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Items: 17

1.

T lymphocytes against solid malignancies: winning ways to defeat tumours.

Caruana I, Simula L, Locatelli F, Campello S.

Cell Stress. 2018 Jul 26;2(8):200-212. doi: 10.15698/cst2018.07.148. Review.

2.

Reversible induction of mitophagy by an optogenetic bimodular system.

D'Acunzo P, Strappazzon F, Caruana I, Meneghetti G, Di Rita A, Simula L, Weber G, Del Bufalo F, Dalla Valle L, Campello S, Locatelli F, Cecconi F.

Nat Commun. 2019 Apr 4;10(1):1533. doi: 10.1038/s41467-019-09487-1.

3.

Role of IFNγ in immune-mediated graft failure occurring after allogeneic hematopoietic stem cell transplantation.

Merli P, Caruana I, De Vito R, Strocchio L, Weber G, Del Bufalo F, Buatois V, Montanari P, Cefalo MG, Pitisci A, Algeri M, Galaverna F, Quintarelli C, Cirillo V, Pagliara D, Ferlin W, Ballabio M, De Min C, Locatelli F.

Haematologica. 2019 Feb 21. pii: haematol.2019.216101. doi: 10.3324/haematol.2019.216101. [Epub ahead of print]

4.

AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis.

Becher J, Simula L, Volpe E, Procaccini C, La Rocca C, D'Acunzo P, Cianfanelli V, Strappazzon F, Caruana I, Nazio F, Weber G, Gigantino V, Botti G, Ciccosanti F, Borsellino G, Campello S, Mandolesi G, De Bardi M, Fimia GM, D'Amelio M, Ruffini F, Furlan R, Centonze D, Martino G, Braghetta P, Chrisam M, Bonaldo P, Matarese G, Locatelli F, Battistini L, Cecconi F.

Dev Cell. 2018 Dec 3;47(5):592-607.e6. doi: 10.1016/j.devcel.2018.11.010.

PMID:
30513302
5.

Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma.

Quintarelli C, Orlando D, Boffa I, Guercio M, Polito VA, Petretto A, Lavarello C, Sinibaldi M, Weber G, Del Bufalo F, Giorda E, Scarsella M, Petrini S, Pagliara D, Locatelli F, De Angelis B, Caruana I.

Oncoimmunology. 2018 Mar 15;7(6):e1433518. doi: 10.1080/2162402X.2018.1433518. eCollection 2018.

6.

Adoptive Immunotherapy Using PRAME-Specific T Cells in Medulloblastoma.

Orlando D, Miele E, De Angelis B, Guercio M, Boffa I, Sinibaldi M, Po A, Caruana I, Abballe L, Carai A, Caruso S, Camera A, Moseley A, Hagedoorn RS, Heemskerk MHM, Giangaspero F, Mastronuzzi A, Ferretti E, Locatelli F, Quintarelli C.

Cancer Res. 2018 Jun 15;78(12):3337-3349. doi: 10.1158/0008-5472.CAN-17-3140. Epub 2018 Apr 3.

7.

Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model.

Bocca P, Di Carlo E, Caruana I, Emionite L, Cilli M, De Angelis B, Quintarelli C, Pezzolo A, Raffaghello L, Morandi F, Locatelli F, Pistoia V, Prigione I.

Oncoimmunology. 2017 Oct 4;7(1):e1378843. doi: 10.1080/2162402X.2017.1378843. eCollection 2017.

8.

Preservation of Antigen-Specific Functions of αβ T Cells and B Cells Removed from Hematopoietic Stem Cell Transplants Suggests Their Use As an Alternative Cell Source for Advanced Manipulation and Adoptive Immunotherapy.

Li Pira G, Di Cecca S, Biagini S, Girolami E, Cicchetti E, Bertaina V, Quintarelli C, Caruana I, Lucarelli B, Merli P, Pagliara D, Brescia LP, Bertaina A, Montanari M, Locatelli F.

Front Immunol. 2017 Mar 23;8:332. doi: 10.3389/fimmu.2017.00332. eCollection 2017.

9.

Overcoming Challenges in CAR T-cell Product CGMP Release.

Quintarelli C, Locatelli F, Caruana I, De Angelis B.

Mol Ther. 2016 May;24(5):845-6. doi: 10.1038/mt.2016.72. No abstract available.

10.

3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus.

Del Bufalo F, Manzo T, Hoyos V, Yagyu S, Caruana I, Jacot J, Benavides O, Rosen D, Brenner MK.

Biomaterials. 2016 Apr;84:76-85. doi: 10.1016/j.biomaterials.2016.01.030. Epub 2016 Jan 20.

PMID:
26826297
11.

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes.

Caruana I, Savoldo B, Hoyos V, Weber G, Liu H, Kim ES, Ittmann MM, Marchetti D, Dotti G.

Nat Med. 2015 May;21(5):524-9. doi: 10.1038/nm.3833. Epub 2015 Apr 13.

12.

K562-Derived Whole-Cell Vaccine Enhances Antitumor Responses of CAR-Redirected Virus-Specific Cytotoxic T Lymphocytes In Vivo.

Caruana I, Weber G, Ballard BC, Wood MS, Savoldo B, Dotti G.

Clin Cancer Res. 2015 Jul 1;21(13):2952-62. doi: 10.1158/1078-0432.CCR-14-2998. Epub 2015 Feb 17.

13.

From monoclonal antibodies to chimeric antigen receptors for the treatment of human malignancies.

Caruana I, Diaconu I, Dotti G.

Semin Oncol. 2014 Oct;41(5):661-6. doi: 10.1053/j.seminoncol.2014.08.005. Epub 2014 Aug 12. Review.

14.

Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors.

Nishio N, Diaconu I, Liu H, Cerullo V, Caruana I, Hoyos V, Bouchier-Hayes L, Savoldo B, Dotti G.

Cancer Res. 2014 Sep 15;74(18):5195-205. doi: 10.1158/0008-5472.CAN-14-0697. Epub 2014 Jul 24.

15.

T lymphocytes redirected against the chondroitin sulfate proteoglycan-4 control the growth of multiple solid tumors both in vitro and in vivo.

Geldres C, Savoldo B, Hoyos V, Caruana I, Zhang M, Yvon E, Del Vecchio M, Creighton CJ, Ittmann M, Ferrone S, Dotti G.

Clin Cancer Res. 2014 Feb 15;20(4):962-71. doi: 10.1158/1078-0432.CCR-13-2218. Epub 2013 Dec 13.

16.

Generation of tumor antigen-specific T cell lines from pediatric patients with acute lymphoblastic leukemia--implications for immunotherapy.

Weber G, Caruana I, Rouce RH, Barrett AJ, Gerdemann U, Leen AM, Rabin KR, Bollard CM.

Clin Cancer Res. 2013 Sep 15;19(18):5079-91. doi: 10.1158/1078-0432.CCR-13-0955. Epub 2013 Jul 9.

17.

Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant.

Weber G, Gerdemann U, Caruana I, Savoldo B, Hensel NF, Rabin KR, Shpall EJ, Melenhorst JJ, Leen AM, Barrett AJ, Bollard CM.

Leukemia. 2013 Jul;27(7):1538-47. doi: 10.1038/leu.2013.66. Epub 2013 Mar 1.

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