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Items: 1 to 50 of 131

1.

Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration.

Reggio A, Rosina M, Krahmer N, Palma A, Petrilli LL, Maiolatesi G, Massacci G, Salvatori I, Valle C, Testa S, Gargioli C, Fuoco C, Castagnoli L, Cesareni G, Sacco F.

Life Sci Alliance. 2020 Feb 4;3(3). pii: e202000646. doi: 10.26508/lsa.202000660. Print 2020 Mar.

2.

Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family.

Mattioni A, Boldt K, Auciello G, Komada M, Rappoport JZ, Ueffing M, Castagnoli L, Cesareni G, Santonico E.

FEBS J. 2020 Jan 27. doi: 10.1111/febs.15226. [Epub ahead of print]

PMID:
31985874
3.

Erratum: Nepravishta, R., et al. CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1. Biomolecules 2019, 9, 284.

Nepravishta R, Ferrentino F, Mandaliti W, Mattioni A, Weber J, Polo S, Castagnoli L, Cesareni G, Paci M, Santonico E.

Biomolecules. 2019 Nov 28;9(12). pii: E803. doi: 10.3390/biom9120803.

4.

SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update.

Licata L, Lo Surdo P, Iannuccelli M, Palma A, Micarelli E, Perfetto L, Peluso D, Calderone A, Castagnoli L, Cesareni G.

Nucleic Acids Res. 2020 Jan 8;48(D1):D504-D510. doi: 10.1093/nar/gkz949.

PMID:
31665520
5.

Myo-REG: A Portal for Signaling Interactions in Muscle Regeneration.

Palma A, Cerquone Perpetuini A, Ferrentino F, Fuoco C, Gargioli C, Giuliani G, Iannuccelli M, Licata L, Micarelli E, Paoluzi S, Perfetto L, Petrilli LL, Reggio A, Rosina M, Sacco F, Vumbaca S, Zuccotti A, Castagnoli L, Cesareni G.

Front Physiol. 2019 Sep 27;10:1216. doi: 10.3389/fphys.2019.01216. eCollection 2019.

6.

CancerGeneNet: linking driver genes to cancer hallmarks.

Iannuccelli M, Micarelli E, Surdo PL, Palma A, Perfetto L, Rozzo I, Castagnoli L, Licata L, Cesareni G.

Nucleic Acids Res. 2020 Jan 8;48(D1):D416-D421. doi: 10.1093/nar/gkz871.

7.

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment.

Koschorke A, Faraci S, Giani D, Chiodoni C, Iorio E, Canese R, Colombo MP, Lamolinara A, Iezzi M, Ladomery M, Vernieri C, de Braud F, Di Nicola M, Tagliabue E, Castagnoli L, Pupa SM.

Cell Oncol (Dordr). 2019 Dec;42(6):815-828. doi: 10.1007/s13402-019-00464-w. Epub 2019 Aug 2.

PMID:
31376137
8.

CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1.

Nepravishta R, Ferrentino F, Mandaliti W, Mattioni A, Weber J, Polo S, Castagnoli L, Cesareni G, Paci M, Santonico E.

Biomolecules. 2019 Jul 17;9(7). pii: E284. doi: 10.3390/biom9070284. Erratum in: Biomolecules. 2019 Nov 28;9(12):.

9.

The d16HER2 Splice Variant: A Friend or Foe of HER2-Positive Cancers?

Castagnoli L, Ladomery M, Tagliabue E, Pupa SM.

Cancers (Basel). 2019 Jun 28;11(7). pii: E902. doi: 10.3390/cancers11070902. Review.

10.

Metformin Delays Satellite Cell Activation and Maintains Quiescence.

Pavlidou T, Marinkovic M, Rosina M, Fuoco C, Vumbaca S, Gargioli C, Castagnoli L, Cesareni G.

Stem Cells Int. 2019 Apr 24;2019:5980465. doi: 10.1155/2019/5980465. eCollection 2019.

11.

Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis.

Marinkovic M, Fuoco C, Sacco F, Cerquone Perpetuini A, Giuliani G, Micarelli E, Pavlidou T, Petrilli LL, Reggio A, Riccio F, Spada F, Vumbaca S, Zuccotti A, Castagnoli L, Mann M, Gargioli C, Cesareni G.

Life Sci Alliance. 2019 Jun 25;2(3). pii: e201900437. doi: 10.26508/lsa.201900437. Print 2019 Jun.

12.

Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response.

Rosina M, Langone F, Giuliani G, Cerquone Perpetuini A, Reggio A, Calderone A, Fuoco C, Castagnoli L, Gargioli C, Cesareni G.

Sci Rep. 2019 Apr 1;9(1):5447. doi: 10.1038/s41598-019-41926-3.

13.

The immunosuppressant drug azathioprine restrains adipogenesis of muscle Fibro/Adipogenic Progenitors from dystrophic mice by affecting AKT signaling.

Reggio A, Spada F, Rosina M, Massacci G, Zuccotti A, Fuoco C, Gargioli C, Castagnoli L, Cesareni G.

Sci Rep. 2019 Mar 13;9(1):4360. doi: 10.1038/s41598-019-39538-y.

14.

CUBAN, a Case Study of Selective Binding: Structural Details of the Discrimination between Ubiquitin and NEDD8.

Santonico E, Nepravishta R, Mandaliti W, Castagnoli L, Cesareni G, Paci M.

Int J Mol Sci. 2019 Mar 8;20(5). pii: E1185. doi: 10.3390/ijms20051185.

15.

The landscape of d16HER2 splice variant expression across HER2-positive cancers.

Volpi CC, Pietrantonio F, Gloghini A, Fucà G, Giordano S, Corso S, Pruneri G, Antista M, Cremolini C, Fasano E, Saggio S, Faraci S, Di Bartolomeo M, de Braud F, Di Nicola M, Tagliabue E, Pupa SM, Castagnoli L.

Sci Rep. 2019 Mar 5;9(1):3545. doi: 10.1038/s41598-019-40310-5.

16.

WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer.

Castagnoli L, Cancila V, Cordoba-Romero SL, Faraci S, Talarico G, Belmonte B, Iorio MV, Milani M, Volpari T, Chiodoni C, Hidalgo-Miranda A, Tagliabue E, Tripodo C, Sangaletti S, Di Nicola M, Pupa SM.

Oncogene. 2019 May;38(21):4047-4060. doi: 10.1038/s41388-019-0700-2. Epub 2019 Jan 31.

17.

Selectivity of the CUBAN domain in the recognition of ubiquitin and NEDD8.

Castagnoli L, Mandaliti W, Nepravishta R, Valentini E, Mattioni A, Procopio R, Iannuccelli M, Polo S, Paci M, Cesareni G, Santonico E.

FEBS J. 2019 Feb;286(4):653-677. doi: 10.1111/febs.14752. Epub 2019 Feb 5.

18.

Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs).

Vernieri C, Pusceddu S, Fucà G, Indelicato P, Centonze G, Castagnoli L, Ferrari E, Ajazi A, Pupa S, Casola S, Foiani M, Mazzaferro V, Pruneri G, Milione M, de Braud F.

Int J Cancer. 2019 Apr 1;144(7):1704-1712. doi: 10.1002/ijc.32042. Epub 2019 Jan 7.

PMID:
30520016
19.

Innovative therapy, monoclonal antibodies, and beyond: Highlights from the eighth annual meeting.

De Santis F, Del Vecchio M, Castagnoli L, De Braud F, Di Cosimo S, Franceschini D, Fucà G, Hiscott J, Malmberg KJ, McGranahan N, Pietrantonio F, Rivoltini L, Sangaletti S, Tagliabue E, Tripodo C, Vernieri C, Zitvogel L, Pupa SM, Di Nicola M.

Cytokine Growth Factor Rev. 2018 Dec;44:1-10. doi: 10.1016/j.cytogfr.2018.10.005. Epub 2018 Oct 30.

PMID:
30393044
20.

Intratumor lactate levels reflect HER2 addiction status in HER2-positive breast cancer.

Castagnoli L, Iorio E, Dugo M, Koschorke A, Faraci S, Canese R, Casalini P, Nanni P, Vernieri C, Di Nicola M, Morelli D, Tagliabue E, Pupa SM.

J Cell Physiol. 2019 Feb;234(2):1768-1779. doi: 10.1002/jcp.27049. Epub 2018 Aug 21.

21.

Group I Paks support muscle regeneration and counteract cancer-associated muscle atrophy.

Cerquone Perpetuini A, Re Cecconi AD, Chiappa M, Martinelli GB, Fuoco C, Desiderio G, Castagnoli L, Gargioli C, Piccirillo R, Cesareni G.

J Cachexia Sarcopenia Muscle. 2018 Aug;9(4):727-746. doi: 10.1002/jcsm.12303. Epub 2018 May 21.

22.

c-MYC G-quadruplex binding by the RNA polymerase I inhibitor BMH-21 and analogues revealed by a combined NMR and biochemical Approach.

Musso L, Mazzini S, Rossini A, Castagnoli L, Scaglioni L, Artali R, Di Nicola M, Zunino F, Dallavalle S.

Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):615-629. doi: 10.1016/j.bbagen.2017.12.002. Epub 2017 Dec 8.

PMID:
29229300
23.

Biomarkers of Primary Resistance to Trastuzumab in HER2-Positive Metastatic Gastric Cancer Patients: the AMNESIA Case-Control Study.

Pietrantonio F, Fucà G, Morano F, Gloghini A, Corso S, Aprile G, Perrone F, De Vita F, Tamborini E, Tomasello G, Gualeni AV, Ongaro E, Busico A, Giommoni E, Volpi CC, Laterza MM, Corallo S, Prisciandaro M, Antista M, Pellegrinelli A, Castagnoli L, Pupa SM, Pruneri G, de Braud F, Giordano S, Cremolini C, Di Bartolomeo M.

Clin Cancer Res. 2018 Mar 1;24(5):1082-1089. doi: 10.1158/1078-0432.CCR-17-2781. Epub 2017 Dec 5.

24.

DISNOR: a disease network open resource.

Lo Surdo P, Calderone A, Iannuccelli M, Licata L, Peluso D, Castagnoli L, Cesareni G, Perfetto L.

Nucleic Acids Res. 2018 Jan 4;46(D1):D527-D534. doi: 10.1093/nar/gkx876.

25.

Regulation of myoblast differentiation by metabolic perturbations induced by metformin.

Pavlidou T, Rosina M, Fuoco C, Gerini G, Gargioli C, Castagnoli L, Cesareni G.

PLoS One. 2017 Aug 31;12(8):e0182475. doi: 10.1371/journal.pone.0182475. eCollection 2017.

26.

Microfluidic-enhanced 3D bioprinting of aligned myoblast-laden hydrogels leads to functionally organized myofibers in vitro and in vivo.

Costantini M, Testa S, Mozetic P, Barbetta A, Fuoco C, Fornetti E, Tamiro F, Bernardini S, Jaroszewicz J, Święszkowski W, Trombetta M, Castagnoli L, Seliktar D, Garstecki P, Cesareni G, Cannata S, Rainer A, Gargioli C.

Biomaterials. 2017 Jul;131:98-110. doi: 10.1016/j.biomaterials.2017.03.026. Epub 2017 Mar 23.

27.

Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases.

Palma A, Tinti M, Paoluzi S, Santonico E, Brandt BW, Hooft van Huijsduijnen R, Masch A, Heringa J, Schutkowski M, Castagnoli L, Cesareni G.

J Biol Chem. 2017 Mar 24;292(12):4942-4952. doi: 10.1074/jbc.M116.757518. Epub 2017 Feb 3.

28.

The cell-autonomous mechanisms underlying the activity of metformin as an anticancer drug.

Sacco F, Calderone A, Castagnoli L, Cesareni G.

Br J Cancer. 2016 Dec 6;115(12):1451-1456. doi: 10.1038/bjc.2016.385. Epub 2016 Nov 22. Review.

29.

Pathobiological implications of the d16HER2 splice variant for stemness and aggressiveness of HER2-positive breast cancer.

Castagnoli L, Ghedini GC, Koschorke A, Triulzi T, Dugo M, Gasparini P, Casalini P, Palladini A, Iezzi M, Lamolinara A, Lollini PL, Nanni P, Chiodoni C, Tagliabue E, Pupa SM.

Oncogene. 2017 Mar 23;36(12):1721-1732. doi: 10.1038/onc.2016.338. Epub 2016 Sep 19.

30.

A subset of RAB proteins modulates PP2A phosphatase activity.

Sacco F, Mattioni A, Boldt K, Panni S, Santonico E, Castagnoli L, Ueffing M, Cesareni G.

Sci Rep. 2016 Sep 9;6:32857. doi: 10.1038/srep32857.

31.

Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State.

Sacco F, Silvestri A, Posca D, Pirrò S, Gherardini PF, Castagnoli L, Mann M, Cesareni G.

Cell Syst. 2016 Mar 23;2(3):159-71. doi: 10.1016/j.cels.2016.02.005. Epub 2016 Mar 3.

32.

Characterization by mass cytometry of different methods for the preparation of muscle mononuclear cells.

Spada F, Fuoco C, Pirrò S, Paoluzi S, Castagnoli L, Gargioli C, Cesareni G.

N Biotechnol. 2016 Sep 25;33(5 Pt A):514-23. doi: 10.1016/j.nbt.2015.12.007. Epub 2016 Jan 7.

33.

SIGNOR: a database of causal relationships between biological entities.

Perfetto L, Briganti L, Calderone A, Cerquone Perpetuini A, Iannuccelli M, Langone F, Licata L, Marinkovic M, Mattioni A, Pavlidou T, Peluso D, Petrilli LL, Pirrò S, Posca D, Santonico E, Silvestri A, Spada F, Castagnoli L, Cesareni G.

Nucleic Acids Res. 2016 Jan 4;44(D1):D548-54. doi: 10.1093/nar/gkv1048. Epub 2015 Oct 13.

34.

Alterations in the phosphoproteomic profile of cells expressing a non-functional form of the SHP2 phosphatase.

Corallino S, Iwai LK, Payne LS, Huang PH, Sacco F, Cesareni G, Castagnoli L.

N Biotechnol. 2016 Sep 25;33(5 Pt A):524-36. doi: 10.1016/j.nbt.2015.08.002. Epub 2015 Aug 24.

PMID:
26316256
35.

Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions.

Silvestri A, Palumbo F, Rasi I, Posca D, Pavlidou T, Paoluzi S, Castagnoli L, Cesareni G.

PLoS One. 2015 Aug 20;10(8):e0136250. doi: 10.1371/journal.pone.0136250. eCollection 2015.

36.

HSPH1 inhibition downregulates Bcl-6 and c-Myc and hampers the growth of human aggressive B-cell non-Hodgkin lymphoma.

Zappasodi R, Ruggiero G, Guarnotta C, Tortoreto M, Tringali C, Cavanè A, Cabras AD, Castagnoli L, Venerando B, Zaffaroni N, Gianni AM, De Braud F, Tripodo C, Pupa SM, Di Nicola M.

Blood. 2015 Mar 12;125(11):1768-71. doi: 10.1182/blood-2014-07-590034. Epub 2015 Jan 8.

PMID:
25573990
37.

Metformin protects skeletal muscle from cardiotoxin induced degeneration.

Langone F, Cannata S, Fuoco C, Lettieri Barbato D, Testa S, Nardozza AP, Ciriolo MR, Castagnoli L, Gargioli C, Cesareni G.

PLoS One. 2014 Dec 2;9(12):e114018. doi: 10.1371/journal.pone.0114018. eCollection 2014.

38.

The adapter protein CD2AP binds to p53 protein in the cytoplasm and can discriminate its polymorphic variants P72R.

Panni S, Salvioli S, Santonico E, Langone F, Storino F, Altilia S, Franceschi C, Cesareni G, Castagnoli L.

J Biochem. 2015 Feb;157(2):101-11. doi: 10.1093/jb/mvu059. Epub 2014 Sep 26.

PMID:
25261582
39.

RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch.

Santonico E, Mattioni A, Panni S, Belleudi F, Mattei M, Torrisi MR, Cesareni G, Castagnoli L.

Oncogene. 2015 Jun;34(26):3377-90. doi: 10.1038/onc.2014.256. Epub 2014 Sep 8.

PMID:
25195858
40.

Activated d16HER2 homodimers and SRC kinase mediate optimal efficacy for trastuzumab.

Castagnoli L, Iezzi M, Ghedini GC, Ciravolo V, Marzano G, Lamolinara A, Zappasodi R, Gasparini P, Campiglio M, Amici A, Chiodoni C, Palladini A, Lollini PL, Triulzi T, Menard S, Nanni P, Tagliabue E, Pupa SM.

Cancer Res. 2014 Nov 1;74(21):6248-59. doi: 10.1158/0008-5472.CAN-14-0983. Epub 2014 Aug 27.

41.

Combining affinity proteomics and network context to identify new phosphatase substrates and adapters in growth pathways.

Sacco F, Boldt K, Calderone A, Panni S, Paoluzi S, Castagnoli L, Ueffing M, Cesareni G.

Front Genet. 2014 May 7;5:115. doi: 10.3389/fgene.2014.00115. eCollection 2014.

42.

Low body weight in females is a risk factor for increased tenofovir exposure and drug-related adverse events.

Gervasoni C, Meraviglia P, Landonio S, Baldelli S, Fucile S, Castagnoli L, Clementi E, Riva A, Galli M, Rizzardini G, Cattaneo D.

PLoS One. 2013 Dec 2;8(12):e80242. doi: 10.1371/journal.pone.0080242. eCollection 2013.

43.

mentha: a resource for browsing integrated protein-interaction networks.

Calderone A, Castagnoli L, Cesareni G.

Nat Methods. 2013 Aug;10(8):690-1. doi: 10.1038/nmeth.2561. No abstract available.

PMID:
23900247
44.

The SH2 domain interaction landscape.

Tinti M, Kiemer L, Costa S, Miller ML, Sacco F, Olsen JV, Carducci M, Paoluzi S, Langone F, Workman CT, Blom N, Machida K, Thompson CM, Schutkowski M, Brunak S, Mann M, Mayer BJ, Castagnoli L, Cesareni G.

Cell Rep. 2013 Apr 25;3(4):1293-305. doi: 10.1016/j.celrep.2013.03.001. Epub 2013 Mar 28.

45.

Mapping the human phosphatome on growth pathways.

Sacco F, Gherardini PF, Paoluzi S, Saez-Rodriguez J, Helmer-Citterich M, Ragnini-Wilson A, Castagnoli L, Cesareni G.

Mol Syst Biol. 2012;8:603. doi: 10.1038/msb.2012.36.

46.

HuPho: the human phosphatase portal.

Liberti S, Sacco F, Calderone A, Perfetto L, Iannuccelli M, Panni S, Santonico E, Palma A, Nardozza AP, Castagnoli L, Cesareni G.

FEBS J. 2013 Jan;280(2):379-87. doi: 10.1111/j.1742-4658.2012.08712.x. Epub 2012 Aug 24.

47.

Counteracting effects operating on Src homology 2 domain-containing protein-tyrosine phosphatase 2 (SHP2) function drive selection of the recurrent Y62D and Y63C substitutions in Noonan syndrome.

Martinelli S, Nardozza AP, Delle Vigne S, Sabetta G, Torreri P, Bocchinfuso G, Flex E, Venanzi S, Palleschi A, Gelb BD, Cesareni G, Stella L, Castagnoli L, Tartaglia M.

J Biol Chem. 2012 Aug 3;287(32):27066-77. doi: 10.1074/jbc.M112.350231. Epub 2012 Jun 18.

48.

The human phosphatase interactome: An intricate family portrait.

Sacco F, Perfetto L, Castagnoli L, Cesareni G.

FEBS Lett. 2012 Aug 14;586(17):2732-9. doi: 10.1016/j.febslet.2012.05.008. Epub 2012 May 21. Review.

49.

Reactive oxygen species and epidermal growth factor are antagonistic cues controlling SHP-2 dimerization.

Nardozza AP, D'Orazio M, Trapannone R, Corallino S, Filomeni G, Tartaglia M, Battistoni A, Cesareni G, Castagnoli L.

Mol Cell Biol. 2012 May;32(10):1998-2009. doi: 10.1128/MCB.06674-11. Epub 2012 Mar 12.

50.

The Protein-Protein Interaction tasks of BioCreative III: classification/ranking of articles and linking bio-ontology concepts to full text.

Krallinger M, Vazquez M, Leitner F, Salgado D, Chatr-Aryamontri A, Winter A, Perfetto L, Briganti L, Licata L, Iannuccelli M, Castagnoli L, Cesareni G, Tyers M, Schneider G, Rinaldi F, Leaman R, Gonzalez G, Matos S, Kim S, Wilbur WJ, Rocha L, Shatkay H, Tendulkar AV, Agarwal S, Liu F, Wang X, Rak R, Noto K, Elkan C, Lu Z, Dogan RI, Fontaine JF, Andrade-Navarro MA, Valencia A.

BMC Bioinformatics. 2011 Oct 3;12 Suppl 8:S3. doi: 10.1186/1471-2105-12-S8-S3.

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