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Items: 1 to 50 of 107

1.

Antihyperalgesic activity of quillaic acid obtained from Quillaja saponaria Mol.

Arrau S, Rodríguez-Díaz M, Cassels BK, Valenzuela-Barra G, Delporte C, Barriga A, Miranda HF.

Curr Top Med Chem. 2019 May 9. doi: 10.2174/1568026619666190509115741. [Epub ahead of print]

PMID:
31072292
2.

Aromatic Bromination Abolishes the Psychomotor Features and Pro-social Responses of MDMA ("Ecstasy") in Rats and Preserves Affinity for the Serotonin Transporter (SERT).

Sáez-Briones P, Castro-Castillo V, Díaz-Véliz G, Valladares L, Barra R, Hernández A, Cassels BK.

Front Pharmacol. 2019 Feb 28;10:157. doi: 10.3389/fphar.2019.00157. eCollection 2019.

3.

5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines.

Toro-Sazo M, Brea J, Loza MI, Cimadevila M, Cassels BK.

PLoS One. 2019 Jan 10;14(1):e0209804. doi: 10.1371/journal.pone.0209804. eCollection 2019.

4.

Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs.

Suárez-Rozas C, Simpson S, Fuentes-Retamal S, Catalán M, Ferreira J, Theoduloz C, Mella J, Cabezas D, Cassels BK, Yáñez C, Castro-Castillo V.

Toxicol In Vitro. 2019 Feb;54:375-390. doi: 10.1016/j.tiv.2018.10.014. Epub 2018 Oct 30.

PMID:
30389605
5.

Dark Classics in Chemical Neuroscience: Mescaline.

Cassels BK, Sáez-Briones P.

ACS Chem Neurosci. 2018 Oct 17;9(10):2448-2458. doi: 10.1021/acschemneuro.8b00215. Epub 2018 Jun 8.

PMID:
29847089
6.

Variation of the alkaloid content of Peumus boldus (boldo).

Fuentes-Barros G, Castro-Saavedra S, Liberona L, Acevedo-Fuentes W, Tirapegui C, Mattar C, Cassels BK.

Fitoterapia. 2018 Jun;127:179-185. doi: 10.1016/j.fitote.2018.02.020. Epub 2018 Feb 14.

PMID:
29454020
7.

Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors: a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia?

Herrera-Marschitz M, Perez-Lobos R, Lespay-Rebolledo C, Tapia-Bustos A, Casanova-Ortiz E, Morales P, Valdes JL, Bustamante D, Cassels BK.

Neurotox Res. 2018 Feb;33(2):461-473. doi: 10.1007/s12640-017-9795-9. Epub 2017 Aug 26. Review.

8.

Functional roles of T3.37 and S5.46 in the activation mechanism of the dopamine D1 receptor.

Hugo EA, Cassels BK, Fierro A.

J Mol Model. 2017 Apr;23(4):142. doi: 10.1007/s00894-017-3313-0. Epub 2017 Mar 31.

PMID:
28361444
9.

Neuroprotective Effect of a New 7,8-Dihydroxycoumarin-Based Fe2+/Cu2+ Chelator in Cell and Animal Models of Parkinson's Disease.

Aguirre P, García-Beltrán O, Tapia V, Muñoz Y, Cassels BK, Núñez MT.

ACS Chem Neurosci. 2017 Jan 18;8(1):178-185. doi: 10.1021/acschemneuro.6b00309. Epub 2016 Nov 16.

PMID:
27806193
10.

(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake.

Quintanilla ME, Rivera-Meza M, Berríos-Cárcamo P, Cassels BK, Herrera-Marschitz M, Israel Y.

Addict Biol. 2016 Nov;21(6):1063-1071. doi: 10.1111/adb.12268. Epub 2015 May 29.

PMID:
26032572
11.

Analysis of 25 C NBOMe in Seized Blotters by HPTLC and GC-MS.

Duffau B, Camargo C, Kogan M, Fuentes E, Cassels BK.

J Chromatogr Sci. 2016 Aug;54(7):1153-8. doi: 10.1093/chromsci/bmw095.

12.

Corrigendum to "The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death" [Biochem. Biophys. Res. Commun. 463 (4) (2015) 787-792].

Mena NP, García-Beltrán O, Lourido F, Urrutia PJ, Mena R, Castro-Castillo V, Cassels BK, Núñez MT.

Biochem Biophys Res Commun. 2016 Apr 22;473(1):361. doi: 10.1016/j.bbrc.2016.03.070. Epub 2016 Mar 26. No abstract available.

PMID:
27087027
13.

Distinguishing rotamers in N-trifluoroacetyl-3-benzazepine derivatives.

Acevedo-Fuentes WA, Cassels BK.

Magn Reson Chem. 2016 Jul;54(7):597-600. doi: 10.1002/mrc.4406. Epub 2016 Jan 13.

PMID:
26763071
14.

Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP+/MPTP-Lesioned Dopaminergic Neurons.

Aguirre P, Mena NP, Carrasco CM, Muñoz Y, Pérez-Henríquez P, Morales RA, Cassels BK, Méndez-Gálvez C, García-Beltrán O, González-Billault C, Núñez MT.

PLoS One. 2015 Dec 14;10(12):e0144848. doi: 10.1371/journal.pone.0144848. eCollection 2015.

15.

The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death.

Mena NP, García-Beltrán O, Lourido F, Urrutia PJ, Mena R, Castro-Castillo V, Cassels BK, Núñez MT.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):787-92. doi: 10.1016/j.bbrc.2015.06.014. Epub 2015 Jun 5. Erratum in: Biochem Biophys Res Commun. 2016 Apr 22;473(1):361.

PMID:
26051278
16.

Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition.

Celis-Barros C, Saavedra-Rivas L, Salgado JC, Cassels BK, Zapata-Torres G.

J Comput Aided Mol Des. 2015 Jan;29(1):37-46. doi: 10.1007/s10822-014-9802-7. Epub 2014 Oct 22.

PMID:
25338130
17.

2-Phenylaminonaphthoquinones and related compounds: synthesis, trypanocidal and cytotoxic activities.

Sieveking I, Thomas P, Estévez JC, Quiñones N, Cuéllar MA, Villena J, Espinosa-Bustos C, Fierro A, Tapia RA, Maya JD, López-Muñoz R, Cassels BK, Estévez RJ, Salas CO.

Bioorg Med Chem. 2014 Sep 1;22(17):4609-20. doi: 10.1016/j.bmc.2014.07.030. Epub 2014 Jul 27.

PMID:
25127463
18.

Synthesis of coumarin derivatives as fluorescent probes for membrane and cell dynamics studies.

García-Beltrán O, Yañez O, Caballero J, Galdámez A, Mena N, Nuñez MT, Cassels BK.

Eur J Med Chem. 2014 Apr 9;76:79-86. doi: 10.1016/j.ejmech.2014.02.016. Epub 2014 Feb 11.

PMID:
24576613
19.

Coumarin-based fluorescent probes for dual recognition of copper(II) and iron(III) ions and their application in bio-imaging.

García-Beltrán O, Cassels BK, Pérez C, Mena N, Núñez MT, Martínez NP, Pavez P, Aliaga ME.

Sensors (Basel). 2014 Jan 13;14(1):1358-71. doi: 10.3390/s140101358.

20.

Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe2+.

García-Beltrán O, Mena N, Yañez O, Caballero J, Vargas V, Nuñez MT, Cassels BK.

Eur J Med Chem. 2013 Sep;67:60-3. doi: 10.1016/j.ejmech.2013.06.022. Epub 2013 Jun 19.

PMID:
23835483
21.

Annulation of substituted anthracene-9,10-diones yields promising selectively antiproliferative compounds.

Castro-Castillo V, Suárez-Rozas C, Castro-Loiza N, Theoduloz C, Cassels BK.

Eur J Med Chem. 2013 Apr;62:688-92. doi: 10.1016/j.ejmech.2013.01.049. Epub 2013 Feb 8.

PMID:
23454511
22.

Varenicline and cytisine: two nicotinic acetylcholine receptor ligands reduce ethanol intake in University of Chile bibulous rats.

Sotomayor-Zárate R, Gysling K, Busto UE, Cassels BK, Tampier L, Quintanilla ME.

Psychopharmacology (Berl). 2013 May;227(2):287-98. doi: 10.1007/s00213-013-2974-3. Epub 2013 Jan 24.

PMID:
23344555
23.

Why is quercetin a better antioxidant than taxifolin? Theoretical study of mechanisms involving activated forms.

Osorio E, Pérez EG, Areche C, Ruiz LM, Cassels BK, Flórez E, Tiznado W.

J Mol Model. 2013 May;19(5):2165-72. doi: 10.1007/s00894-012-1732-5. Epub 2013 Jan 3.

PMID:
23283546
24.

Synthesis and antiplasmodial activity of some 1-azabenzanthrone derivatives.

Castro-Castillo V, Suárez-Rozas C, Pabón A, Pérez EG, Cassels BK, Blair S.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):327-9. doi: 10.1016/j.bmcl.2012.10.092. Epub 2012 Oct 27.

PMID:
23164712
25.

Synthesis and evaluation of N(1)-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands.

Pérez EG, Cassels BK, Eibl C, Gündisch D.

Bioorg Med Chem. 2012 Jun 15;20(12):3719-27. doi: 10.1016/j.bmc.2012.04.050. Epub 2012 May 2.

PMID:
22609074
26.

Salsolinol and isosalsolinol: condensation products of acetaldehyde and dopamine. Separation of their enantiomers in the presence of a large excess of dopamine.

Juricic MA, Berríos-Cárcamo PA, Acevedo ML, Israel Y, Almodóvar I, Cassels BK.

J Pharm Biomed Anal. 2012 Apr 7;63:170-4. doi: 10.1016/j.jpba.2012.02.002. Epub 2012 Feb 10.

PMID:
22370127
27.

Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors.

Pérez EG, Méndez-Gálvez C, Cassels BK.

Nat Prod Rep. 2012 May 1;29(5):555-67. doi: 10.1039/c2np00100d. Epub 2012 Feb 27. Review.

PMID:
22367109
28.

Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivatives.

Rodríguez-Díaz M, Delporte C, Cartagena C, Cassels BK, González P, Silva X, León F, Wessjohann LA.

J Pharm Pharmacol. 2011 May;63(5):718-24. doi: 10.1111/j.2042-7158.2011.01263.x. Epub 2011 Apr 1.

PMID:
21492174
29.

Synthesis of lakshminine and antiproliferative testing of related oxoisoaporphines.

Castro-Castillo V, Rebolledo-Fuentes M, Theoduloz C, Cassels BK.

J Nat Prod. 2010 Nov 29;73(11):1951-3. doi: 10.1021/np100370g. Epub 2010 Oct 20.

PMID:
20961068
30.

Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice.

Arrau S, Delporte C, Cartagena C, Rodríguez-Díaz M, González P, Silva X, Cassels BK, Miranda HF.

J Ethnopharmacol. 2011 Jan 7;133(1):164-7. doi: 10.1016/j.jep.2010.09.016. Epub 2010 Oct 14.

PMID:
20951193
31.

Behavioral profiles in rats distinguish among "ecstasy," methamphetamine and 2,5-dimethoxy-4-iodoamphetamine: Mixed effects for "ecstasy" analogues.

Quinteros-Muñoz D, Sáez-Briones P, Díaz-Véliz G, Mora-Gutiérrez S, Rebolledo-Fuentes M, Cassels BK.

Behav Neurosci. 2010 Oct;124(5):662-76. doi: 10.1037/a0020827.

PMID:
20939666
32.

Antifungal activity of saponin-rich extracts of Phytolacca dioica and of the sapogenins obtained through hydrolysis.

Di Liberto M, Svetaz L, Furlán RL, Zacchino SA, Delporte C, Novoa MA, Asencio M, Cassels BK.

Nat Prod Commun. 2010 Jul;5(7):1013-8.

PMID:
20734930
33.

Molecular determinants for competitive inhibition of alpha4beta2 nicotinic acetylcholine receptors.

Iturriaga-Vásquez P, Carbone A, García-Beltrán O, Livingstone PD, Biggin PC, Cassels BK, Wonnacott S, Zapata-Torres G, Bermudez I.

Mol Pharmacol. 2010 Sep;78(3):366-75. doi: 10.1124/mol.110.065490. Epub 2010 Jun 14.

34.

In silico characterization of cytisinoids docked into an acetylcholine binding protein.

Abin-Carriquiry JA, Zunini MP, Cassels BK, Wonnacott S, Dajas F.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3683-7. doi: 10.1016/j.bmcl.2010.04.092. Epub 2010 May 6.

PMID:
20493692
35.

Alkaloids from the genus Duguetia.

Pérez EG, Cassels BK.

Alkaloids Chem Biol. 2010;68:83-156. Review. No abstract available.

PMID:
20334037
36.

Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats.

Abin-Carriquiry JA, Urbanavicius J, Scorza C, Rebolledo-Fuentes M, Wonnacott S, Cassels BK, Dajas F.

Eur J Pharmacol. 2010 May 25;634(1-3):89-94. doi: 10.1016/j.ejphar.2010.02.030. Epub 2010 Feb 23.

PMID:
20184877
37.

2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.

Lühr S, Vilches-Herrera M, Fierro A, Ramsay RR, Edmondson DE, Reyes-Parada M, Cassels BK, Iturriaga-Vásquez P.

Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. doi: 10.1016/j.bmc.2010.01.029. Epub 2010 Jan 15.

PMID:
20123154
38.

In vivo effects of 3-iodocytisine: pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sites.

Zambrano CA, Marks MJ, Cassels BK, Maccioni RB.

Neuropharmacology. 2009 Sep;57(3):332-42. doi: 10.1016/j.neuropharm.2009.05.004. Epub 2009 May 28.

39.

Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.

Vilches-Herrera M, Miranda-Sepúlveda J, Rebolledo-Fuentes M, Fierro A, Lühr S, Iturriaga-Vasquez P, Cassels BK, Reyes-Parada M.

Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. doi: 10.1016/j.bmc.2009.01.074. Epub 2009 Feb 8.

PMID:
19243954
40.

Molecular modeling of the alpha9alpha10 nicotinic acetylcholine receptor subtype.

Pérez EG, Cassels BK, Zapata-Torres G.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):251-4. doi: 10.1016/j.bmcl.2008.10.094. Epub 2008 Oct 25.

PMID:
19013796
41.

In vivo modulation of dopaminergic nigrostriatal pathways by cytisine derivatives: implications for Parkinson's Disease.

Abin-Carriquiry JA, Costa G, Urbanavicius J, Cassels BK, Rebolledo-Fuentes M, Wonnacott S, Dajas F.

Eur J Pharmacol. 2008 Jul 28;589(1-3):80-4. doi: 10.1016/j.ejphar.2008.05.013. Epub 2008 May 20.

PMID:
18589414
42.

Quantum-chemical, NMR and X-ray diffraction studies on (+/-)-1-[3,4-(methylenedioxy)phenyl]-2-methylaminopropane.

Zapata-Torres G, Cassels BK, Parra-Mouchet J, Mascarenhas YP, Ellena J, De Araujo AS.

J Mol Graph Model. 2008 Jun;26(8):1296-305. doi: 10.1016/j.jmgm.2007.12.004. Epub 2008 Jan 4.

PMID:
18280190
43.

Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies.

Fierro A, Osorio-Olivares M, Cassels BK, Edmondson DE, Sepúlveda-Boza S, Reyes-Parada M.

Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. Epub 2007 May 22.

44.

Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers.

Iturriaga-Vásquez P, Pérez EG, Slater EY, Bermúdez I, Cassels BK.

Bioorg Med Chem. 2007 May 15;15(10):3368-72. Epub 2007 Mar 13.

PMID:
17391965
45.

Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors.

Moya PR, Berg KA, Gutiérrez-Hernandez MA, Sáez-Briones P, Reyes-Parada M, Cassels BK, Clarke WP.

J Pharmacol Exp Ther. 2007 Jun;321(3):1054-61. Epub 2007 Mar 2.

PMID:
17337633
46.

alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine.

Moroni M, Zwart R, Sher E, Cassels BK, Bermudez I.

Mol Pharmacol. 2006 Aug;70(2):755-68. Epub 2006 May 23.

PMID:
16720757
47.

Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae.

Aguirre MC, Delporte C, Backhouse N, Erazo S, Letelier ME, Cassels BK, Silva X, Alegría S, Negrete R.

Bioorg Med Chem. 2006 Aug 15;14(16):5673-7. Epub 2006 May 11.

PMID:
16697209
48.

Characterization of mitochondrial iron uptake in HepG2 cells.

Mazariegos DI, Cabantchik ZI, Cassels BK, Núñez MT.

Biol Res. 2006;39(1):199-201.

49.

Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.

Maya JD, Cassels BK, Iturriaga-Vásquez P, Ferreira J, Faúndez M, Galanti N, Ferreira A, Morello A.

Comp Biochem Physiol A Mol Integr Physiol. 2007 Apr;146(4):601-20. Epub 2006 Mar 12. Review.

PMID:
16626984
50.

C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists.

Abin-Carriquiry JA, Voutilainen MH, Barik J, Cassels BK, Iturriaga-Vásquez P, Bermudez I, Durand C, Dajas F, Wonnacott S.

Eur J Pharmacol. 2006 Apr 24;536(1-2):1-11. Epub 2006 Mar 6.

PMID:
16563372

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