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Items: 1 to 50 of 105

1.

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs.

Rastrojo A, García-Hernández R, Vargas P, Camacho E, Corvo L, Imamura H, Dujardin JC, Castanys S, Aguado B, Gamarro F, Requena JM.

Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):246-264. doi: 10.1016/j.ijpddr.2018.04.002. Epub 2018 Apr 13.

2.

Functional role of highly conserved residues of the N-terminal tail and first transmembrane segment of a P4-ATPase.

Perandrés-López R, Sánchez-Cañete MP, Gamarro F, Castanys S.

Biochem J. 2018 Mar 6;475(5):887-899. doi: 10.1042/BCJ20170749.

PMID:
29438067
3.

Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols.

Perea A, Manzano JI, Kimura Y, Ueda K, Castanys S, Gamarro F.

Biochem J. 2018 Jan 2;475(1):87-97. doi: 10.1042/BCJ20170685.

PMID:
29162656
4.

Leishmania LABCG1 and LABCG2 transporters are involved in virulence and oxidative stress: functional linkage with autophagy.

Manzano JI, Perea A, León-Guerrero D, Campos-Salinas J, Piacenza L, Castanys S, Gamarro F.

Parasit Vectors. 2017 May 30;10(1):267. doi: 10.1186/s13071-017-2198-1.

5.

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum.

Gómez Pérez V, García-Hernandez R, Corpas-López V, Tomás AM, Martín-Sanchez J, Castanys S, Gamarro F.

Int J Parasitol Drugs Drug Resist. 2016 Aug;6(2):133-9. doi: 10.1016/j.ijpddr.2016.04.003. Epub 2016 Jun 4.

6.

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.

Mondelaers A, Sanchez-Cañete MP, Hendrickx S, Eberhardt E, Garcia-Hernandez R, Lachaud L, Cotton J, Sanders M, Cuypers B, Imamura H, Dujardin JC, Delputte P, Cos P, Caljon G, Gamarro F, Castanys S, Maes L.

PLoS One. 2016 Apr 28;11(4):e0154101. doi: 10.1371/journal.pone.0154101. eCollection 2016.

7.

The LABCG2 Transporter from the Protozoan Parasite Leishmania Is Involved in Antimony Resistance.

Perea A, Manzano JI, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2016 May 23;60(6):3489-96. doi: 10.1128/AAC.02813-15. Print 2016 Jun.

8.

Optimization by Molecular Fine Tuning of Dihydro-β-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance.

Callies O, Sánchez-Cañete MP, Gamarro F, Jiménez IA, Castanys S, Bazzocchi IL.

J Med Chem. 2016 Mar 10;59(5):1880-90. doi: 10.1021/acs.jmedchem.5b01429. Epub 2016 Feb 11.

PMID:
26836364
9.

Fitness of Leishmania donovani parasites resistant to drug combinations.

García-Hernández R, Gómez-Pérez V, Castanys S, Gamarro F.

PLoS Negl Trop Dis. 2015 Apr 7;9(4):e0003704. doi: 10.1371/journal.pntd.0003704. eCollection 2015 Apr.

10.

Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-β-agarofuran Sesquiterpenes from Celastrus vulcanicola.

Callies O, Sánchez-Cañete MP, Gamarro F, Jiménez IA, Castanys S, Bazzocchi IL.

J Nat Prod. 2015 Apr 24;78(4):736-45. doi: 10.1021/np500903a. Epub 2015 Feb 19.

PMID:
25695368
11.

Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.

Berg M, García-Hernández R, Cuypers B, Vanaerschot M, Manzano JI, Poveda JA, Ferragut JA, Castanys S, Dujardin JC, Gamarro F.

Antimicrob Agents Chemother. 2015 Apr;59(4):2242-55. doi: 10.1128/AAC.04231-14. Epub 2015 Feb 2.

12.

Mechanisms of action of substituted β-amino alkanols on Leishmania donovani.

Abengózar MÁ, Bustos LA, García-Hernández R, Fernández de Palencia P, Escarcena R, Castanys S, del Olmo E, Gamarro F, San Feliciano A, Rivas L.

Antimicrob Agents Chemother. 2015 Feb;59(2):1211-8. doi: 10.1128/AAC.04003-14. Epub 2014 Dec 8.

13.

Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.

Gómez-Pérez V, Manzano JI, García-Hernández R, Castanys S, Gamarro F, Campos JM.

Eur J Med Chem. 2015 Jan 7;89:362-9. doi: 10.1016/j.ejmech.2014.10.040. Epub 2014 Oct 16.

PMID:
25462252
14.

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

Annang F, Pérez-Moreno G, García-Hernández R, Cordon-Obras C, Martín J, Tormo JR, Rodríguez L, de Pedro N, Gómez-Pérez V, Valente M, Reyes F, Genilloud O, Vicente F, Castanys S, Ruiz-Pérez LM, Navarro M, Gamarro F, González-Pacanowska D.

J Biomol Screen. 2015 Jan;20(1):82-91. doi: 10.1177/1087057114555846. Epub 2014 Oct 20.

PMID:
25332350
15.

4-amino bis-pyridinium derivatives as novel antileishmanial agents.

Gómez-Pérez V, Manzano JI, García-Hernández R, Castanys S, Campos Rosa JM, Gamarro F.

Antimicrob Agents Chemother. 2014 Jul;58(7):4103-12. doi: 10.1128/AAC.02481-13. Epub 2014 May 5.

16.

Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of the Leishmania miltefosine transporter-Cdc50 subunit.

García-Sánchez S, Sánchez-Cañete MP, Gamarro F, Castanys S.

Biochem J. 2014 Apr 1;459(1):83-94. doi: 10.1042/BJ20131318.

PMID:
24447089
17.

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening.

Manzano JI, Lecerf-Schmidt F, Lespinasse MA, Di Pietro A, Castanys S, Boumendjel A, Gamarro F.

J Antimicrob Chemother. 2014 Mar;69(3):664-72. doi: 10.1093/jac/dkt407. Epub 2013 Oct 14.

PMID:
24126793
18.

A new ABC half-transporter in Leishmania major is involved in resistance to antimony.

Manzano JI, García-Hernández R, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2013 Aug;57(8):3719-30. doi: 10.1128/AAC.00211-13. Epub 2013 May 28.

19.

LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of Leishmania.

Campos-Salinas J, León-Guerrero D, González-Rey E, Delgado M, Castanys S, Pérez-Victoria JM, Gamarro F.

PLoS Negl Trop Dis. 2013 Apr 25;7(4):e2179. doi: 10.1371/journal.pntd.0002179. Print 2013. Erratum in: PLoS Negl Trop Dis. 2013 Jun;7(6). doi:10.1371/annotation/6a3b1d53-4e80-45a9-8fab-f3fb56a134de.

20.

Leishmania donovani develops resistance to drug combinations.

García-Hernández R, Manzano JI, Castanys S, Gamarro F.

PLoS Negl Trop Dis. 2012;6(12):e1974. doi: 10.1371/journal.pntd.0001974. Epub 2012 Dec 20.

21.

Oxazolo[3,2-a]pyridine. A new structural scaffold for the reversal of multi-drug resistance in Leishmania.

Caballero E, Manzano JI, Puebla P, Castanys S, Gamarro F, San Feliciano A.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6272-5. doi: 10.1016/j.bmcl.2012.07.100. Epub 2012 Aug 10.

PMID:
22939695
22.

Terpenoids from Maytenus species and assessment of their reversal activity against a multidrug-resistant Leishmania tropica line.

Kennedy ML, Llanos GG, Castanys S, Gamarro F, Bazzocchi IL, Jiménez IA.

Chem Biodivers. 2011 Dec;8(12):2291-8. doi: 10.1002/cbdv.201000356.

PMID:
22162167
23.

Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-β-agarofuran sesquiterpenes.

Perestelo NR, Sánchez-Cañete MP, Gamarro F, Jiménez IA, Castanys S, Bazzocchi IL.

Eur J Med Chem. 2011 Oct;46(10):4915-23. doi: 10.1016/j.ejmech.2011.07.048. Epub 2011 Aug 4.

PMID:
21856049
24.

Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania.

Manzano JI, Carvalho L, García-Hernández R, Poveda JA, Ferragut JA, Castanys S, Gamarro F.

J Antimicrob Chemother. 2011 Nov;66(11):2562-5. doi: 10.1093/jac/dkr345. Epub 2011 Aug 16.

PMID:
21846675
25.

The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase.

Carvalho L, Luque-Ortega JR, López-Martín C, Castanys S, Rivas L, Gamarro F.

Antimicrob Agents Chemother. 2011 Sep;55(9):4204-10. doi: 10.1128/AAC.00520-11. Epub 2011 Jun 13.

26.

Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania.

Pérez-Victoria JM, Bavchvarov BI, Torrecillas IR, Martínez-García M, López-Martín C, Campillo M, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2011 Aug;55(8):3838-44. doi: 10.1128/AAC.00065-11. Epub 2011 Jun 6.

27.

A new ATP-binding cassette protein is involved in intracellular haem trafficking in Leishmania.

Campos-Salinas J, Cabello-Donayre M, García-Hernández R, Pérez-Victoria I, Castanys S, Gamarro F, Pérez-Victoria JM.

Mol Microbiol. 2011 Mar;79(6):1430-44. doi: 10.1111/j.1365-2958.2010.07531.x. Epub 2011 Jan 23.

28.

Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major.

Manzano JI, Carvalho L, Pérez-Victoria JM, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2011 Mar;55(3):1045-52. doi: 10.1128/AAC.01545-10. Epub 2011 Jan 3.

29.

Non-reducing trisaccharide fatty acid monoesters: novel detergents in membrane biochemistry.

Pérez-Victoria I, Pérez-Victoria FJ, Roldán-Vargas S, García-Hernández R, Carvalho L, Castanys S, Gamarro F, Morales JC, Pérez-Victoria JM.

Biochim Biophys Acta. 2011 Mar;1808(3):717-26. doi: 10.1016/j.bbamem.2010.11.031. Epub 2010 Dec 3.

30.

Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion.

Weingärtner A, Drobot B, Herrmann A, Sánchez-Cañete MP, Gamarro F, Castanys S, Günther Pomorski T.

PLoS One. 2010 Aug 26;5(8):e12443. doi: 10.1371/journal.pone.0012443.

31.

Tafenoquine, an antiplasmodial 8-aminoquinoline, targets leishmania respiratory complex III and induces apoptosis.

Carvalho L, Luque-Ortega JR, Manzano JI, Castanys S, Rivas L, Gamarro F.

Antimicrob Agents Chemother. 2010 Dec;54(12):5344-51. doi: 10.1128/AAC.00790-10. Epub 2010 Sep 13.

32.

Leishmanicidal and reversal multidrug resistance constituents from Aeonium lindleyi.

Kennedy ML, Cortés F, Piñero JE, Castanys S, López-Arencibia A, Gamarro F, Bazzocchi IL, Jiménez IA.

Planta Med. 2011 Jan;77(1):77-80. doi: 10.1055/s-0030-1250144. Epub 2010 Jul 21.

PMID:
20665372
33.

CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells.

Muñoz-Martínez F, Torres C, Castanys S, Gamarro F.

Biochem Pharmacol. 2010 Sep 15;80(6):793-800. doi: 10.1016/j.bcp.2010.05.017. Epub 2010 May 25.

PMID:
20510206
34.

Novel dihydro-beta-agarofuran sesquiterpenes as potent modulators of human P-glycoprotein dependent multidrug resistance.

Torres-Romero D, Muñoz-Martínez F, Jiménez IA, Castanys S, Gamarro F, Bazzocchi IL.

Org Biomol Chem. 2009 Dec 21;7(24):5166-72. doi: 10.1039/b915678j. Epub 2009 Oct 15.

PMID:
20024113
35.

Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug.

Sánchez-Cañete MP, Carvalho L, Pérez-Victoria FJ, Gamarro F, Castanys S.

Antimicrob Agents Chemother. 2009 Apr;53(4):1305-13. doi: 10.1128/AAC.01694-08. Epub 2009 Feb 2.

36.

Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.

Jiménez-Alonso S, Pérez-Lomas AL, Estévez-Braun A, Muñoz Martinez F, Chávez Orellana H, Ravelo AG, Gamarro F, Castanys S, López M.

J Med Chem. 2008 Nov 27;51(22):7132-43. doi: 10.1021/jm800403b.

PMID:
18954040
37.

Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes.

López-Martín C, Pérez-Victoria JM, Carvalho L, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2008 Nov;52(11):4030-6. doi: 10.1128/AAC.00964-08. Epub 2008 Sep 15.

38.

Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement.

Castanys-Muñoz E, Pérez-Victoria JM, Gamarro F, Castanys S.

Antimicrob Agents Chemother. 2008 Oct;52(10):3573-9. doi: 10.1128/AAC.00587-08. Epub 2008 Jul 21.

39.

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania.

Delgado-Méndez P, Herrera N, Chávez H, Estévez-Braun A, Ravelo AG, Cortes F, Castanys S, Gamarro F.

Bioorg Med Chem. 2008 Feb 1;16(3):1425-30. Epub 2007 Nov 26.

PMID:
18035546
40.

The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells.

Muñoz-Martínez F, Torres C, Castanys S, Gamarro F.

Biochim Biophys Acta. 2008 Feb;1778(2):530-40. Epub 2007 Oct 25.

41.

Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance.

Reyes CP, Muñoz-Martínez F, Torrecillas IR, Mendoza CR, Gamarro F, Bazzocchi IL, Núñez MJ, Pardo L, Castanys S, Campillo M, Jiménez IA.

J Med Chem. 2007 Oct 4;50(20):4808-17. Epub 2007 Sep 12.

PMID:
17850057
42.

Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo.

Seifert K, Pérez-Victoria FJ, Stettler M, Sánchez-Cañete MP, Castanys S, Gamarro F, Croft SL.

Int J Antimicrob Agents. 2007 Sep;30(3):229-35. Epub 2007 Jul 12.

PMID:
17628445
43.

A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.

Castanys-Muñoz E, Alder-Baerens N, Pomorski T, Gamarro F, Castanys S.

Mol Microbiol. 2007 Jun;64(5):1141-53.

44.

Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux.

Pérez-Victoria JM, Cortés-Selva F, Parodi-Talice A, Bavchvarov BI, Pérez-Victoria FJ, Muñoz-Martínez F, Maitrejean M, Costi MP, Barron D, Di Pietro A, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2006 Sep;50(9):3102-10.

45.

Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.

Pérez-Victoria FJ, Sánchez-Cañete MP, Seifert K, Croft SL, Sundar S, Castanys S, Gamarro F.

Drug Resist Updat. 2006 Feb-Apr;9(1-2):26-39. Review.

PMID:
16814199
46.

Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.

Pérez-Victoria FJ, Sánchez-Cañete MP, Castanys S, Gamarro F.

J Biol Chem. 2006 Aug 18;281(33):23766-75. Epub 2006 Jun 19.

47.

Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein.

Muñoz-Martínez F, Reyes CP, Pérez-Lomas AL, Jiménez IA, Gamarro F, Castanys S.

Biochim Biophys Acta. 2006 Jan;1758(1):98-110. Epub 2006 Jan 11.

48.

Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania.

Cortés-Selva F, Jiménez IA, Munoz-Martínez F, Campillo M, Bazzocchi IL, Pardo L, Ravelo AG, Castanys S, Gamarro F.

Curr Pharm Des. 2005;11(24):3125-39. Review.

PMID:
16178749
49.

Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis.

Muñoz-Martínez F, Mendoza CR, Bazzocchi IL, Castanys S, Jiménez IA, Gamarro F.

J Med Chem. 2005 Jun 30;48(13):4266-75.

PMID:
15974580
50.

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.

Ahmed-Belkacem A, Pozza A, Muñoz-Martínez F, Bates SE, Castanys S, Gamarro F, Di Pietro A, Pérez-Victoria JM.

Cancer Res. 2005 Jun 1;65(11):4852-60.

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