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Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice.

Agassandian K, Grobe JL, Liu X, Agassandian M, Thompson AP, Sigmund CD, Cassell MD.

Am J Physiol Regul Integr Comp Physiol. 2017 Jun 1;312(6):R973-R981. doi: 10.1152/ajpregu.00511.2016. Epub 2017 May 10.


Obesity-induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain.

Horwath JA, Hurr C, Butler SD, Guruju M, Cassell MD, Mark AL, Davisson RL, Young CN.

JCI Insight. 2017 Apr 20;2(8). pii: 90170. doi: 10.1172/jci.insight.90170. eCollection 2017 Apr 20.


Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development.

Stump M, Guo DF, Lu KT, Mukohda M, Cassell MD, Norris AW, Rahmouni K, Sigmund CD.

Endocrinology. 2016 Nov;157(11):4266-4275. Epub 2016 Aug 30.


Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension.

Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD.

Hypertension. 2016 Dec;68(6):1385-1392. Epub 2016 Oct 17.


FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.

von Holstein-Rathlou S, BonDurant LD, Peltekian L, Naber MC, Yin TC, Claflin KE, Urizar AI, Madsen AN, Ratner C, Holst B, Karstoft K, Vandenbeuch A, Anderson CB, Cassell MD, Thompson AP, Solomon TP, Rahmouni K, Kinnamon SC, Pieper AA, Gillum MP, Potthoff MJ.

Cell Metab. 2016 Feb 9;23(2):335-43. doi: 10.1016/j.cmet.2015.12.003. Epub 2015 Dec 24.


The Vulnerable Ventral Tegmental Area in Parkinson's Disease.

Alberico SL, Cassell MD, Narayanan NS.

Basal Ganglia. 2015 Aug 1;5(2-3):51-55.


Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt.

Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD.

Hypertension. 2015 Jun;65(6):1341-8. doi: 10.1161/HYPERTENSIONAHA.115.05377. Epub 2015 Apr 20.


Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake.

Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD.

Am J Physiol Regul Integr Comp Physiol. 2014 Aug 15;307(4):R376-86. doi: 10.1152/ajpregu.00216.2014. Epub 2014 Jun 25.


Interference with peroxisome proliferator-activated receptor-γ in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction.

Borges GR, Morgan DA, Ketsawatsomkron P, Mickle AD, Thompson AP, Cassell MD, Mohapatra DP, Rahmouni K, Sigmund CD.

Hypertension. 2014 Sep;64(3):590-6. doi: 10.1161/HYPERTENSIONAHA.114.03553. Epub 2014 Jun 9.


Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin.

Coble JP, Johnson RF, Cassell MD, Johnson AK, Grobe JL, Sigmund CD.

Hypertension. 2014 Jul;64(1):141-8. doi: 10.1161/HYPERTENSIONAHA.114.03461. Epub 2014 Apr 28.


Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.

Price MP, Gong H, Parsons MG, Kundert JR, Reznikov LR, Bernardinelli L, Chaloner K, Buchanan GF, Wemmie JA, Richerson GB, Cassell MD, Welsh MJ.

Genes Brain Behav. 2014 Feb;13(2):179-94. doi: 10.1111/gbb.12108. Epub 2013 Dec 30.


Dimensions of subcortical infarcts associated with first- to third-order branches of the basal ganglia arteries.

Phan TG, van der Voort S, Beare R, Ma H, Clissold B, Holt M, Ly J, Foster E, Thong E, Stuckey S, Cassell MD, Srikanth V.

Cerebrovasc Dis. 2013;35(3):262-7. doi: 10.1159/000348310. Epub 2013 Mar 26.


Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent.

Littlejohn NK, Siel RB Jr, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR, Thompson AP, Liu X, Cassell MD, Sigmund CD, Grobe JL.

Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R818-28. doi: 10.1152/ajpregu.00082.2013. Epub 2013 Mar 27.


Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension.

Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD.

Hypertension. 2013 Mar;61(3):716-22. doi: 10.1161/HYPERTENSIONAHA.111.00356. Epub 2012 Dec 24.


Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model.

Carter CS, Vogel TW, Zhang Q, Seo S, Swiderski RE, Moninger TO, Cassell MD, Thedens DR, Keppler-Noreuil KM, Nopoulos P, Nishimura DY, Searby CC, Bugge K, Sheffield VC.

Nat Med. 2012 Dec;18(12):1797-804. doi: 10.1038/nm.2996. Epub 2012 Nov 18.


Structural defects in cilia of the choroid plexus, subfornical organ and ventricular ependyma are associated with ventriculomegaly.

Swiderski RE, Agassandian K, Ross JL, Bugge K, Cassell MD, Yeaman C.

Fluids Barriers CNS. 2012 Oct 9;9(1):22. doi: 10.1186/2045-8118-9-22.


Long-term neuropsychological, neuroanatomical, and life outcome in hippocampal amnesia.

Warren DE, Duff MC, Magnotta V, Capizzano AA, Cassell MD, Tranel D.

Clin Neuropsychol. 2012;26(2):335-69. doi: 10.1080/13854046.2012.655781. Epub 2012 Mar 8.


Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation.

Harlan SM, Morgan DA, Agassandian K, Guo DF, Cassell MD, Sigmund CD, Mark AL, Rahmouni K.

Circ Res. 2011 Apr 1;108(7):808-12. doi: 10.1161/CIRCRESAHA.111.240226. Epub 2011 Feb 10.


Amygdala connections with jaw, tongue and laryngo-pharyngeal premotor neurons.

Van Daele DJ, Fazan VP, Agassandian K, Cassell MD.

Neuroscience. 2011 Mar 17;177:93-113. doi: 10.1016/j.neuroscience.2010.12.063. Epub 2011 Jan 4.


Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism.

Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD.

Physiol Genomics. 2011 Mar 29;43(6):286-94. doi: 10.1152/physiolgenomics.00208.2010. Epub 2010 Dec 28.


Bilateral limbic system destruction in man.

Feinstein JS, Rudrauf D, Khalsa SS, Cassell MD, Bruss J, Grabowski TJ, Tranel D.

J Clin Exp Neuropsychol. 2010 Jan;32(1):88-106. doi: 10.1080/13803390903066873.


Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase.

Bianco RA, Agassandian K, Cassell MD, Spector AA, Sigmund CD.

Brain Res. 2009 Sep 29;1291:60-72. doi: 10.1016/j.brainres.2009.07.060. Epub 2009 Jul 28.


Multiple forebrain systems converge on motor neurons innervating the thyroarytenoid muscle.

Van Daele DJ, Cassell MD.

Neuroscience. 2009 Aug 18;162(2):501-24. doi: 10.1016/j.neuroscience.2009.05.005. Epub 2009 May 6.


Parcellation of human temporal polar cortex: a combined analysis of multiple cytoarchitectonic, chemoarchitectonic, and pathological markers.

Ding SL, Van Hoesen GW, Cassell MD, Poremba A.

J Comp Neurol. 2009 Jun 20;514(6):595-623. doi: 10.1002/cne.22053.


Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney.

Mark AL, Agassandian K, Morgan DA, Liu X, Cassell MD, Rahmouni K.

Hypertension. 2009 Feb;53(2):375-80. doi: 10.1161/HYPERTENSIONAHA.108.124255. Epub 2008 Dec 22.


A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity.

Davis RE, Swiderski RE, Rahmouni K, Nishimura DY, Mullins RF, Agassandian K, Philp AR, Searby CC, Andrews MP, Thompson S, Berry CJ, Thedens DR, Yang B, Weiss RM, Cassell MD, Stone EM, Sheffield VC.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19422-7. Epub 2007 Nov 21.


Local production of angiotensin II in the subfornical organ causes elevated drinking.

Sakai K, Agassandian K, Morimoto S, Sinnayah P, Cassell MD, Davisson RL, Sigmund CD.

J Clin Invest. 2007 Apr;117(4):1088-95.


The vascular supply of the functional compartments of the human striatum.

Feekes JA, Cassell MD.

Brain. 2006 Aug;129(Pt 8):2189-201. Epub 2006 Jun 30.


In vitro studies of the neuroform microstent using transparent human intracranial arteries.

Hsu SW, Chaloupka JC, Feekes JA, Cassell MD, Cheng YF.

AJNR Am J Neuroradiol. 2006 May;27(5):1135-9.


Neurotrophic factors in the central nucleus of amygdala may be organized to provide substrates for associative learning.

Agassandian K, Gedney M, Cassell MD.

Brain Res. 2006 Mar 3;1076(1):78-86. Epub 2006 Feb 13.


Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice.

Sherrod M, Davis DR, Zhou X, Cassell MD, Sigmund CD.

Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1763-9. Epub 2005 Aug 18.


Tertiary microvascular territories define lacunar infarcts in the basal ganglia.

Feekes JA, Hsu SW, Chaloupka JC, Cassell MD.

Ann Neurol. 2005 Jul;58(1):18-30.


The blood supply of the common peroneal nerve in the popliteal fossa.

Kadiyala RK, Ramirez A, Taylor AE, Saltzman CL, Cassell MD.

J Bone Joint Surg Br. 2005 Mar;87(3):337-42.


Differential modulation of baroreflex control of heart rate by neuron- vs. glia-derived angiotensin II.

Sakai K, Chapleau MW, Morimoto S, Cassell MD, Sigmund CD.

Physiol Genomics. 2004 Dec 15;20(1):66-72. Epub 2004 Oct 5.


Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain.

Sinnayah P, Lindley TE, Staber PD, Davidson BL, Cassell MD, Davisson RL.

Physiol Genomics. 2004 Jun 17;18(1):25-32. Epub 2004 Jun 17.


Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model.

Lavoie JL, Cassell MD, Gross KW, Sigmund CD.

Hypertension. 2004 May;43(5):1116-9. Epub 2004 Mar 22.


Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model.

Lavoie JL, Cassell MD, Gross KW, Sigmund CD.

Physiol Genomics. 2004 Jan 15;16(2):240-6.


Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning.

Wemmie JA, Askwith CC, Lamani E, Cassell MD, Freeman JH Jr, Welsh MJ.

J Neurosci. 2003 Jul 2;23(13):5496-502.


Increased cellular activity in rat insular cortex after water and salt ingestion induced by fluid depletion.

Pastuskovas CV, Cassell MD, Johnson AK, Thunhorst RL.

Am J Physiol Regul Integr Comp Physiol. 2003 Apr;284(4):R1119-25. Epub 2002 Dec 27.


Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference.

Morimoto S, Cassell MD, Sigmund CD.

J Biol Chem. 2002 Sep 6;277(36):33235-41. Epub 2002 Jun 21.


Neuron-specific expression of human angiotensinogen in brain causes increased salt appetite.

Morimoto S, Cassell MD, Sigmund CD.

Physiol Genomics. 2002;9(2):113-20. Epub 2002 Mar 26.


Selective gene transfer to key cardiovascular regions of the brain: comparison of two viral vector systems.

Sinnayah P, Lindley TE, Staber PD, Cassell MD, Davidson BL, Davisson RL.

Hypertension. 2002 Feb;39(2 Pt 2):603-8.


The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene.

Morimoto S, Cassell MD, Sigmund CD.

Circ Res. 2002 Jan 11;90(1):80-6. Erratum in: Circ Res 2002 Mar 8;90(4):e66.


Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter.

Morimoto S, Cassell MD, Beltz TG, Johnson AK, Davisson RL, Sigmund CD.

Circ Res. 2001 Aug 17;89(4):365-72.


The intrinsic organization of the central extended amygdala.

Cassell MD, Freedman LJ, Shi C.

Ann N Y Acad Sci. 1999 Jun 29;877:217-41. Review.


Expression pattern and in situ localization of the mouse homologue of the human MYOC (GLC1A) gene in adult brain.

Swiderski RE, Ying L, Cassell MD, Alward WL, Stone EM, Sheffield VC.

Brain Res Mol Brain Res. 1999 May 7;68(1-2):64-72.


Perirhinal cortex projections to the amygdaloid complex and hippocampal formation in the rat.

Shi CJ, Cassell MD.

J Comp Neurol. 1999 Apr 12;406(3):299-328.


The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system.

Yang G, Gray TS, Sigmund CD, Cassell MD.

Brain Res. 1999 Jan 30;817(1-2):123-31.


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