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Phase 1 study of the novel enhancer of zeste homolog 2 (EZH2) inhibitor GSK2816126 in patients with advanced hematological and solid tumors.

Yap TA, Winter JN, Giulino-Roth L, Longley J, Lopez JS, Michot JM, Leonard JP, Ribrag V, McCabe MT, Creasy CL, Stern M, Pene Dumitrescu T, Wang X, Frey S, Carver J, Horner T, Oh C, Khaled A, Dhar AX, Johnson PW.

Clin Cancer Res. 2019 Aug 30. pii: clincanres.4121.2018. doi: 10.1158/1078-0432.CCR-18-4121. [Epub ahead of print]


Case Series of Ventricular Tachycardia and Myocarditis From Programmed Cell-Death Protein-1 Inhibitor Treated With Infliximab.

Padegimas A, Agarwal P, Fleitman J, Carver J, Rao S, Mather P, Domenico C, Nazarian S, Riley M, O'Quinn R.

JACC Clin Electrophysiol. 2019 Aug;5(8):989-992. doi: 10.1016/j.jacep.2019.05.001. Epub 2019 Aug 19. No abstract available.


The Kinetics of Amyloid Fibrillar Aggregation of Uperin 3.5 Is Directed by the Peptide's Secondary Structure.

John T, Dealey TJA, Gray NP, Patil NA, Hossain MA, Abel B, Carver JA, Hong Y, Martin LL.

Biochemistry. 2019 Sep 3;58(35):3656-3668. doi: 10.1021/acs.biochem.9b00536. Epub 2019 Aug 21.


Sequence characteristics responsible for protein-protein interactions in the intrinsically disordered regions of caseins, amelogenins, and small heat-shock proteins.

Holt C, Raynes JK, Carver JA.

Biopolymers. 2019 Jul 8:e23319. doi: 10.1002/bip.23319. [Epub ahead of print]


Prospective Study of Cardiac Events During Proteasome Inhibitor Therapy for Relapsed Multiple Myeloma.

Cornell RF, Ky B, Weiss BM, Dahm CN, Gupta DK, Du L, Carver JR, Cohen AD, Engelhardt BG, Garfall AL, Goodman SA, Harrell SL, Kassim AA, Jadhav T, Jagasia M, Moslehi J, O'Quinn R, Savona MR, Slosky D, Smith A, Stadtmauer EA, Vogl DT, Waxman A, Lenihan D.

J Clin Oncol. 2019 Aug 1;37(22):1946-1955. doi: 10.1200/JCO.19.00231. Epub 2019 Jun 12.


Preparing the Cardiovascular Workforce to Care for Oncology Patients: JACC Review Topic of the Week.

Hayek SS, Ganatra S, Lenneman C, Scherrer-Crosbie M, Leja M, Lenihan DJ, Yang E, Ryan TD, Liu J, Carver J, Mousavi N, O'Quinn R, Arnold A, Banchs J, Barac A, Ky B.

J Am Coll Cardiol. 2019 May 7;73(17):2226-2235. doi: 10.1016/j.jacc.2019.02.041. Review.


Detailed phenotyping reveals distinct trajectories of cardiovascular function and symptoms with exposure to modern breast cancer therapy.

Demissei BG, Finkelman BS, Hubbard RA, Zhang L, Smith AM, Sheline K, McDonald C, Narayan HK, Narayan V, Waxman AJ, Domchek SM, DeMichele A, Shah P, Clark AS, Bradbury AR, Carver JR, Upshaw J, Armenian SH, Liu P, Ky B.

Cancer. 2019 Aug 15;125(16):2762-2771. doi: 10.1002/cncr.32149. Epub 2019 May 1.


ProteinExplorer: A Repository-Scale Resource for Exploration of Protein Detection in Public Mass Spectrometry Data Sets.

Pullman BS, Wertz J, Carver J, Bandeira N.

J Proteome Res. 2018 Dec 7;17(12):4227-4234. doi: 10.1021/acs.jproteome.8b00496. Epub 2018 Oct 15.


Integrating anaerobic co-digestion of dairy manure and food waste with cultivation of edible mushrooms for nutrient recovery.

O'Brien BJ, Milligan E, Carver J, Roy ED.

Bioresour Technol. 2019 Aug;285:121312. doi: 10.1016/j.biortech.2019.121312. Epub 2019 Apr 1.


Small heat shock proteins: multifaceted proteins with important implications for life.

Carra S, Alberti S, Benesch JLP, Boelens W, Buchner J, Carver JA, Cecconi C, Ecroyd H, Gusev N, Hightower LE, Klevit RE, Lee HO, Liberek K, Lockwood B, Poletti A, Timmerman V, Toth ME, Vierling E, Wu T, Tanguay RM.

Cell Stress Chaperones. 2019 Mar;24(2):295-308. doi: 10.1007/s12192-019-00979-z. Epub 2019 Feb 13.


The Structure and Stability of the Disulfide-Linked γS-Crystallin Dimer Provide Insight into Oxidation Products Associated with Lens Cataract Formation.

Thorn DC, Grosas AB, Mabbitt PD, Ray NJ, Jackson CJ, Carver JA.

J Mol Biol. 2019 Feb 1;431(3):483-497. doi: 10.1016/j.jmb.2018.12.005. Epub 2018 Dec 13.


Early Changes in Cardiovascular Biomarkers with Contemporary Thoracic Radiation Therapy for Breast Cancer, Lung Cancer, and Lymphoma.

Demissei BG, Freedman G, Feigenberg SJ, Plastaras JP, Maity A, Smith AM, McDonald C, Sheline K, Simone CB 2nd, Lin LL, Carver JR, Liu P, Zhang L, Bekelman JE, Ky B.

Int J Radiat Oncol Biol Phys. 2019 Mar 15;103(4):851-860. doi: 10.1016/j.ijrobp.2018.11.013. Epub 2018 Nov 14.


Fluoropyrimidine Cardiotoxicity: Time for a Contemporaneous Appraisal.

Upshaw JN, O'Neill A, Carver JR, Dimond EP, Denlinger CS, Kircher SM, Wagner LI, Ky B, Brell JM.

Clin Colorectal Cancer. 2019 Mar;18(1):44-51. doi: 10.1016/j.clcc.2018.08.001. Epub 2018 Aug 20.


A Regional Analysis of Hepatitis C Virus Collaborative Care With Pharmacists in Indian Health Service Facilities.

Geiger R, Steinert J, McElwee G, Carver J, Montanez R, Niewoehner J, Clark C, Reilley B.

J Prim Care Community Health. 2018 Jan-Dec;9:2150132718807520. doi: 10.1177/2150132718807520. Erratum in: J Prim Care Community Health. 2019 Jan-Dec;10:2150132718824513.


A 2D LC-MS/MS Strategy for Reliable Detection of 10-ppm Level Residual Host Cell Proteins in Therapeutic Antibodies.

Yang F, Walker DE, Schoenfelder J, Carver J, Zhang A, Li D, Harris R, Stults JT, Yu XC, Michels DA.

Anal Chem. 2018 Nov 20;90(22):13365-13372. doi: 10.1021/acs.analchem.8b03044. Epub 2018 Nov 1.


Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation.

Diot A, Agnew T, Sanderson J, Liao C, Carver J, Neves RPD, Gupta R, Guo Y, Waters C, Seto S, Daniels MJ, Dombi E, Lodge T, Morten K, Williams SA, Enver T, Iborra FJ, Votruba M, Poulton J.

Front Cell Dev Biol. 2018 Sep 19;6:103. doi: 10.3389/fcell.2018.00103. eCollection 2018.


Assembling the Community-Scale Discoverable Human Proteome.

Wang M, Wang J, Carver J, Pullman BS, Cha SW, Bandeira N.

Cell Syst. 2018 Oct 24;7(4):412-421.e5. doi: 10.1016/j.cels.2018.08.004. Epub 2018 Aug 29.


Enhancing research for undergraduates through a nanotechnology training program that utilizes analytical and bioanalytical tools.

Holland LA, Carver JS, Veltri LM, Henderson RJ, Quedado KD.

Anal Bioanal Chem. 2018 Sep;410(24):6041-6050. doi: 10.1007/s00216-018-1274-5. Epub 2018 Aug 18.


De novo DNM1L mutation associated with mitochondrial epilepsy syndrome with fever sensitivity.

Ladds E, Whitney A, Dombi E, Hofer M, Anand G, Harrison V, Fratter C, Carver J, Barbosa IA, Simpson M, Jayawant S, Poulton J.

Neurol Genet. 2018 Aug 2;4(4):e258. doi: 10.1212/NXG.0000000000000258. eCollection 2018 Aug. No abstract available.


Parental Refusal for Treatments, Procedures, and Vaccines in the Newborn Nursery.

Burton T, Saini S, Maldonado L, Carver JD.

Adv Pediatr. 2018 Aug;65(1):89-104. doi: 10.1016/j.yapd.2018.04.006. Epub 2018 Jun 12. Review. No abstract available.


Terminal Regions Confer Plasticity to the Tetrameric Assembly of Human HspB2 and HspB3.

Clark AR, Vree Egberts W, Kondrat FDL, Hilton GR, Ray NJ, Cole AR, Carver JA, Benesch JLP, Keep NH, Boelens WC, Slingsby C.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3297-3310. doi: 10.1016/j.jmb.2018.06.047. Epub 2018 Jun 30.


Developing a Palliative Care Competency Framework for Health Professionals and Volunteers: The Nova Scotian Experience.

McCallum M, Carver J, Dupere D, Ganong S, Henderson JD, McKim A, McNeil-Campbell L, Richardson H, Simpson J, Tschupruk C, Jewers H.

J Palliat Med. 2018 Jul;21(7):947-955. doi: 10.1089/jpm.2017.0655. Epub 2018 May 15.


Proteostasis and the Regulation of Intra- and Extracellular Protein Aggregation by ATP-Independent Molecular Chaperones: Lens α-Crystallins and Milk Caseins.

Carver JA, Ecroyd H, Truscott RJW, Thorn DC, Holt C.

Acc Chem Res. 2018 Mar 20;51(3):745-752. doi: 10.1021/acs.accounts.7b00250. Epub 2018 Feb 14. Review.


Fluoropyrimidine-induced cardiac toxicity: challenging the current paradigm.

Clasen SC, Ky B, O'Quinn R, Giantonio B, Teitelbaum U, Carver JR.

J Gastrointest Oncol. 2017 Dec;8(6):970-979. doi: 10.21037/jgo.2017.09.07.


Carfilzomib-Associated Cardiovascular Adverse Events: A Systematic Review and Meta-analysis.

Waxman AJ, Clasen S, Hwang WT, Garfall A, Vogl DT, Carver J, O'Quinn R, Cohen AD, Stadtmauer EA, Ky B, Weiss BM.

JAMA Oncol. 2018 Mar 8;4(3):e174519. doi: 10.1001/jamaoncol.2017.4519. Epub 2018 Mar 8.


Left atrial abnormality (LAA) as a predictor of ibrutinib-associated atrial fibrillation in patients with chronic lymphocytic leukemia.

Mato AR, Clasen S, Pickens P, Gashonia L, Rhodes J, Svoboda J, Hughes M, Nabhan C, Ali N, Schuster S, Carver J.

Cancer Biol Ther. 2018 Jan 2;19(1):1-2. doi: 10.1080/15384047.2017.1394554. Epub 2017 Dec 27.


Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity.

Woodcock JM, Goodwin KL, Sandow JJ, Coolen C, Perugini MA, Webb AI, Pitson SM, Lopez AF, Carver JA.

J Biol Chem. 2018 Jan 5;293(1):89-99. doi: 10.1074/jbc.M117.801019. Epub 2017 Nov 6.


Functional Amyloid Protection in the Eye Lens: Retention of α-Crystallin Molecular Chaperone Activity after Modification into Amyloid Fibrils.

Garvey M, Ecroyd H, Ray NJ, Gerrard JA, Carver JA.

Biomolecules. 2017 Sep 12;7(3). pii: E67. doi: 10.3390/biom7030067.


Management and outcomes of patients with atrial fibrillation and a history of cancer: the ORBIT-AF registry.

Melloni C, Shrader P, Carver J, Piccini JP, Thomas L, Fonarow GC, Ansell J, Gersh B, Go AS, Hylek E, Herling IM, Mahaffey KW, Yu AF, Peterson ED, Kowey PR; ORBIT-AF Steering Committee.

Eur Heart J Qual Care Clin Outcomes. 2017 Jul 1;3(3):192-197. doi: 10.1093/ehjqcco/qcx004.


Monitoring Early-Stage Protein Aggregation by an Aggregation-Induced Emission Fluorogen.

Kumar M, Hong Y, Thorn DC, Ecroyd H, Carver JA.

Anal Chem. 2017 Sep 5;89(17):9322-9329. doi: 10.1021/acs.analchem.7b02090. Epub 2017 Aug 23.


Arginine-Nitric Oxide Metabolites and Cardiac Dysfunction in Patients With Breast Cancer.

Finkelman BS, Putt M, Wang T, Wang L, Narayan H, Domchek S, DeMichele A, Fox K, Matro J, Shah P, Clark A, Bradbury A, Narayan V, Carver JR, Tang WHW, Ky B.

J Am Coll Cardiol. 2017 Jul 11;70(2):152-162. doi: 10.1016/j.jacc.2017.05.019. Erratum in: J Am Coll Cardiol. 2017 Nov 28;70(21):2738.


Letter to the Editor: A response to Horne and Lucey (2017).

Carver JA, Thorn DC, Ecroyd H, Holt C.

J Dairy Sci. 2017 Jul;100(7):5121-5124. doi: 10.3168/jds.2017-13053. No abstract available.


A structural and functional study of Gln147 deamidation in αA-crystallin, a site of modification in human cataract.

Ray NJ, Hall D, Carver JA.

Exp Eye Res. 2017 Aug;161:163-173. doi: 10.1016/j.exer.2017.05.005. Epub 2017 May 17.


The functional roles of the unstructured N- and C-terminal regions in αB-crystallin and other mammalian small heat-shock proteins.

Carver JA, Grosas AB, Ecroyd H, Quinlan RA.

Cell Stress Chaperones. 2017 Jul;22(4):627-638. doi: 10.1007/s12192-017-0789-6. Epub 2017 Apr 8.


The growing world of small heat shock proteins: from structure to functions.

Carra S, Alberti S, Arrigo PA, Benesch JL, Benjamin IJ, Boelens W, Bartelt-Kirbach B, Brundel BJJM, Buchner J, Bukau B, Carver JA, Ecroyd H, Emanuelsson C, Finet S, Golenhofen N, Goloubinoff P, Gusev N, Haslbeck M, Hightower LE, Kampinga HH, Klevit RE, Liberek K, Mchaourab HS, McMenimen KA, Poletti A, Quinlan R, Strelkov SV, Toth ME, Vierling E, Tanguay RM.

Cell Stress Chaperones. 2017 Jul;22(4):601-611. doi: 10.1007/s12192-017-0787-8. Epub 2017 Mar 31. Review.


A modular and adaptive mass spectrometry-based platform for support of bioprocess development toward optimal host cell protein clearance.

Walker DE, Yang F, Carver J, Joe K, Michels DA, Yu XC.

MAbs. 2017 May/Jun;9(4):654-663. doi: 10.1080/19420862.2017.1303023. Epub 2017 Mar 27.


How to Develop a Cardio-oncology Fellowship.

Johnson MN, Steingart R, Carver J.

Heart Fail Clin. 2017 Apr;13(2):361-366. doi: 10.1016/j.hfc.2016.12.012. Review.


Coaggregation of κ-Casein and β-Lactoglobulin Produces Morphologically Distinct Amyloid Fibrils.

Raynes JK, Day L, Crepin P, Horrocks MH, Carver JA.

Small. 2017 Apr;13(14). doi: 10.1002/smll.201603591. Epub 2017 Feb 1.


Measurement of amyloid formation by turbidity assay-seeing through the cloud.

Zhao R, So M, Maat H, Ray NJ, Arisaka F, Goto Y, Carver JA, Hall D.

Biophys Rev. 2016;8(4):445-471. doi: 10.1007/s12551-016-0233-7. Epub 2016 Nov 23. Review.


Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations.

Liao C, Ashley N, Diot A, Morten K, Phadwal K, Williams A, Fearnley I, Rosser L, Lowndes J, Fratter C, Ferguson DJ, Vay L, Quaghebeur G, Moroni I, Bianchi S, Lamperti C, Downes SM, Sitarz KS, Flannery PJ, Carver J, Dombi E, East D, Laura M, Reilly MM, Mortiboys H, Prevo R, Campanella M, Daniels MJ, Zeviani M, Yu-Wai-Man P, Simon AK, Votruba M, Poulton J.

Neurology. 2017 Jan 10;88(2):131-142. doi: 10.1212/WNL.0000000000003491. Epub 2016 Dec 14.


The ProteomeXchange consortium in 2017: supporting the cultural change in proteomics public data deposition.

Deutsch EW, Csordas A, Sun Z, Jarnuczak A, Perez-Riverol Y, Ternent T, Campbell DS, Bernal-Llinares M, Okuda S, Kawano S, Moritz RL, Carver JJ, Wang M, Ishihama Y, Bandeira N, Hermjakob H, Vizcaíno JA.

Nucleic Acids Res. 2017 Jan 4;45(D1):D1100-D1106. doi: 10.1093/nar/gkw936. Epub 2016 Oct 18.


Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline.

Armenian SH, Lacchetti C, Barac A, Carver J, Constine LS, Denduluri N, Dent S, Douglas PS, Durand JB, Ewer M, Fabian C, Hudson M, Jessup M, Jones LW, Ky B, Mayer EL, Moslehi J, Oeffinger K, Ray K, Ruddy K, Lenihan D.

J Clin Oncol. 2017 Mar 10;35(8):893-911. doi: 10.1200/JCO.2016.70.5400. Epub 2016 Dec 5.


Response: Proposing and Meeting the Need for Interdisciplinary Cardio-Oncology Subspecialty Training by Sherry-Ann Brown, MD, PhD and Nicole Sandhu, MD, PhD.

Lenihan DJ, Dent S, Carver J.

J Card Fail. 2016 Nov;22(11):936. doi: 10.1016/j.cardfail.2016.09.018. Epub 2016 Sep 20. No abstract available.


Small Heat-shock Proteins Prevent α-Synuclein Aggregation via Transient Interactions and Their Efficacy Is Affected by the Rate of Aggregation.

Cox D, Selig E, Griffin MD, Carver JA, Ecroyd H.

J Biol Chem. 2016 Oct 21;291(43):22618-22629. Epub 2016 Sep 1.


Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children.

Diot A, Dombi E, Lodge T, Liao C, Morten K, Carver J, Wells D, Child T, Johnston IG, Williams S, Poulton J.

Biochem Soc Trans. 2016 Aug 15;44(4):1091-100. doi: 10.1042/BST20160095.


Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.

Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N.

Nat Biotechnol. 2016 Aug 9;34(8):828-837. doi: 10.1038/nbt.3597.


Real-time monitoring of amyloid growth in a rigid gel matrix.

Dalpadado RC, Maat H, Carver JA, Hall D.

Anal Biochem. 2016 Oct 15;511:13-6. doi: 10.1016/j.ab.2016.07.024. Epub 2016 Jul 28.


Recognizing and analyzing variability in amyloid formation kinetics: Simulation and statistical methods.

Hall D, Zhao R, So M, Adachi M, Rivas G, Carver JA, Goto Y.

Anal Biochem. 2016 Oct 1;510:56-71. doi: 10.1016/j.ab.2016.07.013. Epub 2016 Jul 16.


The m.13051G>A mitochondrial DNA mutation results in variable neurology and activated mitophagy.

Dombi E, Diot A, Morten K, Carver J, Lodge T, Fratter C, Ng YS, Liao C, Muir R, Blakely EL, Hargreaves I, Al-Dosary M, Sarkar G, Hickman SJ, Downes SM, Jayawant S, Yu-Wai-Man P, Taylor RW, Poulton J.

Neurology. 2016 May 17;86(20):1921-3. doi: 10.1212/WNL.0000000000002688. Epub 2016 Apr 22. No abstract available.


Noninvasive Measures of Ventricular-Arterial Coupling and Circumferential Strain Predict Cancer Therapeutics-Related Cardiac Dysfunction.

Narayan HK, French B, Khan AM, Plappert T, Hyman D, Bajulaiye A, Domchek S, DeMichele A, Clark A, Matro J, Bradbury A, Fox K, Carver JR, Ky B.

JACC Cardiovasc Imaging. 2016 Oct;9(10):1131-1141. doi: 10.1016/j.jcmg.2015.11.024. Epub 2016 Apr 13.

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