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Items: 1 to 50 of 95


Repressive Gene Regulation Synchronizes Development with Cellular Metabolism.

Cassidy JJ, Bernasek SM, Bakker R, Giri R, Peláez N, Eder B, Bobrowska A, Bagheri N, Nunes Amaral LA, Carthew RW.

Cell. 2019 Aug 8;178(4):980-992.e17. doi: 10.1016/j.cell.2019.06.023. Epub 2019 Jul 25.


Out of the testis: biological impacts of new genes.

Nyberg KG, Carthew RW.

Genes Dev. 2017 Sep 15;31(18):1825-1826. doi: 10.1101/gad.307496.117. Review.


Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs.

Church VA, Pressman S, Isaji M, Truscott M, Cizmecioglu NT, Buratowski S, Frolov MV, Carthew RW.

Cell Rep. 2017 Sep 26;20(13):3123-3134. doi: 10.1016/j.celrep.2017.09.010.


MicroRNAs Make a Difference in Cardiovascular Robustness.

Bakker R, Carthew RW.

Dev Cell. 2017 Mar 27;40(6):515-516. doi: 10.1016/j.devcel.2017.03.009.


Hexagonal Patterning of the Insect Compound Eye: Facet Area Variation, Defects, and Disorder.

Kim S, Cassidy JJ, Yang B, Carthew RW, Hilgenfeldt S.

Biophys J. 2016 Dec 20;111(12):2735-2746. doi: 10.1016/j.bpj.2016.11.004.


Spindle-E cycling between nuage and cytoplasm is controlled by Qin and PIWI proteins.

Andress A, Bei Y, Fonslow BR, Giri R, Wu Y, Yates JR 3rd, Carthew RW.

J Cell Biol. 2016 Apr 25;213(2):201-11. doi: 10.1083/jcb.201411076. Epub 2016 Apr 18.


MicroRNA function in Drosophila melanogaster.

Carthew RW, Agbu P, Giri R.

Semin Cell Dev Biol. 2017 May;65:29-37. doi: 10.1016/j.semcdb.2016.03.015. Epub 2016 Mar 18. Review.


Differential Masking of Natural Genetic Variation by miR-9a in Drosophila.

Cassidy JJ, Straughan AJ, Carthew RW.

Genetics. 2016 Feb;202(2):675-87. doi: 10.1534/genetics.115.183822. Epub 2015 Nov 27.


Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation.

Peláez N, Gavalda-Miralles A, Wang B, Navarro HT, Gudjonson H, Rebay I, Dinner AR, Katsaggelos AK, Amaral LA, Carthew RW.

Elife. 2015 Nov 19;4. pii: e08924. doi: 10.7554/eLife.08924.


Drosophila Eye Nuclei Segmentation Based on Graph Cut and Convex Shape Prior.

Qi J, Wang B, Pelaez N, Rebay I, Carthew RW, Katsaggelos AK, Nunes Amaral LA.

Int Conf Signal Process Proc. 2013 Sep 18:670-674.


MicroRNAs and their roles in developmental canalization.

Posadas DM, Carthew RW.

Curr Opin Genet Dev. 2014 Aug;27:1-6. doi: 10.1016/j.gde.2014.03.005. Epub 2014 May 8. Review.


microRNAs suppress cellular phenotypic heterogeneity.

Giri R, Carthew RW.

Cell Cycle. 2014;13(10):1517-8. doi: 10.4161/cc.29013. Epub 2014 Apr 25. No abstract available.


miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor.

Cassidy JJ, Jha AR, Posadas DM, Giri R, Venken KJ, Ji J, Jiang H, Bellen HJ, White KP, Carthew RW.

Cell. 2013 Dec 19;155(7):1556-67. doi: 10.1016/j.cell.2013.10.057. Erratum in: Cell. 2014 Apr 24;157(3):753.


A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling.

Boisclair Lachance JF, Peláez N, Cassidy JJ, Webber JL, Rebay I, Carthew RW.

Dev Biol. 2014 Jan 15;385(2):263-78. doi: 10.1016/j.ydbio.2013.11.002. Epub 2013 Nov 14.


Functionally diverse microRNA effector complexes are regulated by extracellular signaling.

Wu PH, Isaji M, Carthew RW.

Mol Cell. 2013 Oct 10;52(1):113-23. doi: 10.1016/j.molcel.2013.08.023. Epub 2013 Sep 19.


Functional specialization of the small interfering RNA pathway in response to virus infection.

Marques JT, Wang JP, Wang X, de Oliveira KP, Gao C, Aguiar ER, Jafari N, Carthew RW.

PLoS Pathog. 2013;9(8):e1003579. doi: 10.1371/journal.ppat.1003579. Epub 2013 Aug 29. Erratum in: PLoS Pathog. 2013 Oct;9(10): doi: 10.1371/annotation/4e52dfe0-479d-4be7-8545-b4ee8a1eb9ed.


The relationship between long-range chromatin occupancy and polymerization of the Drosophila ETS family transcriptional repressor Yan.

Webber JL, Zhang J, Cote L, Vivekanand P, Ni X, Zhou J, Nègre N, Carthew RW, White KP, Rebay I.

Genetics. 2013 Feb;193(2):633-49. doi: 10.1534/genetics.112.146647. Epub 2012 Nov 19.


Tobacco calmodulin-like protein provides secondary defense by binding to and directing degradation of virus RNA silencing suppressors.

Nakahara KS, Masuta C, Yamada S, Shimura H, Kashihara Y, Wada TS, Meguro A, Goto K, Tadamura K, Sueda K, Sekiguchi T, Shao J, Itchoda N, Matsumura T, Igarashi M, Ito K, Carthew RW, Uyeda I.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10113-8. doi: 10.1073/pnas.1201628109. Epub 2012 Jun 4.


A Systematic Genetic Screen to Dissect the MicroRNA Pathway in Drosophila.

Pressman S, Reinke CA, Wang X, Carthew RW.

G3 (Bethesda). 2012 Apr;2(4):437-48. doi: 10.1534/g3.112.002030. Epub 2012 Apr 1.


Biological robustness and the role of microRNAs: a network perspective.

Peláez N, Carthew RW.

Curr Top Dev Biol. 2012;99:237-55. doi: 10.1016/B978-0-12-387038-4.00009-4. Review.


Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model.

Gemp IM, Carthew RW, Hilgenfeldt S.

PLoS Comput Biol. 2011 Jul;7(7):e1002115. doi: 10.1371/journal.pcbi.1002115. Epub 2011 Jul 21.


Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing.

Harris DA, Kim K, Nakahara K, Vásquez-Doorman C, Carthew RW.

J Cell Biol. 2011 Jul 11;194(1):77-87. doi: 10.1083/jcb.201102021.


Reply to evolutionary flux of canonical microRNAs and mirtrons in Drosophila.

Lu J, Shen Y, Carthew RW, Wang SM, Wu CI.

Nat Genet. 2010 Jan;42(1):9-10. No abstract available.


Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila.

Marques JT, Kim K, Wu PH, Alleyne TM, Jafari N, Carthew RW.

Nat Struct Mol Biol. 2010 Jan;17(1):24-30. doi: 10.1038/nsmb.1735. Epub 2009 Dec 27.


The endo-siRNA pathway is essential for robust development of the Drosophila embryo.

Lucchetta EM, Carthew RW, Ismagilov RF.

PLoS One. 2009 Oct 23;4(10):e7576. doi: 10.1371/journal.pone.0007576.


Silencing by small RNAs is linked to endosomal trafficking.

Lee YS, Pressman S, Andress AP, Kim K, White JL, Cassidy JJ, Li X, Lubell K, Lim DH, Cho IS, Nakahara K, Preall JB, Bellare P, Sontheimer EJ, Carthew RW.

Nat Cell Biol. 2009 Sep;11(9):1150-6. doi: 10.1038/ncb1930. Epub 2009 Aug 16. Erratum in: Nat Cell Biol. 2009 Dec;11(12):1495.


A microRNA imparts robustness against environmental fluctuation during development.

Li X, Cassidy JJ, Reinke CA, Fischboeck S, Carthew RW.

Cell. 2009 Apr 17;137(2):273-82. doi: 10.1016/j.cell.2009.01.058.


Origins and Mechanisms of miRNAs and siRNAs.

Carthew RW, Sontheimer EJ.

Cell. 2009 Feb 20;136(4):642-55. doi: 10.1016/j.cell.2009.01.035. Review.


BMP signaling goes posttranscriptional in a microRNA sort of way.

Reinke CA, Carthew RW.

Dev Cell. 2008 Aug;15(2):174-5. doi: 10.1016/j.devcel.2008.07.015.


Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye.

Hayashi T, Xu C, Carthew RW.

Development. 2008 Aug;135(16):2787-96. doi: 10.1242/dev.006189. Epub 2008 Jul 17.


Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila.

Lim DH, Kim J, Kim S, Carthew RW, Lee YS.

Biochem Biophys Res Commun. 2008 Jul 4;371(3):525-30. doi: 10.1016/j.bbrc.2008.04.118. Epub 2008 Apr 30.


Adaptive evolution of newly emerged micro-RNA genes in Drosophila.

Lu J, Fu Y, Kumar S, Shen Y, Zeng K, Xu A, Carthew R, Wu CI.

Mol Biol Evol. 2008 May;25(5):929-38. doi: 10.1093/molbev/msn040. Epub 2008 Feb 22.


The birth and death of microRNA genes in Drosophila.

Lu J, Shen Y, Wu Q, Kumar S, He B, Shi S, Carthew RW, Wang SM, Wu CI.

Nat Genet. 2008 Mar;40(3):351-5. doi: 10.1038/ng.73. Epub 2008 Feb 17.


Physical modeling of cell geometric order in an epithelial tissue.

Hilgenfeldt S, Erisken S, Carthew RW.

Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):907-11. doi: 10.1073/pnas.0711077105. Epub 2008 Jan 11.


Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye.

Zheng L, Carthew RW.

Mech Dev. 2008 Jan-Feb;125(1-2):18-29. Epub 2007 Oct 22.


Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina.

Käfer J, Hayashi T, Marée AF, Carthew RW, Graner F.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18549-54. Epub 2007 Nov 14.


SnapShot: small RNA-mediated epigenetic modifications.

Bei Y, Pressman S, Carthew R.

Cell. 2007 Aug 24;130(4):756. No abstract available.


Posttranscriptional gene silencing.

Pressman S, Bei Y, Carthew R.

Cell. 2007 Aug 10;130(3):570. No abstract available.


Pattern formation in the Drosophila eye.

Carthew RW.

Curr Opin Genet Dev. 2007 Aug;17(4):309-13. Epub 2007 Jul 6. Review.


A call to arms: coevolution of animal viruses and host innate immune responses.

Marques JT, Carthew RW.

Trends Genet. 2007 Jul;23(7):359-64. Epub 2007 Apr 27. Review.


The RNAi pathway initiated by Dicer-2 in Drosophila.

Kim K, Lee YS, Harris D, Nakahara K, Carthew RW.

Cold Spring Harb Symp Quant Biol. 2006;71:39-44. Review.


Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes.

Kim K, Lee YS, Carthew RW.

RNA. 2007 Jan;13(1):22-9. Epub 2006 Nov 22.


Molecular biology. A new RNA dimension to genome control.

Carthew RW.

Science. 2006 Jul 21;313(5785):305-6. No abstract available.


RNA interference directs innate immunity against viruses in adult Drosophila.

Wang XH, Aliyari R, Li WX, Li HW, Kim K, Carthew R, Atkinson P, Ding SW.

Science. 2006 Apr 21;312(5772):452-4. Epub 2006 Mar 23.


Gene regulation by microRNAs.

Carthew RW.

Curr Opin Genet Dev. 2006 Apr;16(2):203-8. Epub 2006 Feb 28. Review.


Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo.

Bayraktar J, Zygmunt D, Carthew RW.

J Cell Sci. 2006 Feb 15;119(Pt 4):711-21. Epub 2006 Jan 31.


Transcript In Situ Hybridization of Whole-Mount Embryos for Phenotype Analysis of RNAi-Treated Drosophila.

Carthew RW.

CSH Protoc. 2006 Aug 1;2006(3). pii: pdb.prot4519. doi: 10.1101/pdb.prot4519. No abstract available.


Semiquantitative RT-PCR for Phenotype Analysis of RNAi-Treated Drosophila Embryos.

Carthew RW.

CSH Protoc. 2006 Aug 1;2006(3). pii: pdb.prot4518. doi: 10.1101/pdb.prot4518. No abstract available.


Delivery of dsRNA into Drosophila Embryos by Gene Gun.

Carthew RW.

CSH Protoc. 2006 Aug 1;2006(3). pii: pdb.prot4517. doi: 10.1101/pdb.prot4517. No abstract available.


Microinjection of dsRNA into Drosophila Embryos.

Carthew RW.

CSH Protoc. 2006 Aug 1;2006(3). pii: pdb.prot4516. doi: 10.1101/pdb.prot4516. No abstract available.


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