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Items: 10


IL1RAP potentiates multiple oncogenic signaling pathways in AML.

Mitchell K, Barreyro L, Todorova TI, Taylor SJ, Antony-Debré I, Narayanagari SR, Carvajal LA, Leite J, Piperdi Z, Pendurti G, Mantzaris I, Paietta E, Verma A, Gritsman K, Steidl U.

J Exp Med. 2018 Jun 4;215(6):1709-1727. doi: 10.1084/jem.20180147. Epub 2018 May 17.


Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia.

Carvajal LA, Neriah DB, Senecal A, Benard L, Thiruthuvanathan V, Yatsenko T, Narayanagari SR, Wheat JC, Todorova TI, Mitchell K, Kenworthy C, Guerlavais V, Annis DA, Bartholdy B, Will B, Anampa JD, Mantzaris I, Aivado M, Singer RH, Coleman RA, Verma A, Steidl U.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaao3003. doi: 10.1126/scitranslmed.aao3003.


Pharmacological inhibition of the transcription factor PU.1 in leukemia.

Antony-Debré I, Paul A, Leite J, Mitchell K, Kim HM, Carvajal LA, Todorova TI, Huang K, Kumar A, Farahat AA, Bartholdy B, Narayanagari SR, Chen J, Ambesi-Impiombato A, Ferrando AA, Mantzaris I, Gavathiotis E, Verma A, Will B, Boykin DW, Wilson WD, Poon GM, Steidl U.

J Clin Invest. 2017 Dec 1;127(12):4297-4313. doi: 10.1172/JCI92504. Epub 2017 Oct 30.


Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase.

Giono LE, Resnick-Silverman L, Carvajal LA, St Clair S, Manfredi JJ.

Oncogene. 2017 Dec 7;36(49):6762-6773. doi: 10.1038/onc.2017.254. Epub 2017 Aug 14.


Eliminating Cancer Stem Cells in CML with Combination Transcriptional Therapy.

Carvajal LA, Steidl U.

Cell Stem Cell. 2016 Jul 7;19(1):6-8. doi: 10.1016/j.stem.2016.06.005.


p53 Promotes cell survival due to the reversibility of its cell-cycle checkpoints.

Lukin DJ, Carvajal LA, Liu WJ, Resnick-Silverman L, Manfredi JJ.

Mol Cancer Res. 2015 Jan;13(1):16-28. doi: 10.1158/1541-7786.MCR-14-0177. Epub 2014 Aug 26.


The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo.

Hamard PJ, Barthelery N, Hogstad B, Mungamuri SK, Tonnessen CA, Carvajal LA, Senturk E, Gillespie V, Aaronson SA, Merad M, Manfredi JJ.

Genes Dev. 2013 Sep 1;27(17):1868-85. doi: 10.1101/gad.224386.113.


Another fork in the road--life or death decisions by the tumour suppressor p53.

Carvajal LA, Manfredi JJ.

EMBO Rep. 2013 May;14(5):414-21. doi: 10.1038/embor.2013.25. Epub 2013 Apr 16. Review.


E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression.

Carvajal LA, Hamard PJ, Tonnessen C, Manfredi JJ.

Genes Dev. 2012 Jul 15;26(14):1533-45. doi: 10.1101/gad.184911.111.


[Chronology of eruption of permanent teeth. Urban population of Sabaneta].

Estrada MI, Espinosa MM, Carvajal LA.

CES Odontol. 1987;1(1):14-8. Spanish. No abstract available.


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