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Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST; Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI); Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

Pediatr Crit Care Med. 2018 Sep;19(9):884-898. doi: 10.1097/PCC.0000000000001613.


Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Doctor A, Cholette JM, Remy KE, Argent A, Carson JL, Valentine SL, Bateman ST, Lacroix J; Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI); Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

Pediatr Crit Care Med. 2018 Sep;19(9S Suppl 1):S98-S113. doi: 10.1097/PCC.0000000000001590.


Clinical trials evaluating red blood cell transfusion thresholds: An updated systematic review and with additional focus on patients with cardiovascular disease.

Carson JL, Stanworth SJ, Alexander JH, Roubinian N, Fergusson DA, Triulzi DJ, Goodman SG, Rao SV, Doree C, Hebert PC.

Am Heart J. 2018 Jun;200:96-101. doi: 10.1016/j.ahj.2018.04.007. Epub 2018 Apr 7.


Bad Blood or Sick Patient?

Sedhom R, Strair R, Carson JL.

Biol Blood Marrow Transplant. 2018 May;24(5):884-886. doi: 10.1016/j.bbmt.2018.03.014. Epub 2018 Mar 15. No abstract available.


A comparison of outcomes between Canada and the United States in patients recovering from hip fracture repair: secondary analysis of the FOCUS trial.

Beaupre LA, Wai EK, Hoover DR, Noveck H, Roffey DM, Cook DR, Magaziner JS, Carson JL.

Int J Qual Health Care. 2018 Mar 1;30(2):97-103. doi: 10.1093/intqhc/mzx199.


Interleukin-13 stimulates production of nitric oxide in cultured human nasal epithelium.

Carson JL, Hernandez M, Jaspers I, Mills K, Brighton L, Zhou H, Zhang J, Hazucha MJ.

In Vitro Cell Dev Biol Anim. 2018 Mar;54(3):200-204. doi: 10.1007/s11626-018-0233-y. Epub 2018 Jan 29.


Adverse Effects of Red-Cell Transfusion.

Ness PM, Triulzi DJ, Carson JL.

N Engl J Med. 2018 Jan 4;378(1):97-98. doi: 10.1056/NEJMc1714159. No abstract available.


Indications for and Adverse Effects of Red-Cell Transfusion.

Carson JL, Triulzi DJ, Ness PM.

N Engl J Med. 2017 Sep 28;377(13):1261-1272. doi: 10.1056/NEJMra1612789. Review. No abstract available.


Anemia and bleeding in thrombocytopenic patients.

Carson JL, Stanworth SJ.

Blood. 2017 Sep 7;130(10):1178-1179. doi: 10.1182/blood-2017-07-795922. No abstract available.


Temporal structure/function variation in cultured differentiated human nasal epithelium associated with acute single exposure to tobacco smoke or E-cigarette vapor.

Carson JL, Zhou L, Brighton L, Mills KH, Zhou H, Jaspers I, Hazucha M.

Inhal Toxicol. 2017 Feb;29(3):137-144. doi: 10.1080/08958378.2017.1318985.


Regional versus General Anesthesia for Promoting Independence after Hip Fracture (REGAIN): protocol for a pragmatic, international multicentre trial.

Neuman MD, Ellenberg SS, Sieber FE, Magaziner JS, Feng R, Carson JL; REGAIN Investigators.

BMJ Open. 2016 Nov 15;6(11):e013473. doi: 10.1136/bmjopen-2016-013473.


Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion.

Carson JL, Stanworth SJ, Roubinian N, Fergusson DA, Triulzi D, Doree C, Hebert PC.

Cochrane Database Syst Rev. 2016 Oct 12;10:CD002042. Review.


Red blood cell transfusion: 2016 clinical practice guidelines from AABB.

Tobian AA, Heddle NM, Wiegmann TL, Carson JL.

Transfusion. 2016 Oct;56(10):2627-2630. doi: 10.1111/trf.13735. No abstract available.


Clinical Practice Guidelines From the AABB: Red Blood Cell Transfusion Thresholds and Storage.

Carson JL, Guyatt G, Heddle NM, Grossman BJ, Cohn CS, Fung MK, Gernsheimer T, Holcomb JB, Kaplan LJ, Katz LM, Peterson N, Ramsey G, Rao SV, Roback JD, Shander A, Tobian AA.

JAMA. 2016 Nov 15;316(19):2025-2035. doi: 10.1001/jama.2016.9185.


Red Blood Cell Transfusion Strategies in Adult and Pediatric Patients with Malignancy.

Roubinian N, Carson JL.

Hematol Oncol Clin North Am. 2016 Jun;30(3):529-40. doi: 10.1016/j.hoc.2016.01.001. Epub 2016 Feb 18. Review.


Clinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents.

Leigh MW, Ferkol TW, Davis SD, Lee HS, Rosenfeld M, Dell SD, Sagel SD, Milla C, Olivier KN, Sullivan KM, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer J, Hazucha MJ, Knowles MR.

Ann Am Thorac Soc. 2016 Aug;13(8):1305-13. doi: 10.1513/AnnalsATS.201511-748OC.


A comparison of CPAP and CPAPFLEX in the treatment of obstructive sleep apnea in World Trade Center responders: study protocol for a randomized controlled trial.

Ayappa I, Sunderram J, Black K, Twumasi A, Udasin I, Harrison D, Carson JL, Lu SE, Rapoport DM.

Trials. 2015 Sep 10;16:403. doi: 10.1186/s13063-015-0907-7.


The shifting paradigm for transfusion of red blood cells.

Carson JL.

Clin Adv Hematol Oncol. 2015 Mar;13(3):152-4. No abstract available.


Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes.

Zhang Z, Amorosa LF, Coyle SM, Macor MA, Lubitz SE, Carson JL, Birnbaum MJ, Lee LY, Haimovich B.

J Immunol. 2015 Sep 1;195(5):2452-60. doi: 10.4049/jimmunol.1500944. Epub 2015 Jul 31.


Restrictive red blood cell transfusion strategies appear safe in most clinical settings.

Roubinian NH, Carson JL.

Evid Based Med. 2015 Oct;20(5):170. doi: 10.1136/ebmed-2015-110218. Epub 2015 Jul 28. No abstract available.


Recovery of Walking Ability and Return to Community Living within 60 Days of Hip Fracture Does Not Differ Between Male and Female Survivors.

Beaupre LA, Carson JL, Noveck H, Magaziner J.

J Am Geriatr Soc. 2015 Aug;63(8):1640-4. doi: 10.1111/jgs.13535. Epub 2015 Jul 22.


Should red blood cell transfusion be individualized? No.

Holst LB, Carson JL, Perner A.

Intensive Care Med. 2015 Nov;41(11):1977-9. doi: 10.1007/s00134-015-3948-1. Epub 2015 Jul 7. No abstract available.


Stability of postoperative delirium psychomotor subtypes in individuals with hip fracture.

Albrecht JS, Marcantonio ER, Roffey DM, Orwig D, Magaziner J, Terrin M, Carson JL, Barr E, Brown JP, Gentry EG, Gruber-Baldini AL; Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair Cognitive Ancillary Study Investigators.

J Am Geriatr Soc. 2015 May;63(5):970-6. doi: 10.1111/jgs.13334. Epub 2015 May 4.


Effects of red-cell storage duration on patients undergoing cardiac surgery.

Steiner ME, Ness PM, Assmann SF, Triulzi DJ, Sloan SR, Delaney M, Granger S, Bennett-Guerrero E, Blajchman MA, Scavo V, Carson JL, Levy JH, Whitman G, D'Andrea P, Pulkrabek S, Ortel TL, Bornikova L, Raife T, Puca KE, Kaufman RM, Nuttall GA, Young PP, Youssef S, Engelman R, Greilich PE, Miles R, Josephson CD, Bracey A, Cooke R, McCullough J, Hunsaker R, Uhl L, McFarland JG, Park Y, Cushing MM, Klodell CT, Karanam R, Roberts PR, Dyke C, Hod EA, Stowell CP.

N Engl J Med. 2015 Apr 9;372(15):1419-29. doi: 10.1056/NEJMoa1414219.


Transfusion strategies in hematologic and nonhematologic disease.

Carson JL, Strair R.

Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):548-52. doi: 10.1182/asheducation-2014.1.548. Epub 2014 Nov 18. Review.


Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial.

Carson JL, Sieber F, Cook DR, Hoover DR, Noveck H, Chaitman BR, Fleisher L, Beaupre L, Macaulay W, Rhoads GG, Paris B, Zagorin A, Sanders DW, Zakriya KJ, Magaziner J.

Lancet. 2015 Mar 28;385(9974):1183-9. doi: 10.1016/S0140-6736(14)62286-8. Epub 2014 Dec 9.


Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype.

Davis SD, Ferkol TW, Rosenfeld M, Lee HS, Dell SD, Sagel SD, Milla C, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer JP, Hazucha MJ, Cooper ML, Knowles MR, Leigh MW.

Am J Respir Crit Care Med. 2015 Feb 1;191(3):316-24. doi: 10.1164/rccm.201409-1672OC.


Red blood cell transfusion thresholds: can we go even lower?

Carson JL, Patel MS.

Transfusion. 2014 Oct;54(10 Pt 2):2593-4. doi: 10.1111/trf.12812. No abstract available.


Phenotypic modification of human airway epithelial cells in air-liquid interface culture induced by exposure to the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Carson JL, Brighton LE, Jaspers I.

Ultrastruct Pathol. 2015 Apr;39(2):104-9. doi: 10.3109/01913123.2014.960546. Epub 2014 Oct 2.


Transfusion threshold of 7 g per deciliter--the new normal.

Hébert PC, Carson JL.

N Engl J Med. 2014 Oct 9;371(15):1459-61. doi: 10.1056/NEJMe1408976. Epub 2014 Oct 1. No abstract available.


Trends in red blood cell transfusion and 30-day mortality among hospitalized patients.

Roubinian NH, Escobar GJ, Liu V, Swain BE, Gardner MN, Kipnis P, Triulzi DJ, Gottschall JL, Wu Y, Carson JL, Kleinman SH, Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III).

Transfusion. 2014 Oct;54(10 Pt 2):2678-86. doi: 10.1111/trf.12825. Epub 2014 Aug 18.


The Gillings Sampler--an electrostatic air sampler as an alternative method for aerosol in vitro exposure studies.

Zavala J, Lichtveld K, Ebersviller S, Carson JL, Walters GW, Jaspers I, Jeffries HE, Sexton KG, Vizuete W.

Chem Biol Interact. 2014 Sep 5;220:158-68. doi: 10.1016/j.cbi.2014.06.026. Epub 2014 Jul 7.


Decreased red blood cell use and mortality in hospitalized patients.

Roubinian NH, Escobar GJ, Liu V, Gardner MN, Carson JL, Kleinman SH, Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III).

JAMA Intern Med. 2014 Aug;174(8):1405-7. doi: 10.1001/jamainternmed.2014.2889. No abstract available.


Management of postoperative complications: anemia.

Willett LR, Carson JL.

Clin Geriatr Med. 2014 May;30(2):279-84. doi: 10.1016/j.cger.2014.01.006. Epub 2014 Mar 4. Review.


Blood transfusion and risk of infection: new convincing evidence.

Carson JL.

JAMA. 2014 Apr 2;311(13):1293-4. doi: 10.1001/jama.2014.2727. No abstract available. Erratum in: JAMA. 2014 Nov 19;312(19):2045.


Laterality defects other than situs inversus totalis in primary ciliary dyskinesia: insights into situs ambiguus and heterotaxy.

Shapiro AJ, Davis SD, Ferkol T, Dell SD, Rosenfeld M, Olivier KN, Sagel SD, Milla C, Zariwala MA, Wolf W, Carson JL, Hazucha MJ, Burns K, Robinson B, Knowles MR, Leigh MW; Genetic Disorders of Mucociliary Clearance Consortium.

Chest. 2014 Nov;146(5):1176-1186. doi: 10.1378/chest.13-1704.


Mutations in RSPH1 cause primary ciliary dyskinesia with a unique clinical and ciliary phenotype.

Knowles MR, Ostrowski LE, Leigh MW, Sears PR, Davis SD, Wolf WE, Hazucha MJ, Carson JL, Olivier KN, Sagel SD, Rosenfeld M, Ferkol TW, Dell SD, Milla CE, Randell SH, Yin W, Sannuti A, Metjian HM, Noone PG, Noone PJ, Olson CA, Patrone MV, Dang H, Lee HS, Hurd TW, Gee HY, Otto EA, Halbritter J, Kohl S, Kircher M, Krischer J, Bamshad MJ, Nickerson DA, Hildebrandt F, Shendure J, Zariwala MA.

Am J Respir Crit Care Med. 2014 Mar 15;189(6):707-17. doi: 10.1164/rccm.201311-2047OC.


Should we universally adopt a restrictive approach to blood transfusion? It's all about the number.

Carson JL, Hebert PC.

Am J Med. 2014 Feb;127(2):103-4. doi: 10.1016/j.amjmed.2013.10.026. Epub 2013 Nov 21. No abstract available.


Culturing of human nasal epithelial cells at the air liquid interface.

Müller L, Brighton LE, Carson JL, Fischer WA 2nd, Jaspers I.

J Vis Exp. 2013 Oct 8;(80). doi: 10.3791/50646.


Evidence review: periprocedural use of blood products.

Hogshire LC, Patel MS, Rivera E, Carson JL.

J Hosp Med. 2013 Nov;8(11):647-52. doi: 10.1002/jhm.2089. Epub 2013 Oct 12. Review.


Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.

Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O'Toole E, Porath JD, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Hwang DY, Braun DA, Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE, Loges NT, Omran H, Porter ME, King SM, Knowles MR, Drummond IA, Hildebrandt F.

Am J Hum Genet. 2013 Oct 3;93(4):672-86. doi: 10.1016/j.ajhg.2013.08.015.


Response to Dr Sandar et al.

Carson JL, Brooks MM, Abbott JD, Kelsey SF, Triulzi DJ, Menegus MA, Marroquin OC, Rao SV, Smitherman T, Vagaonescu T, Wimmer NJ, Williams DO.

Am Heart J. 2013 Oct;166(4):e27-8. doi: 10.1016/j.ahj.2013.07.022. Epub 2013 Aug 29. No abstract available.


Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms.

Knowles MR, Ostrowski LE, Loges NT, Hurd T, Leigh MW, Huang L, Wolf WE, Carson JL, Hazucha MJ, Yin W, Davis SD, Dell SD, Ferkol TW, Sagel SD, Olivier KN, Jahnke C, Olbrich H, Werner C, Raidt J, Wallmeier J, Pennekamp P, Dougherty GW, Hjeij R, Gee HY, Otto EA, Halbritter J, Chaki M, Diaz KA, Braun DA, Porath JD, Schueler M, Baktai G, Griese M, Turner EH, Lewis AP, Bamshad MJ, Nickerson DA, Hildebrandt F, Shendure J, Omran H, Zariwala MA.

Am J Hum Genet. 2013 Oct 3;93(4):711-20. doi: 10.1016/j.ajhg.2013.07.025. Epub 2013 Sep 19.


Standardizing nasal nitric oxide measurement as a test for primary ciliary dyskinesia.

Leigh MW, Hazucha MJ, Chawla KK, Baker BR, Shapiro AJ, Brown DE, Lavange LM, Horton BJ, Qaqish B, Carson JL, Davis SD, Dell SD, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Rosenfeld M, Milla C, Lee HS, Krischer J, Zariwala MA, Knowles MR.

Ann Am Thorac Soc. 2013 Dec;10(6):574-81. doi: 10.1513/AnnalsATS.201305-110OC.


A new tool improves diagnostic test performance for transmission em evaluation of axonemal dynein arms.

Funkhouser WK 3rd, Niethammer M, Carson JL, Burns KA, Knowles MR, Leigh MW, Zariwala MA, Funkhouser WK Jr.

Ultrastruct Pathol. 2014 Aug;38(4):248-55. doi: 10.3109/01913123.2013.815081. Epub 2013 Aug 19.


Red blood cell transfusion: what is the evidence when to transfuse?

Hogshire L, Carson JL.

Curr Opin Hematol. 2013 Nov;20(6):546-51. doi: 10.1097/MOH.0b013e32836508bd. Review.


Delirium outcomes in a randomized trial of blood transfusion thresholds in hospitalized older adults with hip fracture.

Gruber-Baldini AL, Marcantonio E, Orwig D, Magaziner J, Terrin M, Barr E, Brown JP, Paris B, Zagorin A, Roffey DM, Zakriya K, Blute MR, Hebel JR, Carson JL.

J Am Geriatr Soc. 2013 Aug;61(8):1286-95. doi: 10.1111/jgs.12396. Epub 2013 Jul 30.


DYX1C1 is required for axonemal dynein assembly and ciliary motility.

Tarkar A, Loges NT, Slagle CE, Francis R, Dougherty GW, Tamayo JV, Shook B, Cantino M, Schwartz D, Jahnke C, Olbrich H, Werner C, Raidt J, Pennekamp P, Abouhamed M, Hjeij R, Köhler G, Griese M, Li Y, Lemke K, Klena N, Liu X, Gabriel G, Tobita K, Jaspers M, Morgan LC, Shapiro AJ, Letteboer SJ, Mans DA, Carson JL, Leigh MW, Wolf WE, Chen S, Lucas JS, Onoufriadis A, Plagnol V, Schmidts M, Boldt K; UK10K, Roepman R, Zariwala MA, Lo CW, Mitchison HM, Knowles MR, Burdine RD, Loturco JJ, Omran H.

Nat Genet. 2013 Sep;45(9):995-1003. doi: 10.1038/ng.2707. Epub 2013 Jul 21.


DNA methylation in nasal epithelial cells from smokers: identification of ULBP3-related effects.

Rager JE, Bauer RN, Müller LL, Smeester L, Carson JL, Brighton LE, Fry RC, Jaspers I.

Am J Physiol Lung Cell Mol Physiol. 2013 Sep 15;305(6):L432-8. doi: 10.1152/ajplung.00116.2013. Epub 2013 Jul 5.

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