

Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response.

Silva RC, Sattlegger E, Castilho BA.

J Cell Sci. 2016 Dec 15;129(24):4521-4533. Epub 2016 Nov 16.

5.

IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans.

Ferraz RC, Camara H, De-Souza EA, Pinto S, Pinca AP, Silva RC, Sato VN, Castilho BA, Mori MA.

BMC Biol. 2016 Oct 7;14(1):87.

6.

Phosphorylation of eIF2α on Threonine 169 is not required for Trypanosoma brucei cell cycle arrest during differentiation.

Avila CC, Peacock L, Machado FC, Gibson W, Schenkman S, Carrington M, Castilho BA.

Mol Biochem Parasitol. 2016 Jan-Feb;205(1-2):16-21. doi: 10.1016/j.molbiopara.2016.03.004. Epub 2016 Mar 17.

7.

The Gcn2 Regulator Yih1 Interacts with the Cyclin Dependent Kinase Cdc28 and Promotes Cell Cycle Progression through G2/M in Budding Yeast.

Silva RC, Dautel M, Di Genova BM, Amberg DC, Castilho BA, Sattlegger E.

PLoS One. 2015 Jul 15;10(7):e0131070. doi: 10.1371/journal.pone.0131070. eCollection 2015.

8.

A membrane-bound eIF2 alpha kinase located in endosomes is regulated by heme and controls differentiation and ROS levels in Trypanosoma cruzi.

da Silva Augusto L, Moretti NS, Ramos TC, de Jesus TC, Zhang M, Castilho BA, Schenkman S.

PLoS Pathog. 2015 Feb 6;11(2):e1004618. doi: 10.1371/journal.ppat.1004618. eCollection 2015 Feb.

9.

Keeping the eIF2 alpha kinase Gcn2 in check.

Castilho BA, Shanmugam R, Silva RC, Ramesh R, Himme BM, Sattlegger E.

Biochim Biophys Acta. 2014 Sep;1843(9):1948-68. doi: 10.1016/j.bbamcr.2014.04.006. Epub 2014 Apr 13. Review.

10.

GCN2 kinase plays an important role triggering the remission phase of experimental autoimmune encephalomyelitis (EAE) in mice.

Orsini H, Araujo LP, Maricato JT, Guereschi MG, Mariano M, Castilho BA, Basso AS.

Brain Behav Immun. 2014 Mar;37:177-86. doi: 10.1016/j.bbi.2013.12.012. Epub 2013 Dec 21.

11.

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

Cambiaghi TD, Pereira CM, Shanmugam R, Bolech M, Wek RC, Sattlegger E, Castilho BA.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):592-7. doi: 10.1016/j.bbrc.2013.12.021. Epub 2013 Dec 11.

PMID:
24333428
12.

IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth.

Roffé M, Hajj GN, Azevedo HF, Alves VS, Castilho BA.

J Biol Chem. 2013 Apr 12;288(15):10860-9. doi: 10.1074/jbc.M113.461970. Epub 2013 Feb 27.

13.

Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells.

Chung J, Rocha AA, Tonelli RR, Castilho BA, Schenkman S.

Biochem J. 2013 Apr 15;451(2):257-67. doi: 10.1042/BJ20121553.

PMID:
23368777
14.

Protein synthesis attenuation by phosphorylation of eIF2α is required for the differentiation of Trypanosoma cruzi into infective forms.

Tonelli RR, Augusto Lda S, Castilho BA, Schenkman S.

PLoS One. 2011;6(11):e27904. doi: 10.1371/journal.pone.0027904. Epub 2011 Nov 16.

15.

Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity.

Visweswaraiah J, Lageix S, Castilho BA, Izotova L, Kinzy TG, Hinnebusch AG, Sattlegger E.

J Biol Chem. 2011 Oct 21;286(42):36568-79. doi: 10.1074/jbc.M111.248898. Epub 2011 Aug 17.

16.

Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2.

Sattlegger E, Barbosa JA, Moraes MC, Martins RM, Hinnebusch AG, Castilho BA.

J Biol Chem. 2011 Mar 25;286(12):10341-55. doi: 10.1074/jbc.M110.171587. Epub 2011 Jan 14.

17.

The NIP7 protein is required for accurate pre-rRNA processing in human cells.

Morello LG, Hesling C, Coltri PP, Castilho BA, Rimokh R, Zanchin NI.

Nucleic Acids Res. 2011 Jan;39(2):648-65. doi: 10.1093/nar/gkq758. Epub 2010 Aug 26.

18.

Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR.

Roffé M, Beraldo FH, Bester R, Nunziante M, Bach C, Mancini G, Gilch S, Vorberg I, Castilho BA, Martins VR, Hajj GN.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13147-52. doi: 10.1073/pnas.1000784107. Epub 2010 Jul 6.

19.

Multiple RNAs from the mouse carboxypeptidase M locus: functional RNAs or transcription noise?

Guimarães AO, Motta FL, Alves VS, Castilho BA, Pesquero JB.

BMC Mol Biol. 2009 Feb 8;10:7. doi: 10.1186/1471-2199-10-7.

20.

Characterization of the Trypanosoma cruzi ortholog of the SBDS protein reveals an intrinsically disordered extended C-terminal region showing RNA-interacting activity.

de Oliveira JF, Castilho BA, Sforça ML, Krieger MA, Zeri AC, Guimarães BG, Zanchin NI.

Biochimie. 2009 Apr;91(4):475-83. doi: 10.1016/j.biochi.2008.12.001. Epub 2008 Dec 16.

PMID:
19121363
21.

GCN2 activation and eIF2alpha phosphorylation in the maturation of mouse oocytes.

Alves VS, Motta FL, Roffé M, Delamano A, Pesquero JB, Castilho BA.

Biochem Biophys Res Commun. 2009 Jan 2;378(1):41-4. doi: 10.1016/j.bbrc.2008.10.161. Epub 2008 Nov 6.

PMID:
18996085
22.

Distribution of the protein IMPACT, an inhibitor of GCN2, in the mouse, rat, and marmoset brain.

Bittencourt S, Pereira CM, Avedissian M, Delamano A, Mello LE, Castilho BA.

J Comp Neurol. 2008 Apr 10;507(5):1811-30. doi: 10.1002/cne.21652.

PMID:
18260151
23.

Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma brucei.

Moraes MC, Jesus TC, Hashimoto NN, Dey M, Schwartz KJ, Alves VS, Avila CC, Bangs JD, Dever TE, Schenkman S, Castilho BA.

Eukaryot Cell. 2007 Nov;6(11):1979-91. Epub 2007 Sep 14.

24.

The Shwachman-Bodian-Diamond syndrome associated protein interacts with HsNip7 and its down-regulation affects gene expression at the transcriptional and translational levels.

Hesling C, Oliveira CC, Castilho BA, Zanchin NI.

Exp Cell Res. 2007 Dec 10;313(20):4180-95. Epub 2007 Jul 10. Erratum in: Exp Cell Res. 2008 Feb 15;314(4):936-7.

PMID:
17643419
25.

Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner.

Silva AM, Wang D, Komar AA, Castilho BA, Williams BR.

J Biol Chem. 2007 Apr 6;282(14):10164-71. Epub 2007 Feb 6.

26.

Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus.

Carnevalli LS, Pereira CM, Jaqueta CB, Alves VS, Paiva VN, Vattem KM, Wek RC, Mello LE, Castilho BA.

Biochem J. 2006 Jul 1;397(1):187-94.

27.

IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.

Pereira CM, Sattlegger E, Jiang HY, Longo BM, Jaqueta CB, Hinnebusch AG, Wek RC, Mello LE, Castilho BA.

J Biol Chem. 2005 Aug 5;280(31):28316-23. Epub 2005 Jun 2.

28.
29.

Epitope mapping of a single repetitive unit of the B13 Trypanosoma cruzi antigen as fusions to Escherichia coli LamB protein.

Pereira CM, Franco da Silveira J, Duranti M, Cunha-Neto E, Zingales B, Castilho BA.

FEMS Microbiol Lett. 2004 Jun 15;235(2):237-42.

30.

Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice.

Carnevalli LS, Pereira CM, Longo BM, Jaqueta CB, Avedissian M, Mello LE, Castilho BA.

Neurosci Lett. 2004 Mar 11;357(3):191-4.

PMID:
15003282
31.

Biophysical characterization of Gir2, a highly acidic protein of Saccharomyces cerevisiae with anomalous electrophoretic behavior.

Alves VS, Pimenta DC, Sattlegger E, Castilho BA.

Biochem Biophys Res Commun. 2004 Jan 30;314(1):229-34.

PMID:
14715270
32.
33.

Antibody response against Escherichia coli heat-stable enterotoxin expressed as fusions to flagellin.

Pereira CM, Guth BE, Sbrogio-Almeida ME, Castilho BA.

Microbiology. 2001 Apr;147(Pt 4):861-7.

PMID:
11283282
35.
36.

A Plasmodium vivax vaccine candidate displays limited allele polymorphism, which does not restrict recognition by antibodies.

Soares IS, Barnwell JW, Ferreira MU, Gomes Da Cunha M, Laurino JP, Castilho BA, Rodrigues MM.

Mol Med. 1999 Jul;5(7):459-70.

37.

The beta subunit of eukaryotic translation initiation factor 2 binds mRNA through the lysine repeats and a region comprising the C2-C2 motif.

Laurino JP, Thompson GM, Pacheco E, Castilho BA.

Mol Cell Biol. 1999 Jan;19(1):173-81. Erratum in: Mol Cell Biol 1999 Apr;19(4):3224.

38.

A new tetracycline resistance determinant cloned from Proteus mirabilis.

Magalhães VD, Schuman W, Castilho BA.

Biochim Biophys Acta. 1998 Nov 26;1443(1-2):262-6.

PMID:
9838156
39.

Mapping of B cell epitopes in an immunodominant antigen of Trypanosoma cruzi using fusions to the Escherichia coli LamB protein.

Pereira CM, Yamauchi LM, Levin MJ, da Silveira JF, Castilho BA.

FEMS Microbiol Lett. 1998 Jul 1;164(1):125-31.

40.

Mini-Mu insertions in the tetracycline resistance determinant from Proteus mirabilis.

Magalhães VD, Castilho BA.

Braz J Med Biol Res. 1997 Mar;30(3):363-7.

PMID:
9246234
41.

Specificity of mini-Mu bacteriophage insertions in a small plasmid.

Castilho BA, Casadaban MJ.

J Bacteriol. 1991 Feb;173(3):1339-43.

42.

Plasmid insertion mutagenesis and lac gene fusion with mini-mu bacteriophage transposons.

Castilho BA, Olfson P, Casadaban MJ.

J Bacteriol. 1984 May;158(2):488-95.

43.

In vivo DNA cloning and adjacent gene fusing with a mini-Mu-lac bacteriophage containing a plasmid replicon.

Groisman EA, Castilho BA, Casadaban MJ.

Proc Natl Acad Sci U S A. 1984 Mar;81(5):1480-3.

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