Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 74


Leveraging allelic imbalance to refine fine-mapping for eQTL studies.

Zou J, Hormozdiari F, Jew B, Castel SE, Lappalainen T, Ernst J, Sul JH, Eskin E.

PLoS Genet. 2019 Dec 13;15(12):e1008481. doi: 10.1371/journal.pgen.1008481. eCollection 2019 Dec.


Genetic regulatory variation in populations informs transcriptome analysis in rare disease.

Mohammadi P, Castel SE, Cummings BB, Einson J, Sousa C, Hoffman P, Donkervoort S, Jiang Z, Mohassel P, Foley AR, Wheeler HE, Im HK, Bonnemann CG, MacArthur DG, Lappalainen T.

Science. 2019 Oct 18;366(6463):351-356. doi: 10.1126/science.aay0256. Epub 2019 Oct 10.


Effect of a Psychiatric Emergency Department Expansion on Acute Mental Health and Addiction Service Use Trends in a Large Urban Center.

Reid N, Castel S, Veldhuizen S, Roberts A, Stergiopoulos V.

Psychiatr Serv. 2019 Nov 1;70(11):1053-1056. doi: 10.1176/ Epub 2019 Jul 30.


Modified penetrance of coding variants by cis-regulatory variation contributes to disease risk.

Castel SE, Cervera A, Mohammadi P, Aguet F, Reverter F, Wolman A, Guigo R, Iossifov I, Vasileva A, Lappalainen T.

Nat Genet. 2018 Sep;50(9):1327-1334. doi: 10.1038/s41588-018-0192-y. Epub 2018 Aug 20.


Ketamine augmentation for major depressive disorder and suicidal ideation: Preliminary experience in an inpatient psychiatry setting.

Sinyor M, Williams M, Belo S, Orser B, Vincent M, Mah L, Zarate C Jr, Castel S, Levitt AJ, Schaffer A.

J Affect Disord. 2018 Dec 1;241:103-109. doi: 10.1016/j.jad.2018.07.073. Epub 2018 Jul 29.


The determination of capreomycin in human plasma by LC-MS/MS using ion-pairing chromatography and solid-phase extraction.

Thuboy B, Kellermann T, Castel S, Norman J, Joubert A, Garcia-Prats AJ, Hesseling AC, Wiesner L.

Biomed Chromatogr. 2018 May 3:e4269. doi: 10.1002/bmc.4269. [Epub ahead of print]


Corrigendum: Landscape of X chromosome inactivation across human tissues.

Tukiainen T, Villani AC, Yen A, Rivas MA, Marshall JL, Satija R, Aguirre M, Gauthier L, Fleharty M, Kirby A, Cummings BB, Castel SE, Karczewski KJ, Aguet F, Byrnes A, Consortium G, Lappalainen T, Regev A, Ardlie KG, Hacohen N, MacArthur DG.

Nature. 2018 Mar 7;555(7695):274. doi: 10.1038/nature25993.


Landscape of X chromosome inactivation across human tissues.

Tukiainen T, Villani AC, Yen A, Rivas MA, Marshall JL, Satija R, Aguirre M, Gauthier L, Fleharty M, Kirby A, Cummings BB, Castel SE, Karczewski KJ, Aguet F, Byrnes A; GTEx Consortium; Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group; Statistical Methods groups—Analysis Working Group; Enhancing GTEx (eGTEx) groups; NIH Common Fund; NIH/NCI; NIH/NHGRI; NIH/NIMH; NIH/NIDA; Biospecimen Collection Source Site—NDRI; Biospecimen Collection Source Site—RPCI; Biospecimen Core Resource—VARI; Brain Bank Repository—University of Miami Brain Endowment Bank; Leidos Biomedical—Project Management; ELSI Study; Genome Browser Data Integration &Visualization—EBI; Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz, Lappalainen T, Regev A, Ardlie KG, Hacohen N, MacArthur DG.

Nature. 2017 Oct 11;550(7675):244-248. doi: 10.1038/nature24265. Erratum in: Nature. 2018 Mar 7;555(7695):274.


Therapeutic drug monitoring of amlodipine and the Z-FHL/HHL ratio: Adherence tools in patients referred for apparent treatment-resistant hypertension.

Jones ESW, Lesosky M, Blockman M, Castel S, Decloedt EH, Schwager SLU, Sturrock ED, Wiesner L, Rayner BL.

S Afr Med J. 2017 Sep 22;107(10):887-891. doi: 10.7196/SAMJ.2017.v107i10.12268.


Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change.

Mohammadi P, Castel SE, Brown AA, Lappalainen T.

Genome Res. 2017 Nov;27(11):1872-1884. doi: 10.1101/gr.216747.116. Epub 2017 Oct 11.


Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.

Kim-Hellmuth S, Bechheim M, Pütz B, Mohammadi P, Nédélec Y, Giangreco N, Becker J, Kaiser V, Fricker N, Beier E, Boor P, Castel SE, Nöthen MM, Barreiro LB, Pickrell JK, Müller-Myhsok B, Lappalainen T, Schumacher J, Hornung V.

Nat Commun. 2017 Aug 16;8(1):266. doi: 10.1038/s41467-017-00366-1.


The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly.

Chang AY, Castel SE, Ernst E, Kim HS, Martienssen RA.

Cell Rep. 2017 Jun 20;19(12):2477-2489. doi: 10.1016/j.celrep.2017.05.086.


Cyclic Vomiting Syndrome is characterized by altered functional brain connectivity of the insular cortex: A cross-comparison with migraine and healthy adults.

Ellingsen DM, Garcia RG, Lee J, Lin RL, Kim J, Thurler AH, Castel S, Dimisko L, Rosen BR, Hadjikhani N, Kuo B, Napadow V.

Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13004. Epub 2016 Dec 1.


Effects of an intervention program on maternal and paternal parenting stress after preterm birth: A randomized trial.

Castel S, Creveuil C, Beunard A, Blaizot X, Proia N, Guillois B.

Early Hum Dev. 2016 Dec;103:17-25. doi: 10.1016/j.earlhumdev.2016.05.007. Epub 2016 Jul 21.


Rare variant phasing and haplotypic expression from RNA sequencing with phASER.

Castel SE, Mohammadi P, Chung WK, Shen Y, Lappalainen T.

Nat Commun. 2016 Sep 8;7:12817. doi: 10.1038/ncomms12817.


Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-experienced HIV-infected Children.

Moholisa RR, Schomaker M, Kuhn L, Castel S, Wiesner L, Coovadia A, Strehlau R, Patel F, Pinillos F, Abrams EJ, Maartens G, McIlleron H.

Pediatr Infect Dis J. 2016 Dec;35(12):e378-e383.


Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway.

Fagegaltier D, Falciatori I, Czech B, Castel S, Perrimon N, Simcox A, Hannon GJ.

Genes Dev. 2016 Jul 15;30(14):1623-35. doi: 10.1101/gad.284927.116.


Dicer in action at replication-transcription collisions.

Ren J, Castel SE, Martienssen RA.

Mol Cell Oncol. 2015 Mar 9;2(3):e991224. doi: 10.4161/23723556.2014.991224. eCollection 2015 Jul-Sep.


Differences in genetic variants in lopinavir disposition among HIV-infected Bantu Africans.

Mpeta B, Kampira E, Castel S, Mpye KL, Soko ND, Wiesner L, Smith P, Skelton M, Lacerda M, Dandara C.

Pharmacogenomics. 2016 May;17(7):679-90. doi: 10.2217/pgs.16.14. Epub 2016 May 4.


An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3'-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients.

Swart M, Evans J, Skelton M, Castel S, Wiesner L, Smith PJ, Dandara C.

Front Genet. 2016 Jan 7;6:356. doi: 10.3389/fgene.2015.00356. eCollection 2015.


Population Pharmacokinetics of Rifampin in Pregnant Women with Tuberculosis and HIV Coinfection in Soweto, South Africa.

Denti P, Martinson N, Cohn S, Mashabela F, Hoffmann J, Msandiwa R, Castel S, Wiesner L, Chaisson RE, McIlleron H, Dooley KE.

Antimicrob Agents Chemother. 2015 Dec 7;60(3):1234-41. doi: 10.1128/AAC.02051-15.


Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Newly Diagnosed Pulmonary TB Patients in Tanzania.

Denti P, Jeremiah K, Chigutsa E, Faurholt-Jepsen D, PrayGod G, Range N, Castel S, Wiesner L, Hagen CM, Christiansen M, Changalucha J, McIlleron H, Friis H, Andersen AB.

PLoS One. 2015 Oct 26;10(10):e0141002. doi: 10.1371/journal.pone.0141002. eCollection 2015.


Tools and best practices for data processing in allelic expression analysis.

Castel SE, Levy-Moonshine A, Mohammadi P, Banks E, Lappalainen T.

Genome Biol. 2015 Sep 17;16:195. doi: 10.1186/s13059-015-0762-6.


Effects of CYP2B6 and CYP1A2 Genetic Variation on Nevirapine Plasma Concentration and Pharmacodynamics as Measured by CD4 Cell Count in Zimbabwean HIV-Infected Patients.

Mhandire D, Lacerda M, Castel S, Mhandire K, Zhou D, Swart M, Shamu T, Smith P, Musingwini T, Wiesner L, Stray-Pedersen B, Dandara C.

OMICS. 2015 Sep;19(9):553-62. doi: 10.1089/omi.2015.0104.


Pharmacokinetics and Safety of Ofloxacin in Children with Drug-Resistant Tuberculosis.

Garcia-Prats AJ, Draper HR, Thee S, Dooley KE, McIlleron HM, Seddon JA, Wiesner L, Castel S, Schaaf HS, Hesseling AC.

Antimicrob Agents Chemother. 2015 Oct;59(10):6073-9. doi: 10.1128/AAC.01404-15. Epub 2015 Jul 20.


Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation.

Singh P, Staller K, Barshop K, Dai E, Newman J, Yoon S, Castel S, Kuo B.

World J Gastroenterol. 2015 Jul 14;21(26):8103-9. doi: 10.3748/wjg.v21.i26.8103.


Lipid-based nutrient supplements do not affect efavirenz but lower plasma nevirapine concentrations in Ethiopian adult HIV patients.

Abdissa A, Olsen MF, Yilma D, Tesfaye M, Girma T, Christiansen M, Hagen CM, Wiesner L, Castel S, Aseffa A, McIlleron H, Pedersen C, Friis H, Andersen AB.

HIV Med. 2015 Aug;16(7):403-11. doi: 10.1111/hiv.12225. Epub 2015 May 13.


Evaluation of adherence measures of antiretroviral prophylaxis in HIV exposed infants in the first 6 weeks of life.

Desmond AC, Moodley D, Conolly CA, Castel SA, Coovadia HM.

BMC Pediatr. 2015 Mar 19;15:23. doi: 10.1186/s12887-015-0340-9.


Dicer promotes transcription termination at sites of replication stress to maintain genome stability.

Castel SE, Ren J, Bhattacharjee S, Chang AY, Sánchez M, Valbuena A, Antequera F, Martienssen RA.

Cell. 2014 Oct 23;159(3):572-83. doi: 10.1016/j.cell.2014.09.031. Epub 2014 Oct 16.


Pharmacokinetics and safety of moxifloxacin in children with multidrug-resistant tuberculosis.

Thee S, Garcia-Prats AJ, Draper HR, McIlleron HM, Wiesner L, Castel S, Schaaf HS, Hesseling AC.

Clin Infect Dis. 2015 Feb 15;60(4):549-56. doi: 10.1093/cid/ciu868. Epub 2014 Oct 30.


Pharmacokinetics of efavirenz and treatment of HIV-1 among pregnant women with and without tuberculosis coinfection.

Dooley KE, Denti P, Martinson N, Cohn S, Mashabela F, Hoffmann J, Haas DW, Hull J, Msandiwa R, Castel S, Wiesner L, Chaisson RE, McIlleron H; TSHEPISO Study Team.

J Infect Dis. 2015 Jan 15;211(2):197-205. doi: 10.1093/infdis/jiu429. Epub 2014 Jul 31. Erratum in: J Infect Dis. 2015 Jul 1;212(1):169.


Nutritional supplementation increases rifampin exposure among tuberculosis patients coinfected with HIV.

Jeremiah K, Denti P, Chigutsa E, Faurholt-Jepsen D, PrayGod G, Range N, Castel S, Wiesner L, Hagen CM, Christiansen M, Changalucha J, McIlleron H, Friis H, Andersen AB.

Antimicrob Agents Chemother. 2014 Jun;58(6):3468-74. doi: 10.1128/AAC.02307-13. Epub 2014 Apr 7.


Multilevel analysis of the determinants of the global assessment of functioning in an inpatient population.

Urbanoski KA, Henderson C, Castel S.

BMC Psychiatry. 2014 Mar 4;14:63. doi: 10.1186/1471-244X-14-63.


Pharmacokinetics of ofloxacin and levofloxacin for prevention and treatment of multidrug-resistant tuberculosis in children.

Thee S, Garcia-Prats AJ, McIlleron HM, Wiesner L, Castel S, Norman J, Draper HR, van der Merwe PL, Hesseling AC, Schaaf HS.

Antimicrob Agents Chemother. 2014 May;58(5):2948-51. doi: 10.1128/AAC.02755-13. Epub 2014 Feb 18.


RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond.

Castel SE, Martienssen RA.

Nat Rev Genet. 2013 Feb;14(2):100-12. doi: 10.1038/nrg3355. Review.


Validation and comparison of diagnostic accuracy of four screening tools for mental disorders in people seeking treatment for substance use disorders.

Rush B, Castel S, Brands B, Toneatto T, Veldhuizen S.

J Subst Abuse Treat. 2013 Apr;44(4):375-83. doi: 10.1016/j.jsat.2012.08.221. Epub 2012 Oct 23.


Monitoring drug use among HIV/AIDS patients in Brazil: should we combine self-report and urinalysis?

Malbergier A, do Amaral RA, Cardoso LR, Castel S.

Curr HIV Res. 2012 Dec;10(8):708-12.


[Effect of early intervention programs on neurobehavioral outcome in premature infants after discharge].

Guillois B, Castel S, Beunard A, Blaizot X, Creveuil C, Proia-Lelouey N.

Arch Pediatr. 2012 Sep;19(9):990-7. doi: 10.1016/j.arcped.2012.06.004. Epub 2012 Aug 9. French.


RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II.

Zaratiegui M, Castel SE, Irvine DV, Kloc A, Ren J, Li F, de Castro E, Marín L, Chang AY, Goto D, Cande WZ, Antequera F, Arcangioli B, Martienssen RA.

Nature. 2011 Oct 16;479(7371):135-8. doi: 10.1038/nature10501.


Structural basis of the oxidative activation of the carboxysomal gamma-carbonic anhydrase, CcmM.

Peña KL, Castel SE, de Araujo C, Espie GS, Kimber MS.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2455-60. doi: 10.1073/pnas.0910866107. Epub 2010 Jan 25.


Prevalence of co-occurring substance use and other mental disorders in the Canadian population.

Rush B, Urbanoski K, Bassani D, Castel S, Wild TC, Strike C, Kimberley D, Somers J.

Can J Psychiatry. 2008 Dec;53(12):800-9.


Influence of co-occurring mental and substance use disorders on the prevalence of problem gambling in Canada.

Rush BR, Bassani DG, Urbanoski KA, Castel S.

Addiction. 2008 Nov;103(11):1847-56. doi: 10.1111/j.1360-0443.2008.02338.x.


Sulfated polysaccharides promote the assembly of amyloid beta(1-42) peptide into stable fibrils of reduced cytotoxicity.

Bravo R, Arimon M, Valle-Delgado JJ, García R, Durany N, Castel S, Cruz M, Ventura S, Fernàndez-Busquets X.

J Biol Chem. 2008 Nov 21;283(47):32471-83. doi: 10.1074/jbc.M709870200. Epub 2008 Sep 25.


Smell test predicts performance on delayed recall memory test in elderly with depression.

Scalco MZ, Streiner DL, Rewilak D, Castel S, Van Reekum R.

Int J Geriatr Psychiatry. 2009 Apr;24(4):376-81. doi: 10.1002/gps.2132.


The interaction of co-occurring mental disorders and recovery management checkups on substance abuse treatment participation and recovery.

Rush BR, Dennis ML, Scott CK, Castel S, Funk RR.

Eval Rev. 2008 Feb;32(1):7-38. doi: 10.1177/0193841X07307532.


Substance use disorders and overweight/obesity in bipolar I disorder: preliminary evidence for competing addictions.

McIntyre RS, McElroy SL, Konarski JZ, Soczynska JK, Bottas A, Castel S, Wilkins K, Kennedy SH.

J Clin Psychiatry. 2007 Sep;68(9):1352-7.


PDGF-stimulated cell proliferation and migration of human arterial smooth muscle cells. Colocalization of PDGF isoforms with glycosaminoglycans.

García-Olivas R, Vilaró S, Reina M, Castel S.

Int J Biochem Cell Biol. 2007;39(10):1915-29. Epub 2007 May 25.


Use of mental health care services by Canadians with co-occurring substance dependence and mental disorders.

Urbanoski KA, Rush BR, Wild TC, Bassani DG, Castel S.

Psychiatr Serv. 2007 Jul;58(7):962-9.


Supplemental Content

Loading ...
Support Center