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Items: 50

1.

Impaired brain endocannabinoid tone in the activity-based model of anorexia nervosa.

Collu R, Scherma M, Piscitelli F, Giunti E, Satta V, Castelli MP, Verde R, Fratta W, Bisogno T, Fadda P.

Int J Eat Disord. 2019 Nov;52(11):1251-1262. doi: 10.1002/eat.23157. Epub 2019 Aug 27.

PMID:
31456239
2.

Predisposition to Alcohol Drinking and Alcohol Consumption Alter Expression of Calcitonin Gene-Related Peptide, Neuropeptide Y, and Microglia in Bed Nucleus of Stria Terminalis in a Subnucleus-Specific Manner.

Rossetti I, Zambusi L, Maccioni P, Sau R, Provini L, Castelli MP, Gonciarz K, Colombo G, Morara S.

Front Cell Neurosci. 2019 Apr 30;13:158. doi: 10.3389/fncel.2019.00158. eCollection 2019.

3.

In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5.

Beggiato S, Borelli AC, Tomasini MC, Castelli MP, Pintori N, Cacciaglia R, Loche A, Ferraro L.

Front Pharmacol. 2018 Apr 5;9:327. doi: 10.3389/fphar.2018.00327. eCollection 2018.

4.

Limited Access to a High Fat Diet Alters Endocannabinoid Tone in Female Rats.

Satta V, Scherma M, Piscitelli F, Usai P, Castelli MP, Bisogno T, Fratta W, Fadda P.

Front Neurosci. 2018 Feb 2;12:40. doi: 10.3389/fnins.2018.00040. eCollection 2018.

5.

Rimonabant, a potent CB1 cannabinoid receptor antagonist, is a Gαi/o protein inhibitor.

Porcu A, Melis M, Turecek R, Ullrich C, Mocci I, Bettler B, Gessa GL, Castelli MP.

Neuropharmacology. 2018 May 1;133:107-120. doi: 10.1016/j.neuropharm.2018.01.024.

PMID:
29407764
6.

Suppressing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on chocolate self-administration and reinstatement of chocolate seeking in rats.

Lorrai I, Maccioni P, Carai MA, Capra A, Castelli MP, Riva A, Morazzoni P, Gessa GL, Colombo G.

Neurosci Lett. 2017 Jan 18;638:211-217. doi: 10.1016/j.neulet.2016.12.019. Epub 2016 Dec 19.

PMID:
28007642
7.

In vitro and in vivo pharmacological characterization of SSD114, a novel GABAB positive allosteric modulator.

Porcu A, Lobina C, Giunta D, Solinas M, Mugnaini C, Castelli MP.

Eur J Pharmacol. 2016 Nov 15;791:115-123. doi: 10.1016/j.ejphar.2016.08.032. Epub 2016 Aug 27.

PMID:
27578262
8.

α2A adrenergic receptors highly expressed in mesoprefrontal dopamine neurons.

Castelli MP, Spiga S, Perra A, Madeddu C, Mulas G, Ennas MG, Gessa GL.

Neuroscience. 2016 Sep 22;332:130-9. doi: 10.1016/j.neuroscience.2016.06.037. Epub 2016 Jun 27.

PMID:
27365174
9.

Native CB1 receptor affinity, intrinsic activity and accumbens shell dopamine stimulant properties of third generation SPICE/K2 cannabinoids: BB-22, 5F-PB-22, 5F-AKB-48 and STS-135.

De Luca MA, Castelli MP, Loi B, Porcu A, Martorelli M, Miliano C, Kellett K, Davidson C, Stair JL, Schifano F, Di Chiara G.

Neuropharmacology. 2016 Jun;105:630-638. doi: 10.1016/j.neuropharm.2015.11.017. Epub 2015 Dec 11.

PMID:
26686391
10.

Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent.

Frau L, Costa G, Porceddu PF, Khairnar A, Castelli MP, Ennas MG, Madeddu C, Wardas J, Morelli M.

J Neurochem. 2016 Jan;136(1):148-62. doi: 10.1111/jnc.13377. Epub 2015 Nov 6.

11.

Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats.

Melis M, Sagheddu C, De Felice M, Casti A, Madeddu C, Spiga S, Muntoni AL, Mackie K, Marsicano G, Colombo G, Castelli MP, Pistis M.

J Neurosci. 2014 Sep 17;34(38):12716-24. doi: 10.1523/JNEUROSCI.1844-14.2014.

12.

The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake.

Godar SC, Bortolato M, Castelli MP, Casti A, Casu A, Chen K, Ennas MG, Tambaro S, Shih JC.

J Psychiatr Res. 2014 Sep;56:1-9. doi: 10.1016/j.jpsychires.2014.04.014. Epub 2014 May 15.

13.

Δ9-tetrahydrocannabinol prevents methamphetamine-induced neurotoxicity.

Castelli MP, Madeddu C, Casti A, Casu A, Casti P, Scherma M, Fattore L, Fadda P, Ennas MG.

PLoS One. 2014 May 20;9(5):e98079. doi: 10.1371/journal.pone.0098079. eCollection 2014.

14.

The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, Regulates hippocampal Aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its "anti-alcohol" and anxiolytic properties.

Ferraro L, Loche A, Beggiato S, Tomasini MC, Antonelli T, Colombo G, Lobina C, Carai MA, Porcu A, Castelli MP, Clerici F, Borelli AC, Cacciaglia R, Tanganelli S.

Curr Med Chem. 2013;20(27):3339-57. Review.

PMID:
23862615
15.

Male and female rats differ in brain cannabinoid CB1 receptor density and function and in behavioural traits predisposing to drug addiction: effect of ovarian hormones.

Castelli MP, Fadda P, Casu A, Spano MS, Casti A, Fratta W, Fattore L.

Curr Pharm Des. 2014;20(13):2100-13. Epub 2013 Jul 9.

PMID:
23829370
16.

The role of the endocannabinoid system in eating disorders: neurochemical and behavioural preclinical evidence.

Scherma M, Fattore L, Castelli MP, Fratta W, Fadda P.

Curr Pharm Des. 2014;20(13):2089-99. Epub 2013 Jul 9. Review.

PMID:
23829365
17.

PPARα regulates cholinergic-driven activity of midbrain dopamine neurons via a novel mechanism involving α7 nicotinic acetylcholine receptors.

Melis M, Scheggi S, Carta G, Madeddu C, Lecca S, Luchicchi A, Cadeddu F, Frau R, Fattore L, Fadda P, Ennas MG, Castelli MP, Fratta W, Schilstrom B, Banni S, De Montis MG, Pistis M.

J Neurosci. 2013 Apr 3;33(14):6203-11. doi: 10.1523/JNEUROSCI.4647-12.2013.

18.

Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor.

Mugnaini C, Pedani V, Casu A, Lobina C, Casti A, Maccioni P, Porcu A, Giunta D, Lamponi S, Solinas M, Dragoni S, Valoti M, Colombo G, Castelli MP, Gessa GL, Corelli F.

J Med Chem. 2013 May 9;56(9):3620-35. doi: 10.1021/jm400144w. Epub 2013 Apr 18.

PMID:
23544432
19.

Regional distribution of 5α-reductase type 2 in the adult rat brain: an immunohistochemical analysis.

Castelli MP, Casti A, Casu A, Frau R, Bortolato M, Spiga S, Ennas MG.

Psychoneuroendocrinology. 2013 Feb;38(2):281-93. doi: 10.1016/j.psyneuen.2012.06.008. Epub 2012 Jul 8.

20.

NMDARs mediate the role of monoamine oxidase A in pathological aggression.

Bortolato M, Godar SC, Melis M, Soggiu A, Roncada P, Casu A, Flore G, Chen K, Frau R, Urbani A, Castelli MP, Devoto P, Shih JC.

J Neurosci. 2012 Jun 20;32(25):8574-82. doi: 10.1523/JNEUROSCI.0225-12.2012.

21.

Reversible disruption of pre-pulse inhibition in hypomorphic-inducible and reversible CB1-/- mice.

Marongiu MF, Poddie D, Porcu S, Manchinu MF, Castelli MP, Sogos V, Bini V, Frau R, Caredda E, Collu M, Ristaldi MS.

PLoS One. 2012;7(4):e35013. doi: 10.1371/journal.pone.0035013. Epub 2012 Apr 27.

22.

Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73.

Loche A, Simonetti F, Lobina C, Carai MA, Colombo G, Castelli MP, Barone D, Cacciaglia R.

Front Psychiatry. 2012 Feb 14;3:8. doi: 10.3389/fpsyt.2012.00008. eCollection 2012.

23.

Characterization of COR627 and COR628, two novel positive allosteric modulators of the GABA(B) receptor.

Castelli MP, Casu A, Casti P, Lobina C, Carai MA, Colombo G, Solinas M, Giunta D, Mugnaini C, Pasquini S, Tafi A, Brogi S, Gessa GL, Corelli F.

J Pharmacol Exp Ther. 2012 Mar;340(3):529-38. doi: 10.1124/jpet.111.186460. Epub 2011 Nov 30.

PMID:
22129594
24.

Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain dopamine cells.

Lecca S, Melis M, Luchicchi A, Ennas MG, Castelli MP, Muntoni AL, Pistis M.

Neuropsychopharmacology. 2011 Feb;36(3):589-602. doi: 10.1038/npp.2010.190. Epub 2010 Nov 3.

25.

Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB(1) cannabinoid receptors.

Mateos B, Borcel E, Loriga R, Luesu W, Bini V, Llorente R, Castelli MP, Viveros MP.

J Psychopharmacol. 2011 Dec;25(12):1676-90. doi: 10.1177/0269881110370503. Epub 2010 Jun 18.

PMID:
20562169
26.

Methamphetamine neurotoxicity increases brain expression and alters behavioral functions of CB₁ cannabinoid receptors.

Bortolato M, Frau R, Bini V, Luesu W, Loriga R, Collu M, Gessa GL, Ennas MG, Castelli MP.

J Psychiatr Res. 2010 Oct;44(14):944-55. doi: 10.1016/j.jpsychires.2010.03.002. Epub 2010 Apr 7.

PMID:
20378129
27.

Methamphetamine induces long-term alterations in reactivity to environmental stimuli: correlation with dopaminergic and serotonergic toxicity.

Bortolato M, Frau R, Piras AP, Luesu W, Bini V, Diaz G, Gessa G, Ennas MG, Castelli MP.

Neurotox Res. 2009 Apr;15(3):232-45. doi: 10.1007/s12640-009-9024-2. Epub 2009 Feb 25.

PMID:
19384596
28.
29.

6-Hydroxydopamine lesion in the ventral tegmental area fails to reduce extracellular dopamine in the cerebral cortex.

Devoto P, Flore G, Saba P, Castelli MP, Piras AP, Luesu W, Viaggi MC, Ennas MG, Gessa GL.

J Neurosci Res. 2008 May 15;86(7):1647-58. doi: 10.1002/jnr.21611.

PMID:
18189323
30.

Dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist WIN 55,212-2.

Castelli MP, Paola Piras A, D'Agostino A, Pibiri F, Perra S, Gessa GL, Maccarrone M, Pistis M.

Eur J Pharmacol. 2007 Nov 14;573(1-3):11-9. Epub 2007 Jul 4.

PMID:
17644084
31.

Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice.

Bortolato M, Frau R, Orrù M, Piras AP, Fà M, Tuveri A, Puligheddu M, Gessa GL, Castelli MP, Mereu G, Marrosu F.

Psychopharmacology (Berl). 2007 Oct;194(3):361-9. Epub 2007 Jun 29.

PMID:
17604981
32.

Cannabinoid CB1 receptors in the paraventricular nucleus and central control of penile erection: immunocytochemistry, autoradiography and behavioral studies.

Castelli MP, Piras AP, Melis T, Succu S, Sanna F, Melis MR, Collu S, Ennas MG, Diaz G, Mackie K, Argiolas A.

Neuroscience. 2007 Jun 15;147(1):197-206. Epub 2007 May 15.

PMID:
17507169
33.

Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists.

Manera C, Benetti V, Castelli MP, Cavallini T, Lazzarotti S, Pibiri F, Saccomanni G, Tuccinardi T, Vannacci A, Martinelli A, Ferrarini PL.

J Med Chem. 2006 Oct 5;49(20):5947-57.

PMID:
17004710
34.

Dopamine D3 receptor antisense oligodeoxynucleotide potentiates imipramine-induced dopaminergic behavioural supersensitivity.

D'Aquila PS, Panin F, Castelli MP, Serra G.

Behav Pharmacol. 2006 Mar;17(2):101-6.

PMID:
16495718
35.

The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: involvement of paraventricular glutamic acid and nitric oxide.

Melis MR, Succu S, Mascia MS, Sanna F, Melis T, Castelli MP, Argiolas A.

Neuropharmacology. 2006 Feb;50(2):219-28. Epub 2005 Nov 9.

PMID:
16288932
36.

Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -nonpreferring rats.

Castelli MP, Pibiri F, Piras AP, Carboni G, Orrù A, Gessa GL, Carai MA, Colombo G.

Eur J Pharmacol. 2005 Oct 31;523(1-3):67-70. Epub 2005 Oct 13.

PMID:
16226245
37.

Up-regulation of GABA(B) receptors by chronic administration of the GABA(B) receptor antagonist SCH 50,911.

Pibiri F, Carboni G, Carai MA, Gessa GL, Castelli MP.

Eur J Pharmacol. 2005 May 16;515(1-3):94-8.

PMID:
15893746
38.

A review of pharmacology of NCS-382, a putative antagonist of gamma-hydroxybutyric acid (GHB) receptor.

Castelli MP, Pibiri F, Carboni G, Piras AP.

CNS Drug Rev. 2004 Fall;10(3):243-60. Review.

39.
40.

Stereoselectivity of NCS-382 binding to gamma-hydroxybutyrate receptor in the rat brain.

Castelli MP, Mocci I, Pistis M, Peis M, Berta D, Gelain A, Gessa GL, Cignarella G.

Eur J Pharmacol. 2002 Jun 20;446(1-3):1-5.

PMID:
12098579
41.

Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid.

Carai MA, Colombo G, Reali R, Serra S, Mocci I, Castelli MP, Cignarella G, Gessa GL.

Eur J Pharmacol. 2002 Apr 26;441(3):157-63.

PMID:
12063087
42.

(-)S amisulpride binds with high affinity to cloned dopamine D(3) and D(2) receptors.

Castelli MP, Mocci I, Sanna AM, Gessa GL, Pani L.

Eur J Pharmacol. 2001 Dec 7;432(2-3):143-7.

PMID:
11740949
43.

Quantitative autoradiographic distribution of gamma-hydroxybutyric acid binding sites in human and monkey brain.

Castelli MP, Mocci I, Langlois X, Gommerendagger W, Luyten WH, Leysen JE, Gessa GL.

Brain Res Mol Brain Res. 2000 May 31;78(1-2):91-9.

PMID:
10891588
44.

Reconstitution of the human 5-HT(1D) receptor-G-protein coupling: evidence for constitutive activity and multiple receptor conformations.

Brys R, Josson K, Castelli MP, Jurzak M, Lijnen P, Gommeren W, Leysen JE.

Mol Pharmacol. 2000 Jun;57(6):1132-41.

PMID:
10825383
45.

Distribution of GABA(B) receptor mRNAs in the rat brain and peripheral organs.

Castelli MP, Ingianni A, Stefanini E, Gessa GL.

Life Sci. 1999;64(15):1321-8.

PMID:
10227588
46.

Chronic morphine and naltrexone fail to modify mu-opioid receptor mRNA levels in the rat brain.

Castelli MP, Melis M, Mameli M, Fadda P, Diaz G, Gessa GL.

Brain Res Mol Brain Res. 1997 Apr;45(1):149-53.

PMID:
9105683
47.

Thyroid transcription factor 1 activates the promoter of the thyrotropin receptor gene.

Civitareale D, Castelli MP, Falasca P, Saiardi A.

Mol Endocrinol. 1993 Dec;7(12):1589-95.

PMID:
8145764
48.

Cathepsin G--induced release of PAI-1 in the culture medium of endothelial cells: a new thrombogenic role for polymorphonuclear leukocytes?

Pintucci G, Iacoviello L, Castelli MP, Amore C, Evangelista V, Cerletti C, Donati MB.

J Lab Clin Med. 1993 Jul;122(1):69-79.

PMID:
8320493
49.

Protective, restorative, and therapeutic properties of recombinant human IL-1 in rodent models.

Castelli MP, Black PL, Schneider M, Pennington R, Abe F, Talmadge JE.

J Immunol. 1988 Jun 1;140(11):3830-7.

PMID:
3259600
50.

Continuous subcutaneous insulin infusion (CSII) in pregnant diabetic patients.

Caruso A, Lanzone A, Bianchi V, Massidda M, Castelli MP, Fulghesu AM, Mancuso S.

Prenat Diagn. 1987;7(1):41-50.

PMID:
3823006

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