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Items: 1 to 50 of 165

1.

Structural basis of 7SK RNA 5'-γ-phosphate methylation and retention by MePCE.

Yang Y, Eichhorn CD, Wang Y, Cascio D, Feigon J.

Nat Chem Biol. 2019 Feb;15(2):132-140. doi: 10.1038/s41589-018-0188-z. Epub 2018 Dec 17.

PMID:
30559425
2.

Protein structural biology using cell-free platform from wheat germ.

Novikova IV, Sharma N, Moser T, Sontag R, Liu Y, Collazo MJ, Cascio D, Shokuhfar T, Hellmann H, Knoblauch M, Evans JE.

Adv Struct Chem Imaging. 2018;4(1):13. doi: 10.1186/s40679-018-0062-9. Epub 2018 Nov 10.

3.

The Streptococcus pyogenes Shr protein captures human hemoglobin using two structurally unique binding domains.

Macdonald R, Cascio D, Collazo MJ, Phillips M, Clubb RT.

J Biol Chem. 2018 Nov 23;293(47):18365-18377. doi: 10.1074/jbc.RA118.005261. Epub 2018 Oct 9.

PMID:
30301765
4.

Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition.

Chen W, Mandali S, Hancock SP, Kumar P, Collazo M, Cascio D, Johnson RC.

Elife. 2018 Oct 5;7. pii: e39611. doi: 10.7554/eLife.39611.

5.

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.

Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS.

Nat Struct Mol Biol. 2018 Jun;25(6):463-471. doi: 10.1038/s41594-018-0064-2. Epub 2018 May 21.

6.

Microfocus diffraction from different regions of a protein crystal: structural variations and unit-cell polymorphism.

Thompson MC, Cascio D, Yeates TO.

Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):411-421. doi: 10.1107/S2059798318003479. Epub 2018 Apr 24.

PMID:
29717712
7.

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.

Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS.

Nat Struct Mol Biol. 2018 Apr;25(4):311-319. doi: 10.1038/s41594-018-0045-5. Epub 2018 Mar 12.

8.

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks.

Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS.

Science. 2018 Feb 9;359(6376):698-701. doi: 10.1126/science.aan6398.

9.

Structure-based inhibitors of tau aggregation.

Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS.

Nat Chem. 2018 Feb;10(2):170-176. doi: 10.1038/nchem.2889. Epub 2017 Nov 20.

10.

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.

Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA.

Nat Struct Mol Biol. 2018 Feb;25(2):131-134. doi: 10.1038/s41594-017-0018-0. Epub 2018 Jan 15.

11.

Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.

Rothé B, Leettola CN, Leal-Esteban L, Cascio D, Fortier S, Isenschmid M, Bowie JU, Constam DB.

Structure. 2018 Feb 6;26(2):209-224.e6. doi: 10.1016/j.str.2017.12.002. Epub 2017 Dec 28.

PMID:
29290488
12.

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.

Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS.

J Biol Chem. 2018 Feb 23;293(8):2888-2902. doi: 10.1074/jbc.M117.806109. Epub 2017 Dec 27.

PMID:
29282295
13.

Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser.

Popp D, Loh ND, Zorgati H, Ghoshdastider U, Liow LT, Ivanova MI, Larsson M, DePonte DP, Bean R, Beyerlein KR, Gati C, Oberthuer D, Arnlund D, Brändén G, Berntsen P, Cascio D, Chavas LMG, Chen JPJ, Ding K, Fleckenstein H, Gumprecht L, Harimoorthy R, Mossou E, Sawaya MR, Brewster AS, Hattne J, Sauter NK, Seibert M, Seuring C, Stellato F, Tilp T, Eisenberg DS, Messerschmidt M, Williams GJ, Koglin JE, Makowski L, Millane RP, Forsyth T, Boutet S, White TA, Barty A, Chapman H, Chen SL, Liang M, Neutze R, Robinson RC.

Cytoskeleton (Hoboken). 2017 Dec;74(12):472-481. doi: 10.1002/cm.21378. Epub 2017 Jun 19.

14.

Crystal structure of Mdm12 and combinatorial reconstitution of Mdm12/Mmm1 ERMES complexes for structural studies.

AhYoung AP, Lu B, Cascio D, Egea PF.

Biochem Biophys Res Commun. 2017 Jun 17;488(1):129-135. doi: 10.1016/j.bbrc.2017.05.021. Epub 2017 May 4.

15.

Computational design of self-assembling cyclic protein homo-oligomers.

Fallas JA, Ueda G, Sheffler W, Nguyen V, McNamara DE, Sankaran B, Pereira JH, Parmeggiani F, Brunette TJ, Cascio D, Yeates TR, Zwart P, Baker D.

Nat Chem. 2017 Apr;9(4):353-360. doi: 10.1038/nchem.2673. Epub 2016 Dec 5.

16.

Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.

de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T.

Nat Methods. 2017 Feb 13;14(4):399-402. doi: 10.1038/nmeth.4178.

17.

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.

Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS.

Elife. 2017 Jan 3;6. pii: e19273. doi: 10.7554/eLife.19273.

18.

Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal.

Kattke MD, Chan AH, Duong A, Sexton DL, Sawaya MR, Cascio D, Elliot MA, Clubb RT.

PLoS One. 2016 Dec 9;11(12):e0167763. doi: 10.1371/journal.pone.0167763. eCollection 2016.

19.

Crystal structure of the toxin Msmeg_6760, the structural homolog of Mycobacterium tuberculosis Rv2035, a novel type II toxin involved in the hypoxic response.

Bajaj RA, Arbing MA, Shin A, Cascio D, Miallau L.

Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):863-869. Epub 2016 Nov 19.

20.

De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure.

Colletier JP, Sawaya MR, Gingery M, Rodriguez JA, Cascio D, Brewster AS, Michels-Clark T, Hice RH, Coquelle N, Boutet S, Williams GJ, Messerschmidt M, DePonte DP, Sierra RG, Laksmono H, Koglin JE, Hunter MS, Park HW, Uervirojnangkoorn M, Bideshi DK, Brunger AT, Federici BA, Sauter NK, Eisenberg DS.

Nature. 2016 Nov 3;539(7627):43-47. doi: 10.1038/nature19825. Epub 2016 Sep 28.

21.

Characterization of WY 14,643 and its Complex with Aldose Reductase.

Sawaya MR, Verma M, Balendiran V, Rath NP, Cascio D, Balendiran GK.

Sci Rep. 2016 Oct 10;6:34394. doi: 10.1038/srep34394.

22.

Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.

Sawaya MR, Rodriguez J, Cascio D, Collazo MJ, Shi D, Reyes FE, Hattne J, Gonen T, Eisenberg DS.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11232-11236. Epub 2016 Sep 19.

23.

A PII-Like Protein Regulated by Bicarbonate: Structural and Biochemical Studies of the Carboxysome-Associated CPII Protein.

Wheatley NM, Eden KD, Ngo J, Rosinski JS, Sawaya MR, Cascio D, Collazo M, Hoveida H, Hubbell WL, Yeates TO.

J Mol Biol. 2016 Oct 9;428(20):4013-4030. doi: 10.1016/j.jmb.2016.07.015. Epub 2016 Jul 25.

24.

Accurate design of megadalton-scale two-component icosahedral protein complexes.

Bale JB, Gonen S, Liu Y, Sheffler W, Ellis D, Thomas C, Cascio D, Yeates TO, Gonen T, King NP, Baker D.

Science. 2016 Jul 22;353(6297):389-94. doi: 10.1126/science.aaf8818.

25.

Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project.

Benammar Elgaaied A, Cascio D, Bruno S, Ciaccio MC, Cipolla M, Fauci A, Morgante R, Taormina V, Gorgi Y, Marrakchi Triki R, Ben Ahmed M, Louzir H, Yalaoui S, Imene S, Issaoui Y, Abidi A, Ammar M, Bedhiafi W, Ben Fraj O, Bouhaha R, Hamdi K, Soumaya K, Neili B, Asma G, Lucchese M, Catanzaro M, Barbara V, Brusca I, Fregapane M, Amato G, Friscia G, Neila T, Turkia S, Youssra H, Rekik R, Bouokez H, Vasile Simone M, Fauci F, Raso G.

Biomed Res Int. 2016;2016:2073076. doi: 10.1155/2016/2073076. Epub 2016 Mar 3.

26.

DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis.

Hancock SP, Stella S, Cascio D, Johnson RC.

PLoS One. 2016 Mar 9;11(3):e0150189. doi: 10.1371/journal.pone.0150189. eCollection 2016. Erratum in: PLoS One. 2016;11(6):e0157224.

27.

Structure of a putative ClpS N-end rule adaptor protein from the malaria pathogen Plasmodium falciparum.

AhYoung AP, Koehl A, Vizcarra CL, Cascio D, Egea PF.

Protein Sci. 2016 Mar;25(3):689-701. doi: 10.1002/pro.2868. Epub 2016 Jan 13.

28.

Engineering an allosteric transcription factor to respond to new ligands.

Taylor ND, Garruss AS, Moretti R, Chan S, Arbing MA, Cascio D, Rogers JK, Isaacs FJ, Kosuri S, Baker D, Fields S, Church GM, Raman S.

Nat Methods. 2016 Feb;13(2):177-83. doi: 10.1038/nmeth.3696. Epub 2015 Dec 21.

29.

Origins of stereoselectivity in evolved ketoreductases.

Noey EL, Tibrewal N, Jiménez-Osés G, Osuna S, Park J, Bond CM, Cascio D, Liang J, Zhang X, Huisman GW, Tang Y, Houk KN.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7065-72. doi: 10.1073/pnas.1507910112. Epub 2015 Dec 7.

30.

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.

Brumshtein B, Esswein SR, Salwinski L, Phillips ML, Ly AT, Cascio D, Sawaya MR, Eisenberg DS.

Elife. 2015 Nov 18;4:e10935. doi: 10.7554/eLife.10935.

31.

Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.

Jiang J, Chan H, Cash DD, Miracco EJ, Ogorzalek Loo RR, Upton HE, Cascio D, O'Brien Johnson R, Collins K, Loo JA, Zhou ZH, Feigon J.

Science. 2015 Oct 30;350(6260):aab4070. doi: 10.1126/science.aab4070. Epub 2015 Oct 15.

32.

Uncovering the Mechanism of Aggregation of Human Transthyretin.

Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS.

J Biol Chem. 2015 Nov 27;290(48):28932-43. doi: 10.1074/jbc.M115.659912. Epub 2015 Oct 12.

33.

Structure of the toxic core of α-synuclein from invisible crystals.

Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS.

Nature. 2015 Sep 24;525(7570):486-90. doi: 10.1038/nature15368. Epub 2015 Sep 9.

34.

Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression.

Bale JB, Park RU, Liu Y, Gonen S, Gonen T, Cascio D, King NP, Yeates TO, Baker D.

Protein Sci. 2015 Oct;24(10):1695-701. doi: 10.1002/pro.2748. Epub 2015 Aug 6.

35.

Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis.

Winter JM, Cascio D, Dietrich D, Sato M, Watanabe K, Sawaya MR, Vederas JC, Tang Y.

J Am Chem Soc. 2015 Aug 12;137(31):9885-93. doi: 10.1021/jacs.5b04520. Epub 2015 Jul 30.

36.

Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design.

AhYoung AP, Koehl A, Cascio D, Egea PF.

Protein Sci. 2015 Sep;24(9):1508-20. doi: 10.1002/pro.2739. Epub 2015 Jul 14.

37.

An allosteric model for control of pore opening by substrate binding in the EutL microcompartment shell protein.

Thompson MC, Cascio D, Leibly DJ, Yeates TO.

Protein Sci. 2015 Jun;24(6):956-75. doi: 10.1002/pro.2672. Epub 2015 Mar 31.

38.

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.

Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU.

Mol Cell. 2015 Mar 19;57(6):1011-1021. doi: 10.1016/j.molcel.2015.01.026. Epub 2015 Feb 26.

39.

Indexing amyloid peptide diffraction from serial femtosecond crystallography: new algorithms for sparse patterns.

Brewster AS, Sawaya MR, Rodriguez J, Hattne J, Echols N, McFarlane HT, Cascio D, Adams PD, Eisenberg DS, Sauter NK.

Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt 2):357-66. doi: 10.1107/S1399004714026145. Epub 2015 Jan 23.

40.

Structure and interactions of the CS domain of human H/ACA RNP assembly protein Shq1.

Singh M, Wang Z, Cascio D, Feigon J.

J Mol Biol. 2015 Feb 27;427(4):807-823. doi: 10.1016/j.jmb.2014.12.012. Epub 2014 Dec 29.

41.

Crystal structure and solution characterization of the thioredoxin-2 from Plasmodium falciparum, a constituent of an essential parasitic protein export complex.

Peng M, Cascio D, Egea PF.

Biochem Biophys Res Commun. 2015 Jan 2;456(1):403-9. doi: 10.1016/j.bbrc.2014.11.096. Epub 2014 Dec 2.

42.

Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases.

Vinokur JM, Korman TP, Sawaya MR, Collazo M, Cascio D, Bowie JU.

Protein Sci. 2015 Feb;24(2):212-20. doi: 10.1002/pro.2607. Epub 2014 Dec 26.

43.

Structure of the methanofuran/methanopterin-biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii.

Bobik TA, Morales EJ, Shin A, Cascio D, Sawaya MR, Arbing M, Yeates TO, Rasche ME.

Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1472-9. doi: 10.1107/S2053230X1402130X. Epub 2014 Oct 25.

44.

B-factor Analysis and Conformational Rearrangement of Aldose Reductase.

Balendiran GK, Pandian JR, Drake E, Vinayak A, Verma M, Cascio D.

Curr Proteomics. 2014;11(3):151-160.

45.

Formation of amyloid fibers by monomeric light chain variable domains.

Brumshtein B, Esswein SR, Landau M, Ryan CM, Whitelegge JP, Phillips ML, Cascio D, Sawaya MR, Eisenberg DS.

J Biol Chem. 2014 Oct 3;289(40):27513-25. doi: 10.1074/jbc.M114.585638. Epub 2014 Aug 19.

46.

Protein crystal structure obtained at 2.9 Å resolution from injecting bacterial cells into an X-ray free-electron laser beam.

Sawaya MR, Cascio D, Gingery M, Rodriguez J, Goldschmidt L, Colletier JP, Messerschmidt MM, Boutet S, Koglin JE, Williams GJ, Brewster AS, Nass K, Hattne J, Botha S, Doak RB, Shoeman RL, DePonte DP, Park HW, Federici BA, Sauter NK, Schlichting I, Eisenberg DS.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12769-74. doi: 10.1073/pnas.1413456111. Epub 2014 Aug 18.

47.

Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3.

Leettola CN, Knight MJ, Cascio D, Hoffman S, Bowie JU.

BMC Struct Biol. 2014 Jul 7;14:17. doi: 10.1186/1472-6807-14-17.

48.

Fuzzy technique for microcalcifications clustering in digital mammograms.

Vivona L, Cascio D, Fauci F, Raso G.

BMC Med Imaging. 2014 Jun 24;14:23. doi: 10.1186/1471-2342-14-23.

49.

The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity.

Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1562-70. doi: 10.1073/pnas.1322673111. Epub 2014 Apr 7.

50.

Mammographic images segmentation based on chaotic map clustering algorithm.

Iacomi M, Cascio D, Fauci F, Raso G.

BMC Med Imaging. 2014 Mar 25;14:12. doi: 10.1186/1471-2342-14-12.

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