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Items: 1 to 50 of 53

1.

Liquid chromatographic nanofractionation with parallel mass spectrometric detection for the screening of plasmin inhibitors and (metallo)proteinases in snake venoms.

Zietek BM, Mayar M, Slagboom J, Bruyneel B, Vonk FJ, Somsen GW, Casewell NR, Kool J.

Anal Bioanal Chem. 2018 Sep;410(23):5751-5763. doi: 10.1007/s00216-018-1253-x. Epub 2018 Aug 9.

2.

Venom Complexity in a Pitviper Produced by Facultative Parthenogenesis.

Calvete JJ, Casewell NR, Hernández-Guzmán U, Quesada-Bernat S, Sanz L, Rokyta DR, Storey D, Albulescu LO, Wüster W, Smith CF, Schuett GW, Booth W.

Sci Rep. 2018 Aug 1;8(1):11539. doi: 10.1038/s41598-018-29791-y.

3.

Molecular Adaptations for Sensing and Securing Prey and Insight into Amniote Genome Diversity from the Garter Snake Genome.

Perry BW, Card DC, McGlothlin JW, Pasquesi GIM, Adams RH, Schield DR, Hales NR, Corbin AB, Demuth JP, Hoffmann FG, Vandewege MW, Schott RK, Bhattacharyya N, Chang BSW, Casewell NR, Whiteley G, Reyes-Velasco J, Mackessy SP, Gamble T, Storey KB, Biggar KK, Passow CN, Kuo CH, McGaugh SE, Bronikowski AM, de Koning APJ, Edwards SV, Pfrender ME, Minx P, Brodie ED 3rd, Brodie ED Jr, Warren WC, Castoe TA.

Genome Biol Evol. 2018 Aug 1;10(8):2110-2129. doi: 10.1093/gbe/evy157.

4.

Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins.

Vanzolini KL, Ainsworth S, Bruyneel B, Herzig V, Seraus MGL, Somsen GW, Casewell NR, Cass QB, Kool J.

Toxicon. 2018 Sep 15;152:1-8. doi: 10.1016/j.toxicon.2018.06.080. Epub 2018 Jul 7.

5.

Widespread vulnerability of Malagasy predators to the toxins of an introduced toad.

Marshall BM, Casewell NR, Vences M, Glaw F, Andreone F, Rakotoarison A, Zancolli G, Woog F, Wüster W.

Curr Biol. 2018 Jul 9;28(13):2194. doi: 10.1016/j.cub.2018.06.012. No abstract available.

PMID:
29990449
6.

Widespread vulnerability of Malagasy predators to the toxins of an introduced toad.

Marshall BM, Casewell NR, Vences M, Glaw F, Andreone F, Rakotoarison A, Zancolli G, Woog F, Wüster W.

Curr Biol. 2018 Jun 4;28(11):R654-R655. doi: 10.1016/j.cub.2018.04.024. Erratum in: Curr Biol. 2018 Jul 9;28(13):2194.

PMID:
29870701
7.

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling.

Slagboom J, Otvos RA, Cardoso FC, Iyer J, Visser JC, van Doodewaerd BR, McCleary RJR, Niessen WMA, Somsen GW, Lewis RJ, Kini RM, Smit AB, Casewell NR, Kool J.

Toxicon. 2018 Jun 15;148:213-222. doi: 10.1016/j.toxicon.2018.04.022. Epub 2018 May 4.

8.

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals.

Arbuckle K, Rodríguez de la Vega RC, Casewell NR.

Toxicon. 2017 Dec 15;140:118-131. doi: 10.1016/j.toxicon.2017.10.026. Epub 2017 Oct 27. Review.

PMID:
29111116
9.

Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa.

Harrison RA, Oluoch GO, Ainsworth S, Alsolaiss J, Bolton F, Arias AS, Gutiérrez JM, Rowley P, Kalya S, Ozwara H, Casewell NR.

PLoS Negl Trop Dis. 2017 Oct 18;11(10):e0005969. doi: 10.1371/journal.pntd.0005969. eCollection 2017 Oct.

10.

Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies.

Rogalski A, Soerensen C, Op den Brouw B, Lister C, Dashevsky D, Arbuckle K, Gloria A, Zdenek CN, Casewell NR, Gutiérrez JM, Wüster W, Ali SA, Masci P, Rowley P, Frank N, Fry BG.

Toxicol Lett. 2017 Oct 5;280:159-170. doi: 10.1016/j.toxlet.2017.08.020. Epub 2017 Aug 25.

PMID:
28847519
11.

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.

Ainsworth S, Petras D, Engmark M, Süssmuth RD, Whiteley G, Albulescu LO, Kazandjian TD, Wagstaff SC, Rowley P, Wüster W, Dorrestein PC, Arias AS, Gutiérrez JM, Harrison RA, Casewell NR, Calvete JJ.

J Proteomics. 2018 Feb 10;172:173-189. doi: 10.1016/j.jprot.2017.08.016. Epub 2017 Aug 24.

PMID:
28843532
12.

Evolution: Gene Co-option Underpins Venom Protein Evolution.

Casewell NR.

Curr Biol. 2017 Jul 10;27(13):R647-R649. doi: 10.1016/j.cub.2017.05.091.

13.

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes.

Casewell NR, Visser JC, Baumann K, Dobson J, Han H, Kuruppu S, Morgan M, Romilio A, Weisbecker V, Mardon K, Ali SA, Debono J, Koludarov I, Que I, Bird GC, Cooke GM, Nouwens A, Hodgson WC, Wagstaff SC, Cheney KL, Vetter I, van der Weerd L, Richardson MK, Fry BG.

Curr Biol. 2017 May 22;27(10):1549-1550. doi: 10.1016/j.cub.2017.05.009. No abstract available.

14.

Coagulating Colubrids: Evolutionary, Pathophysiological and Biodiscovery Implications of Venom Variations between Boomslang (Dispholidus typus) and Twig Snake (Thelotornis mossambicanus).

Debono J, Dobson J, Casewell NR, Romilio A, Li B, Kurniawan N, Mardon K, Weisbecker V, Nouwens A, Kwok HF, Fry BG.

Toxins (Basel). 2017 May 19;9(5). pii: E171. doi: 10.3390/toxins9050171.

15.

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes.

Casewell NR, Visser JC, Baumann K, Dobson J, Han H, Kuruppu S, Morgan M, Romilio A, Weisbecker V, Mardon K, Ali SA, Debono J, Koludarov I, Que I, Bird GC, Cooke GM, Nouwens A, Hodgson WC, Wagstaff SC, Cheney KL, Vetter I, van der Weerd L, Richardson MK, Fry BG.

Curr Biol. 2017 Apr 24;27(8):1184-1191. doi: 10.1016/j.cub.2017.02.067. Epub 2017 Mar 30.

16.

Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise.

Slagboom J, Kool J, Harrison RA, Casewell NR.

Br J Haematol. 2017 Jun;177(6):947-959. doi: 10.1111/bjh.14591. Epub 2017 Feb 24. Review.

17.

The Cardiovascular and Neurotoxic Effects of the  Venoms of Six Bony and Cartilaginous Fish Species.

Han H, Baumann K, Casewell NR, Ali SA, Dobson J, Koludarov I, Debono J, Cutmore SC, Rajapakse NW, Jackson TN, Jones R, Hodgson WC, Fry BG, Kuruppu S.

Toxins (Basel). 2017 Feb 16;9(2). pii: E67. doi: 10.3390/toxins9020067.

18.

What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus.

Pla D, Sanz L, Whiteley G, Wagstaff SC, Harrison RA, Casewell NR, Calvete JJ.

Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):814-823. doi: 10.1016/j.bbagen.2017.01.020. Epub 2017 Jan 24.

19.

Venom Evolution: Gene Loss Shapes Phenotypic Adaptation.

Casewell NR.

Curr Biol. 2016 Sep 26;26(18):R849-R851. doi: 10.1016/j.cub.2016.07.082.

20.

Visual Pigments, Ocular Filters and the Evolution of Snake Vision.

Simões BF, Sampaio FL, Douglas RH, Kodandaramaiah U, Casewell NR, Harrison RA, Hart NS, Partridge JC, Hunt DM, Gower DJ.

Mol Biol Evol. 2016 Oct;33(10):2483-95. doi: 10.1093/molbev/msw148. Epub 2016 Aug 16.

PMID:
27535583
21.

Stabilising the Integrity of Snake Venom mRNA Stored under Tropical Field Conditions Expands Research Horizons.

Whiteley G, Logan RA, Leung KY, Newberry FJ, Rowley PD, Dunbar JP, Wagstaff SC, Casewell NR, Harrison RA.

PLoS Negl Trop Dis. 2016 Jun 9;10(6):e0004615. doi: 10.1371/journal.pntd.0004615. eCollection 2016 Jun.

22.

Widespread convergence in toxin resistance by predictable molecular evolution.

Ujvari B, Casewell NR, Sunagar K, Arbuckle K, Wüster W, Lo N, O'Meally D, Beckmann C, King GF, Deplazes E, Madsen T.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11911-6. doi: 10.1073/pnas.1511706112. Epub 2015 Sep 8.

23.

Firing the sting: chemically induced discharge of cnidae reveals novel proteins and peptides from box jellyfish (Chironex fleckeri) venom.

Jouiaei M, Casewell NR, Yanagihara AA, Nouwens A, Cribb BW, Whitehead D, Jackson TN, Ali SA, Wagstaff SC, Koludarov I, Alewood P, Hansen J, Fry BG.

Toxins (Basel). 2015 Mar 18;7(3):936-50. doi: 10.3390/toxins7030936.

24.

Anti-angiogenic activities of snake venom CRISP isolated from Echis carinatus sochureki.

Lecht S, Chiaverelli RA, Gerstenhaber J, Calvete JJ, Lazarovici P, Casewell NR, Harrison R, Lelkes PI, Marcinkiewicz C.

Biochim Biophys Acta. 2015 Jun;1850(6):1169-79. doi: 10.1016/j.bbagen.2015.02.002. Epub 2015 Feb 7.

PMID:
25665484
25.

Venom-related transcripts from Bothrops jararaca tissues provide novel molecular insights into the production and evolution of snake venom.

Junqueira-de-Azevedo IL, Bastos CM, Ho PL, Luna MS, Yamanouye N, Casewell NR.

Mol Biol Evol. 2015 Mar;32(3):754-66. doi: 10.1093/molbev/msu337. Epub 2014 Dec 9.

26.

VTBuilder: a tool for the assembly of multi isoform transcriptomes.

Archer J, Whiteley G, Casewell NR, Harrison RA, Wagstaff SC.

BMC Bioinformatics. 2014 Dec 3;15:389. doi: 10.1186/s12859-014-0389-8.

27.

Expression of venom gene homologs in diverse python tissues suggests a new model for the evolution of snake venom.

Reyes-Velasco J, Card DC, Andrew AL, Shaney KJ, Adams RH, Schield DR, Casewell NR, Mackessy SP, Castoe TA.

Mol Biol Evol. 2015 Jan;32(1):173-83. doi: 10.1093/molbev/msu294. Epub 2014 Oct 21.

PMID:
25338510
28.

Extreme venom variation in Middle Eastern vipers: a proteomics comparison of Eristicophis macmahonii, Pseudocerastes fieldi and Pseudocerastes persicus.

Ali SA, Jackson TN, Casewell NR, Low DH, Rossi S, Baumann K, Fathinia B, Visser J, Nouwens A, Hendrikx I, Jones A, Undheim E, Fry BG.

J Proteomics. 2015 Feb 26;116:106-13. doi: 10.1016/j.jprot.2014.09.003. Epub 2014 Sep 18.

PMID:
25241240
29.

Immunological cross-reactivity and neutralisation of European viper venoms with the monospecific Vipera berus antivenom ViperaTAb.

Casewell NR, Al-Abdulla I, Smith D, Coxon R, Landon J.

Toxins (Basel). 2014 Aug 19;6(8):2471-82. doi: 10.3390/toxins6082471.

30.

A ray of venom: Combined proteomic and transcriptomic investigation of fish venom composition using barb tissue from the blue-spotted stingray (Neotrygon kuhlii).

Baumann K, Casewell NR, Ali SA, Jackson TN, Vetter I, Dobson JS, Cutmore SC, Nouwens A, Lavergne V, Fry BG.

J Proteomics. 2014 Sep 23;109:188-98. doi: 10.1016/j.jprot.2014.06.004. Epub 2014 Jun 16.

PMID:
24946716
31.

Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms.

Casewell NR, Wagstaff SC, Wüster W, Cook DA, Bolton FM, King SI, Pla D, Sanz L, Calvete JJ, Harrison RA.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9205-10. doi: 10.1073/pnas.1405484111. Epub 2014 Jun 9.

32.

Production and assessment of ovine antisera for the manufacture of a veterinary adder antivenom.

Bolton FM, Casewell NR, Al-Abdulla I, Landon J.

Vet Rec. 2014 Apr 19;174(16):406. doi: 10.1136/vr.102286. Epub 2014 Mar 10.

PMID:
24615173
33.

Vintage venoms: proteomic and pharmacological stability of snake venoms stored for up to eight decades.

Jesupret C, Baumann K, Jackson TN, Ali SA, Yang DC, Greisman L, Kern L, Steuten J, Jouiaei M, Casewell NR, Undheim EA, Koludarov I, Debono J, Low DH, Rossi S, Panagides N, Winter K, Ignjatovic V, Summerhayes R, Jones A, Nouwens A, Dunstan N, Hodgson WC, Winkel KD, Monagle P, Fry BG.

J Proteomics. 2014 Jun 13;105:285-94. doi: 10.1016/j.jprot.2014.01.004. Epub 2014 Jan 14.

PMID:
24434587
34.

Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenalf.

Sunagar K, Fry BG, Jackson TN, Casewell NR, Undheim EA, Vidal N, Ali SA, King GF, Vasudevan K, Vasconcelos V, Antunes A.

PLoS One. 2013 Nov 29;8(11):e81827. doi: 10.1371/journal.pone.0081827. eCollection 2013.

35.

The Burmese python genome reveals the molecular basis for extreme adaptation in snakes.

Castoe TA, de Koning AP, Hall KT, Card DC, Schield DR, Fujita MK, Ruggiero RP, Degner JF, Daza JM, Gu W, Reyes-Velasco J, Shaney KJ, Castoe JM, Fox SE, Poole AW, Polanco D, Dobry J, Vandewege MW, Li Q, Schott RK, Kapusta A, Minx P, Feschotte C, Uetz P, Ray DA, Hoffmann FG, Bogden R, Smith EN, Chang BS, Vonk FJ, Casewell NR, Henkel CV, Richardson MK, Mackessy SP, Bronikowski AM, Yandell M, Warren WC, Secor SM, Pollock DD.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20645-50. doi: 10.1073/pnas.1314475110. Epub 2013 Dec 2. Erratum in: Proc Natl Acad Sci U S A. 2013 Dec 17;110(51). doi:10.1073/pnas.1324133111. Bronikowsi, Anne M [corrected to Bronikowski, Anne M]. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3194.

36.

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system.

Vonk FJ, Casewell NR, Henkel CV, Heimberg AM, Jansen HJ, McCleary RJ, Kerkkamp HM, Vos RA, Guerreiro I, Calvete JJ, Wüster W, Woods AE, Logan JM, Harrison RA, Castoe TA, de Koning AP, Pollock DD, Yandell M, Calderon D, Renjifo C, Currier RB, Salgado D, Pla D, Sanz L, Hyder AS, Ribeiro JM, Arntzen JW, van den Thillart GE, Boetzer M, Pirovano W, Dirks RP, Spaink HP, Duboule D, McGlinn E, Kini RM, Richardson MK.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20651-6. doi: 10.1073/pnas.1314702110. Epub 2013 Dec 2.

37.

Single-reagent one-step procedures for the purification of ovine IgG, F(ab')2 and Fab antivenoms by caprylic acid.

Al-Abdulla I, Casewell NR, Landon J.

J Immunol Methods. 2014 Jan 15;402(1-2):15-22. doi: 10.1016/j.jim.2013.11.001. Epub 2013 Nov 15.

PMID:
24246428
38.

Cytotoxic activities of [Ser⁴⁹]phospholipase A₂ from the venom of the saw-scaled vipers Echis ocellatus, Echis pyramidum leakeyi, Echis carinatus sochureki, and Echis coloratus.

Conlon JM, Attoub S, Arafat H, Mechkarska M, Casewell NR, Harrison RA, Calvete JJ.

Toxicon. 2013 Sep;71:96-104. doi: 10.1016/j.toxicon.2013.05.017. Epub 2013 Jun 4.

PMID:
23747272
39.

Long-term physicochemical and immunological stability of a liquid formulated intact ovine immunoglobulin-based antivenom.

Al-Abdulla I, Casewell NR, Landon J.

Toxicon. 2013 Mar 15;64:38-42. doi: 10.1016/j.toxicon.2012.12.022. Epub 2013 Jan 11.

PMID:
23319075
40.
41.

Differential evolution and neofunctionalization of snake venom metalloprotease domains.

Brust A, Sunagar K, Undheim EA, Vetter I, Yang DC, Casewell NR, Jackson TN, Koludarov I, Alewood PF, Hodgson WC, Lewis RJ, King GF, Antunes A, Hendrikx I, Fry BG.

Mol Cell Proteomics. 2013 Mar;12(3):651-63. doi: 10.1074/mcp.M112.023135. Epub 2012 Dec 12. Erratum in: Mol Cell Proteomics. 2013 May;12(5):1488. Yang, Dary C [corrected to Yang, Daryl C].

42.

Complex cocktails: the evolutionary novelty of venoms.

Casewell NR, Wüster W, Vonk FJ, Harrison RA, Fry BG.

Trends Ecol Evol. 2013 Apr;28(4):219-29. doi: 10.1016/j.tree.2012.10.020. Epub 2012 Dec 5. Review.

PMID:
23219381
43.
44.

Dynamic evolution of venom proteins in squamate reptiles.

Casewell NR, Huttley GA, Wüster W.

Nat Commun. 2012;3:1066. doi: 10.1038/ncomms2065.

PMID:
22990862
45.

Novel transcripts in the maxillary venom glands of advanced snakes.

Fry BG, Scheib H, de L M Junqueira de Azevedo I, Silva DA, Casewell NR.

Toxicon. 2012 Jun 1;59(7-8):696-708. doi: 10.1016/j.toxicon.2012.03.005. Epub 2012 Mar 20.

PMID:
22465490
46.

The structural and functional diversification of the Toxicofera reptile venom system.

Fry BG, Casewell NR, Wüster W, Vidal N, Young B, Jackson TN.

Toxicon. 2012 Sep 15;60(4):434-48. doi: 10.1016/j.toxicon.2012.02.013. Epub 2012 Mar 14.

PMID:
22446061
47.

On the ancestral recruitment of metalloproteinases into the venom of snakes.

Casewell NR.

Toxicon. 2012 Sep 15;60(4):449-54. doi: 10.1016/j.toxicon.2012.02.006. Epub 2012 Mar 3.

PMID:
22406471
48.

Research strategies to improve snakebite treatment: challenges and progress.

Harrison RA, Cook DA, Renjifo C, Casewell NR, Currier RB, Wagstaff SC.

J Proteomics. 2011 Aug 24;74(9):1768-80. doi: 10.1016/j.jprot.2011.06.019. Epub 2011 Jun 25.

PMID:
21723969
49.

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa.

Williams DJ, Gutiérrez JM, Calvete JJ, Wüster W, Ratanabanangkoon K, Paiva O, Brown NI, Casewell NR, Harrison RA, Rowley PD, O'Shea M, Jensen SD, Winkel KD, Warrell DA.

J Proteomics. 2011 Aug 24;74(9):1735-67. doi: 10.1016/j.jprot.2011.05.027. Epub 2011 May 19.

PMID:
21640209
50.

Domain loss facilitates accelerated evolution and neofunctionalization of duplicate snake venom metalloproteinase toxin genes.

Casewell NR, Wagstaff SC, Harrison RA, Renjifo C, Wüster W.

Mol Biol Evol. 2011 Sep;28(9):2637-49. doi: 10.1093/molbev/msr091. Epub 2011 Apr 4.

PMID:
21478373

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