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Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [11C]PBR28 HRRT PET study.

Tuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A; HRRT [11C ]PBR28 study group, Collste K, Gallezot JD, Hillmer A, Huang Y, Höglund CO, Johansson J, Jucaite A, Lampa J, Nabulsi N, Pittman B, Sandiego CM, Stenkrona P, Rinne J, Matuskey D, Cervenka S.

Eur J Nucl Med Mol Imaging. 2019 Jul 30. doi: 10.1007/s00259-019-04403-7. [Epub ahead of print]


In vivo imaging of D2 receptors and corticosteroids predict behavioural responses to captivity stress in a wild bird.

Lattin CR, Merullo DP, Riters LV, Carson RE.

Sci Rep. 2019 Jul 18;9(1):10407. doi: 10.1038/s41598-019-46845-x.


Direct List Mode Parametric Reconstruction for Dynamic Cardiac SPECT.

Shi L, Lu Y, Wu J, Gallezot JD, Boutagy N, Thorn S, Sinusas AJ, Carson RE, Liu C.

IEEE Trans Med Imaging. 2019 Jun 10. doi: 10.1109/TMI.2019.2921969. [Epub ahead of print]


Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A).

Li S, Cai Z, Zhang W, Holden D, Lin SF, Finnema SJ, Shirali A, Ropchan J, Carre S, Mercier J, Carson RE, Nabulsi N, Huang Y.

Eur J Nucl Med Mol Imaging. 2019 Aug;46(9):1952-1965. doi: 10.1007/s00259-019-04357-w. Epub 2019 Jun 7.


Human Positron Emission Tomography Neuroimaging.

Hooker JM, Carson RE.

Annu Rev Biomed Eng. 2019 Jun 4;21:551-581. doi: 10.1146/annurev-bioeng-062117-121056.


In vivo synaptic density imaging with 11C-UCB-J detects treatment effects of saracatinib (AZD0530) in a mouse model of Alzheimer's disease.

Toyonaga T, Smith LM, Finnema SJ, Gallezot JD, Naganawa M, Bini J, Mulnix T, Cai Z, Ropchan J, Huang Y, Strittmatter SM, Carson RE.

J Nucl Med. 2019 May 17. pii: jnumed.118.223867. doi: 10.2967/jnumed.118.223867. [Epub ahead of print]


Quantification of PET infusion studies without true equilibrium: A tissue clearance correction.

Hillmer AT, Carson RE.

J Cereb Blood Flow Metab. 2019 May 14:271678X19850000. doi: 10.1177/0271678X19850000. [Epub ahead of print]


In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.

Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Carson RE, Krystal JH, Esterlis I.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11490-11495. doi: 10.1073/pnas.1818871116. Epub 2019 May 13. Erratum in: Proc Natl Acad Sci U S A. 2019 Jun 17;:.


Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study.

Martinez D, Slifstein M, Matuskey D, Nabulsi N, Zheng MQ, Lin SF, Ropchan J, Urban N, Grassetti A, Chang D, Salling M, Foltin R, Carson RE, Huang Y.

Neuropsychopharmacology. 2019 Sep;44(10):1720-1727. doi: 10.1038/s41386-019-0398-4. Epub 2019 Apr 26.


Lower synaptic density is associated with depression severity and network alterations.

Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I.

Nat Commun. 2019 Apr 4;10(1):1529. doi: 10.1038/s41467-019-09562-7.


Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers.

Matuskey D, Dias M, Naganawa M, Pittman B, Henry S, Li S, Gao H, Ropchan J, Nabulsi N, Carson RE, Huang Y.

Neuropsychopharmacology. 2019 Sep;44(10):1714-1719. doi: 10.1038/s41386-019-0379-7. Epub 2019 Mar 30.


A single-center, open-label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers.

Finnema SJ, Rossano S, Naganawa M, Henry S, Gao H, Pracitto R, Maguire RP, Mercier J, Kervyn S, Nicolas JM, Klitgaard H, DeBruyn S, Otoul C, Martin P, Muglia P, Matuskey D, Nabulsi NB, Huang Y, Kaminski RM, Hannestad J, Stockis A, Carson RE.

Epilepsia. 2019 May;60(5):958-967. doi: 10.1111/epi.14701. Epub 2019 Mar 29.


First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1.

Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT.

J Cereb Blood Flow Metab. 2019 Mar 21:271678X19838633. doi: 10.1177/0271678X19838633. [Epub ahead of print]


Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain.

Gallezot JD, Nabulsi N, Henry S, Pracitto R, Planeta B, Ropchan J, Lin SF, Labaree D, Kapinos M, Shirali A, Lara-Jaime T, Gao H, Matuskey D, Walzer M, Marek GJ, Bellaire S, Yuan N, Carson RE, Huang Y.

J Nucl Med. 2019 Aug;60(8):1140-1146. doi: 10.2967/jnumed.118.219766. Epub 2019 Mar 15.


Event-by-event non-rigid data-driven PET respiratory motion correction methods: comparison of principal component analysis and centroid of distribution.

Ren S, Lu Y, Bertolli O, Thielemans K, Carson RE.

Phys Med Biol. 2019 Mar 1. doi: 10.1088/1361-6560/ab0bc9. [Epub ahead of print]


Evaluation of 11C-LSN3172176 as a Novel PET Tracer for Imaging M1 Muscarinic Acetylcholine Receptors in Nonhuman Primates.

Nabulsi NB, Holden D, Zheng MQ, Bois F, Lin SF, Najafzadeh S, Gao H, Ropchan J, Lara-Jaime T, Labaree D, Shirali A, Slieker L, Jesudason C, Barth V, Navarro A, Kant N, Carson RE, Huang Y.

J Nucl Med. 2019 Aug;60(8):1147-1153. doi: 10.2967/jnumed.118.222034. Epub 2019 Feb 7.


Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET.

Lu Y, Gallezot JD, Naganawa M, Ren S, Fontaine K, Wu J, Onofrey JA, Toyonaga T, Boutagy N, Mulnix T, Panin VY, Casey ME, Carson RE, Liu C.

Phys Med Biol. 2019 Mar 8;64(6):065002. doi: 10.1088/1361-6560/ab02c2.


Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates.

Li S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, Gao H, Labaree D, Nabulsi N, Carson RE, Huang Y.

ACS Chem Neurosci. 2019 Mar 20;10(3):1544-1554. doi: 10.1021/acschemneuro.8b00526. Epub 2018 Nov 16.


Clinical and scientific value in the pursuit of quantification of beta cells in the pancreas by PET imaging.

Cline GW, McCarthy TJ, Carson RE, Calle RA.

Diabetologia. 2018 Dec;61(12):2671-2673. doi: 10.1007/s00125-018-4718-8. Epub 2018 Aug 22. No abstract available.


High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors.

Kelada OJ, Decker RH, Nath SK, Johung KL, Zheng MQ, Huang Y, Gallezot JD, Liu C, Carson RE, Oelfke U, Carlson DJ.

Int J Radiat Oncol Biol Phys. 2018 Sep 1;102(1):174-183. doi: 10.1016/j.ijrobp.2018.05.032. Epub 2018 Jun 1.


Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose.

Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C.

Phys Med Biol. 2018 Sep 6;63(17):175015. doi: 10.1088/1361-6560/aad97f.


In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents.

Boutagy NE, Wu J, Cai Z, Zhang W, Booth CJ, Kyriakides TC, Pfau D, Mulnix T, Liu Z, Miller EJ, Young LH, Carson RE, Huang Y, Liu C, Sinusas AJ.

JACC Basic Transl Sci. 2018 May 30;3(3):378-390. doi: 10.1016/j.jacbts.2018.02.003. eCollection 2018 Jun.


Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging.

Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH.

JAMA Neurol. 2018 Oct 1;75(10):1215-1224. doi: 10.1001/jamaneurol.2018.1836.


Kappa opioid receptor binding in major depression: A pilot study.

Miller JM, Zanderigo F, Purushothaman PD, DeLorenzo C, Rubin-Falcone H, Ogden RT, Keilp J, Oquendo MA, Nabulsi N, Huang YH, Parsey RV, Carson RE, Mann JJ.

Synapse. 2018 Sep;72(9):e22042. doi: 10.1002/syn.22042. Epub 2018 Jul 17.


Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging.

Cline GW, Naganawa M, Chen L, Chidsey K, Carvajal-Gonzalez S, Pawlak S, Rossulek M, Zhang Y, Bini J, McCarthy TJ, Carson RE, Calle RA.

Diabetologia. 2018 Dec;61(12):2598-2607. doi: 10.1007/s00125-018-4624-0. Epub 2018 May 2.


Age-Related Change in 5-HT6 Receptor Availability in Healthy Male Volunteers Measured with 11C-GSK215083 PET.

Radhakrishnan R, Nabulsi N, Gaiser E, Gallezot JD, Henry S, Planeta B, Lin SF, Ropchan J, Williams W, Morris E, D'Souza DC, Huang Y, Carson RE, Matuskey D.

J Nucl Med. 2018 Sep;59(9):1445-1450. doi: 10.2967/jnumed.117.206516. Epub 2018 Apr 6.


Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia.

Belfort-DeAguiar R, Gallezot JD, Hwang JJ, Elshafie A, Yeckel CW, Chan O, Carson RE, Ding YS, Sherwin RS.

J Clin Endocrinol Metab. 2018 Jun 1;103(6):2244-2252. doi: 10.1210/jc.2017-02717.


Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects.

D'Souza DC, Carson RE, Driesen N, Johannesen J, Ranganathan M, Krystal JH; Yale GlyT1 Study Group.

Biol Psychiatry. 2018 Sep 15;84(6):413-421. doi: 10.1016/j.biopsych.2017.12.019. Epub 2018 Jan 31.


Simplified Quantification and Acquisition Protocol for 123I-MIBG Dynamic SPECT.

Wu J, Gallezot JD, Lu Y, Ye Q, Liu H, Esserman DA, Kyriakides TC, Thorn SL, Zonouz TH, Liu YH, Lampert RJ, Sinusas AJ, Carson RE, Liu C.

J Nucl Med. 2018 Oct;59(10):1574-1580. doi: 10.2967/jnumed.117.202143. Epub 2018 Feb 23.


Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes.

Naganawa M, Lim K, Nabulsi NB, Lin SF, Labaree D, Ropchan J, Herold KC, Huang Y, Harris P, Ichise M, Cline GW, Carson RE.

Mol Imaging Biol. 2018 Oct;20(5):835-845. doi: 10.1007/s11307-018-1170-6.


Respiratory Motion Compensation for PET/CT with Motion Information Derived from Matched Attenuation-Corrected Gated PET Data.

Lu Y, Fontaine K, Mulnix T, Onofrey JA, Ren S, Panin V, Jones J, Casey ME, Barnett R, Kench P, Fulton R, Carson RE, Liu C.

J Nucl Med. 2018 Sep;59(9):1480-1486. doi: 10.2967/jnumed.117.203000. Epub 2018 Feb 9.


Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of 11C-(+)-PHNO.

Bini J, Naganawa M, Nabulsi N, Huang Y, Ropchan J, Lim K, Najafzadeh S, Herold KC, Cline GW, Carson RE.

J Nucl Med. 2018 Aug;59(8):1249-1254. doi: 10.2967/jnumed.117.197285. Epub 2018 Jan 25.


Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy.

Naganawa M, Gallezot JD, Rossano S, Carson RE.

Bull Math Biol. 2017 Dec 11. doi: 10.1007/s11538-017-0374-2. [Epub ahead of print]


Cardiac-gated parametric images from 82 Rb PET from dynamic frames and direct 4D reconstruction.

Germino M, Carson RE.

Med Phys. 2018 Feb;45(2):639-654. doi: 10.1002/mp.12710. Epub 2017 Dec 30.


Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease.

Mecca AP, Barcelos NM, Wang S, Brück A, Nabulsi N, Planeta-Wilson B, Nadelmann J, Benincasa AL, Ropchan J, Huang Y, Gelernter J, Van Ness PH, Carson RE, van Dyck CH.

Neurobiol Aging. 2018 Jan;61:207-214. doi: 10.1016/j.neurobiolaging.2017.09.027. Epub 2017 Oct 6.


Evaluation of (-)-[18 F]Flubatine-specific binding: Implications for reference region approaches.

Bhatt S, Hillmer AT, Nabulsi N, Matuskey D, Lim K, Lin SF, Esterlis I, Carson RE, Huang Y, Cosgrove KP.

Synapse. 2018 Mar;72(3). doi: 10.1002/syn.22016. Epub 2017 Nov 17.


Non-Rigid Event-by-Event Continuous Respiratory Motion Compensated List-Mode Reconstruction for PET.

Chan C, Onofrey J, Jian Y, Germino M, Papademetris X, Carson RE, Liu C.

IEEE Trans Med Imaging. 2018 Feb;37(2):504-515. doi: 10.1109/TMI.2017.2761756. Epub 2017 Oct 10.


Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study.

Abdallah CG, Hannestad J, Mason GF, Holmes SE, DellaGioia N, Sanacora G, Jiang L, Matuskey D, Satodiya R, Gasparini F, Lin X, Javitch J, Planeta B, Nabulsi N, Carson RE, Esterlis I.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Jul;2(5):449-456. doi: 10.1016/j.bpsc.2017.03.019. Epub 2017 Apr 6.


A 3D-printed modular device for imaging the brain of small birds.

Lattin CR, Emerson MA, Gallezot JD, Mulnix T, Brown JE, Carson RE.

J Neurosci Methods. 2018 Jan 1;293:183-190. doi: 10.1016/j.jneumeth.2017.10.005. Epub 2017 Oct 6.


The Search for a Subtype-Selective PET Imaging Agent for the GABAA Receptor Complex: Evaluation of the Radiotracer [11C]ADO in Nonhuman Primates.

Lin SF, Bois F, Holden D, Nabulsi N, Pracitto R, Gao H, Kapinos M, Teng JK, Shirali A, Ropchan J, Carson RE, Elmore CS, Vasdev N, Huang Y.

Mol Imaging. 2017 Jan-Dec;16:1536012117731258. doi: 10.1177/1536012117731258.


Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand 11C-BMT-136088 for Lung Imaging in Rhesus Monkeys.

Gallezot JD, Nabulsi NB, Holden D, Lin SF, Labaree D, Ropchan J, Najafzadeh S, Donnelly DJ, Cao K, Bonacorsi S, Seiders J, Roppe J, Hayes W, Huang Y, Du S, Carson RE.

J Nucl Med. 2018 Feb;59(2):327-333. doi: 10.2967/jnumed.117.195073. Epub 2017 Sep 1.


Estradiol modulates neural response to conspecific and heterospecific song in female house sparrows: An in vivo positron emission tomography study.

Lattin CR, Stabile FA, Carson RE.

PLoS One. 2017 Aug 23;12(8):e0182875. doi: 10.1371/journal.pone.0182875. eCollection 2017.


Kinetic evaluation and test-retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans.

Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE.

J Cereb Blood Flow Metab. 2018 Nov;38(11):2041-2052. doi: 10.1177/0271678X17724947. Epub 2017 Aug 9.


Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates.

Hillmer AT, Holden D, Fowles K, Nabulsi N, West BL, Carson RE, Cosgrove KP.

EJNMMI Res. 2017 Dec;7(1):59. doi: 10.1186/s13550-017-0305-0. Epub 2017 Jul 24.


Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence.

Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I; Traumatic Stress Brain Study Group.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8390-8395. doi: 10.1073/pnas.1701749114. Epub 2017 Jul 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Sep 5;:.


PET Imaging for Early Detection of Alzheimer's Disease: From Pathologic to Physiologic Biomarkers.

Bao W, Jia H, Finnema S, Cai Z, Carson RE, Huang YH.

PET Clin. 2017 Jul;12(3):329-350. doi: 10.1016/j.cpet.2017.03.001. Epub 2017 May 2. Review.


Data-driven event-by-event respiratory motion correction using TOF PET list-mode centroid of distribution.

Ren S, Jin X, Chan C, Jian Y, Mulnix T, Liu C, Carson RE.

Phys Med Biol. 2017 Jun 21;62(12):4741-4755. doi: 10.1088/1361-6560/aa700c. Epub 2017 May 18.


Direct reconstruction of parametric images for brain PET with event-by-event motion correction: evaluation in two tracers across count levels.

Germino M, Gallezot JD, Yan J, Carson RE.

Phys Med Biol. 2017 Jul 7;62(13):5344-5364. doi: 10.1088/1361-6560/aa731f. Epub 2017 May 15.


Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements.

Kelada OJ, Rockwell S, Zheng MQ, Huang Y, Liu Y, Booth CJ, Decker RH, Oelfke U, Carson RE, Carlson DJ.

Mol Imaging Biol. 2017 Dec;19(6):893-902. doi: 10.1007/s11307-017-1083-9.


Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression.

Esterlis I, DellaGioia N, Pietrzak RH, Matuskey D, Nabulsi N, Abdallah CG, Yang J, Pittenger C, Sanacora G, Krystal JH, Parsey RV, Carson RE, DeLorenzo C.

Mol Psychiatry. 2018 Apr;23(4):824-832. doi: 10.1038/mp.2017.58. Epub 2017 Apr 11.

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