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A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

Moll HP, Mohrherr J, Blaas L, Musteanu M, Stiedl P, Grabner B, Zboray K, König M, Stoiber D, Rülicke T, Strehl S, Eferl R, Casanova E.

Cancers (Basel). 2019 Aug 22;11(9). pii: E1226. doi: 10.3390/cancers11091226.


JAK-STAT inhibition impairs K-RAS-driven lung adenocarcinoma progression.

Mohrherr J, Haber M, Breitenecker K, Aigner P, Moritsch S, Voronin V, Eferl R, Moriggl R, Stoiber D, Győrffy B, Brcic L, László V, Döme B, Moldvay J, Dezső K, Bilban M, Popper H, Moll HP, Casanova E.

Int J Cancer. 2019 Aug 12. doi: 10.1002/ijc.32624. [Epub ahead of print]


Validation of an enzyme-linked immunosorbent assay (ELISA) for quantification of endostatin levels in mice as a biomarker of developing glomerulonephritis.

Wallwitz J, Aigner P, Gadermaier E, Bauer E, Casanova E, Bauer A, Stoiber D.

PLoS One. 2019 Aug 12;14(8):e0220935. doi: 10.1371/journal.pone.0220935. eCollection 2019.


Autologous endothelialized small-caliber vascular grafts engineered from blood-derived induced pluripotent stem cells.

Generali M, Casanova EA, Kehl D, Wanner D, Hoerstrup SP, Cinelli P, Weber B.

Acta Biomater. 2019 Jul 22. pii: S1742-7061(19)30521-5. doi: 10.1016/j.actbio.2019.07.032. [Epub ahead of print]


STAT3β is a tumor suppressor in acute myeloid leukemia.

Aigner P, Mizutani T, Horvath J, Eder T, Heber S, Lind K, Just V, Moll HP, Yeroslaviz A, Fischer MJM, Kenner L, Győrffy B, Sill H, Grebien F, Moriggl R, Casanova E, Stoiber D.

Blood Adv. 2019 Jul 9;3(13):1989-2002. doi: 10.1182/bloodadvances.2018026385.


MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.

Sdelci S, Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G, Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P, Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL, Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, Mechtler K, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J, Kubicek S.

Nat Genet. 2019 Jun;51(6):990-998. doi: 10.1038/s41588-019-0413-z. Epub 2019 May 27.


Autism risk genes are evolutionarily ancient and maintain a unique feature landscape that echoes their function.

Casanova EL, Switala AE, Dandamudi S, Hickman AR, Vandenbrink J, Sharp JL, Feltus FA, Casanova MF.

Autism Res. 2019 Jun;12(6):860-869. doi: 10.1002/aur.2112. Epub 2019 Apr 26.


Four millennia of dairy surplus and deposition revealed through compound-specific stable isotope analysis and radiocarbon dating of Irish bog butters.

Smyth J, Berstan R, Casanova E, McCormick F, Mulhall I, Sikora M, Synnott C, Evershed RP.

Sci Rep. 2019 Mar 14;9(1):4559. doi: 10.1038/s41598-019-40975-y.


Automated digital image quantification of histological staining for the analysis of the trilineage differentiation potential of mesenchymal stem cells.

Eggerschwiler B, Canepa DD, Pape HC, Casanova EA, Cinelli P.

Stem Cell Res Ther. 2019 Feb 26;10(1):69. doi: 10.1186/s13287-019-1170-8.


Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression.

Moll HP, Mohrherr J, Breitenecker K, Haber M, Voronin V, Casanova E.

J Vis Exp. 2019 Jan 19;(143). doi: 10.3791/58101.


Epigallocatechin Gallate Modulates Muscle Homeostasis in Type 2 Diabetes and Obesity by Targeting Energetic and Redox Pathways: A Narrative Review.

Casanova E, Salvadó J, Crescenti A, Gibert-Ramos A.

Int J Mol Sci. 2019 Jan 27;20(3). pii: E532. doi: 10.3390/ijms20030532. Review.


Behavioural and electrophysiological effects of tDCS to prefrontal cortex in patients with disorders of consciousness.

Cavinato M, Genna C, Formaggio E, Gregorio C, Storti SF, Manganotti P, Casanova E, Piperno R, Piccione F.

Clin Neurophysiol. 2019 Feb;130(2):231-238. doi: 10.1016/j.clinph.2018.10.018. Epub 2018 Nov 29.


Breaking bad family ties: Pan-ERBB blockers inhibit KRAS driven lung tumorigenesis.

Moll HP, Casanova E.

Mol Cell Oncol. 2018 Sep 20;5(6):e1513724. doi: 10.1080/23723556.2018.1513724. eCollection 2018.


Widespread Genotype-Phenotype Correlations in Intellectual Disability.

Casanova EL, Gerstner Z, Sharp JL, Casanova MF, Feltus FA.

Front Psychiatry. 2018 Oct 29;9:535. doi: 10.3389/fpsyt.2018.00535. eCollection 2018.


Complex Portal 2018: extended content and enhanced visualization tools for macromolecular complexes.

Meldal BHM, Bye-A-Jee H, Gajdoš L, Hammerová Z, Horácková A, Melicher F, Perfetto L, Pokorný D, Lopez MR, Türková A, Wong ED, Xie Z, Casanova EB, Del-Toro N, Koch M, Porras P, Hermjakob H, Orchard S.

Nucleic Acids Res. 2019 Jan 8;47(D1):D550-D558. doi: 10.1093/nar/gky1001.


The modular organization of the cerebral cortex: Evolutionary significance and possible links to neurodevelopmental conditions.

Casanova MF, Casanova EL.

J Comp Neurol. 2019 Jul 1;527(10):1720-1730. doi: 10.1002/cne.24554. Epub 2018 Nov 15. Review.


Practical Considerations in High-Precision Compound-Specific Radiocarbon Analyses: Eliminating the Effects of Solvent and Sample Cross-Contamination on Accuracy and Precision.

Casanova E, Knowles TDJ, Williams C, Crump MP, Evershed RP.

Anal Chem. 2018 Sep 18;90(18):11025-11032. doi: 10.1021/acs.analchem.8b02713. Epub 2018 Sep 7.


Afatinib restrains K-RAS-driven lung tumorigenesis.

Moll HP, Pranz K, Musteanu M, Grabner B, Hruschka N, Mohrherr J, Aigner P, Stiedl P, Brcic L, Laszlo V, Schramek D, Moriggl R, Eferl R, Moldvay J, Dezso K, Lopez-Casas PP, Stoiber D, Hidalgo M, Penninger J, Sibilia M, Győrffy B, Barbacid M, Dome B, Popper H, Casanova E.

Sci Transl Med. 2018 Jun 20;10(446). pii: eaao2301. doi: 10.1126/scitranslmed.aao2301.


Exploratory Study of rTMS Neuromodulation Effects on Electrocortical Functional Measures of Performance in an Oddball Test and Behavioral Symptoms in Autism.

Sokhadze EM, Lamina EV, Casanova EL, Kelly DP, Opris I, Tasman A, Casanova MF.

Front Syst Neurosci. 2018 May 28;12:20. doi: 10.3389/fnsys.2018.00020. eCollection 2018.


Non-blocking modulation contributes to sodium channel inhibition by a covalently attached photoreactive riluzole analog.

Lukacs P, Földi MC, Valánszki L, Casanova E, Biri-Kovács B, Nyitray L, Málnási-Csizmadia A, Mike A.

Sci Rep. 2018 May 25;8(1):8110. doi: 10.1038/s41598-018-26444-y.


A Cohort Study Comparing Women with Autism Spectrum Disorder with and without Generalized Joint Hypermobility.

Casanova EL, Sharp JL, Edelson SM, Kelly DP, Casanova MF.

Behav Sci (Basel). 2018 Mar 17;8(3). pii: E35. doi: 10.3390/bs8030035.


STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer.

Crnčec I, Modak M, Gordziel C, Svinka J, Scharf I, Moritsch S, Pathria P, Schlederer M, Kenner L, Timelthaler G, Müller M, Strobl B, Casanova E, Bayer E, Mohr T, Stöckl J, Friedrich K, Eferl R.

Mol Oncol. 2018 Apr;12(4):514-528. doi: 10.1002/1878-0261.12178. Epub 2018 Feb 20.


AKT3 drives adenoid cystic carcinoma development in salivary glands.

Zboray K, Mohrherr J, Stiedl P, Pranz K, Wandruszka L, Grabner B, Eferl R, Moriggl R, Stoiber D, Sakamoto K, Wagner KU, Popper H, Casanova E, Moll HP.

Cancer Med. 2018 Feb;7(2):445-453. doi: 10.1002/cam4.1293. Epub 2017 Dec 28.


Atypical Processing of Novel Distracters in a Visual Oddball Task in Autism Spectrum Disorder.

Sokhadze EM, Lamina EV, Casanova EL, Kelly DP, Opris I, Khachidze I, Casanova MF.

Behav Sci (Basel). 2017 Nov 16;7(4). pii: E79. doi: 10.3390/bs7040079.


Corrigendum: Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

Graf U, Casanova EA, Wyck S, Dalcher D, Gatti M, Vollenweider E, Okoniewski MJ, Weber FA, Patel SS, Schmid MW, Li J, Sharif J, Wanner GA, Koseki H, Wong J, Pelczar P, Penengo L, Santoro R, Cinelli P.

Nat Cell Biol. 2017 Jul 28;19(8):1003. doi: 10.1038/ncb3572.


Links Between Patterns of Embryonic Spinal Cord Development and Schizophrenia Risk.

Casanova EL.

Biol Psychiatry. 2017 Aug 1;82(3):e21-e22. doi: 10.1016/j.biopsych.2017.05.006. No abstract available.


Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

Graf U, Casanova EA, Wyck S, Dalcher D, Gatti M, Vollenweider E, Okoniewski MJ, Weber FA, Patel SS, Schmid MW, Li J, Sharif J, Wanner GA, Koseki H, Wong J, Pelczar P, Penengo L, Santoro R, Cinelli P.

Nat Cell Biol. 2017 Jul;19(7):763-773. doi: 10.1038/ncb3554. Epub 2017 Jun 12. Erratum in: Nat Cell Biol. 2017 Jul 28;19(8):1003.


Use of a 700 MHz NMR Microcryoprobe for the Identification and Quantification of Exogenous Carbon in Compounds Purified by Preparative Capillary Gas Chromatography for Radiocarbon Determinations.

Casanova E, Knowles TDJ, Williams C, Crump MP, Evershed RP.

Anal Chem. 2017 Jul 5;89(13):7090-7098. doi: 10.1021/acs.analchem.7b00987. Epub 2017 Jun 14.


The Transcription Factor ZNF683/HOBIT Regulates Human NK-Cell Development.

Post M, Cuapio A, Osl M, Lehmann D, Resch U, Davies DM, Bilban M, Schlechta B, Eppel W, Nathwani A, Stoiber D, Spanholtz J, Casanova E, Hofer E.

Front Immunol. 2017 May 15;8:535. doi: 10.3389/fimmu.2017.00535. eCollection 2017.


Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis.

Svinka J, Pflügler S, Mair M, Marschall HU, Hengstler JG, Stiedl P, Poli V, Casanova E, Timelthaler G, Sibilia M, Eferl R.

J Mol Med (Berl). 2017 Jan;95(1):109-117. doi: 10.1007/s00109-016-1462-8. Epub 2016 Aug 27.


Maintenance therapy with histamine plus IL-2 induces a striking expansion of two CD56bright NK cell subpopulations in patients with acute myeloid leukemia and supports their activation.

Cuapio A, Post M, Cerny-Reiterer S, Gleixner KV, Stefanzl G, Basilio J, Herndlhofer S, Sperr WR, Brons NH, Casanova E, Zimmer J, Valent P, Hofer E.

Oncotarget. 2016 Jul 19;7(29):46466-46481. doi: 10.18632/oncotarget.10191.


Unexpected oncosuppressive role for STAT3 in KRAS-induced lung tumorigenesis.

Grabner B, Moll HP, Casanova E.

Mol Cell Oncol. 2015 May 26;3(3):e1036199. doi: 10.1080/23723556.2015.1036199. eCollection 2016 May.


MET inhibition overcomes radiation resistance of glioblastoma stem-like cells.

De Bacco F, D'Ambrosio A, Casanova E, Orzan F, Neggia R, Albano R, Verginelli F, Cominelli M, Poliani PL, Luraghi P, Reato G, Pellegatta S, Finocchiaro G, Perera T, Garibaldi E, Gabriele P, Comoglio PM, Boccaccio C.

EMBO Mol Med. 2016 May 2;8(5):550-68. doi: 10.15252/emmm.201505890. Print 2016 May.


Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression.

Casanova EL, Sharp JL, Chakraborty H, Sumi NS, Casanova MF.

Mol Autism. 2016 Mar 15;7:18. doi: 10.1186/s13229-016-0082-z. eCollection 2016.


Direct transplantation of native pericytes from adipose tissue: A new perspective to stimulate healing in critical size bone defects.

König MA, Canepa DD, Cadosch D, Casanova E, Heinzelmann M, Rittirsch D, Plecko M, Hemmi S, Simmen HP, Cinelli P, Wanner GA.

Cytotherapy. 2016 Jan;18(1):41-52. doi: 10.1016/j.jcyt.2015.10.002. Epub 2015 Nov 10.


Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers.

Rivero-Buceta E, Carrero P, Casanova E, Doyagüez EG, Madrona A, Quesada E, Peréz-Pérez MJ, Mateos R, Bravo L, Mathys L, Noppen S, Kiselev E, Marchand C, Pommier Y, Liekens S, Balzarini J, Camarasa MJ, San-Félix A.

Eur J Med Chem. 2015 Dec 1;106:132-43. doi: 10.1016/j.ejmech.2015.10.027. Epub 2015 Oct 21.


Abscisic Acid Regulation of Root Hydraulic Conductivity and Aquaporin Gene Expression Is Crucial to the Plant Shoot Growth Enhancement Caused by Rhizosphere Humic Acids.

Olaetxea M, Mora V, Bacaicoa E, Garnica M, Fuentes M, Casanova E, Zamarreño AM, Iriarte JC, Etayo D, Ederra I, Gonzalo R, Baigorri R, García-Mina JM.

Plant Physiol. 2015 Dec;169(4):2587-96. doi: 10.1104/pp.15.00596. Epub 2015 Oct 8.


Up-Regulation of Oligodendrocyte Lineage Markers in the Cerebellum of Autistic Patients: Evidence from Network Analysis of Gene Expression.

Zeidán-Chuliá F, de Oliveira BN, Casanova MF, Casanova EL, Noda M, Salmina AB, Verkhratsky A.

Mol Neurobiol. 2016 Aug;53(6):4019-4025. doi: 10.1007/s12035-015-9351-7. Epub 2015 Jul 21.


Targeting hedgehog signaling reduces self-renewal in embryonal rhabdomyosarcoma.

Satheesha S, Manzella G, Bovay A, Casanova EA, Bode PK, Belle R, Feuchtgruber S, Jaaks P, Dogan N, Koscielniak E, Schäfer BW.

Oncogene. 2016 Apr 21;35(16):2020-30. doi: 10.1038/onc.2015.267. Epub 2015 Jul 20.


Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice.

Pathria P, Gotthardt D, Prchal-Murphy M, Putz EM, Holcmann M, Schlederer M, Grabner B, Crncec I, Svinka J, Musteanu M, Hoffmann T, Filipits M, Berger W, Poli V, Kenner L, Bilban M, Casanova E, Müller M, Strobl B, Bayer E, Mohr T, Sexl V, Eferl R.

Oncoimmunology. 2015 Jan 22;4(4):e998529. eCollection 2015 Apr.


Dietary proanthocyanidins modulate BMAL1 acetylation, Nampt expression and NAD levels in rat liver.

Ribas-Latre A, Baselga-Escudero L, Casanova E, Arola-Arnal A, Salvadó MJ, Bladé C, Arola L.

Sci Rep. 2015 Jun 8;5:10954. doi: 10.1038/srep10954.


Heterologous protein production using euchromatin-containing expression vectors in mammalian cells.

Zboray K, Sommeregger W, Bogner E, Gili A, Sterovsky T, Fauland K, Grabner B, Stiedl P, Moll HP, Bauer A, Kunert R, Casanova E.

Nucleic Acids Res. 2015 Sep 18;43(16):e102. doi: 10.1093/nar/gkv475. Epub 2015 May 14.


Artwork by people with autism.

Svoboda DJ, Hosseini K, Schneider N, Casanova E, Aitch K.

AMA J Ethics. 2015 Apr 1;17(4):362-8. doi: 10.1001/journalofethics.2015.17.4.imhl2-1504. No abstract available.


Long-term supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet-induced obese rats.

Baselga-Escudero L, Pascual-Serrano A, Ribas-Latre A, Casanova E, Salvadó MJ, Arola L, Arola-Arnal A, Bladé C.

Nutr Res. 2015 Apr;35(4):337-45. doi: 10.1016/j.nutres.2015.02.008. Epub 2015 Feb 28.


Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.

Grabner B, Schramek D, Mueller KM, Moll HP, Svinka J, Hoffmann T, Bauer E, Blaas L, Hruschka N, Zboray K, Stiedl P, Nivarthi H, Bogner E, Gruber W, Mohr T, Zwick RH, Kenner L, Poli V, Aberger F, Stoiber D, Egger G, Esterbauer H, Zuber J, Moriggl R, Eferl R, Győrffy B, Penninger JM, Popper H, Casanova E.

Nat Commun. 2015 Mar 3;6:6285. doi: 10.1038/ncomms7285.


Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats.

Ribas-Latre A, Del Bas JM, Baselga-Escudero L, Casanova E, Arola-Arnal A, Salvadó MJ, Arola L, Bladé C.

Mol Nutr Food Res. 2015 May;59(5):865-78. doi: 10.1002/mnfr.201400571. Epub 2015 Mar 23.


Roles of proanthocyanidin rich extracts in obesity.

Salvadó MJ, Casanova E, Fernández-Iglesias A, Arola L, Bladé C.

Food Funct. 2015 Apr;6(4):1053-71. doi: 10.1039/c4fo01035c. Review.


Modeling cancer using genetically engineered mice.

Stiedl P, Grabner B, Zboray K, Bogner E, Casanova E.

Methods Mol Biol. 2015;1267:3-18. doi: 10.1007/978-1-4939-2297-0_1. Review.


Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism.

Casanova EL, Casanova MF.

Front Cell Neurosci. 2014 Nov 19;8:397. doi: 10.3389/fncel.2014.00397. eCollection 2014.


Chronic consumption of dietary proanthocyanidins modulates peripheral clocks in healthy and obese rats.

Ribas-Latre A, Baselga-Escudero L, Casanova E, Arola-Arnal A, Salvadó MJ, Arola L, Bladé C.

J Nutr Biochem. 2015 Feb;26(2):112-9. doi: 10.1016/j.jnutbio.2014.09.006. Epub 2014 Oct 13.


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