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Items: 1 to 50 of 51

1.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Aug 17;13(8):2308-2319. doi: 10.1021/acschembio.8b00466. Epub 2018 Jun 28.

PMID:
29953201
2.

Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration: significant association of twelve variants.

Cascella R, Strafella C, Longo G, Ragazzo M, Manzo L, De Felici C, Errichiello V, Caputo V, Viola F, Eandi CM, Staurenghi G, Cusumano A, Mauriello S, Marsella LT, Ciccacci C, Borgiani P, Sangiuolo F, Novelli G, Ricci F, Giardina E.

Oncotarget. 2017 Dec 12;9(8):7812-7821. doi: 10.18632/oncotarget.23241. eCollection 2018 Jan 30.

3.

Selenium and zinc: Two key players against cadmium-induced neuronal toxicity.

Branca JJV, Morucci G, Maresca M, Tenci B, Cascella R, Paternostro F, Ghelardini C, Gulisano M, Di Cesare Mannelli L, Pacini A.

Toxicol In Vitro. 2018 Apr;48:159-169. doi: 10.1016/j.tiv.2018.01.007.

PMID:
29408665
4.

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.

Fusco G, Chen SW, Williamson PTF, Cascella R, Perni M, Jarvis JA, Cecchi C, Vendruscolo M, Chiti F, Cremades N, Ying L, Dobson CM, De Simone A.

Science. 2017 Dec 15;358(6369):1440-1443. doi: 10.1126/science.aan6160.

5.

KIF3A and IL-4 are disease-specific biomarkers for psoriatic arthritis susceptibility.

Cascella R, Strafella C, Ragazzo M, Manzo L, Costanza G, Bowes J, Hüffmeier U, Potenza S, Sangiuolo F, Reis A, Barton A, Novelli G, Orlandi A, Giardina E.

Oncotarget. 2017 Sep 8;8(56):95401-95411. doi: 10.18632/oncotarget.20727. eCollection 2017 Nov 10.

6.

Towards the application of precision medicine in Age-Related Macular Degeneration.

Cascella R, Strafella C, Caputo V, Errichiello V, Zampatti S, Milano F, Potenza S, Mauriello S, Novelli G, Ricci F, Cusumano A, Giardina E.

Prog Retin Eye Res. 2018 Mar;63:132-146. doi: 10.1016/j.preteyeres.2017.11.004. Epub 2017 Nov 29. Review.

PMID:
29197628
7.

Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload.

Cascella R, Evangelisti E, Bigi A, Becatti M, Fiorillo C, Stefani M, Chiti F, Cecchi C.

J Alzheimers Dis. 2017;60(3):923-938. doi: 10.3233/JAD-170340.

PMID:
28922156
8.

Assessing individual risk for AMD with genetic counseling, family history, and genetic testing.

Cascella R, Strafella C, Longo G, Manzo L, Ragazzo M, De Felici C, Gambardella S, Marsella LT, Novelli G, Borgiani P, Sangiuolo F, Cusumano A, Ricci F, Giardina E.

Eye (Lond). 2018 Feb;32(2):446-450. doi: 10.1038/eye.2017.192. Epub 2017 Sep 15.

PMID:
28912512
9.

Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy.

Cascella R, Fani G, Capitini C, Rusmini P, Poletti A, Cecchi C, Chiti F.

FASEB J. 2017 Dec;31(12):5609-5624. doi: 10.1096/fj.201700292RR. Epub 2017 Aug 25.

10.

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.

Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limbocker R, Sormanni P, Heller GT, Aprile FA, Cremades N, Cecchi C, Chiti F, Nollen EA, Knowles TP, Vendruscolo M, Bax A, Zasloff M, Dobson CM.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1009-E1017. doi: 10.1073/pnas.1610586114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Mar 21;114(12 ):E2543. Limboker, Ryan [corrected to Limbocker, Ryan].

11.

Biomolecular index of therapeutic efficacy in psoriasis treated with anti-TNF-α agents.

Bianchi L, Costanza G, Campione E, Ruzzetti M, Di Stefani A, Diluvio L, Giardina E, Cascella R, Cordiali-Fei P, Bonifati C, Chiricozzi A, Novelli G, Ensoli F, Orlandi A.

G Ital Dermatol Venereol. 2018 Jun;153(3):316-325. doi: 10.23736/S0392-0488.16.05427-4. Epub 2016 Sep 14.

12.

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases.

Evangelisti E, Cascella R, Becatti M, Marrazza G, Dobson CM, Chiti F, Stefani M, Cecchi C.

Sci Rep. 2016 Sep 13;6:32721. doi: 10.1038/srep32721.

13.

Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia.

Scognamiglio PL, Di Natale C, Leone M, Cascella R, Cecchi C, Lirussi L, Antoniali G, Riccardi D, Morelli G, Tell G, Chiti F, Marasco D.

Oncotarget. 2016 Sep 13;7(37):59129-59143. doi: 10.18632/oncotarget.10991.

14.

Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies.

Cascella R, Capitini C, Fani G, Dobson CM, Cecchi C, Chiti F.

J Biol Chem. 2016 Sep 9;291(37):19437-48. doi: 10.1074/jbc.M116.737726. Epub 2016 Jul 21.

15.

Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy.

Oropesa-Nuñez R, Seghezza S, Dante S, Diaspro A, Cascella R, Cecchi C, Stefani M, Chiti F, Canale C.

Oncotarget. 2016 Jul 19;7(29):44991-45004. doi: 10.18632/oncotarget.10449.

16.

Pharmacogenomics of multifactorial diseases: a focus on psoriatic arthritis.

Cascella R, Strafella C, Longo G, Maccarone M, Borgiani P, Sangiuolo F, Novelli G, Giardina E.

Pharmacogenomics. 2016 Jun;17(8):943-51. doi: 10.2217/pgs.16.20. Epub 2016 Jun 7. Review.

PMID:
27269419
17.

Three-hour analysis of non-invasive foetal sex determination: application of Plexor chemistry.

Pietropolli A, Capogna MV, Cascella R, Germani C, Bruno V, Strafella C, Sarta S, Ticconi C, Marmo G, Gallaro S, Longo G, Marsella LT, Novelli A, Novelli G, Piccione E, Giardina E.

Hum Genomics. 2016 Apr 4;10:9. doi: 10.1186/s40246-016-0066-2.

18.

Effect of molecular chaperones on aberrant protein oligomers in vitro: super-versus sub-stoichiometric chaperone concentrations.

Cappelli S, Penco A, Mannini B, Cascella R, Wilson MR, Ecroyd H, Li X, Buxbaum JN, Dobson CM, Cecchi C, Relini A, Chiti F.

Biol Chem. 2016 May;397(5):401-15. doi: 10.1515/hsz-2015-0250.

PMID:
26812789
19.

Two molecular assays for the rapid and inexpensive detection of GJB2 and GJB6 mutations.

Cascella R, Strafella C, Gambardella S, Longo G, Borgiani P, Sangiuolo F, Novelli G, Giardina E.

Electrophoresis. 2016 Mar;37(5-6):860-4. doi: 10.1002/elps.201500346. Epub 2016 Jan 15.

PMID:
26681637
20.

Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Aβ1-42 oligomers.

Calamai M, Evangelisti E, Cascella R, Parenti N, Cecchi C, Stefani M, Pavone F.

Biochim Biophys Acta. 2016 Feb;1858(2):386-92. doi: 10.1016/j.bbamem.2015.12.009. Epub 2015 Dec 4.

21.

May some HCV genotype 1 patients still benefit from dual therapy? The role of very early HCV kinetics.

Tontodonati M, Cento V, Polilli E, Colabattista C, Cascella R, Sciotti M, Di Giammartino D, Trave F, Di Maio VC, Monarca R, Di Candilo F, Prinapori R, Rastrelli E, Vecchiet J, Ceccherini-Silberstein F, Manzoli L, Giardina E, Perno CF, Parruti G.

New Microbiol. 2015 Oct;38(4):491-7. Epub 2015 Oct 20.

22.

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight.

Rigacci S, Miceli C, Nediani C, Berti A, Cascella R, Pantano D, Nardiello P, Luccarini I, Casamenti F, Stefani M.

Oncotarget. 2015 Nov 3;6(34):35344-57. doi: 10.18632/oncotarget.6119.

23.

The Genetics and the Genomics of Primary Congenital Glaucoma.

Cascella R, Strafella C, Germani C, Novelli G, Ricci F, Zampatti S, Giardina E.

Biomed Res Int. 2015;2015:321291. doi: 10.1155/2015/321291. Epub 2015 Sep 16. Review.

24.

FLG (filaggrin) null mutations and sunlight exposure: Evidence of a correlation.

Cascella R, Strafella C, Germani C, Manzo L, Marsella LT, Borgiani P, Sobhy N, Abdelmaksood R, Gerou S, Ioannides D, Sangiuolo F, Novelli G, Hashad D, Vakirlis E, Giardina E.

J Am Acad Dermatol. 2015 Sep;73(3):528-9. doi: 10.1016/j.jaad.2015.06.022. No abstract available.

PMID:
26282804
25.

Comparative analysis between saliva and buccal swabs as source of DNA: lesson from HLA-B*57:01 testing.

Cascella R, Stocchi L, Strafella C, Mezzaroma I, Mannazzu M, Vullo V, Montella F, Parruti G, Borgiani P, Sangiuolo F, Novelli G, Pirazzoli A, Zampatti S, Giardina E.

Pharmacogenomics. 2015;16(10):1039-46. doi: 10.2217/pgs.15.59. Epub 2015 Jul 31.

26.

Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions.

Di Natale C, Scognamiglio PL, Cascella R, Cecchi C, Russo A, Leone M, Penco A, Relini A, Federici L, Di Matteo A, Chiti F, Vitagliano L, Marasco D.

FASEB J. 2015 Sep;29(9):3689-701. doi: 10.1096/fj.14-269522. Epub 2015 May 14.

PMID:
25977257
27.

Absence of filaggrin mutation in a patient affected by pachyonychia congenita and mild atopic dermatitis.

Terrinoni A, Giardina E, Pertusi G, Cascella R, Serra V, Bornacina C, Palombo R, Tiberio R, Gattoni M, Novelli G, Annicchiarico-Petruzzelli M, Melino G, Colombo E.

Eur J Dermatol. 2014 Nov-Dec;24(6):703-4. doi: 10.1684/ejd.2014.2446. No abstract available.

PMID:
25514680
28.

Age-related macular degeneration: insights into inflammatory genes.

Cascella R, Ragazzo M, Strafella C, Missiroli F, Borgiani P, Angelucci F, Marsella LT, Cusumano A, Novelli G, Ricci F, Giardina E.

J Ophthalmol. 2014;2014:582842. doi: 10.1155/2014/582842. Epub 2014 Nov 12. Review.

29.

Direct PCR: a new pharmacogenetic approach for the inexpensive testing of HLA-B*57:01.

Cascella R, Strafella C, Ragazzo M, Zampatti S, Borgiani P, Gambardella S, Pirazzoli A, Novelli G, Giardina E.

Pharmacogenomics J. 2015 Apr;15(2):196-200. doi: 10.1038/tpj.2014.48. Epub 2014 Sep 9.

30.

Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity.

Mannini B, Mulvihill E, Sgromo C, Cascella R, Khodarahmi R, Ramazzotti M, Dobson CM, Cecchi C, Chiti F.

ACS Chem Biol. 2014 Oct 17;9(10):2309-17. doi: 10.1021/cb500505m. Epub 2014 Aug 11.

PMID:
25079908
31.

S-linolenoyl glutathione intake extends life-span and stress resistance via Sir-2.1 upregulation in Caenorhabditis elegans.

Cascella R, Evangelisti E, Zampagni M, Becatti M, D'Adamio G, Goti A, Liguri G, Fiorillo C, Cecchi C.

Free Radic Biol Med. 2014 Aug;73:127-35. doi: 10.1016/j.freeradbiomed.2014.05.004. Epub 2014 May 15.

PMID:
24835770
32.

Plasma membrane injury depends on bilayer lipid composition in Alzheimer's disease.

Evangelisti E, Zampagni M, Cascella R, Becatti M, Fiorillo C, Caselli A, Bagnoli S, Nacmias B, Cecchi C.

J Alzheimers Dis. 2014;41(1):289-300. doi: 10.3233/JAD-131406.

PMID:
24614900
33.

TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells.

Capitini C, Conti S, Perni M, Guidi F, Cascella R, De Poli A, Penco A, Relini A, Cecchi C, Chiti F.

PLoS One. 2014 Jan 30;9(1):e86720. doi: 10.1371/journal.pone.0086720. eCollection 2014.

34.

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro.

Cascella R, Conti S, Mannini B, Li X, Buxbaum JN, Tiribilli B, Chiti F, Cecchi C.

Biochim Biophys Acta. 2013 Dec;1832(12):2302-14. doi: 10.1016/j.bbadis.2013.09.011. Epub 2013 Sep 25.

35.

Haplotypes in IL-8 Gene Are Associated to Age-Related Macular Degeneration: A Case-Control Study.

Ricci F, Staurenghi G, Lepre T, Missiroli F, Zampatti S, Cascella R, Borgiani P, Marsella LT, Eandi CM, Cusumano A, Novelli G, Giardina E.

PLoS One. 2013 Jun 19;8(6):e66978. doi: 10.1371/journal.pone.0066978. Print 2013.

36.

Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.

Cascella R, Conti S, Tatini F, Evangelisti E, Scartabelli T, Casamenti F, Wilson MR, Chiti F, Cecchi C.

Biochim Biophys Acta. 2013 Aug;1832(8):1217-26. doi: 10.1016/j.bbadis.2013.04.012. Epub 2013 Apr 16.

37.

Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients.

Lepre T, Cascella R, Ragazzo M, Galli E, Novelli G, Giardina E.

Br J Dermatol. 2013 May;168(5):1106-8. doi: 10.1111/bjd.12178.

PMID:
23278845
38.

The Pharmacogenomic HLA Biomarker Associated to Adverse Abacavir Reactions: Comparative Analysis of Different Genotyping Methods.

Stocchi L, Cascella R, Zampatti S, Pirazzoli A, Novelli G, Giardina E.

Curr Genomics. 2012 Jun;13(4):314-20. doi: 10.2174/138920212800793311.

39.

Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease.

Evangelisti E, Wright D, Zampagni M, Cascella R, Fiorillo C, Bagnoli S, Relini A, Nichino D, Scartabelli T, Nacmias B, Sorbi S, Cecchi C.

Curr Alzheimer Res. 2013 Feb;10(2):143-53.

PMID:
22950913
40.

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.

Mannini B, Cascella R, Zampagni M, van Waarde-Verhagen M, Meehan S, Roodveldt C, Campioni S, Boninsegna M, Penco A, Relini A, Kampinga HH, Dobson CM, Wilson MR, Cecchi C, Chiti F.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12479-84. doi: 10.1073/pnas.1117799109. Epub 2012 Jul 16.

41.

Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers.

Evangelisti E, Cecchi C, Cascella R, Sgromo C, Becatti M, Dobson CM, Chiti F, Stefani M.

J Cell Sci. 2012 May 15;125(Pt 10):2416-27. doi: 10.1242/jcs.098434. Epub 2012 Feb 17.

42.

Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models.

Zampagni M, Wright D, Cascella R, D'Adamio G, Casamenti F, Evangelisti E, Cardona F, Goti A, Nacmias B, Sorbi S, Liguri G, Cecchi C.

Free Radic Biol Med. 2012 Apr 15;52(8):1362-71. doi: 10.1016/j.freeradbiomed.2012.01.012. Epub 2012 Jan 27.

PMID:
22326489
43.

Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aβ42 aggregate toxicity.

Cecchi C, Evangelisti E, Cascella R, Zampagni M, Benvenuti S, Luciani P, Deledda C, Cellai I, Wright D, Saccardi R, Peri A, Stefani M.

J Alzheimers Dis. 2011;27(3):651-64. doi: 10.3233/JAD-2011-110590.

PMID:
21876252
44.

Polymorphisms in ARMS2 (LOC387715) and LOXL1 genes in the Japanese with age-related macular degeneration.

Lepre T, Cascella R, Missiroli F, De Felici C, Taglia F, Zampatti S, Cusumano A, Ricci F, Giardina E, Eandi CM, Novelli G.

Am J Ophthalmol. 2011 Aug;152(2):325-6; author reply 326. doi: 10.1016/j.ajo.2011.04.021. No abstract available.

PMID:
21784201
45.

Full sequencing of the FLG gene in Italian patients with atopic eczema: evidence of new mutations, but lack of an association.

Cascella R, Foti Cuzzola V, Lepre T, Galli E, Moschese V, Chini L, Mazzanti C, Fortugno P, Novelli G, Giardina E.

J Invest Dermatol. 2011 Apr;131(4):982-4. doi: 10.1038/jid.2010.398. Epub 2011 Feb 3. No abstract available.

46.

A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells.

Zampagni M, Cascella R, Casamenti F, Grossi C, Evangelisti E, Wright D, Becatti M, Liguri G, Mannini B, Campioni S, Chiti F, Cecchi C.

J Cell Mol Med. 2011 Oct;15(10):2106-16. doi: 10.1111/j.1582-4934.2010.01239.x.

47.

Allele specific Taqman-based real-time PCR assay to quantify circulating BRAFV600E mutated DNA in plasma of melanoma patients.

Pinzani P, Salvianti F, Cascella R, Massi D, De Giorgi V, Pazzagli M, Orlando C.

Clin Chim Acta. 2010 Sep 6;411(17-18):1319-24. doi: 10.1016/j.cca.2010.05.024. Epub 2010 May 31.

PMID:
20576522
48.

A preliminary assessment of the occupational risk of acquiring Legionnaires' disease for people working in telephone manholes, a new workplace environment for Legionella growth.

Ricci ML, Fontana S, Bella A, Gaggioli A, Cascella R, Cassone A, Scaturro M; Microbiologists of the Regional Agency for Environmental Protection of Novara.

Am J Infect Control. 2010 Sep;38(7):540-5. doi: 10.1016/j.ajic.2010.04.194. Epub 2010 May 15.

PMID:
20472324
49.

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane.

Zampagni M, Evangelisti E, Cascella R, Liguri G, Becatti M, Pensalfini A, Uberti D, Cenini G, Memo M, Bagnoli S, Nacmias B, Sorbi S, Cecchi C.

J Mol Med (Berl). 2010 Jun;88(6):597-608. doi: 10.1007/s00109-010-0603-8. Epub 2010 Mar 10.

PMID:
20217034
50.

A multiplex molecular assay for the detection of uniparental disomy for human chromosome 7.

Giardina E, Peconi C, Cascella R, Sinibaldi C, Foti Cuzzola V, Nardone AM, Bramanti P, Novelli G.

Electrophoresis. 2009 Jun;30(11):2008-11. doi: 10.1002/elps.200800744.

PMID:
19517448

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