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Items: 1 to 50 of 308

1.

Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells.

Bozdag M, Ferraroni M, Ward C, Carta F, Bua S, Angeli A, Langdon SP, Kunkler IH, Al-Tamimi AS, Supuran CT.

Eur J Med Chem. 2019 Aug 7;182:111600. doi: 10.1016/j.ejmech.2019.111600. [Epub ahead of print]

PMID:
31419777
2.

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity.

Tanini D, Ricci L, Capperucci A, Di Cesare Mannelli L, Ghelardini C, Peat TS, Carta F, Angeli A, Supuran CT.

Eur J Med Chem. 2019 Aug 5;181:111586. doi: 10.1016/j.ejmech.2019.111586. [Epub ahead of print]

PMID:
31401537
3.

A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitors.

Costa G, Carta F, Ambrosio FA, Artese A, Ortuso F, Moraca F, Rocca R, Romeo I, Lupia A, Maruca A, Bagetta D, Catalano R, Vullo D, Alcaro S, Supuran CT.

Eur J Med Chem. 2019 Jul 27;181:111565. doi: 10.1016/j.ejmech.2019.111565. [Epub ahead of print]

PMID:
31387062
4.

Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.

Berrino E, Milazzo L, Micheli L, Vullo D, Angeli A, Bozdag M, Nocentini A, Menicatti M, Bartolucci G, di Cesare Mannelli L, Ghelardini C, Supuran CT, Carta F.

J Med Chem. 2019 Aug 8;62(15):7233-7249. doi: 10.1021/acs.jmedchem.9b00845. Epub 2019 Jul 23.

PMID:
31287314
5.

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties.

Bozdag M, Poli G, Angeli A, Lucarini E, Tuccinardi T, Di Cesare Mannelli L, Selleri S, Ghelardini C, Winum JY, Carta F, Supuran CT.

Bioorg Chem. 2019 Aug;89:103033. doi: 10.1016/j.bioorg.2019.103033. Epub 2019 Jun 6.

PMID:
31212085
6.

Unusual metastasis of papillary renal cell carcinoma to the pyriform sinus: Case report.

Gioia E, Carta F, Mariani C, Gerosa C, Puxeddu R.

Clin Case Rep. 2019 May 14;7(6):1222-1225. doi: 10.1002/ccr3.2162. eCollection 2019 Jun.

7.

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.

Angeli A, Di Cesare Mannelli L, Ghelardini C, Peat TS, Bartolucci G, Menicatti M, Carta F, Supuran CT.

Eur J Med Chem. 2019 Sep 1;177:188-197. doi: 10.1016/j.ejmech.2019.05.058. Epub 2019 May 21.

PMID:
31136893
8.

A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells.

Mboge MY, Chen Z, Khokhar D, Wolff A, Ai L, Heldermon CD, Bozdag M, Carta F, Supuran CT, Brown KD, McKenna R, Frost CJ, Frost SC.

Biochem J. 2019 May 28;476(10):1497-1513. doi: 10.1042/BCJ20190177.

PMID:
31072911
9.

Polypharmacology of epacadostat: a potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII.

Angeli A, Ferraroni M, Nocentini A, Selleri S, Gratteri P, Supuran CT, Carta F.

Chem Commun (Camb). 2019 May 14;55(40):5720-5723. doi: 10.1039/c8cc09568j.

PMID:
31038135
10.

Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis.

Micheli L, Bozdag M, Akgul O, Carta F, Guccione C, Bergonzi MC, Bilia AR, Cinci L, Lucarini E, Parisio C, Supuran CT, Ghelardini C, Di Cesare Mannelli L.

Int J Mol Sci. 2019 Apr 18;20(8). pii: E1923. doi: 10.3390/ijms20081923.

11.

Discovery of new organoselenium compounds as antileishmanial agents.

Al-Tamimi AS, Etxebeste-Mitxeltorena M, Sanmartín C, Jiménez-Ruiz A, Syrjänen L, Parkkila S, Selleri S, Carta F, Angeli A, Supuran CT.

Bioorg Chem. 2019 May;86:339-345. doi: 10.1016/j.bioorg.2019.01.069. Epub 2019 Jan 31.

PMID:
30743174
12.

Carbonic Anhydrase Inhibitors of Different Structures Dilate Pre-Contracted Porcine Retinal Arteries.

Eysteinsson T, Gudmundsdottir H, Hardarson AO, Berrino E, Selleri S, Supuran CT, Carta F.

Int J Mol Sci. 2019 Jan 22;20(3). pii: E467. doi: 10.3390/ijms20030467.

13.

Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.

Mboge MY, Chen Z, Wolff A, Mathias JV, Tu C, Brown KD, Bozdag M, Carta F, Supuran CT, McKenna R, Frost SC.

PLoS One. 2018 Nov 19;13(11):e0207417. doi: 10.1371/journal.pone.0207417. eCollection 2018.

14.

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies.

Aspatwar A, Winum JY, Carta F, Supuran CT, Hammaren M, Parikka M, Parkkila S.

Molecules. 2018 Nov 8;23(11). pii: E2911. doi: 10.3390/molecules23112911. Review.

15.

The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy.

Andreucci E, Ruzzolini J, Peppicelli S, Bianchini F, Laurenzana A, Carta F, Supuran CT, Calorini L.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):117-123. doi: 10.1080/14756366.2018.1532419.

16.

Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines.

Angeli A, Trallori E, Carta F, Di Cesare Mannelli L, Ghelardini C, Supuran CT.

ACS Med Chem Lett. 2018 Aug 29;9(9):947-951. doi: 10.1021/acsmedchemlett.8b00362. eCollection 2018 Sep 13.

PMID:
30258546
17.

CO2 Transoral Microsurgery for Supraglottic Squamous Cell Carcinoma.

Carta F, Mariani C, Sambiagio GB, Chuchueva N, Lecis E, Gerosa C, Puxeddu R.

Front Oncol. 2018 Sep 4;8:321. doi: 10.3389/fonc.2018.00321. eCollection 2018.

18.

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.

Logsdon DP, Shah F, Carta F, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML.

Sci Rep. 2018 Sep 13;8(1):13759. doi: 10.1038/s41598-018-32034-9.

19.

Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae α- and β-class enzymes.

Bua S, Berrino E, Del Prete S, Murthy VS, Vijayakumar V, Tamboli Y, Capasso C, Cerbai E, Mugelli A, Carta F, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1125-1136. doi: 10.1080/14756366.2018.1467901.

20.

Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.

Bozdag M, Carta F, Ceruso M, Ferraroni M, McDonald PC, Dedhar S, Supuran CT.

J Med Chem. 2018 Jul 26;61(14):6328-6338. doi: 10.1021/acs.jmedchem.8b00770. Epub 2018 Jul 17.

PMID:
29962205
21.

Expiratory muscle strength and functional exercise tolerance in adults with cystic fibrosis: a cross-sectional study.

Gambazza S, Turrin V, Speziali C, Brivio A, Valmarana L, Carta F, Bulfamante AMC, Colombo C.

Physiother Res Int. 2018 Oct;23(4):e1720. doi: 10.1002/pri.1720. Epub 2018 Jun 26.

PMID:
29943880
22.

State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes.

Bozdag M, Altamimi ASA, Vullo D, Supuran CT, Carta F.

Curr Med Chem. 2018 Jun 22. doi: 10.2174/0929867325666180622120625. [Epub ahead of print]

PMID:
29932025
23.

Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.

Nocentini A, Ceruso M, Bua S, Lomelino CL, Andring JT, McKenna R, Lanzi C, Sgambellone S, Pecori R, Matucci R, Filippi L, Gratteri P, Carta F, Masini E, Selleri S, Supuran CT.

J Med Chem. 2018 Jun 28;61(12):5380-5394. doi: 10.1021/acs.jmedchem.8b00625. Epub 2018 Jun 13.

PMID:
29851481
24.

Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review.

Puxeddu I, Capecchi R, Carta F, Tavoni AG, Migliorini P, Puxeddu R.

J Immunol Res. 2018 Apr 1;2018:6936727. doi: 10.1155/2018/6936727. eCollection 2018. Review.

25.

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.

Angeli A, di Cesare Mannelli L, Trallori E, Peat TS, Ghelardini C, Carta F, Supuran CT.

ACS Med Chem Lett. 2018 Apr 9;9(5):462-467. doi: 10.1021/acsmedchemlett.8b00076. eCollection 2018 May 10.

26.

Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis.

Akgul O, Di Cesare Mannelli L, Vullo D, Angeli A, Ghelardini C, Bartolucci G, Alfawaz Altamimi AS, Scozzafava A, Supuran CT, Carta F.

J Med Chem. 2018 Jun 14;61(11):4961-4977. doi: 10.1021/acs.jmedchem.8b00420. Epub 2018 May 21.

PMID:
29746127
27.

CO2 Permeability of Rat Hepatocytes and Relation of CO2 Permeability to CO2 Production.

Arias-Hidalgo M, Yuan Q, Carta F, Supuran CT, Gros G, Endeward V.

Cell Physiol Biochem. 2018;46(3):1198-1208. doi: 10.1159/000489070. Epub 2018 Apr 16.

28.

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.

Supuran CT, Alterio V, Di Fiore A, D' Ambrosio K, Carta F, Monti SM, De Simone G.

Med Res Rev. 2018 Sep;38(6):1799-1836. doi: 10.1002/med.21497. Epub 2018 Apr 10. Review.

PMID:
29635752
29.

Deciphering the Mechanism of Human Carbonic Anhydrases Inhibition with Sulfocoumarins: Computational and Experimental Studies.

Nocentini A, Carta F, Tanc M, Selleri S, Supuran CT, Bazzicalupi C, Gratteri P.

Chemistry. 2018 Jun 4;24(31):7840-7844. doi: 10.1002/chem.201800941. Epub 2018 May 3.

PMID:
29603439
30.

Mono- and di-thiocarbamate inhibition studies of the δ-carbonic anhydrase TweCAδ from the marine diatom Thalassiosira weissflogii.

Bua S, Bozdag M, Del Prete S, Carta F, Donald WA, Capasso C, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):707-713. doi: 10.1080/14756366.2018.1450400.

31.

Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry.

Menicatti M, Pallecchi M, Bua S, Vullo D, Di Cesare Mannelli L, Ghelardini C, Carta F, Supuran CT, Bartolucci G.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):671-679. doi: 10.1080/14756366.2018.1445737.

32.

Synthesis of N'-phenyl-N-hydroxyureas and investigation of their inhibitory activities on human carbonic anhydrases.

Bozdag M, Carta F, Angeli A, Osman SM, Alasmary FAS, AlOthman Z, Supuran CT.

Bioorg Chem. 2018 Aug;78:1-6. doi: 10.1016/j.bioorg.2018.02.029. Epub 2018 Mar 1.

PMID:
29524665
33.

Prognostic value of age, subglottic, and anterior commissure involvement for early glottic carcinoma treated with CO2 laser transoral microsurgery: a retrospective, single-center cohort study of 261 patients.

Carta F, Bandino F, Olla AM, Chuchueva N, Gerosa C, Puxeddu R.

Eur Arch Otorhinolaryngol. 2018 May;275(5):1199-1210. doi: 10.1007/s00405-018-4890-y. Epub 2018 Feb 13.

PMID:
29442166
34.

Parotid tumours: clinical and oncologic outcomes after microscope-assisted parotidectomy with intraoperative nerve monitoring.

Carta F, Chuchueva N, Gerosa C, Sionis S, Caria RA, Puxeddu R.

Acta Otorhinolaryngol Ital. 2017 Oct;37(5):375-386. doi: 10.14639/0392-100X-1089.

35.

Acyl selenoureido benzensulfonamides show potent inhibitory activity against carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.

Angeli A, Abbas G, Del Prete S, Carta F, Capasso C, Supuran CT.

Bioorg Chem. 2017 Dec;75:170-172. doi: 10.1016/j.bioorg.2017.09.016. Epub 2017 Sep 21.

PMID:
28957751
36.

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

Angeli A, Tanini D, Peat TS, Di Cesare Mannelli L, Bartolucci G, Capperucci A, Ghelardini C, Supuran CT, Carta F.

ACS Med Chem Lett. 2017 Aug 10;8(9):963-968. doi: 10.1021/acsmedchemlett.7b00280. eCollection 2017 Sep 14.

37.

Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis.

Andreucci E, Peppicelli S, Carta F, Brisotto G, Biscontin E, Ruzzolini J, Bianchini F, Biagioni A, Supuran CT, Calorini L.

J Mol Med (Berl). 2017 Dec;95(12):1341-1353. doi: 10.1007/s00109-017-1590-9. Epub 2017 Sep 19.

PMID:
28929255
38.

Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates.

Nocentini A, Vullo D, Del Prete S, Osman SM, Alasmary FAS, AlOthman Z, Capasso C, Carta F, Gratteri P, Supuran CT.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):1064-1070. doi: 10.1080/14756366.2017.1355307.

39.

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides.

Abdoli M, Angeli A, Bozdag M, Carta F, Kakanejadifard A, Saeidian H, Supuran CT.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):1071-1078. doi: 10.1080/14756366.2017.1356295.

40.

Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?

Kusuzaki K, Matsubara T, Murata H, Logozzi M, Iessi E, Di Raimo R, Carta F, Supuran CT, Fais S.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):908-916. doi: 10.1080/14756366.2017.1335310. Review.

41.

Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors.

Berrino E, Bua S, Mori M, Botta M, Murthy VS, Vijayakumar V, Tamboli Y, Bartolucci G, Mugelli A, Cerbai E, Supuran CT, Carta F.

Molecules. 2017 Jun 24;22(7). pii: E1049. doi: 10.3390/molecules22071049.

42.

β-CA-specific inhibitor dithiocarbamate Fc14-584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis.

Aspatwar A, Hammarén M, Koskinen S, Luukinen B, Barker H, Carta F, Supuran CT, Parikka M, Parkkila S.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):832-840. doi: 10.1080/14756366.2017.1332056.

43.

Advances in new psychoactive substances identification: the U.R.I.To.N. Consortium.

Bertol E, Vaiano F, Mari F, Di Milia MG, Bua S, Supuran CT, Carta F.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):841-849. doi: 10.1080/14756366.2017.1333987.

44.

Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.

Angeli A, Carta F, Bartolucci G, Supuran CT.

Bioorg Med Chem. 2017 Jul 1;25(13):3567-3573. doi: 10.1016/j.bmc.2017.05.014. Epub 2017 May 9.

PMID:
28522267
45.

Sialendoscopy for salivary stones: principles, technical skills and therapeutic experience.

Carta F, Farneti P, Cantore S, Macrì G, Chuchueva N, Cuffaro L, Pasquini E, Puxeddu R.

Acta Otorhinolaryngol Ital. 2017 Apr;37(2):102-112. doi: 10.14639/0392-100X-1599. Review.

46.

Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells.

Meehan J, Ward C, Turnbull A, Bukowski-Wills J, Finch AJ, Jarman EJ, Xintaropoulou C, Martinez-Perez C, Gray M, Pearson M, Mullen P, Supuran CT, Carta F, Harrison DJ, Kunkler IH, Langdon SP.

Oncotarget. 2017 Jun 27;8(26):42857-42875. doi: 10.18632/oncotarget.17143.

47.

N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII.

Ivanova J, Carta F, Vullo D, Leitans J, Kazaks A, Tars K, Žalubovskis R, Supuran CT.

Bioorg Med Chem. 2017 Jul 1;25(13):3583-3589. doi: 10.1016/j.bmc.2017.04.007. Epub 2017 Apr 7.

PMID:
28416101
48.

Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII.

Bozdag M, Alafeefy AM, Altamimi AM, Carta F, Supuran CT, Vullo D.

Bioorg Med Chem. 2017 May 15;25(10):2782-2788. doi: 10.1016/j.bmc.2017.03.054. Epub 2017 Mar 29.

PMID:
28389112
49.

Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides.

Mboge MY, Mahon BP, Lamas N, Socorro L, Carta F, Supuran CT, Frost SC, McKenna R.

Eur J Med Chem. 2017 May 26;132:184-191. doi: 10.1016/j.ejmech.2017.03.026. Epub 2017 Mar 19.

50.

Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.

Carta F, Vullo D, Osman SM, AlOthman Z, Supuran CT.

Bioorg Med Chem. 2017 May 1;25(9):2569-2576. doi: 10.1016/j.bmc.2017.03.027. Epub 2017 Mar 18.

PMID:
28347633

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