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Items: 1 to 50 of 205

1.

Dual inhibitors of LSD1 and spermine oxidase.

Holshouser S, Dunworth M, Murray-Stewart T, Peterson YK, Burger P, Kirkpatrick J, Chen HH, Casero RA Jr, Woster PM.

Medchemcomm. 2019 Feb 8;10(5):778-790. doi: 10.1039/c8md00610e. eCollection 2019 May 1.

PMID:
31191868
2.

DFMO and 5-azacytidine increase M1 macrophages in the tumor microenvironment of murine ovarian cancer.

Travers M, Brown SM, Dunworth M, Holbert CE, Wiehagen KR, Bachman KE, Foley JR, Stone ML, Baylin SB, Casero RA, Zahnow CA.

Cancer Res. 2019 May 14. pii: canres.4018.2018. doi: 10.1158/0008-5472.CAN-18-4018. [Epub ahead of print]

PMID:
31088836
3.

Polyamine Homeostasis in Snyder-Robinson Syndrome.

Murray-Stewart T, Dunworth M, Foley JR, Schwartz CE, Casero RA Jr.

Med Sci (Basel). 2018 Dec 7;6(4). pii: E112. doi: 10.3390/medsci6040112.

4.

Polyamine catabolism and oxidative damage.

Murray Stewart T, Dunston TT, Woster PM, Casero RA Jr.

J Biol Chem. 2018 Nov 30;293(48):18736-18745. doi: 10.1074/jbc.TM118.003337. Epub 2018 Oct 17. Review.

PMID:
30333229
5.

Targeting the aryl hydrocarbon receptor/polyamine biosynthesis axis of evil for cancer therapy.

Casero RA Jr.

J Clin Invest. 2018 Oct 1;128(10):4254-4256. doi: 10.1172/JCI123266. Epub 2018 Sep 10.

6.

Polyamine metabolism and cancer: treatments, challenges and opportunities.

Casero RA Jr, Murray Stewart T, Pegg AE.

Nat Rev Cancer. 2018 Nov;18(11):681-695. doi: 10.1038/s41568-018-0050-3. Review.

7.

Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.

Murray-Stewart T, Dunworth M, Lui Y, Giardiello FM, Woster PM, Casero RA Jr.

PLoS One. 2018 Aug 23;13(8):e0202677. doi: 10.1371/journal.pone.0202677. eCollection 2018.

8.

Polymeric Prodrugs Targeting Polyamine Metabolism Inhibit Zika Virus Replication.

Routhu NK, Xie Y, Dunworth M, Casero RA Jr, Oupicky D, Byrareddy SN.

Mol Pharm. 2018 Sep 4;15(9):4284-4295. doi: 10.1021/acs.molpharmaceut.8b00068. Epub 2018 Aug 6.

9.

Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia.

Gong S, Sovio U, Aye IL, Gaccioli F, Dopierala J, Johnson MD, Wood AM, Cook E, Jenkins BJ, Koulman A, Casero RA Jr, Constância M, Charnock-Jones DS, Smith GC.

JCI Insight. 2018 Jul 12;3(13). pii: 120723. doi: 10.1172/jci.insight.120723.

10.

Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection.

Gobert AP, Al-Greene NT, Singh K, Coburn LA, Sierra JC, Verriere TG, Luis PB, Schneider C, Asim M, Allaman MM, Barry DP, Cleveland JL, Destefano Shields CE, Casero RA Jr, Washington MK, Piazuelo MB, Wilson KT.

Front Immunol. 2018 Jun 5;9:1242. doi: 10.3389/fimmu.2018.01242. eCollection 2018.

11.

Corrigendum to "Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures" [Bioorg. Med. Chem. 23 (2015) 1601-1612].

Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA Jr, Woster PM.

Bioorg Med Chem. 2018 Jul 23;26(12):3728-3729. doi: 10.1016/j.bmc.2018.05.032. Epub 2018 May 30. No abstract available.

PMID:
29859749
12.

Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis.

Cruz-Correa M, Hylind LM, Marrero JH, Zahurak ML, Murray-Stewart T, Casero RA Jr, Montgomery EA, Iacobuzio-Donahue C, Brosens LA, Offerhaus GJ, Umar A, Rodriguez LM, Giardiello FM.

Gastroenterology. 2018 Sep;155(3):668-673. doi: 10.1053/j.gastro.2018.05.031. Epub 2018 May 23.

PMID:
29802852
13.

Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes.

Lane DJR, Bae DH, Siafakas AR, Suryo Rahmanto Y, Al-Akra L, Jansson PJ, Casero RA Jr, Richardson DR.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2793-2813. doi: 10.1016/j.bbadis.2018.05.007. Epub 2018 May 16.

PMID:
29777905
14.

Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features.

Jain V, Raina S, Gheware AP, Singh R, Rehman R, Negi V, Murray Stewart T, Mabalirajan U, Mishra AK, Casero RA Jr, Agrawal A, Ghosh B.

Allergy. 2018 Oct;73(10):2033-2045. doi: 10.1111/all.13472.

PMID:
29729200
15.

Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex.

McKenna J 3rd, Kapfhamer D, Kinchen JM, Wasek B, Dunworth M, Murray-Stewart T, Bottiglieri T, Casero RA Jr, Gambello MJ.

Hum Mol Genet. 2018 Jun 15;27(12):2113-2124. doi: 10.1093/hmg/ddy118.

16.

N1-Nonyl-1,4-diaminobutane ameliorates brain infarction size in photochemically induced thrombosis model mice.

Masuko T, Takao K, Samejima K, Shirahata A, Igarashi K, Casero RA Jr, Kizawa Y, Sugita Y.

Neurosci Lett. 2018 Apr 13;672:118-122. doi: 10.1016/j.neulet.2018.01.054. Epub 2018 Feb 22.

17.

Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy.

Murray-Stewart T, Casero RA.

Med Sci (Basel). 2017 Dec 18;5(4). pii: E38. doi: 10.3390/medsci5040038. Review.

18.

Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury.

Zahedi K, Barone S, Destefano-Shields C, Brooks M, Murray-Stewart T, Dunworth M, Li W, Doherty JR, Hall MA, Smith RD, Cleveland JL, Casero RA Jr, Soleimani M.

PLoS One. 2017 Sep 8;12(9):e0184570. doi: 10.1371/journal.pone.0184570. eCollection 2017.

19.

Elucidating the Structure of N1-Acetylisoputreanine: A Novel Polyamine Catabolite in Human Urine.

Fitzgerald BL, Mahapatra S, Farmer DK, McNeil MR, Casero RA Jr, Belisle JT.

ACS Omega. 2017 Jul 31;2(7):3921-3930. doi: 10.1021/acsomega.7b00872. Epub 2017 Jul 25.

20.

Correction: Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.

Murray-Stewart T, Ferrari E, Xie Y, Yu F, Marton LJ, Oupicky D, Casero RA Jr.

PLoS One. 2017 May 16;12(5):e0178102. doi: 10.1371/journal.pone.0178102. eCollection 2017.

21.

Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth.

Liu Y, Murray-Stewart T, Casero RA Jr, Kagiampakis I, Jin L, Zhang J, Wang H, Che Q, Tong H, Ke J, Jiang F, Wang F, Wan X.

Int J Oncol. 2017 Jun;50(6):2011-2023. doi: 10.3892/ijo.2017.3979. Epub 2017 May 2.

22.

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.

Murray-Stewart T, Ferrari E, Xie Y, Yu F, Marton LJ, Oupicky D, Casero RA Jr.

PLoS One. 2017 Apr 19;12(4):e0175917. doi: 10.1371/journal.pone.0175917. eCollection 2017. Erratum in: PLoS One. 2017 May 16;12 (5):e0178102.

23.

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy.

Xie Y, Murray-Stewart T, Wang Y, Yu F, Li J, Marton LJ, Casero RA Jr, Oupický D.

J Control Release. 2017 Jan 28;246:110-119. doi: 10.1016/j.jconrel.2016.12.017. Epub 2016 Dec 23.

24.

Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.

Almaliti J, Al-Hamashi AA, Negmeldin AT, Hanigan CL, Perera L, Pflum MK, Casero RA Jr, Tillekeratne LM.

J Med Chem. 2016 Dec 8;59(23):10642-10660. Epub 2016 Nov 21.

25.

Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer.

Murray-Stewart T, Sierra JC, Piazuelo MB, Mera RM, Chaturvedi R, Bravo LE, Correa P, Schneider BG, Wilson KT, Casero RA.

Oncogene. 2016 Oct 20;35(42):5480-5488. doi: 10.1038/onc.2016.91. Epub 2016 Apr 4.

26.

Targeting polyamine metabolism for cancer therapy and prevention.

Murray-Stewart TR, Woster PM, Casero RA Jr.

Biochem J. 2016 Oct 1;473(19):2937-53. doi: 10.1042/BCJ20160383. Review.

27.

Decrease in acrolein toxicity based on the decline of polyamine oxidases.

Uemura T, Nakamura M, Sakamoto A, Suzuki T, Dohmae N, Terui Y, Tomitori H, Casero RA Jr, Kashiwagi K, Igarashi K.

Int J Biochem Cell Biol. 2016 Oct;79:151-157. doi: 10.1016/j.biocel.2016.08.039. Epub 2016 Aug 30.

PMID:
27590852
28.

MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition.

Luo H, Shenoy AK, Li X, Jin Y, Jin L, Cai Q, Tang M, Liu Y, Chen H, Reisman D, Wu L, Seto E, Qiu Y, Dou Y, Casero RA Jr, Lu J.

Cell Rep. 2016 Jun 21;15(12):2665-78. doi: 10.1016/j.celrep.2016.05.050. Epub 2016 Jun 9.

29.

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.

Hardbower DM, Asim M, Murray-Stewart T, Casero RA Jr, Verriere T, Lewis ND, Chaturvedi R, Piazuelo MB, Wilson KT.

Amino Acids. 2016 Oct;48(10):2375-88. doi: 10.1007/s00726-016-2231-2. Epub 2016 Apr 13.

30.

Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation: A Perfect Combination for Cancer Therapy.

Zahnow CA, Topper M, Stone M, Murray-Stewart T, Li H, Baylin SB, Casero RA Jr.

Adv Cancer Res. 2016;130:55-111. doi: 10.1016/bs.acr.2016.01.007. Epub 2016 Mar 2. Review.

PMID:
27037751
31.

Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment.

DeStefano Shields CE, Van Meerbeke SW, Housseau F, Wang H, Huso DL, Casero RA Jr, O'Hagan HM, Sears CL.

J Infect Dis. 2016 Jul 1;214(1):122-9. doi: 10.1093/infdis/jiw069. Epub 2016 Feb 21.

32.

Metabolism links bacterial biofilms and colon carcinogenesis.

Johnson CH, Dejea CM, Edler D, Hoang LT, Santidrian AF, Felding BH, Ivanisevic J, Cho K, Wick EC, Hechenbleikner EM, Uritboonthai W, Goetz L, Casero RA Jr, Pardoll DM, White JR, Patti GJ, Sears CL, Siuzdak G.

Cell Metab. 2015 Jun 2;21(6):891-7. doi: 10.1016/j.cmet.2015.04.011. Epub 2015 May 7.

33.

Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.

Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA Jr, Woster PM.

Bioorg Med Chem. 2015 Apr 1;23(7):1601-12. doi: 10.1016/j.bmc.2015.01.049. Epub 2015 Feb 7. Erratum in: Bioorg Med Chem. 2018 Jul 23;26(12):3728-3729.

34.

Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury.

Zahedi K, Barone S, Wang Y, Murray-Stewart T, Roy-Chaudhury P, Smith RD, Casero RA Jr, Soleimani M.

PLoS One. 2014 Nov 12;9(11):e110161. doi: 10.1371/journal.pone.0110161. eCollection 2014.

35.

Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups.

Bhansali P, Hanigan CL, Perera L, Casero RA Jr, Tillekeratne LM.

Eur J Med Chem. 2014 Oct 30;86:528-41. doi: 10.1016/j.ejmech.2014.09.009. Epub 2014 Sep 6.

36.

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.

Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM Jr, Fox JG, Woster PM, Casero RA Jr, Correa P, Wilson KT.

Oncogene. 2015 Jun;34(26):3429-40. doi: 10.1038/onc.2014.273. Epub 2014 Sep 1.

37.

A selective phenelzine analogue inhibitor of histone demethylase LSD1.

Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA Jr, Taverna SD, Qian J, Tackett AJ, Ratan RR, McDonald OG, Feinberg AP, Cole PA.

ACS Chem Biol. 2014 Jun 20;9(6):1284-93. doi: 10.1021/cb500018s. Epub 2014 Apr 7.

38.

Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage.

Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA Jr, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM Jr, Wilson KT.

Gastroenterology. 2014 Jun;146(7):1739-51.e14. doi: 10.1053/j.gastro.2014.02.005. Epub 2014 Feb 13.

39.
40.

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism.

Murray-Stewart T, Hanigan CL, Woster PM, Marton LJ, Casero RA Jr.

Mol Cancer Ther. 2013 Oct;12(10):2088-99. doi: 10.1158/1535-7163.MCT-13-0418. Epub 2013 Aug 13.

41.

Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine.

Chaturvedi R, Asim M, Barry DP, Frye JW, Casero RA Jr, Wilson KT.

Amino Acids. 2014 Mar;46(3):531-42. doi: 10.1007/s00726-013-1531-z. Epub 2013 Jul 3.

42.

Polyamine catabolism in carcinogenesis: potential targets for chemotherapy and chemoprevention.

Battaglia V, DeStefano Shields C, Murray-Stewart T, Casero RA Jr.

Amino Acids. 2014 Mar;46(3):511-9. doi: 10.1007/s00726-013-1529-6. Epub 2013 Jun 15. Review.

43.

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.

Murray-Stewart T, Woster PM, Casero RA Jr.

Amino Acids. 2014 Mar;46(3):585-94. doi: 10.1007/s00726-013-1485-1. Epub 2013 Mar 19.

44.

Pentamines as substrate for human spermine oxidase.

Takao K, Shirahata A, Samejima K, Casero RA, Igarashi K, Sugita Y.

Biol Pharm Bull. 2013;36(3):407-11.

45.

Polyamines and cancer: implications for chemotherapy and chemoprevention.

Nowotarski SL, Woster PM, Casero RA Jr.

Expert Rev Mol Med. 2013 Feb 22;15:e3. doi: 10.1017/erm.2013.3. Review.

46.

Polyamine-based small molecule epigenetic modulators.

Sharma SK, Hazeldine S, Crowley ML, Hanson A, Beattie R, Varghese S, Senanayake TM, Hirata A, Hirata F, Huang Y, Wu Y, Steinbergs N, Murray-Stewart T, Bytheway I, Casero RA Jr, Woster PM.

Medchemcomm. 2012;3(1):14-21. Epub 2011 Nov 26.

47.
48.

Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells.

Zhu Q, Jin L, Casero RA, Davidson NE, Huang Y.

Breast Cancer Res Treat. 2012 Nov;136(1):57-66. doi: 10.1007/s10549-012-2235-x. Epub 2012 Sep 14.

49.

Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.

Hazeldine S, Pachaiyappan B, Steinbergs N, Nowotarski S, Hanson AS, Casero RA Jr, Woster PM.

J Med Chem. 2012 Sep 13;55(17):7378-91. doi: 10.1021/jm3002845. Epub 2012 Sep 4.

50.

Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury.

Zahedi K, Barone SL, Xu J, Steinbergs N, Schuster R, Lentsch AB, Amlal H, Wang J, Casero RA Jr, Soleimani M.

Am J Physiol Gastrointest Liver Physiol. 2012 Sep 1;303(5):G546-60. doi: 10.1152/ajpgi.00431.2011. Epub 2012 Jun 21.

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