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Items: 38


Plasma Ketone and Medium Chain Fatty Acid Response in Humans Consuming Different Medium Chain Triglycerides During a Metabolic Study Day.

St-Pierre V, Vandenberghe C, Lowry CM, Fortier M, Castellano CA, Wagner R, Cunnane SC.

Front Nutr. 2019 Apr 16;6:46. doi: 10.3389/fnut.2019.00046. eCollection 2019.


A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment.

Fortier M, Castellano CA, Croteau E, Langlois F, Bocti C, St-Pierre V, Vandenberghe C, Bernier M, Roy M, Descoteaux M, Whittingstall K, Lepage M, Turcotte ÉE, Fulop T, Cunnane SC.

Alzheimers Dement. 2019 May;15(5):625-634. doi: 10.1016/j.jalz.2018.12.017. Epub 2019 Apr 23.


Links Between Metabolic and Structural Changes in the Brain of Cognitively Normal Older Adults: A 4-Year Longitudinal Follow-Up.

Castellano CA, Hudon C, Croteau E, Fortier M, St-Pierre V, Vandenberghe C, Nugent S, Tremblay S, Paquet N, Lepage M, Fülöp T, Turcotte ÉE, Dionne IJ, Potvin O, Duchesne S, Cunnane SC.

Front Aging Neurosci. 2019 Jan 15;11:15. doi: 10.3389/fnagi.2019.00015. eCollection 2019.


A short-term intervention combining aerobic exercise with medium-chain triglycerides (MCT) is more ketogenic than either MCT or aerobic exercise alone: a comparison of normoglycemic and prediabetic older women.

Vandenberghe C, Castellano CA, Maltais M, Fortier M, St-Pierre V, Dionne IJ, Cunnane SC.

Appl Physiol Nutr Metab. 2019 Jan;44(1):66-73. doi: 10.1139/apnm-2018-0367. Epub 2018 Jul 9.


Emulsification Increases the Acute Ketogenic Effect and Bioavailability of Medium-Chain Triglycerides in Humans: Protein, Carbohydrate, and Fat Metabolism.

Courchesne-Loyer A, Lowry CM, St-Pierre V, Vandenberghe C, Fortier M, Castellano CA, Wagner JR, Cunnane SC.

Curr Dev Nutr. 2017 Jun 21;1(7):e000851. doi: 10.3945/cdn.117.000851. eCollection 2017 Jul.


Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer's Disease.

Croteau E, Castellano CA, Richard MA, Fortier M, Nugent S, Lepage M, Duchesne S, Whittingstall K, Turcotte ÉE, Bocti C, Fülöp T, Cunnane SC.

J Alzheimers Dis. 2018;64(2):551-561. doi: 10.3233/JAD-180202.


Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms.

Wolach O, Sellar RS, Martinod K, Cherpokova D, McConkey M, Chappell RJ, Silver AJ, Adams D, Castellano CA, Schneider RK, Padera RF, DeAngelo DJ, Wadleigh M, Steensma DP, Galinsky I, Stone RM, Genovese G, McCarroll SA, Iliadou B, Hultman C, Neuberg D, Mullally A, Wagner DD, Ebert BL.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan8292. doi: 10.1126/scitranslmed.aan8292.


SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia.

Mar BG, Chu SH, Kahn JD, Krivtsov AV, Koche R, Castellano CA, Kotlier JL, Zon RL, McConkey ME, Chabon J, Chappell R, Grauman PV, Hsieh JJ, Armstrong SA, Ebert BL.

Blood. 2017 Dec 14;130(24):2631-2641. doi: 10.1182/blood-2017-03-775569. Epub 2017 Oct 10.


Automated synthesis of 1-[11C]acetoacetate on a TRASIS AIO module.

Solingapuram Sai KK, Donald Gage H, Almaguel F, Neth B, Hughes TM, Tremblay S, Castellano CA, Cunnane SC, Jorgensen MJ, Craft S, Mintz A.

Appl Radiat Isot. 2017 Nov;129:57-61. doi: 10.1016/j.apradiso.2017.07.066. Epub 2017 Aug 2.


A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease.

Croteau E, Castellano CA, Fortier M, Bocti C, Fulop T, Paquet N, Cunnane SC.

Exp Gerontol. 2018 Jul 1;107:18-26. doi: 10.1016/j.exger.2017.07.004. Epub 2017 Jul 12.


Tricaprylin Alone Increases Plasma Ketone Response More Than Coconut Oil or Other Medium-Chain Triglycerides: An Acute Crossover Study in Healthy Adults.

Vandenberghe C, St-Pierre V, Pierotti T, Fortier M, Castellano CA, Cunnane SC.

Curr Dev Nutr. 2017 Mar 22;1(4):e000257. doi: 10.3945/cdn.116.000257. eCollection 2017 Apr.


Caffeine intake increases plasma ketones: an acute metabolic study in humans.

Vandenberghe C, St-Pierre V, Courchesne-Loyer A, Hennebelle M, Castellano CA, Cunnane SC.

Can J Physiol Pharmacol. 2017 Apr;95(4):455-458. doi: 10.1139/cjpp-2016-0338. Epub 2016 Nov 25.


A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer's Disease: Preliminary Results from a Neuroimaging Study.

Castellano CA, Paquet N, Dionne IJ, Imbeault H, Langlois F, Croteau E, Tremblay S, Fortier M, Matte JJ, Lacombe G, Fülöp T, Bocti C, Cunnane SC.

J Alzheimers Dis. 2017;56(4):1459-1468. doi: 10.3233/JAD-161163.


Spatial distribution of resting-state BOLD regional homogeneity as a predictor of brain glucose uptake: A study in healthy aging.

Bernier M, Croteau E, Castellano CA, Cunnane SC, Whittingstall K.

Neuroimage. 2017 Apr 15;150:14-22. doi: 10.1016/j.neuroimage.2017.01.055. Epub 2017 Jan 24.


Temporal Lobe Atrophy May Be Underrecognized in Older Patients with New-Onset Epilepsy.

Lapointe E, Deacon C, Royer-Perron L, Cunnane S, Castellano CA, Bocti C.

Can J Neurol Sci. 2016 Sep;43(5):731-4. doi: 10.1017/cjn.2016.275. No abstract available.


Evaluation of Body Weight, Body Condition, and Muscle Condition in Cats with Hyperthyroidism.

Peterson ME, Castellano CA, Rishniw M.

J Vet Intern Med. 2016 Nov;30(6):1780-1789. doi: 10.1111/jvim.14591. Epub 2016 Sep 26.


Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study.

Courchesne-Loyer A, Croteau E, Castellano CA, St-Pierre V, Hennebelle M, Cunnane SC.

J Cereb Blood Flow Metab. 2017 Jul;37(7):2485-2493. doi: 10.1177/0271678X16669366. Epub 2016 Jan 1.


Normative Data for the Montreal Cognitive Assessment in Middle-Aged and Elderly Quebec-French People.

Larouche E, Tremblay MP, Potvin O, Laforest S, Bergeron D, Laforce R, Monetta L, Boucher L, Tremblay P, Belleville S, Lorrain D, Gagnon JF, Gosselin N, Castellano CA, Cunnane SC, Macoir J, Hudon C.

Arch Clin Neuropsychol. 2016 Sep 13. [Epub ahead of print]


Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease.

Cunnane SC, Courchesne-Loyer A, Vandenberghe C, St-Pierre V, Fortier M, Hennebelle M, Croteau E, Bocti C, Fulop T, Castellano CA.

Front Mol Neurosci. 2016 Jul 8;9:53. doi: 10.3389/fnmol.2016.00053. eCollection 2016.


Preliminary evaluation of a differential effect of an α-linolenate-rich supplement on ketogenesis and plasma ω-3 fatty acids in young and older adults.

Hennebelle M, Courchesne-Loyer A, St-Pierre V, Vandenberghe C, Castellano CA, Fortier M, Tessier D, Cunnane SC.

Nutrition. 2016 Nov-Dec;32(11-12):1211-6. doi: 10.1016/j.nut.2016.03.025. Epub 2016 Apr 8.


Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease.

Cunnane SC, Courchesne-Loyer A, St-Pierre V, Vandenberghe C, Pierotti T, Fortier M, Croteau E, Castellano CA.

Ann N Y Acad Sci. 2016 Mar;1367(1):12-20. doi: 10.1111/nyas.12999. Epub 2016 Jan 14. Review.


Regional Brain Glucose Hypometabolism in Young Women with Polycystic Ovary Syndrome: Possible Link to Mild Insulin Resistance.

Castellano CA, Baillargeon JP, Nugent S, Tremblay S, Fortier M, Imbeault H, Duval J, Cunnane SC.

PLoS One. 2015 Dec 9;10(12):e0144116. doi: 10.1371/journal.pone.0144116. eCollection 2015.


Relationship of metabolic and endocrine parameters to brain glucose metabolism in older adults: do cognitively-normal older adults have a particular metabolic phenotype?

Nugent S, Castellano CA, Bocti C, Dionne I, Fulop T, Cunnane SC.

Biogerontology. 2016 Feb;17(1):241-55. doi: 10.1007/s10522-015-9595-7. Epub 2015 Sep 12.


Ketogenic response to cotreatment with bezafibrate and medium chain triacylglycerols in healthy humans.

Courchesne-Loyer A, St-Pierre V, Hennebelle M, Castellano CA, Fortier M, Tessier D, Cunnane SC.

Nutrition. 2015 Oct;31(10):1255-9. doi: 10.1016/j.nut.2015.05.015. Epub 2015 Jun 6.


Long-chain n-3 PUFAs from fish oil enhance resting state brain glucose utilization and reduce anxiety in an adult nonhuman primate, the grey mouse lemur.

Pifferi F, Dorieux O, Castellano CA, Croteau E, Masson M, Guillermier M, Van Camp N, Guesnet P, Alessandri JM, Cunnane S, Dhenain M, Aujard F.

J Lipid Res. 2015 Aug;56(8):1511-8. doi: 10.1194/jlr.M058933. Epub 2015 Jun 10.


Lower brain 18F-fluorodeoxyglucose uptake but normal 11C-acetoacetate metabolism in mild Alzheimer's disease dementia.

Castellano CA, Nugent S, Paquet N, Tremblay S, Bocti C, Lacombe G, Imbeault H, Turcotte É, Fulop T, Cunnane SC.

J Alzheimers Dis. 2015;43(4):1343-53. doi: 10.3233/JAD-141074.


Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults.

Nugent S, Castellano CA, Goffaux P, Whittingstall K, Lepage M, Paquet N, Bocti C, Fulop T, Cunnane SC.

Am J Physiol Endocrinol Metab. 2014 Jun 1;306(11):E1315-21. doi: 10.1152/ajpendo.00067.2014. Epub 2014 Apr 15.


Brain glucose and acetoacetate metabolism: a comparison of young and older adults.

Nugent S, Tremblay S, Chen KW, Ayutyanont N, Roontiva A, Castellano CA, Fortier M, Roy M, Courchesne-Loyer A, Bocti C, Lepage M, Turcotte E, Fulop T, Reiman EM, Cunnane SC.

Neurobiol Aging. 2014 Jun;35(6):1386-95. doi: 10.1016/j.neurobiolaging.2013.11.027. Epub 2013 Dec 1.


Safety of dietary conjugated α-linolenic acid (CLNA) in a neonatal pig model.

Castellano CA, Plourde M, Briand SI, Angers P, Giguère A, Matte JJ.

Food Chem Toxicol. 2014 Feb;64:119-25. doi: 10.1016/j.fct.2013.11.025. Epub 2013 Nov 28.


Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline.

Hennebelle M, Plourde M, Chouinard-Watkins R, Castellano CA, Barberger-Gateau P, Cunnane SC.

Proc Nutr Soc. 2014 Feb;73(1):80-6. doi: 10.1017/S0029665113003625. Epub 2013 Oct 9. Review.


Dietary conjugated α-linolenic acid did not improve glucose tolerance in a neonatal pig model.

Castellano CA, Baillargeon JP, Plourde M, Briand SI, Angers P, Giguère A, Matte JJ.

Eur J Nutr. 2014 Apr;53(3):761-8. doi: 10.1007/s00394-013-0580-0. Epub 2013 Sep 5.


Thyroid function and cognition in the euthyroid elderly: a case-control study embedded in Quebec longitudinal study - NuAge.

Castellano CA, Laurin D, Langlois MF, Fortier M, Tessier D, Gaudreau P, Ferland G, Payette H, Lorrain D, Cunnane SC.

Psychoneuroendocrinology. 2013 Sep;38(9):1772-6. doi: 10.1016/j.psyneuen.2013.02.013. Epub 2013 Mar 16.


Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.

Courchesne-Loyer A, Fortier M, Tremblay-Mercier J, Chouinard-Watkins R, Roy M, Nugent S, Castellano CA, Cunnane SC.

Nutrition. 2013 Apr;29(4):635-40. doi: 10.1016/j.nut.2012.09.009. Epub 2012 Dec 28.


Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence?

Cunnane SC, Chouinard-Watkins R, Castellano CA, Barberger-Gateau P.

Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):61-70. doi: 10.1016/j.plefa.2012.04.006. Epub 2012 May 9. Review.


Fish oil diets alter the phospholipid balance, fatty acid composition, and steroid hormone concentrations in testes of adult pigs.

Castellano CA, Audet I, Laforest JP, Matte JJ, Suh M.

Theriogenology. 2011 Oct 1;76(6):1134-45. doi: 10.1016/j.theriogenology.2011.05.022. Epub 2011 Jul 12.


Dietary omega-3 fatty acids (fish oils) have limited effects on boar semen stored at 17 °C or cryopreserved.

Castellano CA, Audet I, Bailey JL, Laforest JP, Matte JJ.

Theriogenology. 2010 Nov;74(8):1482-90. doi: 10.1016/j.theriogenology.2010.06.020. Epub 2010 Aug 12.


Effect of dietary n-3 fatty acids (fish oils) on boar reproduction and semen quality.

Castellano CA, Audet I, Bailey JL, Chouinard PY, Laforest JP, Matte JJ.

J Anim Sci. 2010 Jul;88(7):2346-55. doi: 10.2527/jas.2009-2779. Epub 2010 Mar 26.


Fish oil diets do not improve insulin sensitivity and secretion in healthy adult male pigs.

Castellano CA, Audet I, Laforest JP, Chouinard Y, Matte JJ.

Br J Nutr. 2010 Jan;103(2):189-96. doi: 10.1017/S0007114509991590. Epub 2009 Sep 14.


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