Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 214


Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers.

Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M.

Mol Cancer Ther. 2019 Mar;18(3):693-705. doi: 10.1158/1535-7163.MCT-18-0766.


GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.

Rasheed SAK, Leong HS, Lakshmanan M, Raju A, Dadlani D, Chong FT, Shannon NB, Rajarethinam R, Skanthakumar T, Tan EY, Hwang JSG, Lim KH, Tan DS, Ceppi P, Wang M, Tergaonkar V, Casey PJ, Iyer NG.

Oncogene. 2018 Mar;37(10):1340-1353. doi: 10.1038/s41388-017-0038-6. Epub 2017 Dec 19.


Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis.

Do MT, Chai TF, Casey PJ, Wang M.

Oncogene. 2017 Oct 12;36(41):5757-5767. doi: 10.1038/onc.2017.183. Epub 2017 Jun 12.


c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells.

Udayappan UK, Casey PJ.

Molecules. 2017 Apr 10;22(4). pii: E612. doi: 10.3390/molecules22040612.


Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms.

Lau HY, Tang J, Casey PJ, Wang M.

Oncogene. 2017 Jul 6;36(27):3934-3942. doi: 10.1038/onc.2016.508. Epub 2017 Feb 13.


Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer.

Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M.

Mol Cancer Ther. 2017 May;16(5):914-923. doi: 10.1158/1535-7163.MCT-16-0703. Epub 2017 Feb 6.


Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif).

Ng MY, Wang M, Casey PJ, Gan YH, Hagen T.

PLoS One. 2017 Feb 6;12(2):e0171464. doi: 10.1371/journal.pone.0171464. eCollection 2017.


The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.

Teo CR, Casey PJ, Rasheed SA.

Cell Signal. 2016 Oct;28(10):1479-88. doi: 10.1016/j.cellsig.2016.07.001. Epub 2016 Jul 14.


GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.

Healy JA, Nugent A, Rempel RE, Moffitt AB, Davis NS, Jiang X, Shingleton JR, Zhang J, Love C, Datta J, McKinney ME, Tzeng TJ, Wettschureck N, Offermanns S, Walzer KA, Chi JT, Rasheed SA, Casey PJ, Lossos IS, Dave SS.

Blood. 2016 Jun 2;127(22):2723-31. doi: 10.1182/blood-2015-07-659938. Epub 2016 Mar 17.


Protein prenylation: unique fats make their mark on biology.

Wang M, Casey PJ.

Nat Rev Mol Cell Biol. 2016 Feb;17(2):110-22. doi: 10.1038/nrm.2015.11. Epub 2016 Jan 21. Review.


Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia.

Sun WT, Xiang W, Ng BL, Asari K, Bunte RM, Casey PJ, Wang M, Chuah C.

Exp Hematol. 2016 Mar;44(3):189-93.e2. doi: 10.1016/j.exphem.2015.12.002. Epub 2015 Dec 17.


Protein Geranylgeranyltransferase Type 1 as a Target in Cancer.

Ullah N, Mansha M, Casey PJ.

Curr Cancer Drug Targets. 2016;16(7):563-71. Review.


MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells.

Rasheed SA, Teo CR, Beillard EJ, Voorhoeve PM, Zhou W, Ghosh S, Casey PJ.

Mol Cancer. 2015 Mar 26;14:67. doi: 10.1186/s12943-015-0337-x.


Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism.

Teh JT, Zhu WL, Ilkayeva OR, Li Y, Gooding J, Casey PJ, Summers SA, Newgard CB, Wang M.

Oncogene. 2015 Jun;34(25):3296-304. doi: 10.1038/onc.2014.260. Epub 2014 Aug 25.


Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2.

Chia CY, Kumari U, Casey PJ.

J Mol Signal. 2014 Jun 17;9:6. doi: 10.1186/1750-2187-9-6. eCollection 2014.


An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo.

Lau HY, Ramanujulu PM, Guo D, Yang T, Wirawan M, Casey PJ, Go ML, Wang M.

Cancer Biol Ther. 2014 Sep;15(9):1280-91. doi: 10.4161/cbt.29692. Epub 2014 Jun 27.


Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes.

Kimple ME, Neuman JC, Linnemann AK, Casey PJ.

Exp Mol Med. 2014 Jun 20;46:e102. doi: 10.1038/emm.2014.40. Review.


Gαz regulates BDNF-induction of axon growth in cortical neurons.

Hultman R, Kumari U, Michel N, Casey PJ.

Mol Cell Neurosci. 2014 Jan;58:53-61. doi: 10.1016/j.mcn.2013.12.004. Epub 2013 Dec 7.


Control of RhoA methylation by carboxylesterase I.

Cushman I, Cushman SM, Potter PM, Casey PJ.

J Biol Chem. 2013 Jun 28;288(26):19177-83. doi: 10.1074/jbc.M113.467407. Epub 2013 May 8.


Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).

Ramanujulu PM, Yang T, Yap SQ, Wong FC, Casey PJ, Wang M, Go ML.

Eur J Med Chem. 2013 May;63:378-86. doi: 10.1016/j.ejmech.2013.02.007. Epub 2013 Feb 21.


MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells.

Rasheed SA, Teo CR, Beillard EJ, Voorhoeve PM, Casey PJ.

J Biol Chem. 2013 Mar 15;288(11):7986-95. doi: 10.1074/jbc.M112.437749. Epub 2013 Jan 17.


Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass.

Kimple ME, Moss JB, Brar HK, Rosa TC, Truchan NA, Pasker RL, Newgard CB, Casey PJ.

J Biol Chem. 2012 Jun 8;287(24):20344-55. doi: 10.1074/jbc.M112.359745. Epub 2012 Mar 28.


G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.

Juneja J, Cushman I, Casey PJ.

PLoS One. 2011;6(11):e26085. doi: 10.1371/journal.pone.0026085. Epub 2011 Nov 7.


A role for Rac3 GTPase in the regulation of autophagy.

Zhu WL, Hossain MS, Guo DY, Liu S, Tong H, Khakpoor A, Casey PJ, Wang M.

J Biol Chem. 2011 Oct 7;286(40):35291-8. doi: 10.1074/jbc.M111.280990. Epub 2011 Aug 18.


The effect of growth hormone (GH) and insulin-like growth factor-I (IGF-I) on in vitro maturation of equine oocytes.

Pereira GR, Lorenzo PL, Carneiro GF, Ball BA, Gonçalves PB, Pegoraro LM, Bilodeau-Goeseels S, Kastelic JP, Casey PJ, Liu IK.

Zygote. 2012 Nov;20(4):353-60. doi: 10.1017/S0967199411000335. Epub 2011 Jul 28.


Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis.

Dasgupta S, Cushman I, Kpetemey M, Casey PJ, Vishwanatha JK.

J Biol Chem. 2011 Jul 22;286(29):25935-46. doi: 10.1074/jbc.M111.254599. Epub 2011 May 31.


Site-specific analysis of protein S-acylation by resin-assisted capture.

Forrester MT, Hess DT, Thompson JW, Hultman R, Moseley MA, Stamler JS, Casey PJ.

J Lipid Res. 2011 Feb;52(2):393-8. doi: 10.1194/jlr.D011106. Epub 2010 Nov 2.


Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase.

Go ML, Leow JL, Gorla SK, Schüller AP, Wang M, Casey PJ.

J Med Chem. 2010 Oct 14;53(19):6838-50. doi: 10.1021/jm1002843.


RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.

Cushman I, Casey PJ.

Cell Adh Migr. 2011 Jan-Feb;5(1):11-5. doi: 10.4161/cam.5.1.13196. Epub 2011 Jan 1.


Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth.

Wang M, Hossain MS, Tan W, Coolman B, Zhou J, Liu S, Casey PJ.

Oncogene. 2010 Sep 2;29(35):4959-70. doi: 10.1038/onc.2010.247. Epub 2010 Jul 12.


The effects of systemic hypothermia on a murine model of thoracic aortic ischemia reperfusion.

Kang J, Albadawi H, Casey PJ, Abbruzzese TA, Patel VI, Yoo HJ, Cambria RP, Watkins MT.

J Vasc Surg. 2010 Aug;52(2):435-43. doi: 10.1016/j.jvs.2010.03.021. Epub 2010 Jun 11.


A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity.

Mizrahi A, Berdichevsky Y, Casey PJ, Pick E.

J Biol Chem. 2010 Aug 13;285(33):25485-99. doi: 10.1074/jbc.M110.113779. Epub 2010 Jun 7.


Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.

Kelly P, Bailey CL, Fueger PT, Newgard CB, Casey PJ, Kimple ME.

J Biol Chem. 2010 May 21;285(21):15777-85. doi: 10.1074/jbc.M109.069112. Epub 2010 Mar 25.


Pharmacological targeting of the mitochondrial phosphatase PTPMT1.

Doughty-Shenton D, Joseph JD, Zhang J, Pagliarini DJ, Kim Y, Lu D, Dixon JE, Casey PJ.

J Pharmacol Exp Ther. 2010 May;333(2):584-92. doi: 10.1124/jpet.109.163329. Epub 2010 Feb 18.


Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.

Cushman I, Casey PJ.

J Biol Chem. 2009 Oct 9;284(41):27964-73. doi: 10.1074/jbc.M109.025296. Epub 2009 Aug 3.


Rho GTPase activity modulates Wnt3a/beta-catenin signaling.

Rossol-Allison J, Stemmle LN, Swenson-Fields KI, Kelly P, Fields PE, McCall SJ, Casey PJ, Fields TA.

Cell Signal. 2009 Nov;21(11):1559-68. doi: 10.1016/j.cellsig.2009.05.010. Epub 2009 May 29.


Activation of Rap1 promotes prostate cancer metastasis.

Bailey CL, Kelly P, Casey PJ.

Cancer Res. 2009 Jun 15;69(12):4962-8. doi: 10.1158/0008-5472.CAN-08-4269. Epub 2009 May 26.


Role of G12 proteins in oncogenesis and metastasis.

Juneja J, Casey PJ.

Br J Pharmacol. 2009 Sep;158(1):32-40. doi: 10.1111/j.1476-5381.2009.00180.x. Epub 2009 Apr 30. Review.


PJ34, a poly-ADP-ribose polymerase inhibitor, modulates visceral mitochondrial activity and CD14 expression following thoracic aortic ischemia-reperfusion.

Stone DH, Albadawi H, Conrad MF, Entabi F, Stoner MC, Casey PJ, Cambria RP, Watkins MT.

Am J Surg. 2009 Aug;198(2):250-5. doi: 10.1016/j.amjsurg.2008.09.013. Epub 2009 Mar 6.


Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe.

Wright LP, Court H, Mor A, Ahearn IM, Casey PJ, Philips MR.

Mol Cell Biol. 2009 Apr;29(7):1826-33. doi: 10.1128/MCB.01719-08. Epub 2009 Jan 21.


Pre-freeze bull sperm head morphometry related to post-thaw fertility.

Gravance CG, Casey ME, Casey PJ.

Anim Reprod Sci. 2009 Aug;114(1-3):81-8. doi: 10.1016/j.anireprosci.2008.09.014. Epub 2008 Oct 1.


Interacting targets of the farnesyl of transducin gamma-subunit.

Katadae M, Hagiwara K, Wada A, Ito M, Umeda M, Casey PJ, Fukada Y.

Biochemistry. 2008 Aug 12;47(32):8424-33. doi: 10.1021/bi800359h. Epub 2008 Jul 18.


A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells.

Wang M, Tan W, Zhou J, Leow J, Go M, Lee HS, Casey PJ.

J Biol Chem. 2008 Jul 4;283(27):18678-84. doi: 10.1074/jbc.M801855200. Epub 2008 Apr 23.


Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork.

Rao PV, Peterson YK, Inoue T, Casey PJ.

Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2464-71. doi: 10.1167/iovs.07-1639. Epub 2008 Mar 3.


A global partnership in medical education between Duke University and the National University of Singapore.

Williams RS, Casey PJ, Kamei RK, Buckley EG, Soo KC, Merson MH, Krishnan RK, Dzau VJ.

Acad Med. 2008 Feb;83(2):122-7. doi: 10.1097/ACM.0b013e318160b8bc.


Testicular and spermatozoan parameters in the pukeko (Porphyrio porphyrio melanotus).

Gunn MR, Champion Z, Casey ME, Teal P, Casey PJ.

Anim Reprod Sci. 2008 Dec;109(1-4):330-42. Epub 2007 Nov 19.


Galphaz negatively regulates insulin secretion and glucose clearance.

Kimple ME, Joseph JW, Bailey CL, Fueger PT, Hendry IA, Newgard CB, Casey PJ.

J Biol Chem. 2008 Feb 22;283(8):4560-7. Epub 2007 Dec 20.


beta-Catenin is a Nek2 substrate involved in centrosome separation.

Bahmanyar S, Kaplan DD, Deluca JG, Giddings TH Jr, O'Toole ET, Winey M, Salmon ED, Casey PJ, Nelson WJ, Barth AI.

Genes Dev. 2008 Jan 1;22(1):91-105. Epub 2007 Dec 17.

Supplemental Content

Loading ...
Support Center