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Differential Helicobacter pylori Plasticity in the Gastric Niche of Subjects at Increased Gastric Cancer Risk.

Casarotto M, Pratesi C, Bidoli E, Maiero S, Magris R, Steffan A, Basaglia G, Canzonieri V, De Re V, Cannizzaro R, Zanussi S.

Pathogens. 2019 May 18;8(2). pii: E65. doi: 10.3390/pathogens8020065.


Polymorphism in Toll-Like Receptors and Helicobacter Pylori Motility in Autoimmune Atrophic Gastritis and Gastric Cancer.

De Re V, Repetto O, De Zorzi M, Casarotto M, Tedeschi M, Giuffrida P, Lenti MV, Magris R, Miolo G, Mazzon C, Zanette G, Alessandrini L, Canzonieri V, Caggiari L, Zanussi S, Steffan A, Di Sabatino A, Cannizzaro R.

Cancers (Basel). 2019 May 10;11(5). pii: E648. doi: 10.3390/cancers11050648.


Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

Dulhunty AF, Beard NA, Casarotto MG.

F1000Res. 2018 Nov 27;7. pii: F1000 Faculty Rev-1851. doi: 10.12688/f1000research.16434.1. eCollection 2018. Review.


Exploiting Peptidomimetics to Synthesize Compounds That Activate Ryanodine Receptor Calcium Release Channels.

Robinson K, Easton CJ, Dulhunty AF, Casarotto MG.

ChemMedChem. 2018 Sep 19;13(18):1957-1971. doi: 10.1002/cmdc.201800366. Epub 2018 Aug 28.


Cyclophosphamide with or without fluorouracil followed by subcutaneous or intravenous interleukin-2 use in solid tumors: A feasibility off-label experience.

Lo Re G, Lo Re F, Doretto P, Del Conte A, Amadio M, Cozzi C, Casarotto MM, Maruzzi D, Marus W, Ubiali P, Sandri P.

Cytokine. 2019 Jan;113:50-60. doi: 10.1016/j.cyto.2018.06.005. Epub 2018 Jun 27.


Antiarrhythmic effect linked to melatonin cardiorenal protection involves AT1 reduction and Hsp70-VDR increase.

Prado NJ, Casarotto M, Calvo JP, Mazzei L, Ponce Zumino AZ, García IM, Cuello-Carrión FD, Fornés MW, Ferder L, Diez ER, Manucha W.

J Pineal Res. 2018 Nov;65(4):e12513. doi: 10.1111/jpi.12513. Epub 2018 Aug 1.


Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example.

Xie Y, Dahlin JL, Oakley AJ, Casarotto MG, Board PG, Baell JB.

J Med Chem. 2018 Sep 13;61(17):7448-7470. doi: 10.1021/acs.jmedchem.8b00318. Epub 2018 May 10.


1H, 13C and 15N backbone NMR chemical shift assignments of the C-terminal P4 domain of Ahnak.

Sundararaj S, Shishmarev D, Lin Y, Aditya S, Casarotto MG.

Biomol NMR Assign. 2018 Oct;12(2):253-257. doi: 10.1007/s12104-018-9818-3. Epub 2018 Mar 28.


GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

Menon D, Innes A, Oakley AJ, Dahlstrom JE, Jensen LM, Brüstle A, Tummala P, Rooke M, Casarotto MG, Baell JB, Nguyen N, Xie Y, Cuellar M, Strasser J, Dahlin JL, Walters MA, Burgio G, O'Neill LAJ, Board PG.

Sci Rep. 2017 Dec 19;7(1):17832. doi: 10.1038/s41598-017-17861-6.


Functional and structural characterization of a novel malignant hyperthermia-susceptible variant of DHPR-β1a subunit (CACNB1).

Perez CF, Eltit JM, Lopez JR, Bodnár D, Dulhunty AF, Aditya S, Casarotto MG.

Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C323-C333. doi: 10.1152/ajpcell.00187.2017. Epub 2017 Dec 6.


Publisher's Note: Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding. J. Cell Sci. doi: 10.1242/jcs.204461.

Richardson SJ, Steele GA, Gallant EM, Lam A, Schwartz CE, Board PG, Casarotto MG, Beard NA, Dulhunty AF.

J Cell Sci. 2017 Oct 5. pii: jcs.211243. doi: 10.1242/jcs.211243. [Epub ahead of print] No abstract available.


Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding.

Richardson SJ, Steele GA, Gallant EM, Lam A, Schwartz CE, Board PG, Casarotto MG, Beard NA, Dulhunty AF.

J Cell Sci. 2017 Oct 15;130(20):3588-3600. doi: 10.1242/jcs.204461. Epub 2017 Aug 29. Erratum in: J Cell Sci. 2017 Oct 5;:.


Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels.

Dulhunty AF, Board PG, Beard NA, Casarotto MG.

Adv Pharmacol. 2017;79:287-324. doi: 10.1016/bs.apha.2016.12.001. Epub 2017 Feb 22.


Protein signature characterizing Helicobacter pylori strains of patients with autoimmune atrophic gastritis, duodenal ulcer and gastric cancer.

De Re V, Repetto O, Zanussi S, Casarotto M, Caggiari L, Canzonieri V, Cannizzaro R.

Infect Agent Cancer. 2017 Apr 27;12:22. doi: 10.1186/s13027-017-0133-x. eCollection 2017.


Structural and biophysical analyses of the skeletal dihydropyridine receptor β subunit β1a reveal critical roles of domain interactions for stability.

Norris NC, Joseph S, Aditya S, Karunasekara Y, Board PG, Dulhunty AF, Oakley AJ, Casarotto MG.

J Biol Chem. 2017 May 19;292(20):8401-8411. doi: 10.1074/jbc.M116.763896. Epub 2017 Mar 28.


Core skeletal muscle ryanodine receptor calcium release complex.

Dulhunty AF, Wei-LaPierre L, Casarotto MG, Beard NA.

Clin Exp Pharmacol Physiol. 2017 Jan;44(1):3-12. doi: 10.1111/1440-1681.12676. Review.


The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes.

Hewawasam RP, Liu D, Casarotto MG, Board PG, Dulhunty AF.

PLoS One. 2016 Sep 9;11(9):e0162415. doi: 10.1371/journal.pone.0162415. eCollection 2016.


Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation.

Li J, Hardy K, Phetsouphanh C, Tu WJ, Sutcliffe EL, McCuaig R, Sutton CR, Zafar A, Munier CM, Zaunders JJ, Xu Y, Theodoratos A, Tan A, Lim PS, Knaute T, Masch A, Zerweck J, Brezar V, Milburn PJ, Dunn J, Casarotto MG, Turner SJ, Seddiki N, Kelleher AD, Rao S.

J Cell Sci. 2016 Jun 15;129(12):2448-61. doi: 10.1242/jcs.181248. Epub 2016 May 5.


Changes in renal WT-1 expression preceding hypertension development.

Mazzei L, García M, Calvo JP, Casarotto M, Fornés M, Abud MA, Cuello-Carrión D, Ferder L, Manucha W.

BMC Nephrol. 2016 Mar 24;17:34. doi: 10.1186/s12882-016-0250-6.


Probing interactions of Vpu from HIV-1 with amiloride-based compounds.

Rosenberg MR, Weaver LM, Casarotto MG.

Biochim Biophys Acta. 2016 Apr;1858(4):733-9. doi: 10.1016/j.bbamem.2015.12.028. Epub 2015 Dec 23.


Glutathione transferase M2 variants inhibit ryanodine receptor function in adult mouse cardiomyocytes.

Samarasinghe K, Liu D, Tummala P, Cappello J, Pace SM, Arnolda L, Casarotto MG, Dulhunty AF, Board PG.

Biochem Pharmacol. 2015 Oct 1;97(3):269-80. doi: 10.1016/j.bcp.2015.08.004. Epub 2015 Aug 7.


Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit.

Rebbeck RT, Willemse H, Groom L, Casarotto MG, Board PG, Beard NA, Dirksen RT, Dulhunty AF.

Skelet Muscle. 2015 Jul 22;5:23. doi: 10.1186/s13395-015-0049-3. eCollection 2015.


Identification of a pathogenic variant in TREX1 in early-onset cerebral systemic lupus erythematosus by Whole-exome sequencing.

Ellyard JI, Jerjen R, Martin JL, Lee AY, Field MA, Jiang SH, Cappello J, Naumann SK, Andrews TD, Scott HS, Casarotto MG, Goodnow CC, Chaitow J, Pascual V, Hertzog P, Alexander SI, Cook MC, Vinuesa CG.

Arthritis Rheumatol. 2014 Dec;66(12):3382-6.


Differential proteomics of Helicobacter pylori associated with autoimmune atrophic gastritis.

Repetto O, Zanussi S, Casarotto M, Canzonieri V, De Paoli P, Cannizzaro R, De Re V.

Mol Med. 2014 Feb 28;20:57-71. doi: 10.2119/molmed.2013.00076.


Skeletal muscle excitation-contraction coupling: who are the dancing partners?

Rebbeck RT, Karunasekara Y, Board PG, Beard NA, Casarotto MG, Dulhunty AF.

Int J Biochem Cell Biol. 2014 Mar;48:28-38. doi: 10.1016/j.biocel.2013.12.001. Epub 2013 Dec 24. Review.


Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors.

Zhao X, Jie Y, Rosenberg MR, Wan J, Zeng S, Cui W, Xiao Y, Li Z, Tu Z, Casarotto MG, Hu W.

Antiviral Res. 2012 Nov;96(2):91-9. doi: 10.1016/j.antiviral.2012.09.001. Epub 2012 Sep 13.


Chromatinized Protein Kinase C-θ: Can It Escape the Clutches of NF-κB?

Sutcliffe EL, Li J, Zafar A, Hardy K, Ghildyal R, McCuaig R, Norris NC, Lim PS, Milburn PJ, Casarotto MG, Denyer G, Rao S.

Front Immunol. 2012 Aug 28;3:260. doi: 10.3389/fimmu.2012.00260. eCollection 2012.


An α-helical C-terminal tail segment of the skeletal L-type Ca2+ channel β1a subunit activates ryanodine receptor type 1 via a hydrophobic surface.

Karunasekara Y, Rebbeck RT, Weaver LM, Board PG, Dulhunty AF, Casarotto MG.

FASEB J. 2012 Dec;26(12):5049-59. doi: 10.1096/fj.12-211334. Epub 2012 Sep 7.


Selective modulation of different GABAA receptor isoforms by diazepam and etomidate in hippocampal neurons.

Seymour VA, Curmi JP, Howitt SM, Casarotto MG, Laver DR, Tierney ML.

Int J Biochem Cell Biol. 2012 Sep;44(9):1491-500. doi: 10.1016/j.biocel.2012.06.001. Epub 2012 Jun 13.


The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor.

Liu D, Hewawasam R, Karunasekara Y, Casarotto MG, Dulhunty AF, Board PG.

Biochem Pharmacol. 2012 Jun 1;83(11):1523-9. doi: 10.1016/j.bcp.2012.02.020. Epub 2012 Mar 1.


3D Mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM.

Perálvarez-Marín A, Tae H, Board PG, Casarotto MG, Dulhunty AF, Samsó M.

PLoS One. 2011;6(10):e25813. doi: 10.1371/journal.pone.0025813. Epub 2011 Oct 5.


Cyclization of the intrinsically disordered α1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function.

Tae HS, Cui Y, Karunasekara Y, Board PG, Dulhunty AF, Casarotto MG.

J Biol Chem. 2011 Jun 24;286(25):22589-99. doi: 10.1074/jbc.M110.205476. Epub 2011 Apr 27.


A structural basis for cellular uptake of GST-fold proteins.

Morris MJ, Liu D, Weaver LM, Board PG, Casarotto MG.

PLoS One. 2011 Mar 24;6(3):e17864. doi: 10.1371/journal.pone.0017864.


Regulation of the cardiac muscle ryanodine receptor by glutathione transferases.

Dulhunty AF, Hewawasam R, Liu D, Casarotto MG, Board PG.

Drug Metab Rev. 2011 May;43(2):236-52. doi: 10.3109/03602532.2010.549134. Epub 2011 Feb 17. Review.


The β(1a) subunit of the skeletal DHPR binds to skeletal RyR1 and activates the channel via its 35-residue C-terminal tail.

Rebbeck RT, Karunasekara Y, Gallant EM, Board PG, Beard NA, Casarotto MG, Dulhunty AF.

Biophys J. 2011 Feb 16;100(4):922-30. doi: 10.1016/j.bpj.2011.01.022.


The ryanodine receptor: a pivotal Ca2+ regulatory protein and potential therapeutic drug target.

Dulhunty AF, Casarotto MG, Beard NA.

Curr Drug Targets. 2011 May;12(5):709-23. Review.


The elusive role of the SPRY2 domain in RyR1.

Tae H, Wei L, Willemse H, Mirza S, Gallant EM, Board PG, Dirksen RT, Casarotto MG, Dulhunty A.

Channels (Austin). 2011 Mar-Apr;5(2):148-60. Epub 2011 Mar 1.


Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1.

Zhou H, Brock J, Casarotto MG, Oakley AJ, Board PG.

J Biol Chem. 2011 Feb 11;286(6):4271-9. doi: 10.1074/jbc.M110.197822. Epub 2010 Nov 24.


Coexistence of two adamantane binding sites in the influenza A M2 ion channel.

Rosenberg MR, Casarotto MG.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13866-71. doi: 10.1073/pnas.1002051107. Epub 2010 Jul 19.


The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor.

Hewawasam R, Liu D, Casarotto MG, Dulhunty AF, Board PG.

Biochem Pharmacol. 2010 Aug 1;80(3):381-8. doi: 10.1016/j.bcp.2010.04.019. Epub 2010 Apr 22.


Use of recombinant activated factor VII in severe post-partum haemorrhage: data from the Italian Registry: a multicentric observational retrospective study.

Barillari G, Frigo MG, Casarotto M, Farnia A, Massè B, Wetzl R, Bianchin A, Rabi A, Malacarne P, Pasca S, Bigotto E; Italian rFVIIa-PPH Study Group.

Thromb Res. 2009 Dec;124(6):e41-7. doi: 10.1016/j.thromres.2009.08.018. Epub 2009 Sep 24.


The voltage-gated calcium-channel beta subunit: more than just an accessory.

Karunasekara Y, Dulhunty AF, Casarotto MG.

Eur Biophys J. 2009 Dec;39(1):75-81. doi: 10.1007/s00249-009-0467-4. Epub 2009 May 20. Review.


Ubiquitous SPRY domains and their role in the skeletal type ryanodine receptor.

Tae H, Casarotto MG, Dulhunty AF.

Eur Biophys J. 2009 Dec;39(1):51-9. doi: 10.1007/s00249-009-0455-8. Epub 2009 Apr 28. Review.


Further evidence that mutations in FGD4/frabin cause Charcot-Marie-Tooth disease type 4H.

Fabrizi GM, Taioli F, Cavallaro T, Ferrari S, Bertolasi L, Casarotto M, Rizzuto N, Deconinck T, Timmerman V, De Jonghe P.

Neurology. 2009 Mar 31;72(13):1160-4. doi: 10.1212/01.wnl.0000345373.58618.b6.


Dissection of the inhibition of cardiac ryanodine receptors by human glutathione transferase GSTM2-2.

Liu D, Hewawasam R, Pace SM, Gallant EM, Casarotto MG, Dulhunty AF, Board PG.

Biochem Pharmacol. 2009 Apr 1;77(7):1181-93. doi: 10.1016/j.bcp.2008.12.024. Epub 2009 Jan 13.


Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling.

Kimura T, Lueck JD, Harvey PJ, Pace SM, Ikemoto N, Casarotto MG, Dirksen RT, Dulhunty AF.

Cell Calcium. 2009 Mar;45(3):264-74. doi: 10.1016/j.ceca.2008.11.005. Epub 2009 Jan 7.


Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved spry domain of the type 1 ryanodine receptor.

Tae HS, Norris NC, Cui Y, Karunasekara Y, Board PG, Dulhunty AF, Casarotto MG.

Clin Exp Pharmacol Physiol. 2009 Mar;36(3):346-9. doi: 10.1111/j.1440-1681.2008.05130.x. Epub 2008 Nov 28. Review.


Transport of glutathione transferase-fold structured proteins into living cells.

Morris MJ, Craig SJ, Sutherland TM, Board PG, Casarotto MG.

Biochim Biophys Acta. 2009 Mar;1788(3):676-85. doi: 10.1016/j.bbamem.2008.10.018. Epub 2008 Nov 6.


A dihydropyridine receptor alpha1s loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor.

Cui Y, Tae HS, Norris NC, Karunasekara Y, Pouliquin P, Board PG, Dulhunty AF, Casarotto MG.

Int J Biochem Cell Biol. 2009 Mar;41(3):677-86. doi: 10.1016/j.biocel.2008.08.004. Epub 2008 Aug 8.


Combined effects of botulinum toxin and casting treatments on lower limb spasticity after stroke.

Farina S, Migliorini C, Gandolfi M, Bertolasi L, Casarotto M, Manganotti P, Fiaschi A, Smania N.

Funct Neurol. 2008 Apr-Jun;23(2):87-91.


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