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Mild Chronic Traumatic Encephalopathy Neuropathology in People With No Known Participation in Contact Sports or History of Repetitive Neurotrauma.

Iverson GL, Luoto TM, Karhunen PJ, Castellani RJ.

J Neuropathol Exp Neurol. 2019 Jun 6. pii: nlz045. doi: 10.1093/jnen/nlz045. [Epub ahead of print]


Nanodelivery of cerebrolysin reduces pathophysiology of Parkinson's disease.

Ozkizilcik A, Sharma A, Lafuente JV, Muresanu DF, Castellani RJ, Nozari A, Tian ZR, Mössler H, Sharma HS.

Prog Brain Res. 2019;245:201-246. doi: 10.1016/bs.pbr.2019.03.014. Epub 2019 Apr 2. Review.


Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease.

Sharma HS, Muresanu DF, Castellani RJ, Nozari A, Lafuente JV, Tian ZR, Ozkizilcik A, Manzhulo I, Mössler H, Sharma A.

Prog Brain Res. 2019;245:145-200. doi: 10.1016/bs.pbr.2019.03.009. Epub 2019 Apr 2. Review.


The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation.

Castellani RJ, Plascencia-Villa G, Perry G.

Lab Invest. 2019 Feb 13. doi: 10.1038/s41374-019-0231-z. [Epub ahead of print] Review.


No Evidence of Increased Chronic Traumatic Encephalopathy Pathology or Neurodegenerative Proteinopathy in Former Military Service Members: A Preliminary Study.

Tripathy A, Shade A, Erskine B, Bailey K, Grande A, deLong JJ, Perry G, Castellani RJ.

J Alzheimers Dis. 2019;67(4):1277-1289. doi: 10.3233/JAD-181039.


Chronic Traumatic Encephalopathy Pathology After Shotgun Injury to the Brain.

Tribett T, Erskine B, Bailey K, Brown T, Castellani RJ.

J Forensic Sci. 2019 Jan 15. doi: 10.1111/1556-4029.14001. [Epub ahead of print]


Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges.

Castellani RJ, Perry G.

J Alzheimers Dis. 2019;67(2):447-467. doi: 10.3233/JAD-180721.


Can Neck Contusions in Unexplained Pediatric Deaths be Explained by Cardiopulmonary Resuscitation?

Wells K, Castellani RJ, deJong JL.

J Forensic Sci. 2019 May;64(3):770-772. doi: 10.1111/1556-4029.13919. Epub 2018 Oct 12.


Differential expression of the TWEAK receptor Fn14 in IDH1 wild-type and mutant gliomas.

Hersh DS, Peng S, Dancy JG, Galisteo R, Eschbacher JM, Castellani RJ, Heath JE, Legesse T, Kim AJ, Woodworth GF, Tran NL, Winkles JA.

J Neurooncol. 2018 Jun;138(2):241-250. doi: 10.1007/s11060-018-2799-3. Epub 2018 Feb 16.


Commentary on: Schuman MJ, Hutchins KD. Severe retinal hemorrhages with retinoschisis in infants are not pathognomonic for abusive head trauma. J Forensic Sci 2017;62(3):807-11.

Castellani RJ, DeJong JL, Schmidt CJ.

J Forensic Sci. 2017 Nov;62(6):1677-1678. doi: 10.1111/1556-4029.13628. No abstract available.


Novel Treatment Strategies Using TiO2-Nanowired Delivery of Histaminergic Drugs and Antibodies to Tau With Cerebrolysin for Superior Neuroprotection in the Pathophysiology of Alzheimer's Disease.

Sharma A, Menon PK, Patnaik R, Muresanu DF, Lafuente JV, Tian ZR, Ozkizilcik A, Castellani RJ, Mössler H, Sharma HS.

Int Rev Neurobiol. 2017;137:123-165. doi: 10.1016/bs.irn.2017.09.002. Epub 2017 Nov 6. Review.


The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features.

Iverson GL, Keene CD, Perry G, Castellani RJ.

J Alzheimers Dis. 2018;61(1):17-28. doi: 10.3233/JAD-170654. Review.


Dementia Pugilistica Revisited.

Castellani RJ, Perry G.

J Alzheimers Dis. 2017;60(4):1209-1221. doi: 10.3233/JAD-170669. Review.


Infographic: Consensus statement on concussion in sport.

McCrory P, Meeuwisse W, Dvorak J, Aubry M, Bailes J, Broglio S, Cantu RC, Cassidy D, Echemendia RJ, Castellani RJ, Davis GA, Ellenbogen R, Emery C, Engebretsen L, Feddermann-Demont N, Giza CC, Guskiewicz KM, Herring S, Iverson GL, Johnston KM, Kissick J, Kutcher J, Leddy JJ, Maddocks D, Makdissi M, Manley G, McCrea M, Meehan WP, Nagahiro S, Patricios J, Putukian M, Schneider KJ, Sills A, Tator CH, Turner M, Vos PE.

Br J Sports Med. 2017 Nov;51(21):1557-1558. doi: 10.1136/bjsports-2017-098065. Epub 2017 Sep 12. No abstract available.


Histamine H3 Inverse Agonist BF 2649 or Antagonist with Partial H4 Agonist Activity Clobenpropit Reduces Amyloid Beta Peptide-Induced Brain Pathology in Alzheimer's Disease.

Patnaik R, Sharma A, Skaper SD, Muresanu DF, Lafuente JV, Castellani RJ, Nozari A, Sharma HS.

Mol Neurobiol. 2018 Jan;55(1):312-321. doi: 10.1007/s12035-017-0743-8.


Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer's Disease.

Sharma HS, Muresanu DF, Lafuente JV, Patnaik R, Tian ZR, Ozkizilcik A, Castellani RJ, Mössler H, Sharma A.

Mol Neurobiol. 2018 Jan;55(1):300-311. doi: 10.1007/s12035-017-0742-9.


A Unique Type of Birth Trauma Mistaken for Abuse.

Isaac CV, Cornelison JB, Castellani RJ, deJong JL.

J Forensic Sci. 2018 Mar;63(2):602-607. doi: 10.1111/1556-4029.13557. Epub 2017 Jun 12.


A systematic review of potential long-term effects of sport-related concussion.

Manley G, Gardner AJ, Schneider KJ, Guskiewicz KM, Bailes J, Cantu RC, Castellani RJ, Turner M, Jordan BD, Randolph C, Dvořák J, Hayden KA, Tator CH, McCrory P, Iverson GL.

Br J Sports Med. 2017 Jun;51(12):969-977. doi: 10.1136/bjsports-2017-097791. Epub 2017 Apr 28. Review.


Consensus statement on concussion in sport-the 5th international conference on concussion in sport held in Berlin, October 2016.

McCrory P, Meeuwisse W, Dvořák J, Aubry M, Bailes J, Broglio S, Cantu RC, Cassidy D, Echemendia RJ, Castellani RJ, Davis GA, Ellenbogen R, Emery C, Engebretsen L, Feddermann-Demont N, Giza CC, Guskiewicz KM, Herring S, Iverson GL, Johnston KM, Kissick J, Kutcher J, Leddy JJ, Maddocks D, Makdissi M, Manley GT, McCrea M, Meehan WP, Nagahiro S, Patricios J, Putukian M, Schneider KJ, Sills A, Tator CH, Turner M, Vos PE.

Br J Sports Med. 2017 Jun;51(11):838-847. doi: 10.1136/bjsports-2017-097699. Epub 2017 Apr 26. No abstract available.


Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer.

Connolly NP, Stokum JA, Schneider CS, Ozawa T, Xu S, Galisteo R, Castellani RJ, Kim AJ, Simard JM, Winkles JA, Holland EC, Woodworth GF.

PLoS One. 2017 Mar 30;12(3):e0174557. doi: 10.1371/journal.pone.0174557. eCollection 2017.


Symptomatic Acute-on-Chronic Subdural Hematoma: A Clinicopathological Study.

Castellani RJ, Mojica-Sanchez G, Schwartzbauer G, Hersh DS.

Am J Forensic Med Pathol. 2017 Jun;38(2):126-130. doi: 10.1097/PAF.0000000000000300.


The Role of the Iron Stain in Assessing Intracranial Hemorrhage.

Castellani RJ, Mojica G, Perry G.

Open Neurol J. 2016 Oct 28;10:136-142. eCollection 2016.


Molecular Mapping Alzheimer's Disease: MALDI Imaging of Formalin-fixed, Paraffin-embedded Human Hippocampal Tissue.

Kelley AR, Perry G, Bethea C, Castellani RJ, Bach SB.

Open Neurol J. 2016 Sep 30;10:88-98. eCollection 2016.


Summary of the 2015 University of Michigan Sport Concussion Summit.

Broglio SP, Baldwin G, Castellani RJ, Chrisman SP, Duma S, Hainline B, Gerstner JC, Guskiewicz K, Kutcher J, Lamba A, McCrea M, Pachman S, Randolph C, McLeod TCV.

Concussion. 2016 Sep 23;1(4):CNC23. doi: 10.2217/cnc-2016-0007. eCollection 2016 Dec. Review.


Demyelination as a harbinger of lymphoma: a case report and review of primary central nervous system lymphoma preceded by multifocal sentinel demyelination.

Kvarta MD, Sharma D, Castellani RJ, Morales RE, Reich SG, Kimball AS, Shin RK.

BMC Neurol. 2016 May 21;16:72. doi: 10.1186/s12883-016-0596-1.


Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits.

Hersh DS, Houbova P, Castellani RJ, Rodriguez FJ, Mehta MP, Woodworth GF.

J Clin Neurosci. 2016 Aug;30:143-145. doi: 10.1016/j.jocn.2016.01.022. Epub 2016 Mar 4.


Laser-Induced In-Source Decay Applied to the Determination of Amyloid-Beta in Alzheimer's Brains.

Kelley AR, Perry G, Castellani RJ, Bach SB.

ACS Chem Neurosci. 2016 Mar 16;7(3):261-8. doi: 10.1021/acschemneuro.5b00295. Epub 2016 Jan 6.


Chondromyxoid fibroma invasion of the transverse-sigmoid sinus junction causing posterior fossa hemorrhage.

Hersh DS, Firempong AO, Chesler D, Castellani RJ, Woodworth GF.

J Clin Neurosci. 2016 Feb;24:149-50. doi: 10.1016/j.jocn.2015.08.009. Epub 2015 Oct 9.


A critical review of chronic traumatic encephalopathy.

Iverson GL, Gardner AJ, McCrory P, Zafonte R, Castellani RJ.

Neurosci Biobehav Rev. 2015 Sep;56:276-93. doi: 10.1016/j.neubiorev.2015.05.008. Epub 2015 Jul 14. Review.


Sur1-Trpm4 Cation Channel Expression in Human Cerebral Infarcts.

Mehta RI, Tosun C, Ivanova S, Tsymbalyuk N, Famakin BM, Kwon MS, Castellani RJ, Gerzanich V, Simard JM.

J Neuropathol Exp Neurol. 2015 Aug;74(8):835-49. doi: 10.1097/NEN.0000000000000223.


Neurodegeneration and sport.

Davis GA, Castellani RJ, McCrory P.

Neurosurgery. 2015 Jun;76(6):643-55; discussion 655-6. doi: 10.1227/NEU.0000000000000722. Review.


Chronic effects of mild neurotrauma: putting the cart before the horse?

Castellani RJ, Perry G, Iverson GL.

J Neuropathol Exp Neurol. 2015 Jun;74(6):493-9. doi: 10.1097/NEN.0000000000000193. Review.


Simultaneous onset of Alzheimer's disease in a husband and wife in their mid-fifties: what do we really know about environmental factors?

Pelcovits A, Marriotti R, Heath J, Perry G, Castellani RJ.

Open Neurol J. 2015 Mar 31;9:1-3. doi: 10.2174/1874205X01509010001. eCollection 2015.


Chronic traumatic encephalopathy: A paradigm in search of evidence?

Castellani RJ.

Lab Invest. 2015 Jun;95(6):576-84. doi: 10.1038/labinvest.2015.54. Epub 2015 Apr 13.


Alzheimer Disease Pathology in Middle Age Reveals a Spatial-Temporal Disconnect Between Amyloid-β and Phosphorylated Tau.

Fornicola W, Pelcovits A, Li BX, Heath J, Perry G, Castellani RJ.

Open Neurol J. 2014 Dec 12;8:22-6. doi: 10.2174/1874205X01408010022. eCollection 2014.


Cerebrovascular and mitochondrial abnormalities in Alzheimer's disease: a brief overview.

Carvalho C, Correia SC, Perry G, Castellani RJ, Moreira PI.

J Neural Transm (Vienna). 2016 Feb;123(2):107-11. doi: 10.1007/s00702-015-1367-7. Epub 2015 Jan 22. Review.


A case report comparing clinical, imaging and neuropsychological assessment findings in twins discordant for the VCP p.R155C mutation.

Surampalli A, Gold BT, Smith C, Castellani RJ, Khare M, Yu H, Nguyen C, Lan M, Wencel M, Wigal S, Caiozzo V, Kimonis V.

Neuromuscul Disord. 2015 Feb;25(2):177-83. doi: 10.1016/j.nmd.2014.10.003. Epub 2014 Oct 22.


Hydrophilic polymer embolism and associated vasculopathy of the lung: prevalence in a retrospective autopsy study.

Mehta RI, Mehta RI, Choi JM, Mukherjee A, Castellani RJ.

Hum Pathol. 2015 Feb;46(2):191-201. doi: 10.1016/j.humpath.2014.09.011. Epub 2014 Oct 7.


Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes.

Choi J, Ravipati A, Nimmagadda V, Schubert M, Castellani RJ, Russell JW.

Mitochondrion. 2014 Sep;18:41-8. doi: 10.1016/j.mito.2014.09.005. Epub 2014 Sep 23.


"Rapidly" Progressive Supranuclear Palsy.

Armstrong MJ, Castellani RJ, Reich SG.

Mov Disord Clin Pract. 2014 Apr 10;1(1):70-72. doi: 10.1002/mdc3.12011. eCollection 2014 Apr. No abstract available.


Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice.

Palm R, Chang J, Blair J, Garcia-Mesa Y, Lee HG, Castellani RJ, Smith MA, Zhu X, Casadesus G.

J Neurochem. 2014 Jul;130(1):115-25. doi: 10.1111/jnc.12706. Epub 2014 Apr 2.


Accumulation of intraneuronal amyloid-β is common in normal brain.

Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG.

Curr Alzheimer Res. 2014 May;11(4):317-24.


The complexities of the pathology-pathogenesis relationship in Alzheimer disease.

Castellani RJ, Perry G.

Biochem Pharmacol. 2014 Apr 15;88(4):671-6. doi: 10.1016/j.bcp.2014.01.009. Epub 2014 Jan 18. Review.


Apolipoprotein E4 prevents growth of malaria at the intraerythrocyte stage: implications for differences in racial susceptibility to Alzheimer's disease.

Fujioka H, Phelix CF, Friedland RP, Zhu X, Perry EA, Castellani RJ, Perry G.

J Health Care Poor Underserved. 2013 Nov;24(4 Suppl):70-8. doi: 10.1353/hpu.2014.0009.


Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain.

Williams WM, Torres S, Siedlak SL, Castellani RJ, Perry G, Smith MA, Zhu X.

J Neuroinflammation. 2013 Oct 18;10:127. doi: 10.1186/1742-2094-10-127.


Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage.

Tosun C, Kurland DB, Mehta R, Castellani RJ, deJong JL, Kwon MS, Woo SK, Gerzanich V, Simard JM.

Stroke. 2013 Dec;44(12):3522-8. doi: 10.1161/STROKEAHA.113.002904. Epub 2013 Oct 10.


Undifferentiated sarcoma of the liver: a case study of an erythropoietin-secreting tumor.

Lin JM, Heath JE, Twaddell WS, Castellani RJ.

Int J Surg Pathol. 2014 Sep;22(6):555-8. doi: 10.1177/1066896913503490. Epub 2013 Sep 13.


Sulfonylurea receptor 1 expression in human cerebral infarcts.

Mehta RI, Ivanova S, Tosun C, Castellani RJ, Gerzanich V, Simard JM.

J Neuropathol Exp Neurol. 2013 Sep;72(9):871-83. doi: 10.1097/NEN.0b013e3182a32e40.


A novel PGC-1α isoform in brain localizes to mitochondria and associates with PINK1 and VDAC.

Choi J, Batchu VV, Schubert M, Castellani RJ, Russell JW.

Biochem Biophys Res Commun. 2013 Jun 14;435(4):671-7. doi: 10.1016/j.bbrc.2013.05.041. Epub 2013 May 17.


Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links.

Perry EA, Castellani RJ, Moreira PI, Nunomura A, Lui Q, Harris PL, Sayre LM, Szweda PA, Szweda LI, Zhu X, Smith MA, Perry G.

Free Radic Res. 2013 Jul;47(6-7):507-10. doi: 10.3109/10715762.2013.794265. Epub 2013 May 10.

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