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Items: 1 to 50 of 57

1.

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome.

Wang G, Gormley M, Qiao J, Zhao Q, Wang M, Di Sante G, Deng S, Dong L, Pestell T, Ju X, Casimiro MC, Addya S, Ertel A, Tozeren A, Li Q, Yu Z, Pestell RG.

Theranostics. 2018 Mar 11;8(8):2251-2263. doi: 10.7150/thno.23877. eCollection 2018.

2.

Hormone-induced DNA damage response and repair mediated by cyclin D1 in breast and prostate cancer.

Di Sante G, Di Rocco A, Pupo C, Casimiro MC, Pestell RG.

Oncotarget. 2017 Jul 20;8(47):81803-81812. doi: 10.18632/oncotarget.19413. eCollection 2017 Oct 10. Review.

3.

Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth.

Pestell TG, Jiao X, Kumar M, Peck AR, Prisco M, Deng S, Li Z, Ertel A, Casimiro MC, Ju X, Di Rocco A, Di Sante G, Katiyar S, Shupp A, Lisanti MP, Jain P, Wu K, Rui H, Hooper DC, Yu Z, Goldman AR, Speicher DW, Laury-Kleintop L, Pestell RG.

Oncotarget. 2017 Aug 4;8(47):81754-81775. doi: 10.18632/oncotarget.19953. eCollection 2017 Oct 10.

4.

Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis.

Casimiro MC, Di Sante G, Di Rocco A, Loro E, Pupo C, Pestell TG, Bisetto S, Velasco-Velázquez MA, Jiao X, Li Z, Kusminski CM, Seifert EL, Wang C, Ly D, Zheng B, Shen CH, Scherer PE, Pestell RG.

Cancer Res. 2017 Jul 1;77(13):3391-3405. doi: 10.1158/0008-5472.CAN-16-0425. Epub 2017 May 18.

5.

Biological functions of CDK5 and potential CDK5 targeted clinical treatments.

Shupp A, Casimiro MC, Pestell RG.

Oncotarget. 2017 Mar 7;8(10):17373-17382. doi: 10.18632/oncotarget.14538. Review.

6.

Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage.

Marampon F, Gravina GL, Ju X, Vetuschi A, Sferra R, Casimiro MC, Pompili S, Festuccia C, Colapietro A, Gaudio E, Di Cesare E, Tombolini V, Pestell RG.

Oncotarget. 2016 Sep 27;7(39):64526. doi: 10.18632/oncotarget.12267. No abstract available.

7.

v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1.

Ju X, Jiao X, Ertel A, Casimiro MC, Di Sante G, Deng S, Li Z, Di Rocco A, Zhan T, Hawkins A, Stoyanova T, Andò S, Fatatis A, Lisanti MP, Gomella LG, Languino LR, Pestell RG.

Cancer Res. 2016 Nov 15;76(22):6723-6734. doi: 10.1158/0008-5472.CAN-15-3327. Epub 2016 Sep 15.

8.

Time-Lapse Video Microscopy for Assessment of EYFP-Parkin Aggregation as a Marker for Cellular Mitophagy.

Di Sante G, Casimiro MC, Pestell TG, Pestell RG.

J Vis Exp. 2016 May 4;(111). doi: 10.3791/53657.

9.

Cyclin D1 Promotes Androgen-Dependent DNA Damage Repair in Prostate Cancer Cells.

Casimiro MC, Di Sante G, Ju X, Li Z, Chen K, Crosariol M, Yaman I, Gormley M, Meng H, Lisanti MP, Pestell RG.

Cancer Res. 2016 Jan 15;76(2):329-38. doi: 10.1158/0008-5472.CAN-15-0999. Epub 2015 Nov 18.

10.

Kinase independent oncogenic cyclin D1.

Casimiro MC, Arnold A, Pestell RG.

Aging (Albany NY). 2015 Jul;7(7):455-6. No abstract available.

PMID:
26187783
Free PMC Article
11.

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis.

Casimiro MC, Di Sante G, Crosariol M, Loro E, Dampier W, Ertel A, Yu Z, Saria EA, Papanikolaou A, Li Z, Wang C, Addya S, Lisanti MP, Fortina P, Cardiff RD, Tozeren A, Knudsen ES, Arnold A, Pestell RG.

Oncotarget. 2015 Apr 20;6(11):8525-38.

12.

The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module.

Chen K, Wu K, Jiao X, Wang L, Ju X, Wang M, Di Sante G, Xu S, Wang Q, Li K, Sun X, Xu C, Li Z, Casimiro MC, Ertel A, Addya S, McCue PA, Lisanti MP, Wang C, Davis RJ, Mardon G, Pestell RG.

Cancer Res. 2015 May 15;75(10):1992-2004. doi: 10.1158/0008-5472.CAN-14-0611. Epub 2015 Mar 13.

13.

Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration.

Di Sante G, Wang L, Wang C, Jiao X, Casimiro MC, Chen K, Pestell TG, Yaman I, Di Rocco A, Sun X, Horio Y, Powell MJ, He X, McBurney MW, Pestell RG.

Mol Endocrinol. 2015 Feb;29(2):200-12. doi: 10.1210/me.2014-1228. Epub 2014 Dec 29.

14.

Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria.

Di Sante G, Pestell TG, Casimiro MC, Bisetto S, Powell MJ, Lisanti MP, Cordon-Cardo C, Castillo-Martin M, Bonal DM, Debattisti V, Chen K, Wang L, He X, McBurney MW, Pestell RG.

Am J Pathol. 2015 Jan;185(1):266-79. doi: 10.1016/j.ajpath.2014.09.014.

15.

Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells.

Tian L, Wang C, Hagen FK, Gormley M, Addya S, Soccio R, Casimiro MC, Zhou J, Powell MJ, Xu P, Deng H, Sauve AA, Pestell RG.

Oncotarget. 2014 Sep 15;5(17):7303-15.

16.

Cyclin D1 integrates estrogen-mediated DNA damage repair signaling.

Li Z, Chen K, Jiao X, Wang C, Willmarth NE, Casimiro MC, Li W, Ju X, Kim SH, Lisanti MP, Katzenellenbogen JA, Pestell RG.

Cancer Res. 2014 Jul 15;74(14):3959-70. doi: 10.1158/0008-5472.CAN-13-3137. Epub 2014 May 15.

17.

Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present.

Casimiro MC, Velasco-Velázquez M, Aguirre-Alvarado C, Pestell RG.

Expert Opin Investig Drugs. 2014 Mar;23(3):295-304. doi: 10.1517/13543784.2014.867017. Epub 2014 Jan 3. Review.

PMID:
24387133
18.

Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer.

Yu Z, Wang L, Wang C, Ju X, Wang M, Chen K, Loro E, Li Z, Zhang Y, Wu K, Casimiro MC, Gormley M, Ertel A, Fortina P, Chen Y, Tozeren A, Liu Z, Pestell RG.

Nat Commun. 2013;4:2812. doi: 10.1038/ncomms3812.

19.

Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraint.

Ju X, Casimiro MC, Gormley M, Meng H, Jiao X, Katiyar S, Crosariol M, Chen K, Wang M, Quong AA, Lisanti MP, Ertel A, Pestell RG.

Cancer Res. 2014 Jan 15;74(2):508-19. doi: 10.1158/0008-5472.CAN-13-1313. Epub 2013 Nov 26.

20.

Cyclin D1 determines estrogen signaling in the mammary gland in vivo.

Casimiro MC, Wang C, Li Z, Di Sante G, Willmart NE, Addya S, Chen L, Liu Y, Lisanti MP, Pestell RG.

Mol Endocrinol. 2013 Sep;27(9):1415-28. doi: 10.1210/me.2013-1065. Epub 2013 Jul 17.

21.

Cyclins and cell cycle control in cancer and disease.

Casimiro MC, Crosariol M, Loro E, Li Z, Pestell RG.

Genes Cancer. 2012 Nov;3(11-12):649-57. doi: 10.1177/1947601913479022.

22.

Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures.

Ju X, Ertel A, Casimiro MC, Yu Z, Meng H, McCue PA, Walters R, Fortina P, Lisanti MP, Pestell RG.

Cancer Res. 2013 Jan 15;73(2):978-89. doi: 10.1158/0008-5472.CAN-12-2133. Epub 2012 Nov 30.

23.

Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth.

Guido C, Whitaker-Menezes D, Lin Z, Pestell RG, Howell A, Zimmers TA, Casimiro MC, Aquila S, Ando' S, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.

Oncotarget. 2012 Aug;3(8):798-810.

24.

Cyclin d1 induces chromosomal instability.

Casimiro MC, Pestell RG.

Oncotarget. 2012 Mar;3(3):224-5.

25.

ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice.

Casimiro MC, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, Saria EA, Papanikolaou A, Stanek TJ, Li Z, Wang C, Fortina P, Addya S, Tozeren A, Knudsen ES, Arnold A, Pestell RG.

J Clin Invest. 2012 Mar;122(3):833-43. doi: 10.1172/JCI60256. Epub 2012 Feb 6. Erratum in: J Clin Invest. 2013 May 1;123(5):2332.

26.

Mammary gland selective excision of c-jun identifies its role in mRNA splicing.

Katiyar S, Jiao X, Addya S, Ertel A, Covarrubias Y, Rose V, Casimiro MC, Zhou J, Lisanti MP, Nasim T, Fortina P, Pestell RG.

Cancer Res. 2012 Feb 15;72(4):1023-34. doi: 10.1158/0008-5472.CAN-11-3647. Epub 2011 Dec 15.

27.

Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate.

Bryant KG, Camacho J, Jasmin JF, Wang C, Addya S, Casimiro MC, Fortina P, Balasubramaniam S, Knudsen KE, Schwarting R, Lisanti MP, Mercier I.

Int J Biochem Cell Biol. 2011 Sep;43(9):1318-29. doi: 10.1016/j.biocel.2011.04.019. Epub 2011 May 12.

PMID:
21601007
28.

Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.

Powell MJ, Casimiro MC, Cordon-Cardo C, He X, Yeow WS, Wang C, McCue PA, McBurney MW, Pestell RG.

Cancer Res. 2011 Feb 1;71(3):964-75. doi: 10.1158/0008-5472.CAN-10-3172. Epub 2010 Dec 28.

29.

The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion.

Liu M, Sakamaki T, Casimiro MC, Willmarth NE, Quong AA, Ju X, Ojeifo J, Jiao X, Yeow WS, Katiyar S, Shirley LA, Joyce D, Lisanti MP, Albanese C, Pestell RG.

Cancer Res. 2010 Dec 15;70(24):10464-73. doi: 10.1158/0008-5472.CAN-10-0732.

30.

Cell fate determination factor Dachshund reprograms breast cancer stem cell function.

Wu K, Jiao X, Li Z, Katiyar S, Casimiro MC, Yang W, Zhang Q, Willmarth NE, Chepelev I, Crosariol M, Wei Z, Hu J, Zhao K, Pestell RG.

J Biol Chem. 2011 Jan 21;286(3):2132-42. doi: 10.1074/jbc.M110.148395. Epub 2010 Oct 11.

31.

C-jun inhibits mammary apoptosis in vivo.

Katiyar S, Casimiro MC, Dettin L, Ju X, Wagner EF, Tanaka H, Pestell RG.

Mol Biol Cell. 2010 Dec;21(23):4264-74. doi: 10.1091/mbc.E10-08-0705. Epub 2010 Oct 6.

32.

HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis.

Chiavarina B, Whitaker-Menezes D, Migneco G, Martinez-Outschoorn UE, Pavlides S, Howell A, Tanowitz HB, Casimiro MC, Wang C, Pestell RG, Grieshaber P, Caro J, Sotgia F, Lisanti MP.

Cell Cycle. 2010 Sep 1;9(17):3534-51. Epub 2010 Sep 4.

33.

The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.

Pavlides S, Tsirigos A, Migneco G, Whitaker-Menezes D, Chiavarina B, Flomenberg N, Frank PG, Casimiro MC, Wang C, Pestell RG, Martinez-Outschoorn UE, Howell A, Sotgia F, Lisanti MP.

Cell Cycle. 2010 Sep 1;9(17):3485-505. doi: 10.4161/cc.9.17.12721.

34.

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation.

Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.

Cell Cycle. 2010 Jun 1;9(11):2201-19.

PMID:
20519932
35.

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling".

Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Pestell RG, Martinez-Outschoorn UE, Howell A, Sotgia F, Lisanti MP.

Aging (Albany NY). 2010 Apr;2(4):185-99.

36.

Attenuation of Forkhead signaling by the retinal determination factor DACH1.

Zhou J, Wang C, Wang Z, Dampier W, Wu K, Casimiro MC, Chepelev I, Popov VM, Quong A, Tozeren A, Zhao K, Lisanti MP, Pestell RG.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6864-9. doi: 10.1073/pnas.1002746107. Epub 2010 Mar 29.

37.

Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis.

Tian L, Zhou J, Casimiro MC, Liang B, Ojeifo JO, Wang M, Hyslop T, Wang C, Pestell RG.

Cancer Res. 2009 Dec 15;69(24):9236-44. doi: 10.1158/0008-5472.CAN-09-2067.

38.

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma.

Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.

Cell Cycle. 2009 Dec;8(23):3984-4001. Epub 2009 Dec 5.

PMID:
19923890
39.

p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo.

Liu M, Casimiro MC, Wang C, Shirley LA, Jiao X, Katiyar S, Ju X, Li Z, Yu Z, Zhou J, Johnson M, Fortina P, Hyslop T, Windle JJ, Pestell RG.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19035-9. doi: 10.1073/pnas.0910009106. Epub 2009 Oct 26.

40.

PPARgamma activation induces autophagy in breast cancer cells.

Zhou J, Zhang W, Liang B, Casimiro MC, Whitaker-Menezes D, Wang M, Lisanti MP, Lanza-Jacoby S, Pestell RG, Wang C.

Int J Biochem Cell Biol. 2009 Nov;41(11):2334-42. doi: 10.1016/j.biocel.2009.06.007. Epub 2009 Jun 26.

41.

Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy.

Witkiewicz AK, Casimiro MC, Dasgupta A, Mercier I, Wang C, Bonuccelli G, Jasmin JF, Frank PG, Pestell RG, Kleer CG, Sotgia F, Lisanti MP.

Cell Cycle. 2009 Jun 1;8(11):1654-8.

PMID:
19448435
42.

Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature.

Bonuccelli G, Casimiro MC, Sotgia F, Wang C, Liu M, Katiyar S, Zhou J, Dew E, Capozza F, Daumer KM, Minetti C, Milliman JN, Alpy F, Rio MC, Tomasetto C, Mercier I, Flomenberg N, Frank PG, Pestell RG, Lisanti MP.

Am J Pathol. 2009 May;174(5):1650-62. doi: 10.2353/ajpath.2009.080648.

43.

Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo.

Liu M, Ju X, Willmarth NE, Casimiro MC, Ojeifo J, Sakamaki T, Katiyar S, Jiao X, Popov VM, Yu Z, Wu K, Joyce D, Wang C, Pestell RG.

Am J Pathol. 2009 May;174(5):1910-20. doi: 10.2353/ajpath.2009.080706. Epub 2009 Apr 6.

44.

Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions.

Mercier I, Casimiro MC, Zhou J, Wang C, Plymire C, Bryant KG, Daumer KM, Sotgia F, Bonuccelli G, Witkiewicz AK, Lin J, Tran TH, Milliman J, Frank PG, Jasmin JF, Rui H, Pestell RG, Lisanti MP.

Am J Pathol. 2009 Apr;174(4):1172-90. doi: 10.2353/ajpath.2009.080882.

45.

Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.

Sotgia F, Del Galdo F, Casimiro MC, Bonuccelli G, Mercier I, Whitaker-Menezes D, Daumer KM, Zhou J, Wang C, Katiyar S, Xu H, Bosco E, Quong AA, Aronow B, Witkiewicz AK, Minetti C, Frank PG, Jimenez SA, Knudsen ES, Pestell RG, Lisanti MP.

Am J Pathol. 2009 Mar;174(3):746-61. doi: 10.2353/ajpath.2009.080658.

46.

Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation.

Sotgia F, Casimiro MC, Bonuccelli G, Liu M, Whitaker-Menezes D, Er O, Daumer KM, Mercier I, Witkiewicz AK, Minetti C, Capozza F, Gormley M, Quong AA, Rui H, Frank PG, Milliman JN, Knudsen ES, Zhou J, Wang C, Pestell RG, Lisanti MP.

Am J Pathol. 2009 Feb;174(2):613-29. doi: 10.2353/ajpath.2009.080653.

47.

ErbB2 induces Notch1 activity and function in breast cancer cells.

Lindsay J, Jiao X, Sakamaki T, Casimiro MC, Shirley LA, Tran TH, Ju X, Liu M, Li Z, Wang C, Katiyar S, Rao M, Allen KG, Glazer RI, Ge C, Stanley P, Lisanti MP, Rui H, Pestell RG.

Clin Transl Sci. 2008 Sep;1(2):107-15. doi: 10.1111/j.1752-8062.2008.00041.x.

48.

A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.

Yu Z, Wang C, Wang M, Li Z, Casimiro MC, Liu M, Wu K, Whittle J, Ju X, Hyslop T, McCue P, Pestell RG.

J Cell Biol. 2008 Aug 11;182(3):509-17. doi: 10.1083/jcb.200801079.

49.

Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy.

Mercier I, Casimiro MC, Wang C, Rosenberg AL, Quong J, Minkeu A, Allen KG, Danilo C, Sotgia F, Bonuccelli G, Jasmin JF, Xu H, Bosco E, Aronow B, Witkiewicz A, Pestell RG, Knudsen ES, Lisanti MP.

Cancer Biol Ther. 2008 Aug;7(8):1212-25. Epub 2008 Aug 30.

PMID:
18458534
50.

Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB.

Marampon F, Casimiro MC, Fu M, Powell MJ, Popov VM, Lindsay J, Zani BM, Ciccarelli C, Watanabe G, Lee RJ, Pestell RG.

Mol Biol Cell. 2008 Jun;19(6):2566-78. doi: 10.1091/mbc.E06-12-1110. Epub 2008 Mar 26.

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