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Items: 44

1.

The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance.

Ferent J, Constable S, Gigante ED, Yam PT, Mariani LE, Legué E, Liem KF Jr, Caspary T, Charron F.

Cell Rep. 2019 Dec 10;29(11):3356-3366.e3. doi: 10.1016/j.celrep.2019.11.015.

PMID:
31825820
2.

Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion.

Rutkowski TP, Purcell RH, Pollak RM, Grewenow SM, Gafford GM, Malone T, Khan UA, Schroeder JP, Epstein MP, Bassell GJ, Warren ST, Weinshenker D, Caspary T, Mulle JG.

Mol Psychiatry. 2019 Apr 11. doi: 10.1038/s41380-019-0413-5. [Epub ahead of print]

3.

Corrigendum to "Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response" [Develop. Biol. 437 (2018) 152-162].

Gigante ED, Long AB, Ben-Ami J, Caspary T.

Dev Biol. 2019 Jun 1;450(1):63. doi: 10.1016/j.ydbio.2019.02.005. Epub 2019 Mar 21. No abstract available.

4.

Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response.

Gigante ED, Long AB, Ben-Ami J, Caspary T.

Dev Biol. 2018 May 15;437(2):152-162. doi: 10.1016/j.ydbio.2018.03.019. Epub 2018 Mar 20. Erratum in: Dev Biol. 2019 Jun 1;450(1):63.

5.

Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation.

Bay SN, Long AB, Caspary T.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1570-1575. doi: 10.1073/pnas.1706977115. Epub 2018 Jan 29.

6.

A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity.

Rafiullah R, Long AB, Ivanova AA, Ali H, Berkel S, Mustafa G, Paramasivam N, Schlesner M, Wiemann S, Wade RC, Bolthauser E, Blum M, Kahn RA, Caspary T, Rappold GA.

Eur J Hum Genet. 2017 Dec;25(12):1324-1334. doi: 10.1038/s41431-017-0031-0. Epub 2017 Nov 15.

7.

Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity.

Guo J, Otis JM, Higginbotham H, Monckton C, Cheng J, Asokan A, Mykytyn K, Caspary T, Stuber GD, Anton ES.

Dev Cell. 2017 Aug 7;42(3):286-300.e4. doi: 10.1016/j.devcel.2017.07.010.

8.

Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).

Ivanova AA, Caspary T, Seyfried NT, Duong DM, West AB, Liu Z, Kahn RA.

J Biol Chem. 2017 Jun 30;292(26):11091-11108. doi: 10.1074/jbc.M117.784025. Epub 2017 May 9.

9.

Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders.

Rutkowski TP, Schroeder JP, Gafford GM, Warren ST, Weinshenker D, Caspary T, Mulle JG.

J Neurosci Res. 2017 May;95(5):1144-1160. doi: 10.1002/jnr.23970. Epub 2016 Nov 8. Review.

10.

Arl13b regulates Shh signaling from both inside and outside the cilium.

Mariani LE, Bijlsma MF, Ivanova AA, Suciu SK, Kahn RA, Caspary T.

Mol Biol Cell. 2016 Sep 28. pii: mbc.E16-03-0189. [Epub ahead of print] Erratum in: Mol Biol Cell. 2017 Apr 1;28(7):996. Ivanova, Anna I [corrected to Ivanova, Anna A].

11.

Methods for Visualization of Neuronal Cilia.

Caspary T, Marazziti D, Berbari NF.

Methods Mol Biol. 2016;1454:203-14. doi: 10.1007/978-1-4939-3789-9_13. Review.

PMID:
27514924
12.

Arl13b and the exocyst interact synergistically in ciliogenesis.

Seixas C, Choi SY, Polgar N, Umberger NL, East MP, Zuo X, Moreiras H, Ghossoub R, Benmerah A, Kahn RA, Fogelgren B, Caspary T, Lipschutz JH, Barral DC.

Mol Biol Cell. 2016 Jan 15;27(2):308-20. doi: 10.1091/mbc.E15-02-0061. Epub 2015 Nov 18.

13.

Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of rapamycin signaling and diminished PP2A activity.

Umberger NL, Caspary T.

Mol Biol Cell. 2015 Jan 15;26(2):350-8. doi: 10.1091/mbc.E14-05-0952. Epub 2014 Nov 12.

14.

Identification of a novel ARL13B variant in a Joubert syndrome-affected patient with retinal impairment and obesity.

Thomas S, Cantagrel V, Mariani L, Serre V, Lee JE, Elkhartoufi N, de Lonlay P, Desguerre I, Munnich A, Boddaert N, Lyonnet S, Vekemans M, Lisgo SN, Caspary T, Gleeson J, Attié-Bitach T.

Eur J Hum Genet. 2015 May;23(5):621-7. doi: 10.1038/ejhg.2014.156. Epub 2014 Aug 20.

15.

Left-right asymmetry: lessons from Cancún.

Burdine RD, Caspary T.

Development. 2013 Nov;140(22):4465-70. doi: 10.1242/dev.097907.

16.

Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development.

Long AB, Kaiser WJ, Mocarski ES, Caspary T.

Cell Death Differ. 2013 Nov;20(11):1510-20. doi: 10.1038/cdd.2013.97. Epub 2013 Jul 26.

17.

Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation.

Higginbotham H, Guo J, Yokota Y, Umberger NL, Su CY, Li J, Verma N, Hirt J, Ghukasyan V, Caspary T, Anton ES.

Nat Neurosci. 2013 Aug;16(8):1000-7. doi: 10.1038/nn.3451. Epub 2013 Jun 30.

18.

Ex vivo live imaging of single cell divisions in mouse neuroepithelium.

Piotrowska-Nitsche K, Caspary T.

J Vis Exp. 2013 Apr 30;(74):e4439. doi: 10.3791/4439.

19.

What are those cilia doing in the neural tube?

Bay SN, Caspary T.

Cilia. 2012 Oct 1;1(1):19. doi: 10.1186/2046-2530-1-19.

20.

Arl13b in primary cilia regulates the migration and placement of interneurons in the developing cerebral cortex.

Higginbotham H, Eom TY, Mariani LE, Bachleda A, Hirt J, Gukassyan V, Cusack CL, Lai C, Caspary T, Anton ES.

Dev Cell. 2012 Nov 13;23(5):925-38. doi: 10.1016/j.devcel.2012.09.019.

21.

Live imaging of individual cell divisions in mouse neuroepithelium shows asymmetry in cilium formation and Sonic hedgehog response.

Piotrowska-Nitsche K, Caspary T.

Cilia. 2012 May 1;1(1). pii: 6. doi: 10.1186/2046-2530-1-6. Epub 2012 May 2.

22.

Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time.

Su CY, Bay SN, Mariani LE, Hillman MJ, Caspary T.

Development. 2012 Nov;139(21):4062-71. doi: 10.1242/dev.082321. Epub 2012 Sep 26.

23.

Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia.

Larkins CE, Long AB, Caspary T.

Dev Biol. 2012 Jul 1;367(1):15-24. doi: 10.1016/j.ydbio.2012.04.011. Epub 2012 Apr 24.

24.

Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse.

Sun M, Mondal K, Patel V, Horner VL, Long AB, Cutler DJ, Caspary T, Zwick ME.

G3 (Bethesda). 2012 Jan;2(1):143-50. doi: 10.1534/g3.111.001669. Epub 2012 Jan 1.

25.

Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins.

Larkins CE, Aviles GD, East MP, Kahn RA, Caspary T.

Mol Biol Cell. 2011 Dec;22(23):4694-703. doi: 10.1091/mbc.E10-12-0994. Epub 2011 Oct 5.

26.

Creating a "hopeful monster": mouse forward genetic screens.

Horner VL, Caspary T.

Methods Mol Biol. 2011;770:313-36. doi: 10.1007/978-1-61779-210-6_12.

27.

Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling.

Horner VL, Caspary T.

Dev Biol. 2011 Jul 1;355(1):43-54. doi: 10.1016/j.ydbio.2011.04.019. Epub 2011 Apr 22.

28.

Microarray oligonucleotide probe designer (MOPeD): A web service.

Patel VC, Mondal K, Shetty AC, Horner VL, Bedoyan JK, Martin D, Caspary T, Cutler DJ, Zwick ME.

Open Access Bioinformatics. 2010 Nov 1;2(2010):145-155.

29.

RIP3 mediates the embryonic lethality of caspase-8-deficient mice.

Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R, Caspary T, Mocarski ES.

Nature. 2011 Mar 17;471(7338):368-72. doi: 10.1038/nature09857. Epub 2011 Mar 2.

30.

SeqAnt: a web service to rapidly identify and annotate DNA sequence variations.

Shetty AC, Athri P, Mondal K, Horner VL, Steinberg KM, Patel V, Caspary T, Cutler DJ, Zwick ME.

BMC Bioinformatics. 2010 Sep 20;11:471. doi: 10.1186/1471-2105-11-471.

31.

Phenotype-driven mouse ENU mutagenesis screens.

Caspary T.

Methods Enzymol. 2010;477:313-27. doi: 10.1016/S0076-6879(10)77016-6.

PMID:
20699148
32.

Mitochondrial retention of Opa1 is required for mouse embryogenesis.

Moore BA, Gonzalez Aviles GD, Larkins CE, Hillman MJ, Caspary T.

Mamm Genome. 2010 Aug;21(7-8):350-60. doi: 10.1007/s00335-010-9272-8. Epub 2010 Jul 21.

PMID:
20652258
33.

A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice.

Tapanes-Castillo A, Weaver EJ, Smith RP, Kamei Y, Caspary T, Hamilton-Nelson KL, Slifer SH, Martin ER, Bixby JL, Lemmon VP.

Neurogenetics. 2010 Feb;11(1):53-71. doi: 10.1007/s10048-009-0203-3. Epub 2009 Jun 30.

34.

Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome.

Cantagrel V, Silhavy JL, Bielas SL, Swistun D, Marsh SE, Bertrand JY, Audollent S, Attié-Bitach T, Holden KR, Dobyns WB, Traver D, Al-Gazali L, Ali BR, Lindner TH, Caspary T, Otto EA, Hildebrandt F, Glass IA, Logan CV, Johnson CA, Bennett C, Brancati F; International Joubert Syndrome Related Disorders Study Group, Valente EM, Woods CG, Gleeson JG.

Am J Hum Genet. 2008 Aug;83(2):170-9. doi: 10.1016/j.ajhg.2008.06.023.

35.

Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation.

Alisch RS, Jin P, Epstein M, Caspary T, Warren ST.

PLoS Genet. 2007 Dec 28;3(12):e227. doi: 10.1371/journal.pgen.0030227.

36.

The graded response to Sonic Hedgehog depends on cilia architecture.

Caspary T, Larkins CE, Anderson KV.

Dev Cell. 2007 May;12(5):767-78.

37.
38.

Analysis of mouse embryonic patterning and morphogenesis by forward genetics.

García-García MJ, Eggenschwiler JT, Caspary T, Alcorn HL, Wyler MR, Huangfu D, Rakeman AS, Lee JD, Feinberg EH, Timmer JR, Anderson KV.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5913-9. Epub 2005 Mar 8.

39.

Patterning cell types in the dorsal spinal cord: what the mouse mutants say.

Caspary T, Anderson KV.

Nat Rev Neurosci. 2003 Apr;4(4):289-97. Review. No abstract available.

PMID:
12671645
40.

Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.

Caspary T, García-García MJ, Huangfu D, Eggenschwiler JT, Wyler MR, Rakeman AS, Alcorn HL, Anderson KV.

Curr Biol. 2002 Sep 17;12(18):1628-32.

41.

Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.

Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, Tilghman SM.

Genes Dev. 1999 Dec 1;13(23):3115-24.

42.

Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster.

Caspary T, Cleary MA, Baker CC, Guan XJ, Tilghman SM.

Mol Cell Biol. 1998 Jun;18(6):3466-74.

43.

Competitive edge at the imprinted Prader-Willi/Angelman region?

Tilghman SM, Caspary T, Ingram RS.

Nat Genet. 1998 Mar;18(3):206-8. No abstract available.

PMID:
9500535
44.

Genomic imprinting of Mash2, a mouse gene required for trophoblast development.

Guillemot F, Caspary T, Tilghman SM, Copeland NG, Gilbert DJ, Jenkins NA, Anderson DJ, Joyner AL, Rossant J, Nagy A.

Nat Genet. 1995 Mar;9(3):235-42.

PMID:
7773285

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