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Items: 1 to 50 of 68

1.

Peripheral Blood Gene Expression Signatures of Eosinophilic Chronic Obstructive Pulmonary Disease.

Yun JH, Chase R, Parker MM, Saferali A, Castaldi PJ, Silverman EK, Hersh CP.

Am J Respir Cell Mol Biol. 2019 Sep;61(3):398-401. doi: 10.1165/rcmb.2019-0112LE. No abstract available.

PMID:
31469299
2.

Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts.

Parker MM, Hao Y, Guo F, Pham B, Chase R, Platig J, Cho MH, Hersh CP, Thannickal VJ, Crapo J, Washko G, Randell SH, Silverman EK, San José Estépar R, Zhou X, Castaldi PJ.

Elife. 2019 Jul 25;8. pii: e42720. doi: 10.7554/eLife.42720.

3.

Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene.

Saferali A, Yun JH, Parker MM, Sakornsakolpat P, Chase RP, Lamb A, Hobbs BD, Boezen MH, Dai X, de Jong K, Beaty TH, Wei W, Zhou X, Silverman EK, Cho MH, Castaldi PJ, Hersh CP; COPDGene Investigators; International COPD Genetics Consortium Investigators.

PLoS Genet. 2019 Jul 3;15(7):e1008229. doi: 10.1371/journal.pgen.1008229. eCollection 2019 Jul.

4.

Unsupervised discovery of phenotype-specific multi-omics networks.

Shi WJ, Zhuang Y, Russell PH, Hobbs BD, Parker MM, Castaldi PJ, Rudra P, Vestal B, Hersh CP, Saba LM, Kechris K.

Bioinformatics. 2019 Nov 1;35(21):4336-4343. doi: 10.1093/bioinformatics/btz226.

PMID:
30957844
5.

Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene.

Ragland MF, Benway CJ, Lutz SM, Bowler RP, Hecker J, Hokanson JE, Crapo JD, Castaldi PJ, DeMeo DL, Hersh CP, Hobbs BD, Lange C, Beaty TH, Cho MH, Silverman EK.

Am J Respir Crit Care Med. 2019 Sep 15;200(6):677-690. doi: 10.1164/rccm.201808-1455SO.

PMID:
30908940
6.

Omics and the Search for Blood Biomarkers in Chronic Obstructive Pulmonary Disease. Insights from COPDGene.

Regan EA, Hersh CP, Castaldi PJ, DeMeo DL, Silverman EK, Crapo JD, Bowler RP.

Am J Respir Cell Mol Biol. 2019 Aug;61(2):143-149. doi: 10.1165/rcmb.2018-0245PS.

PMID:
30874442
7.

Assessing pleiotropy and mediation in genetic loci associated with chronic obstructive pulmonary disease.

Parker MM, Lutz SM, Hobbs BD, Busch R, McDonald MN, Castaldi PJ, Beaty TH, Hokanson JE, Silverman EK, Cho MH.

Genet Epidemiol. 2019 Apr;43(3):318-329. doi: 10.1002/gepi.22192. Epub 2019 Feb 11.

PMID:
30740764
8.

New Spirometry Indices for Detecting Mild Airflow Obstruction.

Bhatt SP, Bhakta NR, Wilson CG, Cooper CB, Barjaktarevic I, Bodduluri S, Kim YI, Eberlein M, Woodruff PG, Sciurba FC, Castaldi PJ, Han MK, Dransfield MT, Nakhmani A.

Sci Rep. 2018 Nov 30;8(1):17484. doi: 10.1038/s41598-018-35930-2.

9.

Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.

Wells JM, Parker MM, Oster RA, Bowler RP, Dransfield MT, Bhatt SP, Cho MH, Kim V, Curtis JL, Martinez FJ, Paine R 3rd, O'Neal W, Labaki WW, Kaner RJ, Barjaktarevic I, Han MK, Silverman EK, Crapo JD, Barr RG, Woodruff P, Castaldi PJ, Gaggar A, Investigators TSAC.

JCI Insight. 2018 Nov 15;3(22). pii: 123614. doi: 10.1172/jci.insight.123614.

10.

Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution.

Boueiz A, Pham B, Chase R, Lamb A, Lee S, Naing ZZC, Cho MH, Parker MM, Sakornsakolpat P, Hersh CP, Crapo JD, Stergachis AB, Tal-Singer R, DeMeo DL, Silverman EK, Zhou X, Castaldi PJ; COPDGene investigators, by Core Units:, ECLIPSE Investigators:, GenKOLS Investigators:.

Am J Respir Cell Mol Biol. 2019 Apr;60(4):388-398. doi: 10.1165/rcmb.2018-0110OC.

PMID:
30335480
11.

Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke.

Glass K, Thibault D, Guo F, Mitchel JA, Pham B, Qiu W, Li Y, Jiang Z, Castaldi PJ, Silverman EK, Raby B, Park JA, Yuan GC, Zhou X.

Sci Rep. 2018 Aug 24;8(1):12750. doi: 10.1038/s41598-018-30781-3.

12.

Identification of Functional Variants in the FAM13A Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Locus by Massively Parallel Reporter Assays.

Castaldi PJ, Guo F, Qiao D, Du F, Naing ZZC, Li Y, Pham B, Mikkelsen TS, Cho MH, Silverman EK, Zhou X.

Am J Respir Crit Care Med. 2019 Jan 1;199(1):52-61. doi: 10.1164/rccm.201802-0337OC.

PMID:
30079747
13.

Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study.

Kinney GL, Santorico SA, Young KA, Cho MH, Castaldi PJ, San José Estépar R, Ross JC, Dy JG, Make BJ, Regan EA, Lynch DA, Everett DC, Lutz SM, Silverman EK, Washko GR, Crapo JD, Hokanson JE; COPDGene Investigators.

Am J Epidemiol. 2018 Oct 1;187(10):2109-2116. doi: 10.1093/aje/kwy087.

14.

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease.

Yun JH, Lamb A, Chase R, Singh D, Parker MM, Saferali A, Vestbo J, Tal-Singer R, Castaldi PJ, Silverman EK, Hersh CP; COPDGene and ECLIPSE Investigators.

J Allergy Clin Immunol. 2018 Jun;141(6):2037-2047.e10. doi: 10.1016/j.jaci.2018.04.010. Epub 2018 Apr 28.

15.

Longitudinal Modeling of Lung Function Trajectories in Smokers with and without Chronic Obstructive Pulmonary Disease.

Ross JC, Castaldi PJ, Cho MH, Hersh CP, Rahaghi FN, Sánchez-Ferrero GV, Parker MM, Litonjua AA, Sparrow D, Dy JG, Silverman EK, Washko GR, San José Estépar R.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):1033-1042. doi: 10.1164/rccm.201707-1405OC.

16.

Integrative genomics identifies new genes associated with severe COPD and emphysema.

Sakornsakolpat P, Morrow JD, Castaldi PJ, Hersh CP, Bossé Y, Silverman EK, Manichaikul A, Cho MH.

Respir Res. 2018 Mar 22;19(1):46. doi: 10.1186/s12931-018-0744-9.

17.

Systemic Markers of Adaptive and Innate Immunity Are Associated with Chronic Obstructive Pulmonary Disease Severity and Spirometric Disease Progression.

Halper-Stromberg E, Yun JH, Parker MM, Singer RT, Gaggar A, Silverman EK, Leach S, Bowler RP, Castaldi PJ.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):500-509. doi: 10.1165/rcmb.2017-0373OC.

18.

The value of blood cytokines and chemokines in assessing COPD.

Bradford E, Jacobson S, Varasteh J, Comellas AP, Woodruff P, O'Neal W, DeMeo DL, Li X, Kim V, Cho M, Castaldi PJ, Hersh C, Silverman EK, Crapo JD, Kechris K, Bowler RP.

Respir Res. 2017 Oct 24;18(1):180. doi: 10.1186/s12931-017-0662-2.

19.

RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking.

Parker MM, Chase RP, Lamb A, Reyes A, Saferali A, Yun JH, Himes BE, Silverman EK, Hersh CP, Castaldi PJ.

BMC Med Genomics. 2017 Oct 6;10(1):58. doi: 10.1186/s12920-017-0295-9.

20.

Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression.

Boueiz A, Chang Y, Cho MH, Washko GR, San José Estépar R, Bowler RP, Crapo JD, DeMeo DL, Dy JG, Silverman EK, Castaldi PJ; COPDGene Investigators.

Chest. 2018 Jan;153(1):65-76. doi: 10.1016/j.chest.2017.09.022. Epub 2017 Sep 21.

21.

Subtyping Chronic Obstructive Pulmonary Disease Using Peripheral Blood Proteomics.

Zarei S, Mirtar A, Morrow JD, Castaldi PJ, Belloni P, Hersh CP.

Chronic Obstr Pulm Dis. 2017 Feb 8;4(2):97-108. doi: 10.15326/jcopdf.4.2.2016.0147.

22.

Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts.

Castaldi PJ, Benet M, Petersen H, Rafaels N, Finigan J, Paoletti M, Marike Boezen H, Vonk JM, Bowler R, Pistolesi M, Puhan MA, Anto J, Wauters E, Lambrechts D, Janssens W, Bigazzi F, Camiciottoli G, Cho MH, Hersh CP, Barnes K, Rennard S, Boorgula MP, Dy J, Hansel NN, Crapo JD, Tesfaigzi Y, Agusti A, Silverman EK, Garcia-Aymerich J.

Thorax. 2017 Nov;72(11):998-1006. doi: 10.1136/thoraxjnl-2016-209846. Epub 2017 Jun 21.

23.

Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease.

Obeidat M, Nie Y, Chen V, Shannon CP, Andiappan AK, Lee B, Rotzschke O, Castaldi PJ, Hersh CP, Fishbane N, Ng RT, McManus B, Miller BE, Rennard S, Paré PD, Sin DD.

Respir Res. 2017 Apr 24;18(1):72. doi: 10.1186/s12931-017-0558-1.

24.

Screening for interaction effects in gene expression data.

Castaldi PJ, Cho MH, Liang L, Silverman EK, Hersh CP, Rice K, Aschard H.

PLoS One. 2017 Mar 16;12(3):e0173847. doi: 10.1371/journal.pone.0173847. eCollection 2017.

25.

Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects.

Busch R, Hobbs BD, Zhou J, Castaldi PJ, McGeachie MJ, Hardin ME, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Agusti A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Tal-Singer R, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Paré PD, Levy RD, Rennard SI, Beaty TH, Hokanson J, Silverman EK, Cho MH; National Emphysema Treatment Trial Genetics; Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points; International COPD Genetics Network; COPDGene Investigators.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):35-46. doi: 10.1165/rcmb.2016-0331OC.

26.

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, Wain LV, Hall IP, Jackson VE, Wyss AB, London SJ, North KE, Franceschini N, Strachan DP, Beaty TH, Hokanson JE, Crapo JD, Castaldi PJ, Chase RP, Bartz TM, Heckbert SR, Psaty BM, Gharib SA, Zanen P, Lammers JW, Oudkerk M, Groen HJ, Locantore N, Tal-Singer R, Rennard SI, Vestbo J, Timens W, Paré PD, Latourelle JC, Dupuis J, O'Connor GT, Wilk JB, Kim WJ, Lee MK, Oh YM, Vonk JM, de Koning HJ, Leng S, Belinsky SA, Tesfaigzi Y, Manichaikul A, Wang XQ, Rich SS, Barr RG, Sparrow D, Litonjua AA, Bakke P, Gulsvik A, Lahousse L, Brusselle GG, Stricker BH, Uitterlinden AG, Ampleford EJ, Bleecker ER, Woodruff PG, Meyers DA, Qiao D, Lomas DA, Yim JJ, Kim DK, Hawrylkiewicz I, Sliwinski P, Hardin M, Fingerlin TE, Schwartz DA, Postma DS, MacNee W, Tobin MD, Silverman EK, Boezen HM, Cho MH; COPDGene Investigators; ECLIPSE Investigators; LifeLines Investigators; SPIROMICS Research Group; International COPD Genetics Network Investigators; UK BiLEVE Investigators; International COPD Genetics Consortium.

Nat Genet. 2017 Mar;49(3):426-432. doi: 10.1038/ng.3752. Epub 2017 Feb 6.

27.

A Bayesian Nonparametric Model for Disease Subtyping: Application to Emphysema Phenotypes.

Ross JC, Castaldi PJ, Cho MH, Chen J, Chang Y, Dy JG, Silverman EK, Washko GR, Jose Estepar RS.

IEEE Trans Med Imaging. 2017 Jan;36(1):343-354. doi: 10.1109/TMI.2016.2608782.

28.

Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.

McDonald MN, Won S, Mattheisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip WK, Rennard SI, Lomas DA, Wouters EFM, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK.

J Cachexia Sarcopenia Muscle. 2017 Jun;8(3):428-436. doi: 10.1002/jcsm.12171. Epub 2017 Jan 2.

29.

Whole genome prediction and heritability of childhood asthma phenotypes.

McGeachie MJ, Clemmer GL, Croteau-Chonka DC, Castaldi PJ, Cho MH, Sordillo JE, Lasky-Su JA, Raby BA, Tantisira KG, Weiss ST.

Immun Inflamm Dis. 2016 Nov 28;4(4):487-496. eCollection 2016 Dec.

30.

Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.

Hardin M, Cho MH, Sharma S, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O'Connor GT, Dupuis J, Hokanson J, Crapo JD, Beaty TH, Laird N, Silverman EK, DeMeo DL; COPDGene and Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points Investigators.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):332-341. doi: 10.1165/rcmb.2016-0172OC.

31.

Visual Assessment of Chest Computed Tomographic Images Is Independently Useful for Genetic Association Analysis in Studies of Chronic Obstructive Pulmonary Disease.

Halper-Stromberg E, Cho MH, Wilson C, Nevrekar D, Crapo JD, Washko G, Estépar RS, Lynch DA, Silverman EK, Leach S, Castaldi PJ.

Ann Am Thorac Soc. 2017 Jan;14(1):33-40. doi: 10.1513/AnnalsATS.201606-427OC.

32.

Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.

Boueiz A, Lutz SM, Cho MH, Hersh CP, Bowler RP, Washko GR, Halper-Stromberg E, Bakke P, Gulsvik A, Laird NM, Beaty TH, Coxson HO, Crapo JD, Silverman EK, Castaldi PJ, DeMeo DL; COPDGene and ECLIPSE Investigators.

Am J Respir Crit Care Med. 2017 Mar 15;195(6):757-771. doi: 10.1164/rccm.201605-0997OC.

33.

Bipartite Community Structure of eQTLs.

Platig J, Castaldi PJ, DeMeo D, Quackenbush J.

PLoS Comput Biol. 2016 Sep 12;12(9):e1005033. doi: 10.1371/journal.pcbi.1005033. eCollection 2016 Sep.

34.

A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria.

Dilektasli AG, Porszasz J, Casaburi R, Stringer WW, Bhatt SP, Pak Y, Rossiter HB, Washko G, Castaldi PJ, Estepar RSJ, Hansen JE; COPDGene investigators.

Chest. 2016 Nov;150(5):1080-1090. doi: 10.1016/j.chest.2016.06.047. Epub 2016 Jul 22.

35.

Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma.

McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Strunk RC, Weiss ST; CAMP Research Group.

Am J Respir Crit Care Med. 2016 Dec 15;194(12):1465-1474.

36.

Recognizing the Many Faces of Chronic Obstructive Pulmonary Disease.

Castaldi PJ, Vachani A.

Am J Respir Crit Care Med. 2016 Jun 1;193(11):1190-2. doi: 10.1164/rccm.201601-0125ED. No abstract available.

37.

Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma.

McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Weiss ST, Strunk RC.

N Engl J Med. 2016 May 12;374(19):1842-1852. doi: 10.1056/NEJMoa1513737.

38.

A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.

Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X.

Am J Respir Crit Care Med. 2016 Jul 15;194(2):185-97. doi: 10.1164/rccm.201505-0999OC.

39.

Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease.

Hobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Castaldi PJ, Hersh CP, Morrow J, Celli BR, Pinto-Plata VM, Criner GJ, Marchetti N, Bueno R, Agustí A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Zhou X, Laird NM, Lin X, Beaty TH, Silverman EK, Cho MH; NETT Genetics Investigators; ECLIPSE Investigators; COPDGene Investigators; International COPD Genetics Network Investigators.

Am J Respir Crit Care Med. 2016 Jul 1;194(1):48-57. doi: 10.1164/rccm.201510-2053OC.

40.

A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK; ECLIPSE Investigators; COPDGene Investigators.

BMC Genet. 2015 Dec 3;16:138. doi: 10.1186/s12863-015-0299-4.

42.

A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes.

Cho MH, Castaldi PJ, Hersh CP, Hobbs BD, Barr RG, Tal-Singer R, Bakke P, Gulsvik A, San José Estépar R, Van Beek EJ, Coxson HO, Lynch DA, Washko GR, Laird NM, Crapo JD, Beaty TH, Silverman EK; NETT Genetics, ECLIPSE, and COPDGene Investigators.

Am J Respir Crit Care Med. 2015 Sep 1;192(5):559-69. doi: 10.1164/rccm.201501-0148OC.

43.

External validation of new risk prediction models is infrequent and reveals worse prognostic discrimination.

Siontis GC, Tzoulaki I, Castaldi PJ, Ioannidis JP.

J Clin Epidemiol. 2015 Jan;68(1):25-34. doi: 10.1016/j.jclinepi.2014.09.007. Epub 2014 Oct 23.

PMID:
25441703
44.

Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.

Hersh CP, Make BJ, Lynch DA, Barr RG, Bowler RP, Calverley PM, Castaldi PJ, Cho MH, Coxson HO, DeMeo DL, Foreman MG, Han MK, Harshfield BJ, Hokanson JE, Lutz S, Ramsdell JW, Regan EA, Rennard SI, Schroeder JD, Sciurba FC, Steiner RM, Tal-Singer R, van Beek E Jr, Silverman EK, Crapo JD; COPDGene and ECLIPSE Investigators.

BMC Pulm Med. 2014 Oct 24;14:164. doi: 10.1186/1471-2466-14-164.

45.

Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci.

Castaldi PJ, Cho MH, Zhou X, Qiu W, Mcgeachie M, Celli B, Bakke P, Gulsvik A, Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-Singer R, Riley JH, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh CP.

Hum Mol Genet. 2015 Feb 15;24(4):1200-10. doi: 10.1093/hmg/ddu525. Epub 2014 Oct 14.

46.

Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease.

Hobbs BD, Foreman MG, Bowler R, Jacobson F, Make BJ, Castaldi PJ, San José Estépar R, Silverman EK, Hersh CP; COPDGene Investigators.

Ann Am Thorac Soc. 2014 Nov;11(9):1387-94. doi: 10.1513/AnnalsATS.201405-224OC.

47.

Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene.

Lee JH, Cho MH, McDonald ML, Hersh CP, Castaldi PJ, Crapo JD, Wan ES, Dy JG, Chang Y, Regan EA, Hardin M, DeMeo DL, Silverman EK; COPDGene Investigators.

Respir Med. 2014 Oct;108(10):1469-80. doi: 10.1016/j.rmed.2014.07.018. Epub 2014 Aug 11.

48.

DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.

Lee JH, McDonald ML, Cho MH, Wan ES, Castaldi PJ, Hunninghake GM, Marchetti N, Lynch DA, Crapo JD, Lomas DA, Coxson HO, Bakke PS, Silverman EK, Hersh CP; COPDGene and ECLIPSE Investigators.

Respir Res. 2014 Aug 20;15:97. doi: 10.1186/s12931-014-0097-y.

49.

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.

Wan ES, Castaldi PJ, Cho MH, Hokanson JE, Regan EA, Make BJ, Beaty TH, Han MK, Curtis JL, Curran-Everett D, Lynch DA, DeMeo DL, Crapo JD, Silverman EK; COPDGene Investigators.

Respir Res. 2014 Aug 6;15:89. doi: 10.1186/s12931-014-0089-y.

50.

Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.

Castaldi PJ, Cho MH, San José Estépar R, McDonald ML, Laird N, Beaty TH, Washko G, Crapo JD, Silverman EK; COPDGene Investigators.

Am J Respir Crit Care Med. 2014 Aug 15;190(4):399-409. doi: 10.1164/rccm.201403-0569OC.

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