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Items: 1 to 50 of 61

1.

Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.

Shenderov K, Barber DL, Mayer-Barber KD, Gurcha SS, Jankovic D, Feng CG, Oland S, Hieny S, Caspar P, Yamasaki S, Lin X, Ting JP, Trinchieri G, Besra GS, Cerundolo V, Sher A.

J Immunol. 2013 Jun 1;190(11):5722-30. doi: 10.4049/jimmunol.1203343. Epub 2013 Apr 29.

3.

NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection.

Goldszmid RS, Caspar P, Rivollier A, White S, Dzutsev A, Hieny S, Kelsall B, Trinchieri G, Sher A.

Immunity. 2012 Jun 29;36(6):1047-59. doi: 10.1016/j.immuni.2012.03.026.

4.

Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.

Mayer-Barber KD, Andrade BB, Barber DL, Hieny S, Feng CG, Caspar P, Oland S, Gordon S, Sher A.

Immunity. 2011 Dec 23;35(6):1023-34. doi: 10.1016/j.immuni.2011.12.002.

5.

Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice.

Barber DL, Mayer-Barber KD, Antonelli LR, Wilson MS, White S, Caspar P, Hieny S, Sereti I, Sher A.

Blood. 2010 Nov 4;116(18):3485-93. doi: 10.1182/blood-2010-05-286336. Epub 2010 Jul 23.

6.

Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo.

Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Núñez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A.

J Immunol. 2010 Apr 1;184(7):3326-30. doi: 10.4049/jimmunol.0904189. Epub 2010 Mar 3.

7.

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1).

Steinfelder S, Andersen JF, Cannons JL, Feng CG, Joshi M, Dwyer D, Caspar P, Schwartzberg PL, Sher A, Jankovic D.

J Exp Med. 2009 Aug 3;206(8):1681-90. doi: 10.1084/jem.20082462. Epub 2009 Jul 27.

8.

Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells.

Goldszmid RS, Coppens I, Lev A, Caspar P, Mellman I, Sher A.

J Exp Med. 2009 Feb 16;206(2):399-410. doi: 10.1084/jem.20082108. Epub 2009 Jan 19.

9.

The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death.

Feng CG, Zheng L, Jankovic D, Báfica A, Cannons JL, Watford WT, Chaussabel D, Hieny S, Caspar P, Schwartzberg PL, Lenardo MJ, Sher A.

Nat Immunol. 2008 Nov;9(11):1279-87. doi: 10.1038/ni.1653. Epub 2008 Sep 21.

10.

TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production.

Goldszmid RS, Bafica A, Jankovic D, Feng CG, Caspar P, Winkler-Pickett R, Trinchieri G, Sher A.

J Exp Med. 2007 Oct 29;204(11):2591-602. Epub 2007 Oct 8.

11.

Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production.

Feng CG, Jankovic D, Kullberg M, Cheever A, Scanga CA, Hieny S, Caspar P, Yap GS, Sher A.

J Immunol. 2005 Apr 1;174(7):4185-92.

12.

Structural determinants of the anti-HIV activity of a CCR5 antagonist derived from Toxoplasma gondii.

Yarovinsky F, Andersen JF, King LR, Caspar P, Aliberti J, Golding H, Sher A.

J Biol Chem. 2004 Dec 17;279(51):53635-42. Epub 2004 Oct 6.

14.

Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope.

Kullberg MC, Andersen JF, Gorelick PL, Caspar P, Suerbaum S, Fox JG, Cheever AW, Jankovic D, Sher A.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15830-5. Epub 2003 Dec 12.

18.

Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis.

Kullberg MC, Jankovic D, Gorelick PL, Caspar P, Letterio JJ, Cheever AW, Sher A.

J Exp Med. 2002 Aug 19;196(4):505-15.

19.
20.

Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation.

Kullberg MC, Rothfuchs AG, Jankovic D, Caspar P, Wynn TA, Gorelick PL, Cheever AW, Sher A.

Infect Immun. 2001 Jul;69(7):4232-41.

21.
22.

Host resistance and immune deviation in pigeon cytochrome c T-cell receptor transgenic mice infected with Toxoplasma gondii.

Collazo CM, Miller C, Yap G, Hieny S, Caspar P, Schwartz RH, Sher A.

Infect Immun. 2000 May;68(5):2713-9.

23.
24.

Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile.

Jankovic D, Kullberg MC, Noben-Trauth N, Caspar P, Ward JM, Cheever AW, Paul WE, Sher A.

J Immunol. 1999 Jul 1;163(1):337-42.

25.

Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanisms.

Jankovic D, Wynn TA, Kullberg MC, Hieny S, Caspar P, James S, Cheever AW, Sher A.

J Immunol. 1999 Jan 1;162(1):345-51.

26.

Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism.

Kullberg MC, Ward JM, Gorelick PL, Caspar P, Hieny S, Cheever A, Jankovic D, Sher A.

Infect Immun. 1998 Nov;66(11):5157-66.

27.
29.
30.

IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease.

Wynn TA, Cheever AW, Williams ME, Hieny S, Caspar P, Kühn R, Müller W, Sher A.

J Immunol. 1998 May 1;160(9):4473-80.

31.

CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling.

Jankovic D, Cheever AW, Kullberg MC, Wynn TA, Yap G, Caspar P, Lewis FA, Clynes R, Ravetch JV, Sher A.

J Exp Med. 1998 Feb 16;187(4):619-29.

32.

Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp120.

Jankovic D, Caspar P, Zweig M, Garcia-Moll M, Showalter SD, Vogel FR, Sher A.

J Immunol. 1997 Sep 1;159(5):2409-17.

PMID:
9278332
33.

Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii.

Denkers EY, Yap G, Scharton-Kersten T, Charest H, Butcher BA, Caspar P, Heiny S, Sher A.

J Immunol. 1997 Aug 15;159(4):1903-8.

PMID:
9257855
34.

Fc epsilonRI-deficient mice infected with Schistosoma mansoni mount normal Th2-type responses while displaying enhanced liver pathology.

Jankovic D, Kullberg MC, Dombrowicz D, Barbieri S, Caspar P, Wynn TA, Paul WE, Cheever AW, Kinet JP, Sher A.

J Immunol. 1997 Aug 15;159(4):1868-75.

PMID:
9257851
36.
37.
38.

IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite.

Wynn TA, Reynolds A, James S, Cheever AW, Caspar P, Hieny S, Jankovic D, Strand M, Sher A.

J Immunol. 1996 Nov 1;157(9):4068-78.

PMID:
8892641
39.

Calpain is the target antigen of a Th1 clone that transfers protective immunity against Schistosoma mansoni.

Jankovic D, Aslund L, Oswald IP, Caspar P, Champion C, Pearce E, Coligan JE, Strand M, Sher A, James SL.

J Immunol. 1996 Jul 15;157(2):806-14.

PMID:
8752932
41.
42.

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection.

Wynn TA, Cheever AW, Jankovic D, Poindexter RW, Caspar P, Lewis FA, Sher A.

Nature. 1995 Aug 17;376(6541):594-6.

PMID:
7637808
43.
44.

Linked in vivo expression of soluble interleukin-4 receptor and interleukin-4 in murine schistosomiasis.

Fernandez-Botran R, Wynn TA, Hieny S, Caspar P, Chilton PM, Sher A.

Eur J Immunol. 1995 Mar;25(3):649-56.

PMID:
7705393
45.

Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni.

Wynn TA, Oswald IP, Eltoum IA, Caspar P, Lowenstein CJ, Lewis FA, James SL, Sher A.

J Immunol. 1994 Dec 1;153(11):5200-9.

PMID:
7525727
46.

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

Gazzinelli RT, Wysocka M, Hayashi S, Denkers EY, Hieny S, Caspar P, Trinchieri G, Sher A.

J Immunol. 1994 Sep 15;153(6):2533-43.

PMID:
7915739
48.

IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni.

Oswald IP, Caspar P, Jankovic D, Wynn TA, Pearce EJ, Sher A.

J Immunol. 1994 Aug 15;153(4):1707-13.

PMID:
7913944
49.

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

Cheever AW, Williams ME, Wynn TA, Finkelman FD, Seder RA, Cox TM, Hieny S, Caspar P, Sher A.

J Immunol. 1994 Jul 15;153(2):753-9.

PMID:
8021510
50.

Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide.

Oswald IP, Eltoum I, Wynn TA, Schwartz B, Caspar P, Paulin D, Sher A, James SL.

Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):999-1003.

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