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A Longitudinal Study of the Neurologic Safety of Acute Baclofen Use After Spinal Cord Injury.

Cragg JJ, Tong B, Jutzeler CR, Warner FM, Cashman N, Geisler F, Kramer JLK.

Neurotherapeutics. 2019 Feb 6. doi: 10.1007/s13311-019-00713-8. [Epub ahead of print]


CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice.

Cheng WH, Martens KM, Bashir A, Cheung H, Stukas S, Gibbs E, Namjoshi DR, Button EB, Wilkinson A, Barron CJ, Cashman NR, Cripton PA, Wellington CL.

Alzheimers Res Ther. 2019 Jan 12;11(1):6. doi: 10.1186/s13195-018-0461-0.


CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1.

Silverman JM, Christy D, Shyu CC, Moon KM, Fernando S, Gidden Z, Cowan CM, Ban Y, Stacey RG, Grad LI, McAlary L, Mackenzie IR, Foster LJ, Cashman NR.

J Biol Chem. 2019 Mar 8;294(10):3744-3759. doi: 10.1074/jbc.RA118.004825. Epub 2019 Jan 11.


Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics.

DuVal MG, Hinge VK, Snyder N, Kanyo R, Bratvold J, Pokrishevsky E, Cashman NR, Blinov N, Kovalenko A, Allison WT.

Neurobiol Dis. 2019 Apr;124:297-310. doi: 10.1016/j.nbd.2018.11.025. Epub 2018 Dec 4.


Accelerated onset of chronic wasting disease in elk (Cervus canadensis) vaccinated with a PrPSc-specific vaccine and housed in a prion contaminated environment.

Wood ME, Griebel P, Huizenga ML, Lockwood S, Hansen C, Potter A, Cashman N, Mapletoft JW, Napper S.

Vaccine. 2018 Nov 29;36(50):7737-7743. doi: 10.1016/j.vaccine.2018.10.057. Epub 2018 Nov 7.


Prediction of Misfolding-Specific Epitopes in SOD1 Using Collective Coordinates.

Peng X, Cashman NR, Plotkin SS.

J Phys Chem B. 2018 Dec 13;122(49):11662-11676. doi: 10.1021/acs.jpcb.8b07680. Epub 2018 Nov 5.


Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells.

Pokrishevsky E, McAlary L, Farrawell NE, Zhao B, Sher M, Yerbury JJ, Cashman NR.

Sci Rep. 2018 Oct 22;8(1):15590. doi: 10.1038/s41598-018-32835-y.


Induction of Cu/Zn Superoxide Dismutase (SOD1) Aggregation in Living Cells.

Pokrishevsky E, Nan J, Cashman NR.

Methods Mol Biol. 2019;1873:213-224. doi: 10.1007/978-1-4939-8820-4_13.


Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis.

Paré B, Lehmann M, Beaudin M, Nordström U, Saikali S, Julien JP, Gilthorpe JD, Marklund SL, Cashman NR, Andersen PM, Forsberg K, Dupré N, Gould P, Brännström T, Gros-Louis F.

Sci Rep. 2018 Sep 21;8(1):14223. doi: 10.1038/s41598-018-31773-z.


A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.

Ladner-Keay CL, Ross L, Perez-Pineiro R, Zhang L, Bjorndahl TC, Cashman N, Wishart DS.

Prion. 2018;12(5-6):280-300. doi: 10.1080/19336896.2018.1525254. Epub 2018 Oct 9.


Investigation of Anti-SOD1 Antibodies Yields New Structural Insight into SOD1 Misfolding and Surprising Behavior of the Antibodies Themselves.

Atlasi RS, Malik R, Corrales CI, Tzeplaeff L, Whitelegge JP, Cashman NR, Bitan G.

ACS Chem Biol. 2018 Sep 21;13(9):2794-2807. doi: 10.1021/acschembio.8b00729. Epub 2018 Aug 30.


Prion-like mechanisms in amyotrophic lateral sclerosis.

Ayers JI, Cashman NR.

Handb Clin Neurol. 2018;153:337-354. doi: 10.1016/B978-0-444-63945-5.00018-0. Review.


A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers.

Silverman JM, Gibbs E, Peng X, Martens KM, Balducci C, Wang J, Yousefi M, Cowan CM, Lamour G, Louadi S, Ban Y, Robert J, Stukas S, Forloni G, Hsiung GR, Plotkin SS, Wellington CL, Cashman NR.

ACS Chem Neurosci. 2018 Jul 18;9(7):1591-1606. doi: 10.1021/acschemneuro.7b00469. Epub 2018 Apr 16.


Enteroviral Infection: The Forgotten Link to Amyotrophic Lateral Sclerosis?

Xue YC, Feuer R, Cashman N, Luo H.

Front Mol Neurosci. 2018 Mar 12;11:63. doi: 10.3389/fnmol.2018.00063. eCollection 2018. Review.


Prevalence of chronic pain among individuals with neurological conditions.

Cragg JJ, Warner FM, Shupler MS, Jutzeler CR, Cashman N, Whitehurst DGT, Kramer JK.

Health Rep. 2018 Mar 21;29(3):11-16.


A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.

Mercer RCC, Daude N, Dorosh L, Fu ZL, Mays CE, Gapeshina H, Wohlgemuth SL, Acevedo-Morantes CY, Yang J, Cashman NR, Coulthart MB, Pearson DM, Joseph JT, Wille H, Safar JG, Jansen GH, Stepanova M, Sykes BD, Westaway D.

PLoS Pathog. 2018 Jan 16;14(1):e1006826. doi: 10.1371/journal.ppat.1006826. eCollection 2018 Jan.


Induction of PrPSc-specific systemic and mucosal immune responses in white-tailed deer with an oral vaccine for chronic wasting disease.

Taschuk R, Scruten E, Woodbury M, Cashman N, Potter A, Griebel P, Tikoo SK, Napper S.

Prion. 2017 Sep 3;11(5):368-380. doi: 10.1080/19336896.2017.1367083.


The effect of patient gender on outcomes after reverse total shoulder arthroplasty.

Wong SE, Pitcher AA, Ding DY, Cashman N, Zhang AL, Ma CB, Feeley BT.

J Shoulder Elbow Surg. 2017 Nov;26(11):1889-1896. doi: 10.1016/j.jse.2017.07.013. Epub 2017 Sep 11.


Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells.

Pokrishevsky E, Hong RH, Mackenzie IR, Cashman NR.

PLoS One. 2017 Sep 6;12(9):e0184384. doi: 10.1371/journal.pone.0184384. eCollection 2017.


Intercellular Prion-Like Conversion and Transmission of Cu/Zn Superoxide Dismutase (SOD1) in Cell Culture.

Grad LI, Pokrishevsky E, Cashman NR.

Methods Mol Biol. 2017;1658:357-367. doi: 10.1007/978-1-4939-7244-9_24.


High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture.

Robert J, Button EB, Stukas S, Boyce GK, Gibbs E, Cowan CM, Gilmour M, Cheng WH, Soo SK, Yuen B, Bahrabadi A, Kang K, Kulic I, Francis G, Cashman N, Wellington CL.

Mol Neurodegener. 2017 Aug 22;12(1):60. doi: 10.1186/s13024-017-0201-0.


Determinants of neurological disease: Synthesis of systematic reviews.

Krewski D, Barakat-Haddad C, Donnan J, Martino R, Pringsheim T, Tremlett H, van Lieshout P, Walsh SJ, Birkett NJ, Gomes J, Little J, Bowen S, Candundo H, Chao TK, Collins K, Crispo JAG, Duggan T, El Sherif R, Farhat N, Fortin Y, Gaskin J, Gupta P, Hersi M, Hu J, Irvine B, Jahanfar S, MacDonald D, McKay K, Morrissey A, Quach P, Rashid R, Shin S, Sikora L, Tkachuk S, Taher MK, Wang MD, Darshan S, Cashman NR.

Neurotoxicology. 2017 Jul;61:266-289. doi: 10.1016/j.neuro.2017.04.002. Epub 2017 Apr 12. Review.


Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS).

Grad LI, Rouleau GA, Ravits J, Cashman NR.

Cold Spring Harb Perspect Med. 2017 Aug 1;7(8). pii: a024117. doi: 10.1101/cshperspect.a024117. Review.


Journal Club: Depression before and after diagnosis with amyotrophic lateral sclerosis.

Cragg JJ, Seals R, Cashman N, Weisskopf MG.

Neurology. 2016 Nov 22;87(21):e257-e259. No abstract available.


The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS.

Brahimi F, Maira M, Barcelona PF, Galan A, Aboulkassim T, Teske K, Rogers ML, Bertram L, Wang J, Yousefi M, Rush R, Fabian M, Cashman N, Saragovi HU.

PLoS One. 2016 Oct 3;11(10):e0162307. doi: 10.1371/journal.pone.0162307. eCollection 2016.


Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex.

Beraldo FH, Ostapchenko VG, Caetano FA, Guimaraes AL, Ferretti GD, Daude N, Bertram L, Nogueira KO, Silva JL, Westaway D, Cashman NR, Martins VR, Prado VF, Prado MA.

J Biol Chem. 2016 Oct 14;291(42):21945-21955. Epub 2016 Aug 25.


Expert elicitation on the uncertainties associated with chronic wasting disease.

Tyshenko MG, Oraby T, Darshan S, Westphal M, Croteau MC, Aspinall W, Elsaadany S, Krewski D, Cashman N.

J Toxicol Environ Health A. 2016;79(16-17):729-45. doi: 10.1080/15287394.2016.1174007.


Using expert judgments to improve chronic wasting disease risk management in Canada.

Oraby T, Tyshenko MG, Westphal M, Darshan S, Croteau MC, Aspinall W, Elsaadany S, Cashman N, Krewski D.

J Toxicol Environ Health A. 2016;79(16-17):713-28. doi: 10.1080/15287394.2016.1174005.


Preface-Prion research in perspective IV.

Cashman N, Darshan S, Tyshenko MG.

J Toxicol Environ Health A. 2016;79(16-17):675-6. doi: 10.1080/15287394.2016.1173985. No abstract available.


Five-Year Incidence of Amyotrophic Lateral Sclerosis in British Columbia (2010-2015).

Golby R, Poirier B, Fabros M, Cragg JJ, Yousefi M, Cashman N.

Can J Neurol Sci. 2016 Nov;43(6):791-795. Epub 2016 Aug 1.


Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis.

Wang MD, Little J, Gomes J, Cashman NR, Krewski D.

Neurotoxicology. 2017 Jul;61:101-130. doi: 10.1016/j.neuro.2016.06.015. Epub 2016 Jul 1. Review.


ALS-linked misfolded SOD1 species have divergent impacts on mitochondria.

Pickles S, Semmler S, Broom HR, Destroismaisons L, Legroux L, Arbour N, Meiering E, Cashman NR, Vande Velde C.

Acta Neuropathol Commun. 2016 Apr 27;4(1):43. doi: 10.1186/s40478-016-0313-8.


TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion.

Pokrishevsky E, Grad LI, Cashman NR.

Sci Rep. 2016 Mar 1;6:22155. doi: 10.1038/srep22155.


Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.

Silverman JM, Fernando SM, Grad LI, Hill AF, Turner BJ, Yerbury JJ, Cashman NR.

Cell Mol Neurobiol. 2016 Apr;36(3):377-81. doi: 10.1007/s10571-015-0294-3. Epub 2016 Feb 23. Review.


Walking the tightrope: proteostasis and neurodegenerative disease.

Yerbury JJ, Ooi L, Dillin A, Saunders DN, Hatters DM, Beart PM, Cashman NR, Wilson MR, Ecroyd H.

J Neurochem. 2016 May;137(4):489-505. doi: 10.1111/jnc.13575. Epub 2016 Mar 8. Review.


Evidence for transmissibility of Alzheimer disease pathology: Cause for concern?

Coulthart MB, Jansen GH, Cashman NR.

CMAJ. 2016 Jul 12;188(10):E210-E212. doi: 10.1503/cmaj.151257. Epub 2016 Feb 1. No abstract available.


SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation.

Zeineddine R, Pundavela JF, Corcoran L, Stewart EM, Do-Ha D, Bax M, Guillemin G, Vine KL, Hatters DM, Ecroyd H, Dobson CM, Turner BJ, Ooi L, Wilson MR, Cashman NR, Yerbury JJ.

Mol Neurodegener. 2015 Oct 31;10:57. doi: 10.1186/s13024-015-0053-4.


Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.

Mackenzie IR, Frick P, Grässer FA, Gendron TF, Petrucelli L, Cashman NR, Edbauer D, Kremmer E, Prudlo J, Troost D, Neumann M.

Acta Neuropathol. 2015 Dec;130(6):845-61. doi: 10.1007/s00401-015-1476-2. Epub 2015 Sep 15.


In vitro neutralization of prions with PrP(Sc)-specific antibodies.

Taschuk R, Van der Merwe J, Marciniuk K, Potter A, Cashman N, Griebel P, Napper S.

Prion. 2015;9(4):292-303. doi: 10.1080/19336896.2015.1071761.


Propagated protein misfolding: New opportunities for therapeutics, new public health risk.

Cashman NR.

Can Commun Dis Rep. 2015 Aug 6;41(8):196-199. eCollection 2015 Aug 6.


Creutzfeldt-Jakob disease mortality in Canada, 1998 to 2013.

Coulthart MB, Jansen GH, Connolly T, D'Amour R, Kruse J, Lynch J, Sabourin S, Wang Z, Giulivi A, Ricketts MN, Cashman NR.

Can Commun Dis Rep. 2015 Aug 6;41(8):182-191. eCollection 2015 Aug 6.


Assessing transmissible spongiform encephalopathy species barriers with an in vitro prion protein conversion assay.

Johnson CJ, Carlson CM, Morawski AR, Manthei A, Cashman NR.

J Vis Exp. 2015 Mar 10;(97). doi: 10.3791/52522.


From molecule to molecule and cell to cell: prion-like mechanisms in amyotrophic lateral sclerosis.

Grad LI, Fernando SM, Cashman NR.

Neurobiol Dis. 2015 May;77:257-65. doi: 10.1016/j.nbd.2015.02.009. Epub 2015 Feb 17. Review.


Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding.

Grad LI, Pokrishevsky E, Silverman JM, Cashman NR.

Prion. 2014;8(5):331-5. doi: 10.4161/19336896.2014.983398.


A meta-analysis of observational studies of the association between chronic occupational exposure to lead and amyotrophic lateral sclerosis.

Wang MD, Gomes J, Cashman NR, Little J, Krewski D.

J Occup Environ Med. 2014 Dec;56(12):1235-42. doi: 10.1097/JOM.0000000000000323. Review.


Intermediate CAG repeat expansion in the ATXN2 gene is a unique genetic risk factor for ALS--a systematic review and meta-analysis of observational studies.

Wang MD, Gomes J, Cashman NR, Little J, Krewski D.

PLoS One. 2014 Aug 22;9(8):e105534. doi: 10.1371/journal.pone.0105534. eCollection 2014. Review.


A special focus issue on the materials of PRION 2013 meeting in Banff, Alberta Canada.

Keough K, Cashman N.

Prion. 2014 Jan-Feb;8(1):1. No abstract available.


Update on the provisional estimation of developing iatrogenic variant Creutzfeldt-Jakob disease from human islet cell transplantation procedures.

Tyshenko MG, Bertram L, Li L, ElSaadany S, Samis J, Krewski D, Cashman NR.

Transplantation. 2014 Jun 27;97(12):e73-5. doi: 10.1097/TP.0000000000000176. No abstract available.


Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms.

Grad LI, Yerbury JJ, Turner BJ, Guest WC, Pokrishevsky E, O'Neill MA, Yanai A, Silverman JM, Zeineddine R, Corcoran L, Kumita JR, Luheshi LM, Yousefi M, Coleman BM, Hill AF, Plotkin SS, Mackenzie IR, Cashman NR.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3620-5. doi: 10.1073/pnas.1312245111. Epub 2014 Feb 18.


Safety, specificity and immunogenicity of a PrP(Sc)-specific prion vaccine based on the YYR disease specific epitope.

Taschuk R, Marciniuk K, Määttänen P, Madampage C, Hedlin P, Potter A, Lee J, Cashman NR, Griebel PJ, Napper S.

Prion. 2014 Jan-Feb;8(1):51-9.


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