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Type I Interferon Therapy Limits CNS Autoimmunity by Inhibiting CXCR3-Mediated Trafficking of Pathogenic Effector T Cells.

Wang W, Chong WP, Li C, Chen Z, Wu S, Zhou H, Wan Y, Chen W, Gery I, Liu Y, Caspi RR, Chen J.

Cell Rep. 2019 Jul 9;28(2):486-497.e4. doi: 10.1016/j.celrep.2019.06.021.


Tellurium Compounds Prevent and Reverse Type-1 Diabetes in NOD Mice by Modulating α4β7 Integrin Activity, IL-1β, and T Regulatory Cells.

Yossipof TE, Bazak ZR, Kenigsbuch-Sredni D, Caspi RR, Kalechman Y, Sredni B.

Front Immunol. 2019 May 29;10:979. doi: 10.3389/fimmu.2019.00979. eCollection 2019.


Interleukin 22 ameliorates neuropathology and protects from central nervous system autoimmunity.

Mattapallil MJ, Kielczewski JL, Zárate-Bladés CR, St Leger AJ, Raychaudhuri K, Silver PB, Jittayasothorn Y, Chan CC, Caspi RR.

J Autoimmun. 2019 Aug;102:65-76. doi: 10.1016/j.jaut.2019.04.017. Epub 2019 May 9.


AS101 ameliorates experimental autoimmune uveitis by regulating Th1 and Th17 responses and inducing Treg cells.

Bing SJ, Shemesh I, Chong WP, Horai R, Jittayasothorn Y, Silver PB, Sredni B, Caspi RR.

J Autoimmun. 2019 Jun;100:52-61. doi: 10.1016/j.jaut.2019.02.006. Epub 2019 Mar 8.


Microbiome and Autoimmune Uveitis.

Horai R, Caspi RR.

Front Immunol. 2019 Feb 19;10:232. doi: 10.3389/fimmu.2019.00232. eCollection 2019. Review.


Pseudovirus rVSVΔG-ZEBOV-GP Infects Neurons in Retina and CNS, Causing Apoptosis and Neurodegeneration in Neonatal Mice.

McWilliams IL, Kielczewski JL, Ireland DDC, Sykes JS, Lewkowicz AP, Konduru K, Xu BC, Chan CC, Caspi RR, Manangeeswaran M, Verthelyi D.

Cell Rep. 2019 Feb 12;26(7):1718-1726.e4. doi: 10.1016/j.celrep.2019.01.069.


Clinical and Functional Evaluation of Ocular Inflammatory Disease Using the Model of Experimental Autoimmune Uveitis.

Chen J, Caspi RR.

Methods Mol Biol. 2019;1899:211-227. doi: 10.1007/978-1-4939-8938-6_15.


Tolerance Induction in Relation to the Eye.

Gery I, Caspi RR.

Front Immunol. 2018 Oct 9;9:2304. doi: 10.3389/fimmu.2018.02304. eCollection 2018. Review.


Visions of Eye Commensals: The Known and the Unknown About How the Microbiome Affects Eye Disease.

St Leger AJ, Caspi RR.

Bioessays. 2018 Nov;40(11):e1800046. doi: 10.1002/bies.201800046. Epub 2018 Oct 5. Review.


IL-20 receptor cytokines in autoimmune diseases.

Chen J, Caspi RR, Chong WP.

J Leukoc Biol. 2018 Nov;104(5):953-959. doi: 10.1002/JLB.MR1117-471R. Epub 2018 Sep 7. Review.


TMP778, a selective inhibitor of RORγt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations.

Lyu C, Bing SJ, Wandu WS, Xu B, Shi G, Hinshaw SJ, Lobera M, Caspi RR, Lu L, Yang J, Gery I.

Eur J Immunol. 2018 Nov;48(11):1810-1816. doi: 10.1002/eji.201747029. Epub 2018 Oct 9.


ZIKA virus infection causes persistent chorioretinal lesions.

Manangeeswaran M, Kielczewski JL, Sen HN, Xu BC, Ireland DDC, McWilliams IL, Chan CC, Caspi RR, Verthelyi D.

Emerg Microbes Infect. 2018 May 25;7(1):96. doi: 10.1038/s41426-018-0096-z.


STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection.

St Leger AJ, Hansen AM, Karauzum H, Horai R, Yu CR, Laurence A, Mayer-Barber KD, Silver P, Villasmil R, Egwuagu C, Datta SK, Caspi RR.

J Exp Med. 2018 Apr 2;215(4):1079-1090. doi: 10.1084/jem.20170369. Epub 2018 Feb 28.


Targeting CD6 for the treatment of experimental autoimmune uveitis.

Zhang L, Li Y, Qiu W, Bell BA, Dvorina N, Baldwin WM 3rd, Singer N, Kern T, Caspi RR, Fox DA, Lin F.

J Autoimmun. 2018 Jun;90:84-93. doi: 10.1016/j.jaut.2018.02.004. Epub 2018 Feb 19.


IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis.

Choi JK, Dambuza IM, He C, Yu CR, Uche AN, Mattapallil MJ, Caspi RR, Egwuagu CE.

Front Immunol. 2017 Oct 5;8:1258. doi: 10.3389/fimmu.2017.01258. eCollection 2017.


IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease.

Dambuza IM, He C, Choi JK, Yu CR, Wang R, Mattapallil MJ, Wingfield PT, Caspi RR, Egwuagu CE.

Nat Commun. 2017 Sep 28;8(1):719. doi: 10.1038/s41467-017-00838-4.


Complement Component C4 Regulates the Development of Experimental Autoimmune Uveitis through a T Cell-Intrinsic Mechanism.

Zhang L, Bell BA, Li Y, Caspi RR, Lin F.

Front Immunol. 2017 Sep 11;8:1116. doi: 10.3389/fimmu.2017.01116. eCollection 2017.


Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism.

Brown BR, Lee EJ, Snow PE, Vance EE, Iwakura Y, Ohno N, Miura N, Lin X, Brown GD, Wells CA, Smith JR, Caspi RR, Rosenzweig HL.

Clin Exp Immunol. 2017 Dec;190(3):293-303. doi: 10.1111/cei.13021. Epub 2017 Aug 30.


An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells.

St Leger AJ, Desai JV, Drummond RA, Kugadas A, Almaghrabi F, Silver P, Raychaudhuri K, Gadjeva M, Iwakura Y, Lionakis MS, Caspi RR.

Immunity. 2017 Jul 18;47(1):148-158.e5. doi: 10.1016/j.immuni.2017.06.014. Epub 2017 Jul 11.


The Small Tellurium Compound AS101 Ameliorates Rat Crescentic Glomerulonephritis: Association with Inhibition of Macrophage Caspase-1 Activity via Very Late Antigen-4 Inactivation.

Hachmo Y, Kalechman Y, Skornick I, Gafter U, Caspi RR, Sredni B.

Front Immunol. 2017 Mar 7;8:240. doi: 10.3389/fimmu.2017.00240. eCollection 2017.


Compliments of Factor H: What's in it for AMD?

Mattapallil MJ, Caspi RR.

Immunity. 2017 Feb 21;46(2):167-169. doi: 10.1016/j.immuni.2017.02.008.


Preparation of Protein-containing Extracts from Microbiota-rich Intestinal Contents.

Dillenburg-Pilla P, Zárate-Bladés CR, Silver PB, Horai R, Caspi RR.

Bio Protoc. 2016 Sep 20;6(18). pii: e1936.


Commensal microbiota as a potential trigger of autoimmune uveitis.

Horai R, Sen HN, Caspi RR.

Expert Rev Clin Immunol. 2017 Apr;13(4):291-293. doi: 10.1080/1744666X.2017.1288098. Epub 2017 Feb 15. No abstract available.


Gut microbiota as a source of a surrogate antigen that triggers autoimmunity in an immune privileged site.

Zárate-Bladés CR, Horai R, Mattapallil MJ, Ajami NJ, Wong M, Petrosino JF, Itoh K, Chan CC, Caspi RR.

Gut Microbes. 2017 Jan 2;8(1):59-66. doi: 10.1080/19490976.2016.1273996. Epub 2017 Jan 3. Review.


Regulation of Autoimmunity by the Microbiome.

Zárate-Bladés CR, Horai R, Caspi RR.

DNA Cell Biol. 2016 Sep;35(9):455-8. doi: 10.1089/dna.2016.3432. Epub 2016 Jul 27.


Analysis of Th Cell-related Cytokine Production in Behçet Disease Patients with Uveitis Before and After Infliximab Treatment.

Takeuchi M, Karasawa Y, Harimoto K, Tanaka A, Shibata M, Sato T, Caspi RR, Ito M.

Ocul Immunol Inflamm. 2017 Feb;25(1):52-61. doi: 10.3109/09273948.2016.1158276. Epub 2016 Apr 12.


Complete Genome Sequence of Turicibacter sp. Strain H121, Isolated from the Feces of a Contaminated Germ-Free Mouse.

Auchtung TA, Holder ME, Gesell JR, Ajami NJ, Duarte RT, Itoh K, Caspi RR, Petrosino JF, Horai R, Zárate-Bladés CR.

Genome Announc. 2016 Mar 24;4(2). pii: e00114-16. doi: 10.1128/genomeA.00114-16.


Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye.

Lee EJ, Brown BR, Vance EE, Snow PE, Silver PB, Heinrichs D, Lin X, Iwakura Y, Wells CA, Caspi RR, Rosenzweig HL.

J Immunol. 2016 Apr 1;196(7):3148-58. doi: 10.4049/jimmunol.1502355. Epub 2016 Feb 26.


Tertiary Lymphoid Tissue Forms in Retinas of Mice with Spontaneous Autoimmune Uveitis and Has Consequences on Visual Function.

Kielczewski JL, Horai R, Jittayasothorn Y, Chan CC, Caspi RR.

J Immunol. 2016 Feb 1;196(3):1013-25. doi: 10.4049/jimmunol.1501570. Epub 2015 Dec 28.


Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis.

Zhang L, Bell BA, Yu M, Chan CC, Peachey NS, Fung J, Zhang X, Caspi RR, Lin F.

J Leukoc Biol. 2016 Mar;99(3):447-54. doi: 10.1189/jlb.3A0415-157R. Epub 2015 Sep 22.


NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis.

Chong WP, van Panhuys N, Chen J, Silver PB, Jittayasothorn Y, Mattapallil MJ, Germain RN, Caspi RR.

J Exp Med. 2015 Sep 21;212(10):1739-52. doi: 10.1084/jem.20141678. Epub 2015 Sep 7.


Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site.

Horai R, Zárate-Bladés CR, Dillenburg-Pilla P, Chen J, Kielczewski JL, Silver PB, Jittayasothorn Y, Chan CC, Yamane H, Honda K, Caspi RR.

Immunity. 2015 Aug 18;43(2):343-53. doi: 10.1016/j.immuni.2015.07.014.


Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype.

Mattapallil MJ, Silver PB, Cortes LM, St Leger AJ, Jittayasothorn Y, Kielczewski JL, Moon JJ, Chan CC, Caspi RR.

Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5439-49. doi: 10.1167/iovs.15-17280.


Spontaneous Ocular Autoimmunity in Mice Expressing a Transgenic T Cell Receptor Specific to Retina: A Tool to Dissect Mechanisms of Uveitis.

Horai R, Chong WP, Zhou R, Chen J, Silver PB, Agarwal RK, Caspi RR.

Curr Mol Med. 2015;15(6):511-6.


Mouse Models of Experimental Autoimmune Uveitis: Comparative Analysis of Adjuvant-Induced vs Spontaneous Models of Uveitis.

Chen J, Qian H, Horai R, Chan CC, Caspi RR.

Curr Mol Med. 2015;15(6):550-7. Review.


Correction: Retina-Specific T Regulatory Cells Bring About Resolution and Maintain Remission of Autoimmune Uveitis.

Silver PB, Horai R, Chen J, Jittayasothorn Y, Chan CC, Villasmil R, Kesen MR, Caspi RR.

J Immunol. 2015 Jul 1;195(1):393. doi: 10.4049/jimmunol.1501038. No abstract available.


Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

Rodriguez-Peña AB, Gomez-Rodriguez J, Kortum RL, Palmer DC, Yu Z, Guittard GC, Wohlfert EA, Silver PB, Misplon JA, Sommers CL, Feigenbaum L, Epstein SL, Caspi RR, Belkaid Y, Restifo NP, Samelson LE, Balagopalan L.

Gene Ther. 2015 Oct;22(10):781-92. doi: 10.1038/gt.2015.48. Epub 2015 Jun 18.


Immune mechanisms in inflammatory and degenerative eye disease.

Perez VL, Caspi RR.

Trends Immunol. 2015 Jun;36(6):354-63. doi: 10.1016/ Epub 2015 May 13. Review.


Retina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis.

Silver PB, Horai R, Chen J, Jittayasothorn Y, Chan CC, Villasmil R, Kesen MR, Caspi RR.

J Immunol. 2015 Apr 1;194(7):3011-9. doi: 10.4049/jimmunol.1402650. Epub 2015 Feb 25. Erratum in: J Immunol. 2015 Jul 1;195(1):393. Silver, Phyllis [Corrected to Silver, Phyllis B].


Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.

Kim A, Hartman IZ, Poore B, Boronina T, Cole RN, Song N, Ciudad MT, Caspi RR, Jaraquemada D, Sadegh-Nasseri S.

Nat Commun. 2014 Nov 21;5:5369. doi: 10.1038/ncomms6369.


Immune privilege and the philosophy of immunology.

Stein-Streilein J, Caspi RR.

Front Immunol. 2014 Mar 19;5:110. doi: 10.3389/fimmu.2014.00110. eCollection 2014. No abstract available.


Effective Arrestin-Specific Immunotherapy of Experimental Autoimmune Uveitis with RTL: A Prospect for Treatment of Human Uveitis.

Kyger M, Worley A, Huan J, McDowell H, Smith WC, Burrows GG, Mattapallil MJ, Caspi RR, Adamus G.

Transl Vis Sci Technol. 2013 Feb;2(2):1. Epub 2013 Feb 5.


IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses.

Chong WP, Horai R, Mattapallil MJ, Silver PB, Chen J, Zhou R, Sergeev Y, Villasmil R, Chan CC, Caspi RR.

J Autoimmun. 2014 May;50:12-22. doi: 10.1016/j.jaut.2013.08.003. Epub 2013 Sep 7.


Comparative analysis of induced vs. spontaneous models of autoimmune uveitis targeting the interphotoreceptor retinoid binding protein.

Chen J, Qian H, Horai R, Chan CC, Falick Y, Caspi RR.

PLoS One. 2013 Aug 28;8(8):e72161. doi: 10.1371/journal.pone.0072161. eCollection 2013.


Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen.

Horai R, Silver PB, Chen J, Agarwal RK, Chong WP, Jittayasothorn Y, Mattapallil MJ, Nguyen S, Natarajan K, Villasmil R, Wang P, Karabekian Z, Lytton SD, Chan CC, Caspi RR.

J Autoimmun. 2013 Aug;44:21-33. doi: 10.1016/j.jaut.2013.06.003. Epub 2013 Jun 28.


Use of optical coherence tomography and electroretinography to evaluate retinal pathology in a mouse model of autoimmune uveitis.

Chen J, Qian H, Horai R, Chan CC, Caspi RR.

PLoS One. 2013 May 14;8(5):e63904. doi: 10.1371/journal.pone.0063904. Print 2013.


Essential role of NK cells in IgG therapy for experimental autoimmune encephalomyelitis.

Chong WP, Ling MT, Liu Y, Caspi RR, Wong WM, Wu W, Tu W, Lau YL.

PLoS One. 2013;8(4):e60862. doi: 10.1371/journal.pone.0060862. Epub 2013 Apr 5.


Functional macrophage heterogeneity in a mouse model of autoimmune central nervous system pathology.

London A, Benhar I, Mattapallil MJ, Mack M, Caspi RR, Schwartz M.

J Immunol. 2013 Apr 1;190(7):3570-8. doi: 10.4049/jimmunol.1202076. Epub 2013 Feb 27.


In this issue: Immunology of the eye--inside and out.

Caspi RR.

Int Rev Immunol. 2013 Feb;32(1):1-3. doi: 10.3109/08830185.2012.750138. No abstract available.

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