Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 497


Host Pathways of Hemostasis that Regulate Group A Streptococcus Pyogenes Pathogenicity.

Ploplis VA, Castellino FJ.

Curr Drug Targets. 2019 Sep 26. doi: 10.2174/1389450120666190926152914. [Epub ahead of print]


Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis.

Urano T, Suzuki Y, Iwaki T, Sano H, Honkura N, Castellino FJ.

Curr Drug Targets. 2019;20(16):1695-1701. doi: 10.2174/1389450120666190715102510.


Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.

Yuan Y, Ayinuola YA, Singh D, Ayinuola O, Mayfield JA, Quek A, Whisstock JC, Law RHP, Lee SW, Ploplis VA, Castellino FJ.

J Struct Biol. 2019 Oct 1;208(1):18-29. doi: 10.1016/j.jsb.2019.07.005. Epub 2019 Jul 10.


Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding.

Quek AJH, Mazzitelli BA, Wu G, Leung EWW, Caradoc-Davies TT, Lloyd GJ, Jeevarajah D, Conroy PJ, Sanderson-Smith M, Yuan Y, Ayinuola YA, Castellino FJ, Whisstock JC, Law RHP.

J Mol Biol. 2019 Sep 6;431(19):3804-3813. doi: 10.1016/j.jmb.2019.07.003. Epub 2019 Jul 8.


Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review.

Walsh M, Moore EE, Moore H, Thomas S, Lune SV, Zimmer D, Dynako J, Hake D, Crowell Z, McCauley R, Larson EE, Miller M, Pohlman T, Achneck HE, Martin P, Nielsen N, Shariff F, Ploplis VA, Castellino FJ.

Semin Thromb Hemost. 2019 Jun;45(4):354-372. doi: 10.1055/s-0039-1688497. Epub 2019 May 20. Review.


Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection.

Ly D, Donahue D, Walker MJ, Ploplis VA, McArthur JD, Ranson M, Castellino FJ, Sanderson-Smith ML.

Microbes Infect. 2019 Oct - Nov;21(8-9):412-417. doi: 10.1016/j.micinf.2019.04.004. Epub 2019 Apr 19.


Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen.

Qiu C, Yuan Y, Liang Z, Lee SW, Ploplis VA, Castellino FJ.

J Struct Biol. 2019 May 1;206(2):193-203. doi: 10.1016/j.jsb.2019.03.003. Epub 2019 Mar 14.


Altered Gut Microbiota in Type 2 Diabetes: Just a Coincidence?

Sircana A, Framarin L, Leone N, Berrutti M, Castellino F, Parente R, De Michieli F, Paschetta E, Musso G.

Curr Diab Rep. 2018 Sep 13;18(10):98. doi: 10.1007/s11892-018-1057-6. Review.


Contributions of different modules of the plasminogen-binding Streptococcus pyogenes M-protein that mediate its functional dimerization.

Qiu C, Yuan Y, Zajicek J, Liang Z, Balsara RD, Brito-Robionson T, Lee SW, Ploplis VA, Castellino FJ.

J Struct Biol. 2018 Nov;204(2):151-164. doi: 10.1016/j.jsb.2018.07.017. Epub 2018 Jul 30.


Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1╬▓ Activity Reduces Pathology During Early Group A Streptococcal Skin Infection.

Flaherty RA, Donahue DL, Carothers KE, Ross JN, Ploplis VA, Castellino FJ, Lee SW.

Front Cell Infect Microbiol. 2018 Jul 3;8:211. doi: 10.3389/fcimb.2018.00211. eCollection 2018.


Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia.

Miyajima C, Iwaki T, Umemura K, Ploplis VA, Castellino FJ.

Biomed Res Int. 2018 Jun 7;2018:1878964. doi: 10.1155/2018/1878964. eCollection 2018.


Draft Genome Sequences of Six Skin Isolates of Streptococcus pyogenes.

Liang Z, Stephens M, Ploplis VA, Lee SW, Castellino FJ.

Genome Announc. 2018 Jun 28;6(26). pii: e00592-18. doi: 10.1128/genomeA.00592-18.


Regulation of plasminogen activation on cell surfaces and fibrin.

Urano T, Castellino FJ, Suzuki Y.

J Thromb Haemost. 2018 May 20. doi: 10.1111/jth.14157. [Epub ahead of print] Review.


The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation.

Miles LA, Baik N, Bai H, Makarenkova HP, Kiosses WB, Krajewski S, Castellino FJ, Valenzuela A, Varki NM, Mueller BM, Parmer RJ.

J Thromb Haemost. 2018 May;16(5):919-932. doi: 10.1111/jth.13988. Epub 2018 Apr 1.


Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48.

Fields FR, Carothers KE, Balsara RD, Ploplis VA, Castellino FJ, Lee SW.

J Antibiot (Tokyo). 2018 Jun;71(6):592-600. doi: 10.1038/s41429-018-0032-4. Epub 2018 Feb 20.


A deficiency of the GluN2C subunit of the N-methyl-D-aspartate receptor is neuroprotective in a mouse model of ischemic stroke.

Holmes A, Zhou N, Donahue DL, Balsara R, Castellino FJ.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):136-144. doi: 10.1016/j.bbrc.2017.10.171. Epub 2017 Oct 31.


Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen.

Yuan Y, Zajicek J, Qiu C, Chandrahas V, Lee SW, Ploplis VA, Castellino FJ.

J Biol Chem. 2017 Sep 8;292(36):15016-15027. doi: 10.1074/jbc.M117.794198. Epub 2017 Jul 19.


Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation.

Stroo I, Zeerleder S, Ding C, Luken BM, Roelofs JJTH, de Boer OJ, Meijers JCM, Castellino FJ, van 't Veer C, van der Poll T.

Thromb Haemost. 2017 Jul 26;117(8):1601-1614. doi: 10.1160/TH16-12-0920. Epub 2017 May 11.


Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation.

Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA.

Sci Rep. 2017 Mar 23;7(1):365. doi: 10.1038/s41598-017-00418-y.


Variable region in streptococcal M-proteins provides stable binding with host fibrinogen for plasminogen-mediated bacterial invasion.

Glinton K, Beck J, Liang Z, Qiu C, Lee SW, Ploplis VA, Castellino FJ.

J Biol Chem. 2017 Apr 21;292(16):6775-6785. doi: 10.1074/jbc.M116.768937. Epub 2017 Mar 9.


Fibrinolysis in Trauma: "Myth," "Reality," or "Something in Between".

Walsh M, Shreve J, Thomas S, Moore E, Moore H, Hake D, Pohlman T, Davis P, Ploplis V, Piscoya A, Wegner J, Bryant J, Crepinsek A, Lantry J, Sheppard F, Castellino F.

Semin Thromb Hemost. 2017 Mar;43(2):200-212. doi: 10.1055/s-0036-1597900. Epub 2017 Feb 20. Review.


A Case of Successful Thromboelastographic Guided Resuscitation after Postpartum Hemorrhage and Cardiac Arrest.

Hurwich M, Zimmer D, Guerra E, Evans E, Shire T, Abernathy M, Shreve JT, Kolettis GR, McCurdy MT, Castellino FJ, Walsh M.

J Extra Corpor Technol. 2016 Dec;48(4):194-197.


Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors.

Yuan Y, Balsara RD, Zajicek J, Kunda S, Castellino FJ.

Biochemistry. 2016 Dec 27;55(51):7112-7122. doi: 10.1021/acs.biochem.6b00962. Epub 2016 Dec 16.


Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII.

Stroo I, Yang J, de Boer JD, Roelofs JJ, van 't Veer C, Castellino FJ, Zeerleder S, van der Poll T.

Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L163-L171. doi: 10.1152/ajplung.00320.2016. Epub 2016 Dec 2.


Tranexamic Acid for Trauma Resuscitation in the United States of America.

Walsh M, Thomas S, Moore E, Moore H, Piscoya A, Hake D, Son M, Pohlman T, Wegner J, Bryant J, Grassetto A, Davis P, Nielsen N, Crepinsek A, Shreve JT, Castellino F.

Semin Thromb Hemost. 2017 Mar;43(2):213-223. doi: 10.1055/s-0036-1586226. Epub 2016 Dec 1. Review.


Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps.

Bao YJ, Shapiro BJ, Lee SW, Ploplis VA, Castellino FJ.

Sci Rep. 2016 Nov 8;6:36644. doi: 10.1038/srep36644.


Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis.

Higashi DL, Biais N, Donahue DL, Mayfield JA, Tessier CR, Rodriguez K, Ashfeld BL, Luchetti J, Ploplis VA, Castellino FJ, Lee SW.

Nat Microbiol. 2016 Jan 18;1:15004. doi: 10.1038/nmicrobiol.2015.4.


Functional characterization of a monoclonal antibody epitope using a lambda phage display-deep sequencing platform.

Domina M, Lanza Cariccio V, Benfatto S, Venza M, Venza I, Borgogni E, Castellino F, Midiri A, Galbo R, Romeo L, Biondo C, Masignani V, Teti G, Felici F, Beninati C.

Sci Rep. 2016 Aug 17;6:31458. doi: 10.1038/srep31458.


Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans.

Spensieri F, Siena E, Borgogni E, Zedda L, Cantisani R, Chiappini N, Schiavetti F, Rosa D, Castellino F, Montomoli E, Bodinham CL, Lewis DJ, Medini D, Bertholet S, Del Giudice G.

PLoS One. 2016 Jun 23;11(6):e0157066. doi: 10.1371/journal.pone.0157066. eCollection 2016.


Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potential for evolutionary persistence.

Bao YJ, Liang Z, Mayfield JA, McShan WM, Lee SW, Ploplis VA, Castellino FJ.

Microbiology. 2016 Aug;162(8):1346-1359. doi: 10.1099/mic.0.000326. Epub 2016 Jun 21.


Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4.

Gupta KK, Xu Z, Castellino FJ, Ploplis VA.

Biochem Biophys Res Commun. 2016 Aug 26;477(3):503-8. doi: 10.1016/j.bbrc.2016.06.065. Epub 2016 Jun 15.


Thromboelastography in Orthopaedic Trauma Acute Pelvic Fracture Resuscitation: A Descriptive Pilot Study.

Mamczak CN, Maloney M, Fritz B, Boyer B, Thomas S, Evans E, Ploplis VA, Castellino FJ, McCollester J, Walsh M.

J Orthop Trauma. 2016 Jun;30(6):299-305. doi: 10.1097/BOT.0000000000000537.


Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury.

Yasui H, Donahue DL, Walsh M, Castellino FJ, Ploplis VA.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L74-86. doi: 10.1152/ajplung.00429.2015. Epub 2016 May 17.


Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity.

Bao YJ, Liang Z, Mayfield JA, Donahue DL, Carothers KE, Lee SW, Ploplis VA, Castellino FJ.

J Bacteriol. 2016 May 27;198(12):1712-24. doi: 10.1128/JB.01019-15. Print 2016 Jun 15.


Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy.

Walsh M, Fritz S, Hake D, Son M, Greve S, Jbara M, Chitta S, Fritz B, Miller A, Bader MK, McCollester J, Binz S, Liew-Spilger A, Thomas S, Crepinsek A, Shariff F, Ploplis V, Castellino FJ.

Curr Drug Targets. 2016;17(8):954-70. Review.


Streptococcus pyogenes Employs Strain-dependent Mechanisms of C3b Inactivation to Inhibit Phagocytosis and Killing of Bacteria.

Agrahari G, Liang Z, Glinton K, Lee SW, Ploplis VA, Castellino FJ.

J Biol Chem. 2016 Apr 22;291(17):9181-9. doi: 10.1074/jbc.M115.704221. Epub 2016 Mar 4.


Pharmacology of triheteromeric N-Methyl-D-Aspartate Receptors.

Cheriyan J, Balsara RD, Hansen KB, Castellino FJ.

Neurosci Lett. 2016 Mar 23;617:240-6. doi: 10.1016/j.neulet.2016.02.032. Epub 2016 Feb 23.


A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

Motley MP, Madsen DH, J├╝rgensen HJ, Spencer DE, Szabo R, Holmbeck K, Flick MJ, Lawrence DA, Castellino FJ, Weigert R, Bugge TH.

Blood. 2016 Mar 3;127(9):1085-96. doi: 10.1182/blood-2015-05-644260. Epub 2015 Dec 8.


CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants.

Bao YJ, Liang Z, Mayfield JA, Lee SW, Ploplis VA, Castellino FJ.

J Bacteriol. 2015 Oct;197(19):3191-205. doi: 10.1128/JB.00511-15. Epub 2015 Jul 27.


Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein.

Chandrahas V, Glinton K, Liang Z, Donahue DL, Ploplis VA, Castellino FJ.

J Biol Chem. 2015 Jul 24;290(30):18833-42. doi: 10.1074/jbc.M115.655365. Epub 2015 Jun 12.


Innate Response Activator (IRA) B Cells Reside in Human Tonsils and Internalize Bacteria In Vitro.

Chiappini N, Cantisani R, Pancotto L, Ruggiero P, Rosa D, Manetti A, Romano A, Montagnani F, Bertholet S, Castellino F, Del Giudice G.

PLoS One. 2015 Jun 12;10(6):e0129879. doi: 10.1371/journal.pone.0129879. eCollection 2015.


Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors.

Kunda S, Yuan Y, Balsara RD, Zajicek J, Castellino FJ.

J Biol Chem. 2015 Jul 17;290(29):18156-72. doi: 10.1074/jbc.M115.650341. Epub 2015 Jun 5.


MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life.

Mastelic Gavillet B, Eberhardt CS, Auderset F, Castellino F, Seubert A, Tregoning JS, Lambert PH, de Gregorio E, Del Giudice G, Siegrist CA.

J Immunol. 2015 May 15;194(10):4836-45. doi: 10.4049/jimmunol.1402071. Epub 2015 Apr 13.


Conantokin-G attenuates detrimental effects of NMDAR hyperactivity in an ischemic rat model of stroke.

Balsara R, Dang A, Donahue DL, Snow T, Castellino FJ.

PLoS One. 2015 Mar 30;10(3):e0122840. doi: 10.1371/journal.pone.0122840. eCollection 2015.


Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia.

Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA.

PLoS One. 2015 Mar 23;10(3):e0120728. doi: 10.1371/journal.pone.0120728. eCollection 2015.


Non-invasive imaging and analysis of cerebral ischemia in living rats using positron emission tomography with 18F-FDG.

Balsara RD, Chapman SE, Sander IM, Donahue DL, Liepert L, Castellino FJ, Leevy WM.

J Vis Exp. 2014 Dec 28;(94). doi: 10.3791/51495.


Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine.

Cheriyan J, Mezes C, Zhou N, Balsara RD, Castellino FJ.

Biochemistry. 2015 Jan 27;54(3):787-94. doi: 10.1021/bi501437s. Epub 2015 Jan 8.


Rapid profiling of the antigen regions recognized by serum antibodies using massively parallel sequencing of antigen-specific libraries.

Domina M, Lanza Cariccio V, Benfatto S, D'Aliberti D, Venza M, Borgogni E, Castellino F, Biondo C, D'Andrea D, Grassi L, Tramontano A, Teti G, Felici F, Beninati C.

PLoS One. 2014 Dec 4;9(12):e114159. doi: 10.1371/journal.pone.0114159. eCollection 2014.


Optimized fluorescent labeling to identify memory B cells specific for Neisseria meningitidis serogroup B vaccine antigens ex vivo.

Nair N, Buti L, Faenzi E, Buricchi F, Nuti S, Sammicheli C, Tavarini S, Popp MW, Ploegh H, Berti F, Pizza M, Castellino F, Finco O, Rappuoli R, Del Giudice G, Galli G, Bardelli M.

Immun Inflamm Dis. 2013 Oct;1(1):3-13. doi: 10.1002/iid3.3. Epub 2013 Oct 30.

Supplemental Content

Loading ...
Support Center