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Items: 16


The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts.

Visochek L, Atias D, Spektor I, Castiel A, Golan T, Cohen-Armon M.

Oncotarget. 2019 Oct 22;10(58):6269-6282. doi: 10.18632/oncotarget.27268. eCollection 2019 Oct 22.


Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer.

Rabinowicz N, Mangala LS, Brown KR, Checa-Rodriguez C, Castiel A, Moskovich O, Zarfati G, Trakhtenbrot L, Levy-Barda A, Jiang D, Rodriguez-Aguayo C, Pradeep S, van Praag Y, Lopez-Berestein G, David A, Novikov I, Huertas P, Rottapel R, Sood AK, Izraeli S.

Oncotarget. 2017 Apr 18;8(16):27380-27392. doi: 10.18632/oncotarget.16068.


Exclusive destruction of mitotic spindles in human cancer cells.

Visochek L, Castiel A, Mittelman L, Elkin M, Atias D, Golan T, Izraeli S, Peretz T, Cohen-Armon M.

Oncotarget. 2017 Mar 28;8(13):20813-20824. doi: 10.18632/oncotarget.15343.


A PARP1-ERK2 synergism is required for the induction of LTP.

Visochek L, Grigoryan G, Kalal A, Milshtein-Parush H, Gazit N, Slutsky I, Yeheskel A, Shainberg A, Castiel A, Seger R, Langelier MF, Dantzer F, Pascal JM, Segal M, Cohen-Armon M.

Sci Rep. 2016 Apr 28;6:24950. doi: 10.1038/srep24950.


In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma.

Fisher T, Golan H, Schiby G, PriChen S, Smoum R, Moshe I, Peshes-Yaloz N, Castiel A, Waldman D, Gallily R, Mechoulam R, Toren A.

Curr Oncol. 2016 Mar;23(2):S15-22. doi: 10.3747/co.23.2893. Epub 2016 Mar 16.


Cell death associated with abnormal mitosis observed by confocal imaging in live cancer cells.

Castiel A, Visochek L, Mittelman L, Zilberstein Y, Dantzer F, Izraeli S, Cohen-Armon M.

J Vis Exp. 2013 Aug 21;(78):e50568. doi: 10.3791/50568.


STIL is required for centriole duplication in human cells.

Vulprecht J, David A, Tibelius A, Castiel A, Konotop G, Liu F, Bestvater F, Raab MS, Zentgraf H, Izraeli S, Krämer A.

J Cell Sci. 2012 Mar 1;125(Pt 5):1353-62. doi: 10.1242/jcs.104109. Epub 2012 Feb 20.


A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells.

Castiel A, Visochek L, Mittelman L, Dantzer F, Izraeli S, Cohen-Armon M.

BMC Cancer. 2011 Sep 26;11:412. doi: 10.1186/1471-2407-11-412.


The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.

Castiel A, Danieli MM, David A, Moshkovitz S, Aplan PD, Kirsch IR, Brandeis M, Krämer A, Izraeli S.

J Cell Sci. 2011 Feb 15;124(Pt 4):532-9. doi: 10.1242/jcs.079731. Epub 2011 Jan 18.


A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors.

Inbar-Rozensal D, Castiel A, Visochek L, Castel D, Dantzer F, Izraeli S, Cohen-Armon M.

Breast Cancer Res. 2009;11(6):R78. doi: 10.1186/bcr2445. Epub 2009 Nov 9.


Hypersensitive response to Aphis gossypii Glover in melon genotypes carrying the Vat gene.

Villada ES, González EG, López-Sesé AI, Castiel AF, Gómez-Guillamón ML.

J Exp Bot. 2009;60(11):3269-77. doi: 10.1093/jxb/erp163. Epub 2009 May 27.


The mitotic checkpoint gene, SIL is regulated by E2F1.

Erez A, Chaussepied M, Castiel A, Colaizzo-Anas T, Aplan PD, Ginsberg D, Izraeli S.

Int J Cancer. 2008 Oct 1;123(7):1721-5. doi: 10.1002/ijc.23665.


The SIL gene is essential for mitotic entry and survival of cancer cells.

Erez A, Castiel A, Trakhtenbrot L, Perelman M, Rosenthal E, Goldstein I, Stettner N, Harmelin A, Eldar-Finkelman H, Campaner S, Kirsch I, Izraeli S.

Cancer Res. 2007 May 1;67(9):4022-7. Epub 2007 Apr 24. Erratum in: Cancer Res. 2007 Jun 15;67(12):5998.


Molecular pathways regulating pro-migratory effects of Hedgehog signaling.

Hochman E, Castiel A, Jacob-Hirsch J, Amariglio N, Izraeli S.

J Biol Chem. 2006 Nov 10;281(45):33860-70. Epub 2006 Aug 30.


Single point mutations in the zinc finger motifs of the human immunodeficiency virus type 1 nucleocapsid alter RNA binding specificities of the gag protein and enhance packaging and infectivity.

Mark-Danieli M, Laham N, Kenan-Eichler M, Castiel A, Melamed D, Landau M, Bouvier NM, Evans MJ, Bacharach E.

J Virol. 2005 Jun;79(12):7756-67.


The conserved carboxy terminus of the capsid domain of human immunodeficiency virus type 1 gag protein is important for virion assembly and release.

Melamed D, Mark-Danieli M, Kenan-Eichler M, Kraus O, Castiel A, Laham N, Pupko T, Glaser F, Ben-Tal N, Bacharach E.

J Virol. 2004 Sep;78(18):9675-88.

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