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Separating dopamine D2 and D3 receptor sources of [11C]-(+)-PHNO binding potential: Independent component analysis of competitive binding.

Smart K, Gallezot JD, Nabulsi N, Labaree D, Zheng MQ, Huang Y, Carson RE, Hillmer AT, Worhunsky PD.

Neuroimage. 2020 Mar 19;214:116762. doi: 10.1016/j.neuroimage.2020.116762. [Epub ahead of print]


Kinetic modeling and test-retest reproducibility of 11C-EKAP and 11C-FEKAP, novel agonist radiotracers for PET imaging of the kappa opioid receptor in humans.

Naganawa M, Li S, Nabulsi NB, Lin SF, Labaree D, Ropchan J, Gao H, Mei M, Henry S, Matuskey D, Carson RE, Huang Y.

J Nucl Med. 2020 Mar 13. pii: jnumed.119.227694. doi: 10.2967/jnumed.119.227694. [Epub ahead of print]


Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study.

Bini J, Bhatt S, Hillmer AT, Gallezot JD, Nabulsi N, Pracitto R, Labaree D, Kapinos M, Ropchan J, Matuskey D, Sherwin RS, Jastreboff AM, Carson RE, Cosgrove K, Huang Y.

Mol Imaging Biol. 2020 Mar 4. doi: 10.1007/s11307-020-01490-z. [Epub ahead of print]


Guidelines for the content and format of PET brain data in publications and archives: A consensus paper.

Knudsen GM, Ganz M, Appelhoff S, Boellaard R, Bormans G, Carson RE, Catana C, Doudet D, Gee AD, Greve DN, Gunn RN, Halldin C, Herscovitch P, Huang H, Keller SH, Lammertsma AA, Lanzenberger R, Liow JS, Lohith TG, Lubberink M, Lyoo CH, Mann JJ, Matheson GJ, Nichols TE, Nørgaard M, Ogden T, Parsey R, Pike VW, Price J, Rizzo G, Rosa-Neto P, Schain M, Scott PJ, Searle G, Slifstein M, Suhara T, Talbot PS, Thomas A, Veronese M, Wong DF, Yaqub M, Zanderigo F, Zoghbi S, Innis RB.

J Cereb Blood Flow Metab. 2020 Feb 16:271678X20905433. doi: 10.1177/0271678X20905433. [Epub ahead of print] No abstract available.


Tobacco smoking in people is not associated with altered 18 kDa-translocator protein levels: A Positron Emission Tomography study.

Hillmer AT, Matuskey D, Huang H, Nabulsi NB, Ropchan J, Carson RE, O'Malley SS, Cosgrove KP.

J Nucl Med. 2020 Jan 31. pii: jnumed.119.237735. doi: 10.2967/jnumed.119.237735. [Epub ahead of print]


Data-driven motion detection and event-by-event correction for brain PET: Comparison with Vicra.

Lu Y, Naganawa M, Toyonaga T, Gallezot JD, Fontaine K, Ren S, Revilla EM, Mulnix T, Carson RE.

J Nucl Med. 2020 Jan 31. pii: jnumed.119.235515. doi: 10.2967/jnumed.119.235515. [Epub ahead of print]


Synthesis and Preclinical Evaluation of an 18F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [18F]SynVesT-2.

Cai Z, Li S, Zhang W, Pracitto R, Wu X, Baum E, Finnema SJ, Holden D, Toyonaga T, Lin SF, Lindemann M, Shirali A, Labaree DC, Ropchan J, Nabulsi N, Carson RE, Huang Y.

ACS Chem Neurosci. 2020 Feb 19;11(4):592-603. doi: 10.1021/acschemneuro.9b00618. Epub 2020 Feb 4.


PET imaging of mGluR5 in Alzheimer's disease.

Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH.

Alzheimers Res Ther. 2020 Jan 18;12(1):15. doi: 10.1186/s13195-020-0582-0.


Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging.

Matuskey D, Tinaz S, Wilcox KC, Naganawa M, Toyonaga T, Dias M, Henry S, Pittman B, Ropchan J, Nabulsi N, Suridjan I, Comley RA, Huang Y, Finnema SJ, Carson RE.

Ann Neurol. 2020 Mar;87(3):329-338. doi: 10.1002/ana.25682. Epub 2020 Feb 5.


In vivo 5-HT6 and 5-HT2A receptor availability in antipsychotic treated schizophrenia patients vs. unmedicated healthy humans measured with [11C]GSK215083 PET.

Radhakrishnan R, Matuskey D, Nabulsi N, Gaiser E, Gallezot JD, Henry S, Planeta B, Lin SF, Ropchan J, Huang Y, Carson RE, D'Souza DC.

Psychiatry Res Neuroimaging. 2020 Jan 30;295:111007. doi: 10.1016/j.pscychresns.2019.111007. Epub 2019 Nov 12.


Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET.

Holmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I.

J Cereb Blood Flow Metab. 2019 Nov 19:271678X19886316. doi: 10.1177/0271678X19886316. [Epub ahead of print] No abstract available.


Anti-edema and antioxidant combination therapy for ischemic stroke via glyburide-loaded betulinic acid nanoparticles.

Deng G, Ma C, Zhao H, Zhang S, Liu J, Liu F, Chen Z, Chen AT, Yang X, Avery J, Zou P, Du F, Lim KP, Holden D, Li S, Carson RE, Huang Y, Chen Q, Kimberly WT, Simard JM, Sheth KN, Zhou J.

Theranostics. 2019 Sep 21;9(23):6991-7002. doi: 10.7150/thno.35791. eCollection 2019.


Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [11C] MRB.

Sanchez-Rangel E, Gallezot JD, Yeckel CW, Lam W, Belfort-DeAguiar R, Chen MK, Carson RE, Sherwin R, Hwang JJ.

Int J Obes (Lond). 2020 Apr;44(4):964-967. doi: 10.1038/s41366-019-0471-4. Epub 2019 Oct 21.


PET Imaging of Pancreatic Dopamine D2 and D3 Receptor Density with 11C-(+)-PHNO in Type 1 Diabetes.

Bini J, Sanchez-Rangel E, Gallezot JD, Naganawa M, Nabulsi N, Lim K, Najafzadeh S, Shirali A, Ropchan J, Matuskey D, Huang Y, Herold KC, Harris PE, Sherwin RS, Carson RE, Cline GW.

J Nucl Med. 2020 Apr;61(4):570-576. doi: 10.2967/jnumed.119.234013. Epub 2019 Oct 10.


Assessment of a white matter reference region for 11C-UCB-J PET quantification.

Rossano S, Toyonaga T, Finnema SJ, Naganawa M, Lu Y, Nabulsi N, Ropchan J, De Bruyn S, Otoul C, Stockis A, Nicolas JM, Martin P, Mercier J, Huang Y, Maguire RP, Carson RE.

J Cereb Blood Flow Metab. 2019 Sep 30:271678X19879230. doi: 10.1177/0271678X19879230. [Epub ahead of print]


Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [11C]PBR28 HRRT PET study.

Tuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A; HRRT [11C ]PBR28 study group, Collste K, Gallezot JD, Hillmer A, Huang Y, Höglund CO, Johansson J, Jucaite A, Lampa J, Nabulsi N, Pittman B, Sandiego CM, Stenkrona P, Rinne J, Matuskey D, Cervenka S.

Eur J Nucl Med Mol Imaging. 2019 Oct;46(11):2329-2338. doi: 10.1007/s00259-019-04403-7. Epub 2019 Jul 30.


In vivo imaging of D2 receptors and corticosteroids predict behavioural responses to captivity stress in a wild bird.

Lattin CR, Merullo DP, Riters LV, Carson RE.

Sci Rep. 2019 Jul 18;9(1):10407. doi: 10.1038/s41598-019-46845-x.


Direct List Mode Parametric Reconstruction for Dynamic Cardiac SPECT.

Shi L, Lu Y, Wu J, Gallezot JD, Boutagy N, Thorn S, Sinusas AJ, Carson RE, Liu C.

IEEE Trans Med Imaging. 2020 Jan;39(1):119-128. doi: 10.1109/TMI.2019.2921969. Epub 2019 Jun 10.


Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A).

Li S, Cai Z, Zhang W, Holden D, Lin SF, Finnema SJ, Shirali A, Ropchan J, Carre S, Mercier J, Carson RE, Nabulsi N, Huang Y.

Eur J Nucl Med Mol Imaging. 2019 Aug;46(9):1952-1965. doi: 10.1007/s00259-019-04357-w. Epub 2019 Jun 7.


Human Positron Emission Tomography Neuroimaging.

Hooker JM, Carson RE.

Annu Rev Biomed Eng. 2019 Jun 4;21:551-581. doi: 10.1146/annurev-bioeng-062117-121056.


In Vivo Synaptic Density Imaging with 11C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer Disease.

Toyonaga T, Smith LM, Finnema SJ, Gallezot JD, Naganawa M, Bini J, Mulnix T, Cai Z, Ropchan J, Huang Y, Strittmatter SM, Carson RE.

J Nucl Med. 2019 Dec;60(12):1780-1786. doi: 10.2967/jnumed.118.223867. Epub 2019 May 17.


Quantification of PET infusion studies without true equilibrium: A tissue clearance correction.

Hillmer AT, Carson RE.

J Cereb Blood Flow Metab. 2020 Apr;40(4):860-874. doi: 10.1177/0271678X19850000. Epub 2019 May 14.


In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.

Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Carson RE, Krystal JH, Esterlis I.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11490-11495. doi: 10.1073/pnas.1818871116. Epub 2019 May 13. Erratum in: Proc Natl Acad Sci U S A. 2019 Jun 17;:.


Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study.

Martinez D, Slifstein M, Matuskey D, Nabulsi N, Zheng MQ, Lin SF, Ropchan J, Urban N, Grassetti A, Chang D, Salling M, Foltin R, Carson RE, Huang Y.

Neuropsychopharmacology. 2019 Sep;44(10):1720-1727. doi: 10.1038/s41386-019-0398-4. Epub 2019 Apr 26.


Lower synaptic density is associated with depression severity and network alterations.

Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I.

Nat Commun. 2019 Apr 4;10(1):1529. doi: 10.1038/s41467-019-09562-7.


Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers.

Matuskey D, Dias M, Naganawa M, Pittman B, Henry S, Li S, Gao H, Ropchan J, Nabulsi N, Carson RE, Huang Y.

Neuropsychopharmacology. 2019 Sep;44(10):1714-1719. doi: 10.1038/s41386-019-0379-7. Epub 2019 Mar 30.


A single-center, open-label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers.

Finnema SJ, Rossano S, Naganawa M, Henry S, Gao H, Pracitto R, Maguire RP, Mercier J, Kervyn S, Nicolas JM, Klitgaard H, DeBruyn S, Otoul C, Martin P, Muglia P, Matuskey D, Nabulsi NB, Huang Y, Kaminski RM, Hannestad J, Stockis A, Carson RE.

Epilepsia. 2019 May;60(5):958-967. doi: 10.1111/epi.14701. Epub 2019 Mar 29.


First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1.

Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT.

J Cereb Blood Flow Metab. 2020 Apr;40(4):695-704. doi: 10.1177/0271678X19838633. Epub 2019 Mar 21.


Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain.

Gallezot JD, Nabulsi N, Henry S, Pracitto R, Planeta B, Ropchan J, Lin SF, Labaree D, Kapinos M, Shirali A, Lara-Jaime T, Gao H, Matuskey D, Walzer M, Marek GJ, Bellaire S, Yuan N, Carson RE, Huang Y.

J Nucl Med. 2019 Aug;60(8):1140-1146. doi: 10.2967/jnumed.118.219766. Epub 2019 Mar 15.


Event-by-event non-rigid data-driven PET respiratory motion correction methods: comparison of principal component analysis and centroid of distribution.

Ren S, Lu Y, Bertolli O, Thielemans K, Carson RE.

Phys Med Biol. 2019 Aug 21;64(16):165014. doi: 10.1088/1361-6560/ab0bc9.


Evaluation of 11C-LSN3172176 as a Novel PET Tracer for Imaging M1 Muscarinic Acetylcholine Receptors in Nonhuman Primates.

Nabulsi NB, Holden D, Zheng MQ, Bois F, Lin SF, Najafzadeh S, Gao H, Ropchan J, Lara-Jaime T, Labaree D, Shirali A, Slieker L, Jesudason C, Barth V, Navarro A, Kant N, Carson RE, Huang Y.

J Nucl Med. 2019 Aug;60(8):1147-1153. doi: 10.2967/jnumed.118.222034. Epub 2019 Feb 7. Erratum in: J Nucl Med. 2019 Nov;60(11):1648.


Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET.

Lu Y, Gallezot JD, Naganawa M, Ren S, Fontaine K, Wu J, Onofrey JA, Toyonaga T, Boutagy N, Mulnix T, Panin VY, Casey ME, Carson RE, Liu C.

Phys Med Biol. 2019 Mar 8;64(6):065002. doi: 10.1088/1361-6560/ab02c2.


Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates.

Li S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, Gao H, Labaree D, Nabulsi N, Carson RE, Huang Y.

ACS Chem Neurosci. 2019 Mar 20;10(3):1544-1554. doi: 10.1021/acschemneuro.8b00526. Epub 2018 Nov 16.


Clinical and scientific value in the pursuit of quantification of beta cells in the pancreas by PET imaging.

Cline GW, McCarthy TJ, Carson RE, Calle RA.

Diabetologia. 2018 Dec;61(12):2671-2673. doi: 10.1007/s00125-018-4718-8. Epub 2018 Aug 22. No abstract available.


High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors.

Kelada OJ, Decker RH, Nath SK, Johung KL, Zheng MQ, Huang Y, Gallezot JD, Liu C, Carson RE, Oelfke U, Carlson DJ.

Int J Radiat Oncol Biol Phys. 2018 Sep 1;102(1):174-183. doi: 10.1016/j.ijrobp.2018.05.032. Epub 2018 Jun 1.


Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose.

Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C.

Phys Med Biol. 2018 Sep 6;63(17):175015. doi: 10.1088/1361-6560/aad97f.


In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents.

Boutagy NE, Wu J, Cai Z, Zhang W, Booth CJ, Kyriakides TC, Pfau D, Mulnix T, Liu Z, Miller EJ, Young LH, Carson RE, Huang Y, Liu C, Sinusas AJ.

JACC Basic Transl Sci. 2018 May 30;3(3):378-390. doi: 10.1016/j.jacbts.2018.02.003. eCollection 2018 Jun.


Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging.

Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH.

JAMA Neurol. 2018 Oct 1;75(10):1215-1224. doi: 10.1001/jamaneurol.2018.1836.


Kappa opioid receptor binding in major depression: A pilot study.

Miller JM, Zanderigo F, Purushothaman PD, DeLorenzo C, Rubin-Falcone H, Ogden RT, Keilp J, Oquendo MA, Nabulsi N, Huang YH, Parsey RV, Carson RE, Mann JJ.

Synapse. 2018 Sep;72(9):e22042. doi: 10.1002/syn.22042. Epub 2018 Jul 17.


Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging.

Cline GW, Naganawa M, Chen L, Chidsey K, Carvajal-Gonzalez S, Pawlak S, Rossulek M, Zhang Y, Bini J, McCarthy TJ, Carson RE, Calle RA.

Diabetologia. 2018 Dec;61(12):2598-2607. doi: 10.1007/s00125-018-4624-0. Epub 2018 May 2.


Age-Related Change in 5-HT6 Receptor Availability in Healthy Male Volunteers Measured with 11C-GSK215083 PET.

Radhakrishnan R, Nabulsi N, Gaiser E, Gallezot JD, Henry S, Planeta B, Lin SF, Ropchan J, Williams W, Morris E, D'Souza DC, Huang Y, Carson RE, Matuskey D.

J Nucl Med. 2018 Sep;59(9):1445-1450. doi: 10.2967/jnumed.117.206516. Epub 2018 Apr 6.


Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia.

Belfort-DeAguiar R, Gallezot JD, Hwang JJ, Elshafie A, Yeckel CW, Chan O, Carson RE, Ding YS, Sherwin RS.

J Clin Endocrinol Metab. 2018 Jun 1;103(6):2244-2252. doi: 10.1210/jc.2017-02717.


Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects.

D'Souza DC, Carson RE, Driesen N, Johannesen J, Ranganathan M, Krystal JH; Yale GlyT1 Study Group.

Biol Psychiatry. 2018 Sep 15;84(6):413-421. doi: 10.1016/j.biopsych.2017.12.019. Epub 2018 Jan 31.


Simplified Quantification and Acquisition Protocol for 123I-MIBG Dynamic SPECT.

Wu J, Gallezot JD, Lu Y, Ye Q, Liu H, Esserman DA, Kyriakides TC, Thorn SL, Zonouz TH, Liu YH, Lampert RJ, Sinusas AJ, Carson RE, Liu C.

J Nucl Med. 2018 Oct;59(10):1574-1580. doi: 10.2967/jnumed.117.202143. Epub 2018 Feb 23.


Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes.

Naganawa M, Lim K, Nabulsi NB, Lin SF, Labaree D, Ropchan J, Herold KC, Huang Y, Harris P, Ichise M, Cline GW, Carson RE.

Mol Imaging Biol. 2018 Oct;20(5):835-845. doi: 10.1007/s11307-018-1170-6.


Respiratory Motion Compensation for PET/CT with Motion Information Derived from Matched Attenuation-Corrected Gated PET Data.

Lu Y, Fontaine K, Mulnix T, Onofrey JA, Ren S, Panin V, Jones J, Casey ME, Barnett R, Kench P, Fulton R, Carson RE, Liu C.

J Nucl Med. 2018 Sep;59(9):1480-1486. doi: 10.2967/jnumed.117.203000. Epub 2018 Feb 9.


Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of 11C-(+)-PHNO.

Bini J, Naganawa M, Nabulsi N, Huang Y, Ropchan J, Lim K, Najafzadeh S, Herold KC, Cline GW, Carson RE.

J Nucl Med. 2018 Aug;59(8):1249-1254. doi: 10.2967/jnumed.117.197285. Epub 2018 Jan 25.


Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy.

Naganawa M, Gallezot JD, Rossano S, Carson RE.

Bull Math Biol. 2019 Sep;81(9):3508-3541. doi: 10.1007/s11538-017-0374-2. Epub 2017 Dec 11.


Cardiac-gated parametric images from 82 Rb PET from dynamic frames and direct 4D reconstruction.

Germino M, Carson RE.

Med Phys. 2018 Feb;45(2):639-654. doi: 10.1002/mp.12710. Epub 2017 Dec 30.


Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease.

Mecca AP, Barcelos NM, Wang S, Brück A, Nabulsi N, Planeta-Wilson B, Nadelmann J, Benincasa AL, Ropchan J, Huang Y, Gelernter J, Van Ness PH, Carson RE, van Dyck CH.

Neurobiol Aging. 2018 Jan;61:207-214. doi: 10.1016/j.neurobiolaging.2017.09.027. Epub 2017 Oct 6.

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